DK174104B1 - 1-Tetrazol-5-yl-1H-indol-carboxamidderivater, fremgangsmåde til fremstilling deraf samt lægemidde indeholdende forbindelserne - Google Patents

1-Tetrazol-5-yl-1H-indol-carboxamidderivater, fremgangsmåde til fremstilling deraf samt lægemidde indeholdende forbindelserne Download PDF

Info

Publication number
DK174104B1
DK174104B1 DK198505688A DK568885A DK174104B1 DK 174104 B1 DK174104 B1 DK 174104B1 DK 198505688 A DK198505688 A DK 198505688A DK 568885 A DK568885 A DK 568885A DK 174104 B1 DK174104 B1 DK 174104B1
Authority
DK
Denmark
Prior art keywords
indole
carbon atoms
methoxy
carboxamide
phenyl
Prior art date
Application number
DK198505688A
Other languages
Danish (da)
English (en)
Other versions
DK568885A (da
DK568885D0 (da
Inventor
David T Connor
Paul C Unangst
S Russell Stabler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK568885D0 publication Critical patent/DK568885D0/da
Publication of DK568885A publication Critical patent/DK568885A/da
Application granted granted Critical
Publication of DK174104B1 publication Critical patent/DK174104B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Cosmetics (AREA)
DK198505688A 1984-12-10 1985-12-09 1-Tetrazol-5-yl-1H-indol-carboxamidderivater, fremgangsmåde til fremstilling deraf samt lægemidde indeholdende forbindelserne DK174104B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68011684A 1984-12-10 1984-12-10
US68011684 1984-12-10
US06/788,111 US4675332A (en) 1984-12-10 1985-10-21 Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
US78811185 1985-10-21

Publications (3)

Publication Number Publication Date
DK568885D0 DK568885D0 (da) 1985-12-09
DK568885A DK568885A (da) 1986-06-11
DK174104B1 true DK174104B1 (da) 2002-06-17

Family

ID=27102395

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198505688A DK174104B1 (da) 1984-12-10 1985-12-09 1-Tetrazol-5-yl-1H-indol-carboxamidderivater, fremgangsmåde til fremstilling deraf samt lægemidde indeholdende forbindelserne

Country Status (18)

