DK174394B1 - Racematspaltning af 3-acyloxy-bicyklo[3,3,0]-octan-2-carboxylsyreestere ved stereospecifik enzymatisk eller mikrobiologisk acylathydrolyse til fremstilling af optisk aktive (+)-bicyklo-[3,3,0]octanolderivater - Google Patents

Racematspaltning af 3-acyloxy-bicyklo[3,3,0]-octan-2-carboxylsyreestere ved stereospecifik enzymatisk eller mikrobiologisk acylathydrolyse til fremstilling af optisk aktive (+)-bicyklo-[3,3,0]octanolderivater Download PDF

Info

Publication number
DK174394B1
DK174394B1 DK198803891A DK389188A DK174394B1 DK 174394 B1 DK174394 B1 DK 174394B1 DK 198803891 A DK198803891 A DK 198803891A DK 389188 A DK389188 A DK 389188A DK 174394 B1 DK174394 B1 DK 174394B1
Authority
DK
Denmark
Prior art keywords
bicyclo
atoms
octane
carboxylic acid
octanol
Prior art date
Application number
DK198803891A
Other languages
Danish (da)
English (en)
Other versions
DK389188A (da
DK389188D0 (da
Inventor
Werner Skuballa
Karl Petzoldt
Helmut Dahl
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of DK389188A publication Critical patent/DK389188A/da
Publication of DK389188D0 publication Critical patent/DK389188D0/da
Application granted granted Critical
Publication of DK174394B1 publication Critical patent/DK174394B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D317/00Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/72Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/005Analogues or derivatives having the five membered ring replaced by other rings
    • C07C405/0075Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system
    • C07C405/0083Analogues or derivatives having the five membered ring replaced by other rings having the side-chains or their analogues or derivatives attached to a condensed ring system which is only ortho or peri condensed, e.g. carbacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D319/00Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/041,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/081,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/24Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26Ketones
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK198803891A 1986-11-13 1988-07-12 Racematspaltning af 3-acyloxy-bicyklo[3,3,0]-octan-2-carboxylsyreestere ved stereospecifik enzymatisk eller mikrobiologisk acylathydrolyse til fremstilling af optisk aktive (+)-bicyklo-[3,3,0]octanolderivater DK174394B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3638758 1986-11-13
DE19863638758 DE3638758A1 (de) 1986-11-13 1986-11-13 Racematspaltung von 3-acyloxy-bicyclo(3.3.0)octan-7-on-2- carbonsaeureestern durch stereospezifische enzymatische oder mikrobiologische acylat-hydrolyse
DE8700513 1987-11-12
PCT/DE1987/000513 WO1988003567A1 (fr) 1986-11-13 1987-11-12 Clivage racemique de 3-acyloxy-bicyclo [3.3.0] octane-7-one-2 esters d'acide carboxylique par hydrolyse d'acylate stereospecifique enzimatique ou microbiologique

Publications (3)

Publication Number Publication Date
DK389188A DK389188A (da) 1988-07-12
DK389188D0 DK389188D0 (da) 1988-07-12
DK174394B1 true DK174394B1 (da) 2003-01-27

Family

ID=6313858

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198803891A DK174394B1 (da) 1986-11-13 1988-07-12 Racematspaltning af 3-acyloxy-bicyklo[3,3,0]-octan-2-carboxylsyreestere ved stereospecifik enzymatisk eller mikrobiologisk acylathydrolyse til fremstilling af optisk aktive (+)-bicyklo-[3,3,0]octanolderivater

Country Status (20)

Country Link
US (1) US4894336A (ja)
EP (1) EP0271432B1 (ja)
JP (2) JP2736066B2 (ja)
AT (1) ATE80664T1 (ja)
AU (1) AU613328B2 (ja)
BG (1) BG48099A3 (ja)
CA (1) CA1301100C (ja)
CS (1) CS268542B2 (ja)
DD (1) DD264233A5 (ja)
DE (2) DE3638758A1 (ja)
DK (1) DK174394B1 (ja)
ES (1) ES2044969T3 (ja)
FI (1) FI92499C (ja)
GR (1) GR3006013T3 (ja)
HU (1) HU202596B (ja)
IE (1) IE61662B1 (ja)
NO (1) NO172903C (ja)
RU (1) RU1788968C (ja)
WO (1) WO1988003567A1 (ja)
ZA (1) ZA878542B (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
DE3638760A1 (de) * 1986-11-13 1988-05-26 Schering Ag Verfahren zur herstellung von optisch aktiven bicyclo(3.3.0)octandioncarbonsaeureestern
JPH01257484A (ja) * 1987-12-14 1989-10-13 Idemitsu Kosan Co Ltd 光学活性な二級アルコールの製造方法
CA2118795A1 (en) * 1991-09-20 1993-04-01 John Crosby Pyranones

