DK174394B1 - Racematspaltning af 3-acyloxy-bicyklo[3,3,0]-octan-2-carboxylsyreestere ved stereospecifik enzymatisk eller mikrobiologisk acylathydrolyse til fremstilling af optisk aktive (+)-bicyklo-[3,3,0]octanolderivater - Google Patents
Racematspaltning af 3-acyloxy-bicyklo[3,3,0]-octan-2-carboxylsyreestere ved stereospecifik enzymatisk eller mikrobiologisk acylathydrolyse til fremstilling af optisk aktive (+)-bicyklo-[3,3,0]octanolderivater Download PDFInfo
- Publication number
- DK174394B1 DK174394B1 DK198803891A DK389188A DK174394B1 DK 174394 B1 DK174394 B1 DK 174394B1 DK 198803891 A DK198803891 A DK 198803891A DK 389188 A DK389188 A DK 389188A DK 174394 B1 DK174394 B1 DK 174394B1
- Authority
- DK
- Denmark
- Prior art keywords
- bicyclo
- atoms
- octane
- carboxylic acid
- octanol
- Prior art date
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 101150095588 pgi2 gene Proteins 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 229940014800 succinic anhydride Drugs 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000010626 work up procedure Methods 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/005—Analogues or derivatives having the five membered ring replaced by other rings
- C07C405/0075—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
- C07C405/0083—Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
- C12P7/26—Ketones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863638758 DE3638758A1 (de) | 1986-11-13 | 1986-11-13 | Racematspaltung von 3-acyloxy-bicyclo(3.3.0)octan-7-on-2- carbonsaeureestern durch stereospezifische enzymatische oder mikrobiologische acylat-hydrolyse |
| DE3638758 | 1986-11-13 | ||
| PCT/DE1987/000513 WO1988003567A1 (fr) | 1986-11-13 | 1987-11-12 | Clivage racemique de 3-acyloxy-bicyclo [3.3.0] octane-7-one-2 esters d'acide carboxylique par hydrolyse d'acylate stereospecifique enzimatique ou microbiologique |
| DE8700513 | 1987-11-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK389188A DK389188A (da) | 1988-07-12 |
| DK389188D0 DK389188D0 (da) | 1988-07-12 |
| DK174394B1 true DK174394B1 (da) | 2003-01-27 |
Family
ID=6313858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198803891A DK174394B1 (da) | 1986-11-13 | 1988-07-12 | Racematspaltning af 3-acyloxy-bicyklo[3,3,0]-octan-2-carboxylsyreestere ved stereospecifik enzymatisk eller mikrobiologisk acylathydrolyse til fremstilling af optisk aktive (+)-bicyklo-[3,3,0]octanolderivater |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4894336A (ru) |
| EP (1) | EP0271432B1 (ru) |
| JP (2) | JP2736066B2 (ru) |
| AT (1) | ATE80664T1 (ru) |
| AU (1) | AU613328B2 (ru) |
| BG (1) | BG48099A3 (ru) |
| CA (1) | CA1301100C (ru) |
| CS (1) | CS268542B2 (ru) |
| DD (1) | DD264233A5 (ru) |
| DE (2) | DE3638758A1 (ru) |
| DK (1) | DK174394B1 (ru) |
| ES (1) | ES2044969T3 (ru) |
| FI (1) | FI92499C (ru) |
| GR (1) | GR3006013T3 (ru) |
| HU (1) | HU202596B (ru) |
| IE (1) | IE61662B1 (ru) |
| NO (1) | NO172903C (ru) |
| RU (1) | RU1788968C (ru) |
| WO (1) | WO1988003567A1 (ru) |
| ZA (1) | ZA878542B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8600245D0 (en) * | 1986-01-07 | 1986-02-12 | Shell Int Research | Preparation of 2-arylpropionic acids |
| DE3638760A1 (de) * | 1986-11-13 | 1988-05-26 | Schering Ag | Verfahren zur herstellung von optisch aktiven bicyclo(3.3.0)octandioncarbonsaeureestern |
| JPH01257484A (ja) * | 1987-12-14 | 1989-10-13 | Idemitsu Kosan Co Ltd | 光学活性な二級アルコールの製造方法 |
| CA2118795A1 (en) * | 1991-09-20 | 1993-04-01 | John Crosby | Pyranones |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4644068A (en) * | 1983-08-19 | 1987-02-17 | Sagami Chemical Research Center | Bicyclo[3.3.0]octenylaldehyde derivatives |
| US4681951A (en) * | 1983-12-27 | 1987-07-21 | Sagami Chemical Research Center | Bicyclo(3.3.0)octene derivatives |
| JPS61280294A (ja) * | 1985-06-04 | 1986-12-10 | Nisshin Flour Milling Co Ltd | 光学活性カルバサイクリン中間体の製造方法 |
-
1986
- 1986-11-13 DE DE19863638758 patent/DE3638758A1/de not_active Withdrawn
-
1987
- 1987-11-11 DD DD87308936A patent/DD264233A5/de not_active IP Right Cessation
- 1987-11-12 AT AT87730144T patent/ATE80664T1/de not_active IP Right Cessation
- 1987-11-12 WO PCT/DE1987/000513 patent/WO1988003567A1/de active IP Right Grant
- 1987-11-12 HU HU875804A patent/HU202596B/hu unknown
- 1987-11-12 JP JP62506737A patent/JP2736066B2/ja not_active Expired - Lifetime
- 1987-11-12 EP EP87730144A patent/EP0271432B1/de not_active Expired - Lifetime
- 1987-11-12 ES ES87730144T patent/ES2044969T3/es not_active Expired - Lifetime
- 1987-11-12 AU AU82364/87A patent/AU613328B2/en not_active Expired
- 1987-11-12 CA CA000551618A patent/CA1301100C/en not_active Expired - Lifetime
- 1987-11-12 US US07/237,109 patent/US4894336A/en not_active Expired - Lifetime
- 1987-11-12 IE IE304687A patent/IE61662B1/en not_active IP Right Cessation
- 1987-11-12 DE DE8787730144T patent/DE3781775D1/de not_active Expired - Lifetime
- 1987-11-13 CS CS878151A patent/CS268542B2/cs unknown
- 1987-11-13 ZA ZA878542A patent/ZA878542B/xx unknown
-
1988
- 1988-07-12 NO NO883109A patent/NO172903C/no not_active IP Right Cessation
- 1988-07-12 RU SU884356253A patent/RU1788968C/ru active
- 1988-07-12 BG BG084851A patent/BG48099A3/xx unknown
- 1988-07-12 DK DK198803891A patent/DK174394B1/da not_active IP Right Cessation
- 1988-07-12 FI FI883316A patent/FI92499C/fi not_active IP Right Cessation
-
1992
- 1992-12-09 GR GR920402865T patent/GR3006013T3/el unknown
-
1997
- 1997-07-14 JP JP9187953A patent/JP2786437B2/ja not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUP | Patent expired |