DK586789A - METHOD FOR PREPARING 2- (2- (4 - (((4-CHLORPHENYL) PHENYLMETHYL) -1-PIPERAZINYL) ETHOXY) ACETIC ACID AND ITS DIHYDROCHLORIDE - Google Patents

METHOD FOR PREPARING 2- (2- (4 - (((4-CHLORPHENYL) PHENYLMETHYL) -1-PIPERAZINYL) ETHOXY) ACETIC ACID AND ITS DIHYDROCHLORIDE

Info

Publication number
DK586789A
DK586789A DK586789A DK586789A DK586789A DK 586789 A DK586789 A DK 586789A DK 586789 A DK586789 A DK 586789A DK 586789 A DK586789 A DK 586789A DK 586789 A DK586789 A DK 586789A
Authority
DK
Denmark
Prior art keywords
chlorphenyl
phenylmethyl
dihydrochloride
piperazinyl
ethoxy
Prior art date
Application number
DK586789A
Other languages
Danish (da)
Other versions
DK174543B1 (en
DK586789D0 (en
Inventor
Eric Cossement
Genevieve Motte
Guy Bodson
Jean Gobert
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of DK586789D0 publication Critical patent/DK586789D0/en
Publication of DK586789A publication Critical patent/DK586789A/en
Application granted granted Critical
Publication of DK174543B1 publication Critical patent/DK174543B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK198905867A 1988-11-23 1989-11-22 Process for the preparation of 2- [2- [4 - [[((4-chlorophenyl) phenylmethyl)] - 1-piperazinyl] ethoxy] acetic acid and its dihydrochloride and starting compound for use in the process DK174543B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888827391A GB8827391D0 (en) 1988-11-23 1988-11-23 Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827391 1988-11-23

Publications (3)

Publication Number Publication Date
DK586789D0 DK586789D0 (en) 1989-11-22
DK586789A true DK586789A (en) 1990-05-24
DK174543B1 DK174543B1 (en) 2003-05-19

Family

ID=10647347

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198905867A DK174543B1 (en) 1988-11-23 1989-11-22 Process for the preparation of 2- [2- [4 - [[((4-chlorophenyl) phenylmethyl)] - 1-piperazinyl] ethoxy] acetic acid and its dihydrochloride and starting compound for use in the process

Country Status (16)