Country Link
US (1) US4675332A (es)
EP (1) EP0186367B1 (es)
JP (1) JPH0653736B2 (es)
KR (1) KR890000292B1 (es)
CN (1) CN1005974B (es)
AT (1) ATE86252T1 (es)
AU (1) AU576131B2 (es)
CA (1) CA1259317A (es)
DE (1) DE3587148T2 (es)
DK (1) DK174104B1 (es)
ES (1) ES8700252A1 (es)
FI (1) FI84719C (es)
GR (1) GR852948B (es)
IE (1) IE58554B1 (es)
NO (1) NO159653C (es)
NZ (1) NZ214480A (es)
PH (1) PH24075A (es)
PT (1) PT81637B (es)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64995B1 (en) * 1987-07-14 1995-09-20 Warner Lambert Co Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome
IT1228893B (it) * 1989-02-24 1991-07-09 Valeas Spa Derivati tetrazol ammidici di acidi alchenil eterociclici e loroimpiego come sostanze antiallergiche
LU87611A1 (fr) * 1989-10-20 1991-05-07 Oreal Composition tinctoriale pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs amino indoliques,procedes de teinture mettant en oeuvre ces compositions et composes nouveaux
US5051442A (en) * 1990-04-25 1991-09-24 Merrell Dow Pharmaceuticals Inc. 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
CA2054339C (en) * 1990-11-02 2002-12-24 Francesco G. Salituro 3-amidoindolyl derivatives
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
US5599774A (en) * 1992-01-22 1997-02-04 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5395817A (en) * 1992-01-22 1995-03-07 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902459D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
US6436965B1 (en) * 2000-03-02 2002-08-20 Merck Frosst Canada & Co. PDE IV inhibiting amides, compositions and methods of treatment
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
JP4497930B2 (ja) * 2002-04-23 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド インターロイキン−４遺伝子発現抑制剤としての３−置換アミノ−１Ｈ−インドール−２−カルボン酸および３−置換アミノ−ベンゾ（ｂ）チオフェン−２−カルボン酸誘導体
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
WO2004014364A1 (en) * 2002-08-07 2004-02-19 Idenix (Cayman) Limited Substituted phenylindoles for the treatment of hiv
EP1479677A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
WO2004108708A1 (en) * 2003-06-05 2004-12-16 Warner-Lambert Company Llc 3-substituted indoles and derivatives thereof as therapeutic agents
DK1747220T3 (da) * 2003-12-11 2009-08-10 Aventis Pharma Inc Substituerede 1H-pyrrolo[3,2-B, 3,2-C og 2,3-C]pyridin-2-carboxamider og relaterede analoger som inhibitorer af casein kinase I epsilon
ES2315877T3 (es) 2004-06-18 2009-04-01 Biolipox Ab Indoles utiles en el tratamiento de inflamaciones.
EA200701504A1 (ru) 2005-01-19 2008-02-28 Биолипокс Аб Индолы, пригодные для лечения воспалений
PL1888548T3 (pl) 2005-05-26 2013-01-31 Neuron Systems Inc Pochodna chinoliny do leczenia schorzeń siatkówki
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
WO2012081893A2 (ko) * 2010-12-13 2012-06-21 한국화학연구원 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
AU2013361314A1 (en) 2012-12-20 2015-07-02 Aldeyra Therapeutics, Inc. Peri-carbinols
KR102435676B1 (ko) 2013-01-23 2022-08-24 알데이라 테라퓨틱스, 아이엔씨. 독성 알데히드 관련된 질병 및 치료
EP2948436A4 (en) 2013-01-25 2016-07-13 Aldeyra Therapeutics Inc NOVEL CASES IN THE TREATMENT OF MACULAR GENERATION
BR112018003250A2 (pt) 2015-08-21 2018-09-25 Aldeyra Therapeutics Inc compostos deuterados e usos dos mesmos
AU2017264697A1 (en) 2016-05-09 2018-11-22 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
WO2018170476A1 (en) 2017-03-16 2018-09-20 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CA3077362A1 (en) 2017-10-10 2019-04-18 Aldeyra Therapeutics, Inc. Treatment of inflammatory disorders
WO2019199979A1 (en) 2018-04-10 2019-10-17 The General Hospital Corporation Antibacterial compounds
US12006298B2 (en) 2018-08-06 2024-06-11 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CA3137301A1 (en) 2019-05-02 2020-11-05 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
US12098132B2 (en) 2019-05-02 2024-09-24 Aldeyra Therapeutics, Inc. Process for preparation of aldehyde scavenger and intermediates
CN112028815A (zh) * 2019-06-03 2020-12-04 中国药科大学 吲哚类衍生物及其医药用途
EP4149470A4 (en) 2020-05-13 2024-04-24 Aldeyra Therapeutics, Inc. PHARMACEUTICAL FORMULATIONS AND USES THEREOF

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417096A (en) * 1965-07-01 1968-12-17 Bristol Myers Co Certain 5(1-benzoyl-3-indolylmethyl) tetrazoles
US4316904A (en) * 1978-06-05 1982-02-23 Brown Richard E Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic activity
US4432986A (en) * 1979-06-18 1984-02-21 Riker Laboratories, Inc. Tetrazoles bonded to certain polycyclic aromatic systems and anti-allergic use thereof
US4333943A (en) * 1980-04-24 1982-06-08 Miles Laboratories, Inc. Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
DE3131527A1 (de) * 1981-08-08 1983-02-24 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB2111050B (en) * 1981-11-19 1985-09-11 Ciba Geigy Ag N-substituted-2-pyridylindoles
US4567201A (en) * 1981-11-25 1986-01-28 Takeda Chemical Industries, Ltd. Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof
US4436746A (en) * 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
IE58555B1 (en) * 1984-12-10 1993-10-06 Warner Almbert Company Novel benzothiophenes and benzofurans having antiallergy activity