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644068A (en) * 1983-08-19 1987-02-17 Sagami Chemical Research Center Bicyclo[3.3.0]octenylaldehyde derivatives
US4681951A (en) * 1983-12-27 1987-07-21 Sagami Chemical Research Center Bicyclo(3.3.0)octene derivatives
JPS61280294A (ja) * 1985-06-04 1986-12-10 Nisshin Flour Milling Co Ltd 光学活性カルバサイクリン中間体の製造方法

Also Published As

Publication number Publication date
ES2044969T3 (es) 1994-01-16
FI92499B (fi) 1994-08-15
EP0271432B1 (de) 1992-09-16
CS815187A2 (en) 1989-06-13
AU8236487A (en) 1988-06-01
ZA878542B (en) 1988-10-26
IE873046L (en) 1988-05-13
FI92499C (fi) 1994-11-25
NO172903C (no) 1993-09-22
IE61662B1 (en) 1994-11-16
FI883316A (fi) 1988-07-12
WO1988003567A1 (fr) 1988-05-19
NO883109D0 (no) 1988-07-12
JP2786437B2 (ja) 1998-08-13
CA1301100C (en) 1992-05-19
GR3006013T3 (ja) 1993-06-21
FI883316A0 (fi) 1988-07-12
HU202596B (en) 1991-03-28
CS268542B2 (en) 1990-03-14
ATE80664T1 (de) 1992-10-15
DK389188A (da) 1988-07-12
EP0271432A2 (de) 1988-06-15
DK389188D0 (da) 1988-07-12
JP2736066B2 (ja) 1998-04-02
US4894336A (en) 1990-01-16
NO883109L (no) 1988-07-12
DD264233A5 (de) 1989-01-25
AU613328B2 (en) 1991-08-01
JPH1057095A (ja) 1998-03-03
NO172903B (no) 1993-06-14
HUT47157A (en) 1989-01-30
BG48099A3 (en) 1990-11-15
RU1788968C (ru) 1993-01-15
DE3638758A1 (de) 1988-05-26
EP0271432A3 (en) 1988-06-22
DE3781775D1 (de) 1992-10-22
JPH01501202A (ja) 1989-04-27

Similar Documents

Publication Publication Date Title
FR2483912A1 (fr) Derives hydroxycarboxyles du compose ml-236b, leur procede de preparation et leur application therapeutique
US5219743A (en) Method for optical resolution of corey lactone diols
DK174394B1 (da) Racematspaltning af 3-acyloxy-bicyklo[3,3,0]-octan-2-carboxylsyreestere ved stereospecifik enzymatisk eller mikrobiologisk acylathydrolyse til fremstilling af optisk aktive (+)-bicyklo-[3,3,0]octanolderivater
JPH06237790A (ja) ヘテロ−二環式アルコールエナンチオマーの酵素による立体選択的製造方法
US5102793A (en) Stereospecific keto reduction of bicyclooctandione-carboxylic acid esters by microorganisms
CA2074674C (en) Process for preparing (2s, 3r)- or (2r, 3s)-3- (alkylphenyl) glycidic acid esters using hydrolase
US5248609A (en) Racemic separation of 7α-acyloxy-6β-hydroxymethyl-2-oxabicyclo[3.]-octan-3-ones by stereospecific enzymatic acylate hydrolysis
NZ247636A (en) Separation of racemic mixtures of deltavalerolactones using an enzyme; the pure enantiomers
US5459067A (en) Method for producing optically active norborneol by ester hydrolysis
US5256800A (en) Optically active 2,2-dimethyl-1,3-dioxin-4-ones and method for preparing same
JP3007461B2 (ja) 光学活性2−シクロヘキセニル酢酸及びそのエステルの製造方法
JPH04279576A (ja) 光学活性4−ペンタノライド誘導体の製法
HU198098B (en) New process for producing penem derivatives
JPH10127299A (ja) 光学活性グリシド酸エステル及び光学活性グリセリン酸エステルの製造方法
JPH1087613A (ja) 光学活性アジリン類およびその製造法
BE519106A (ja)
CH350286A (fr) Procédé de préparation de dérivés du prégnane 6B-hydroxylés

Legal Events

Date Code Title Description
PUP Patent expired