Country Link
KR (1) KR970009728B1 (en)
AT (1) AT398971B (en)
CA (1) CA1317300C (en)
CY (1) CY1671A (en)
DK (1) DK174543B1 (en)
ES (1) ES2021907A6 (en)
FI (1) FI91862C (en)
GB (2) GB8827391D0 (en)
GR (1) GR1000553B (en)
HK (1) HK95892A (en)
HU (1) HU205094B (en)
NO (1) NO172342C (en)
PH (1) PH25982A (en)
PL (1) PL161379B1 (en)
PT (1) PT92364B (en)
SG (1) SG89492G (en)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0661975T3 (en) * 1992-09-24 1999-09-27 Sepracor Inc Transdermal treatment of hives using optically pure (+) - cetirizine
JPH08501561A (en) * 1992-09-24 1996-02-20 セプラコア，インコーポレイテッド (-) Composition for treating allergic diseases using cetirizine
AU703690B2 (en) * 1992-09-24 1999-04-01 Sepracor, Inc. Methods for treating allergic disorders using optically pure (+)cetirizine
GB9305282D0 (en) * 1993-03-15 1993-05-05 Ucb Sa Enantiomers of 1-(4-chlorophenyl)phenylmethyl)-4-(4-methylphenyl)sulphonyl)piperazine
US6469009B1 (en) 1996-04-08 2002-10-22 Ucb, S.A. Pharmaceutical compositions for the treatment of rhinitis
BE1010094A3 (en) * 1996-04-10 1997-12-02 Ucb Sa NEW [2- (1-piperazinyl) ethoxy] SUBSTITUTED.
BE1010095A3 (en) * 1996-04-10 1997-12-02 Ucb Sa METHOD OF PREPARATION OF ACID 2- [2- [4 - [(4-Chlorophenyl) phenylmethyl] -1-PIPERAZINYL] ETHOXY] acetic acid AND ITS SALTS.
JP3476475B2 (en) 1997-06-04 2003-12-10 株式会社アズウェル Method for producing piperazine sulfonamide derivative and salt thereof
EP0919550A1 (en) * 1997-11-26 1999-06-02 Ucb, S.A. Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride
IL124195A (en) * 1998-04-23 2000-08-31 Chemagis Ltd Process for the preparation of esters of 2-¬4-¬4-chlorophenyl¾phenylmethyl¾-1-piperazinyl¬ethoxy¾acetic acid
GR990100135A (en) * 1999-04-22 2000-12-29 Genepharm �.�. Method of preparation 2-(2-{4-[(4-chlorophenyl)(phenyl)methhyl]piperasine}-ethoxy)acetic acid and its bihydrochloric salt
JP2002249487A (en) * 2001-02-22 2002-09-06 Sumitomo Chem Co Ltd 4-(tert-butoxycarbonyl)piperazine derivative, optically active acid addition salt of the same, method for producing them and optically active 1-[(substituted phenyl)phenylmethylpiperazine which uses them
US6977301B1 (en) 2001-05-29 2005-12-20 Ucb, S.A. Process for preparing (S) and (R)—2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
US7199241B1 (en) 2001-05-29 2007-04-03 Ucb, S.A. Process for preparing (S) and (R)-2-[4-(4-chlorobenzhydryl)piperazin-1-yl]-ethoxyacetamide
WO2004065360A2 (en) * 2003-01-23 2004-08-05 Ucb Farchim Sa Piperazine derivatives and their use as synthesis intermediates
KR100503443B1 (en) 2004-02-02 2005-07-22 한림제약(주) Processes for preparing an optically active cetirizine or its salt
ATE433444T1 (en) * 2005-03-03 2009-06-15 Ucb Farchim Sa PYROGLUTAMAT SALTS AND THEIR USE IN THE OPTICAL SEPARATION OF INTERMEDIATE PRODUCTS FOR THE SYNTHESIS OF DEXTROCETIRIZINE AND LEVOCETIRIZINE
HU227325B1 (en) * 2005-12-08 2011-03-28 Egis Gyogyszergyar Nyrt Process for the production of an intermediate of (dextro- and levo)- cetirizine
SI22489A (en) * 2007-03-12 2008-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto New procedure for preparation of levocetirizine and its intermediates
WO2008110586A2 (en) 2007-03-12 2008-09-18 Krka, Tovarna Zdravil, D.D., Novo Mesto New process for the preparation of levocetirizine and intermediates thereof
US8084606B2 (en) 2007-06-15 2011-12-27 Symed Labs Limited Process for preparation of substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine using novel intermediates
WO2009062036A2 (en) * 2007-11-09 2009-05-14 Dr. Reddy's Laboratories Ltd. Processes for preparing levocetirizine and pharmaceutically acceptable salts thereof
DE602007012725D1 (en) 2007-11-21 2011-04-07 Synthon Bv Process for the preparation of N- (diphenylmethyl) piperazines
US7989623B2 (en) 2007-11-21 2011-08-02 Synthon Bv Process for making n-(diphenylmethyl)piperazines
CN102046612A (en) 2008-06-02 2011-05-04 希普拉有限公司 Processes for the synthesis of levocetirizine and intermediates for use therein
WO2009150147A1 (en) * 2008-06-11 2009-12-17 Krka, Tovarna Zdravil, D.D., Novo Mesto New process for the preparation of levocetirizine and intermediates thereof
KR100998067B1 (en) 2008-09-08 2010-12-03 주식회사 삼오제약 A novel Bis1-[4-chlorophenylphenylmethyl]piperazine-2,3-Dibenzoyl tartarate intermediate salt and the method for isolating optically active 1-[4-chlorophenylphenylmethyl]piperazine using thereby
US20110172425A1 (en) 2008-09-17 2011-07-14 Calyx Chemicals And Pharmaceuticals Pvt. Ltd. Novel water based process for the preparation of substituted diphenylmethyl piperazines
WO2010107404A1 (en) 2009-03-16 2010-09-23 Mahmut Bilgic Stable pharmaceutical combinations
TR201007652A2 (en) 2010-09-20 2012-04-24 Bi̇lgi̇ç Mahmut Synergistic effect.
TR201009398A2 (en) 2010-11-11 2012-05-21 Bi̇lgi̇ç Mahmut Tablet formulations with improved physical properties
WO2012101475A1 (en) 2011-01-27 2012-08-02 Jubilant Life Sciences Limited An improved process for the preparation of antihistaminic drugs via a novel carbamate intermediate
CN103044355A (en) * 2011-10-13 2013-04-17 湖南九典制药有限公司 Key intermediate for synthesizing levocetirizine and preparation method thereof
KR101418404B1 (en) 2012-01-06 2014-07-10 한미약품 주식회사 Stable pharmaceutical formulation for oral administration comprising levocetirizine or a pharmaceutically acceptable salt thereof, and montelukast or a pharmaceutically acceptable salt thereof
KR102226833B1 (en) 2013-06-28 2021-03-12 한미약품 주식회사 Complex granule formulation having improved stability comprising levocetirizine and montelukast
CN104045607B (en) * 2014-05-21 2016-04-13 丽珠医药集团股份有限公司 A kind of purification process of cetrizine hcl
CN105924409B (en) * 2016-05-12 2019-01-08 浙江永宁药业股份有限公司 The method for splitting of one kind (R) -1- ((2- chlorphenyl)-(phenyl)-methyl)-piperazine
CN111205247B (en) * 2020-04-22 2020-08-14 湖南九典宏阳制药有限公司 Preparation method of levocetirizine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO155805C (en) * 1981-02-06 1987-06-10 Ucb Sa ANALOGY PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVITY 2- (4- (DIPHENYLMETHYL) -1-PIPERAZINYL) -ACDIC ACIDS AND THEIR AMIDS AND NON-TOXIC SALTS.

Also Published As

Publication number Publication date
PT92364A (en) 1990-05-31
GR1000553B (en) 1992-08-26
GB8827391D0 (en) 1988-12-29
HU896131D0 (en) 1990-02-28
HUT53627A (en) 1990-11-28
PH25982A (en) 1992-01-13
NO894651D0 (en) 1989-11-22
PT92364B (en) 1995-07-18
PL161379B1 (en) 1993-06-30
FI91862B (en) 1994-05-13
CY1671A (en) 1993-05-14
DK174543B1 (en) 2003-05-19
FI91862C (en) 1994-08-25
ATA266589A (en) 1994-07-15
KR900007825A (en) 1990-06-02
NO172342B (en) 1993-03-29
AT398971B (en) 1995-02-27
FI895564A0 (en) 1989-11-22
HK95892A (en) 1992-12-11
ES2021907A6 (en) 1991-11-16
CA1317300C (en) 1993-05-04
GR890100770A (en) 1990-12-31
NO894651L (en) 1990-05-25
GB8926243D0 (en) 1990-01-10
NO172342C (en) 1993-07-07
DK586789D0 (en) 1989-11-22
SG89492G (en) 1992-12-04
GB2225321B (en) 1992-04-08
KR970009728B1 (en) 1997-06-17
HU205094B (en) 1992-03-30
GB2225321A (en) 1990-05-30

Similar Documents

Publication Publication Date Title
DK586789A (en) METHOD FOR PREPARING 2- (2- (4 - (((4-CHLORPHENYL) PHENYLMETHYL) -1-PIPERAZINYL) ETHOXY) ACETIC ACID AND ITS DIHYDROCHLORIDE
DK586589D0 (en) METHOD FOR PREPARING 2- (2- (4 - (((4-CHLORPHENYL) PHENYLMETHYL) -1-PIPERAZINYL) ETHOXY) ACETIC ACID AND ITS DIHYDROCHLORIDE
PL294704A1 (en) Method of obtaining 4-(2-(2-hydroxy-2-phenylethylamine)ethoxy) phenyloacetic acid and its bioprecursor substances
ATE267185T1 (en) THERAPEUTICALLY EFFECTIVE LEFT-WINDING AND RIGHT-WOTTING 1-((4-CHLORPHENYL)PHENYLMETHYL) PIPERAZINE
DK108891D0 (en) 4- (4-PHENYL-1-PIPERAZINYL) PHENOLES AND PROCEDURES FOR PREPARING THEREOF
NO880352D0 (en) PROCEDURE FOR THE PREPARATION OF 4-ARYL-N- (2- (DIALCYLAMINO AND HETEROCYCLIC AMINO) ALKYL) -1-PIPERAZINE CARBOXAMIDES.
SE8105341L (en) N - ((4- (3-SUBSTITUTED PYRIDYL) PIPERAZINO) ALKYL) AZASPIRODE SCANDIONS
NO306860B1 (en) Process for the preparation of 2- [2- [4 - [(4-chlorophenyl) phenylmethyl] -1-piperazinyl] ethoxy] acetic acid and its salts
PL287224A1 (en) Method of obtaining 2-(2-(4-(/4-chlorophenyl/phenylmethyl)-1-piperazinyl) ethoxy) acetic acid and its dihydrohloride
JPS57149282A (en) 2-(4-(diphenylmethyl)-1-piperazinyl)acetic acid and their derivatives as medicine
DK557184A (en) 2- (3-PYRIDYL) -2-PHENYLAMINO ACETIC ACID DERIVATIVES, METHOD OF PREPARING THEREOF AND USING SUCH DERIVATIVES AS ANTI-FUNGUS AGENTS
DK590084D0 (en) 2- (1-IMIDAZOLYL) -ETHANOL DERIVATIVES, PROCEDURES FOR THEIR PREPARATION AND THEIR USE
PH23922A (en) Crystalline 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole dihydrochloride
NO168824C (en) PROCEDURE FOR PREPARING 2- (SUBSTITUTED-3-GUANIDINO) -4- (2-METHYL-4-IMIDAZOLYL) -TIAZOL AND N- (SUBSTITUTED AMIDINO) TIOUREA THEREOF

Legal Events

Date Code Title Description
PBP Patent lapsed

Country of ref document: DK