Also Published As

Publication number Publication date
AU576131B2 (en) 1988-08-11
US4675332A (en) 1987-06-23
FI854821A0 (fi) 1985-12-04
ES8700252A1 (es) 1986-10-16
EP0186367A3 (en) 1988-01-07
CN85109061A (zh) 1987-01-21
PT81637B (pt) 1988-02-17
GR852948B (es) 1986-04-11
ATE86252T1 (de) 1993-03-15
JPS61191683A (ja) 1986-08-26
NZ214480A (en) 1988-05-30
EP0186367B1 (en) 1993-03-03
DK568885A (da) 1986-06-11
FI854821A (fi) 1986-06-11
KR890000292B1 (ko) 1989-03-13
EP0186367A2 (en) 1986-07-02
KR860004882A (ko) 1986-07-14
NO159653B (no) 1988-10-17
ES549768A0 (es) 1986-04-16
PT81637A (en) 1986-01-01
CA1259317A (en) 1989-09-12
NO854941L (no) 1986-06-11
DE3587148T2 (de) 1993-07-15
NO159653C (no) 1989-01-25
JPH0653736B2 (ja) 1994-07-20
PH24075A (en) 1990-03-05
CN1005974B (zh) 1989-12-06
IE852841L (en) 1986-06-10
DK568885D0 (da) 1985-12-09
FI84719B (fi) 1991-09-30
FI84719C (fi) 1992-01-10
IE58554B1 (en) 1993-10-06
DE3587148D1 (de) 1993-04-08
AU5050885A (en) 1986-06-19

Similar Documents

Publication Publication Date Title
DK174104B1 (da) 1-Tetrazol-5-yl-1H-indol-carboxamidderivater, fremgangsmåde til fremstilling deraf samt lægemidde indeholdende forbindelserne
US5338756A (en) Benzimidazole compounds
US4788199A (en) Pharmacologically active amides, processes for their preparation and pharmaceutical compositions containing them
JPH05186431A (ja) Ｎ−置換ヘテロ環誘導体、製法および医薬組成物
NO151966B (no) Analogifremgangsmaate for fremstilling av terapeutisk virksomme imidazol-5-eddiksyrederivater
NO871879L (no) Fremgangsmaate for fremstilling av nye, terapeutisk aktive heterocykliske forbindelser.
EP0544821A1 (en) INDOLE DERIVATIVES FOR USE AS ANTIALLERGIC AND ANTI-INFLAMMATORY AGENTS.
NO301929B1 (no) 4-aryl-tiazol- eller -imidazol-derivater
AU593605B2 (en) New dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics
FR2630328A1 (fr) Derive de l'histamine, sa preparation et son application en therapeutique
US4952584A (en) 9H-pyrido[2,B-8]indole-3-carboxylic acid ester compounds having useful pharmaceutical activity
JPH07149763A (ja) 新規なベンゾチオフェンおよびベンゾフラン誘導体
JPH01110682A (ja) 抗アレルギー性活性を有する新規ベンゾチオフエン
US4444981A (en) 10 Oxo-4,5-dihydro-10H-benzo 5,6 cycloheph[1,2-B]pyrryls
MX2007015070A (es) Compuestos novedosos de indolina.
IE61901B1 (en) "Substituted 1h-imidazoles"
NO832810L (no) 1,3-dioksolo(4,5-g)-kinoliner og fremgangsmaate for deres fremstilling.
EP0330340A1 (en) Therapeutic agents
SU1433411A3 (ru) Способ получени производных 2-(1Н)-хинолона или их фармацевтически приемлемых солей
EP0287971B1 (en) Benzimidazole derivatives and process for their preparations
IE52102B1 (en) Indole and indoline derivatives
US5112836A (en) Cyclic anthranililc acid carboxylic acid derivatives and medical therapeutic use thereof
FR2551753A2 (fr) Benzotriazine-1,2,3-ones-4, procede de preparation et medicaments les contenant
JPH05279355A (ja) キノリン誘導体及びこれを含有する医薬
JP2007537228A (ja) 中枢神経系、胃腸系及び循環系の疾患の治療のためのインドール−２−オン誘導体

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK