NO854941L - Fremgangsmaate for fremstilling av terapeutisk aktive, sure indol-derivater. - Google Patents

Fremgangsmaate for fremstilling av terapeutisk aktive, sure indol-derivater.

Info

Publication number
NO854941L
NO854941L NO854941A NO854941A NO854941L NO 854941 L NO854941 L NO 854941L NO 854941 A NO854941 A NO 854941A NO 854941 A NO854941 A NO 854941A NO 854941 L NO854941 L NO 854941L
Authority
NO
Norway
Prior art keywords
carbon atoms
radical
substituted
compounds
amino group
Prior art date
Application number
NO854941A
Other languages
English (en)
Other versions
NO159653B (no
NO159653C (no
Inventor
David T Connor
Paul C Unangst
S Russell Stabler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of NO854941L publication Critical patent/NO854941L/no
Publication of NO159653B publication Critical patent/NO159653B/no
Publication of NO159653C publication Critical patent/NO159653C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Lubricants (AREA)
  • Cosmetics (AREA)
NO854941A 1984-12-10 1985-12-09 Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater. NO159653C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68011684A 1984-12-10 1984-12-10
US06/788,111 US4675332A (en) 1984-12-10 1985-10-21 Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents

Publications (3)

Publication Number Publication Date
NO854941L true NO854941L (no) 1986-06-11
NO159653B NO159653B (no) 1988-10-17
NO159653C NO159653C (no) 1989-01-25

Family

ID=27102395

Family Applications (1)

Application Number Title Priority Date Filing Date
NO854941A NO159653C (no) 1984-12-10 1985-12-09 Analogifremgangsm te for fremstilling av terapeutisk aktive, sure indol-derivater.

Country Status (18)

Country Link
US (1) US4675332A (no)
EP (1) EP0186367B1 (no)
JP (1) JPH0653736B2 (no)
KR (1) KR890000292B1 (no)
CN (1) CN1005974B (no)
AT (1) ATE86252T1 (no)
AU (1) AU576131B2 (no)
CA (1) CA1259317A (no)
DE (1) DE3587148T2 (no)
DK (1) DK174104B1 (no)
ES (1) ES8700252A1 (no)
FI (1) FI84719C (no)
GR (1) GR852948B (no)
IE (1) IE58554B1 (no)
NO (1) NO159653C (no)
NZ (1) NZ214480A (no)
PH (1) PH24075A (no)
PT (1) PT81637B (no)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64995B1 (en) * 1987-07-14 1995-09-20 Warner Lambert Co Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome
IT1228893B (it) * 1989-02-24 1991-07-09 Valeas Spa Derivati tetrazol ammidici di acidi alchenil eterociclici e loroimpiego come sostanze antiallergiche
LU87611A1 (fr) * 1989-10-20 1991-05-07 Oreal Composition tinctoriale pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs amino indoliques,procedes de teinture mettant en oeuvre ces compositions et composes nouveaux
US5051442A (en) * 1990-04-25 1991-09-24 Merrell Dow Pharmaceuticals Inc. 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
AU641052B2 (en) * 1990-11-02 1993-09-09 Aventisub Ii Inc. 3-amidoindolyl derivatives
US5395817A (en) * 1992-01-22 1995-03-07 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5599774A (en) * 1992-01-22 1997-02-04 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9902461D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902459D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
US6436965B1 (en) * 2000-03-02 2002-08-20 Merck Frosst Canada & Co. PDE IV inhibiting amides, compositions and methods of treatment
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
GB0217920D0 (en) 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
DE60328675D1 (de) * 2002-04-23 2009-09-17 Aventis Pharma Inc 3-(substitutierte amino)-1h-indole-2-carbonsäureester und 3-(substitutierte amino)-benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression
AU2003258145A1 (en) * 2002-08-07 2004-02-25 Idenix (Cayman) Limited Substituted phenylindoles for the treatment of hiv
EP1479677A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
JP2006526605A (ja) * 2003-06-05 2006-11-24 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 治療剤としての３−置換インドール類及びそれらの誘導体
ATE428711T1 (de) 2003-12-11 2009-05-15 Aventis Pharma Inc Substituierte 1h-pyrroloä3,2-b, 3,2-c und 2,3- cüpyridin-2-carbonsäureamide und verwandte analoga als inhibitoren von caseinkinase-i- epsilon
DE602005009209D1 (de) 2004-06-18 2008-10-02 Biolipox Ab Zur behandlung von entzündungen geeignete indole
ATE501119T1 (de) 2005-01-19 2011-03-15 Biolipox Ab Entzündungshemmende indol-derivate
ES2441873T3 (es) 2005-05-26 2014-02-06 Aldexa Therapeutics, Inc. Derivados de quinolina para el tratamiento de enfermedades retinianas
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
WO2012081893A2 (ko) * 2010-12-13 2012-06-21 한국화학연구원 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
CN105073714A (zh) 2012-12-20 2015-11-18 奥尔德拉医疗公司 迫位原醇
EP2948149A4 (en) 2013-01-23 2016-12-14 Aldeyra Therapeutics Inc BY TOXIC ALDEHYDIC DISEASES AND TREATMENT
WO2014116593A1 (en) 2013-01-25 2014-07-31 Aldexa Therapeutics, Inc. Novel traps in the treatment of macular degeneration
KR102664994B1 (ko) 2015-08-21 2024-05-13 알데이라 테라퓨틱스, 아이엔씨. 중수소화 화합물 및 이의 용도
AU2017264697A1 (en) 2016-05-09 2018-11-22 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
CN110431130A (zh) 2017-03-16 2019-11-08 奥尔德拉医疗公司 多晶型化合物和其用途
US11040039B2 (en) 2017-10-10 2021-06-22 Aldeyra Therapeutics, Inc. Treatment of inflammatory disorders
US11690824B2 (en) 2018-04-10 2023-07-04 The General Hospital Corporation Antibacterial compounds
WO2020033344A1 (en) 2018-08-06 2020-02-13 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CN113784954A (zh) 2019-05-02 2021-12-10 奥尔德拉医疗公司 多晶型化合物和其用途
CN112028815A (zh) * 2019-06-03 2020-12-04 中国药科大学 吲哚类衍生物及其医药用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417096A (en) * 1965-07-01 1968-12-17 Bristol Myers Co Certain 5(1-benzoyl-3-indolylmethyl) tetrazoles
US4316904A (en) * 1978-06-05 1982-02-23 Brown Richard E Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic activity
US4432986A (en) * 1979-06-18 1984-02-21 Riker Laboratories, Inc. Tetrazoles bonded to certain polycyclic aromatic systems and anti-allergic use thereof
US4333943A (en) * 1980-04-24 1982-06-08 Miles Laboratories, Inc. Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
DE3131527A1 (de) * 1981-08-08 1983-02-24 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB2111050B (en) * 1981-11-19 1985-09-11 Ciba Geigy Ag N-substituted-2-pyridylindoles
US4567201A (en) * 1981-11-25 1986-01-28 Takeda Chemical Industries, Ltd. Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof
US4436746A (en) * 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
IE58555B1 (en) * 1984-12-10 1993-10-06 Warner Almbert Company Novel benzothiophenes and benzofurans having antiallergy activity

Also Published As

Publication number Publication date
NZ214480A (en) 1988-05-30
GR852948B (no) 1986-04-11
PT81637B (pt) 1988-02-17
FI84719C (fi) 1992-01-10
FI854821A (fi) 1986-06-11
ES8700252A1 (es) 1986-10-16
DE3587148D1 (de) 1993-04-08
PH24075A (en) 1990-03-05
DE3587148T2 (de) 1993-07-15
DK174104B1 (da) 2002-06-17
AU5050885A (en) 1986-06-19
EP0186367A2 (en) 1986-07-02
EP0186367A3 (en) 1988-01-07
US4675332A (en) 1987-06-23
JPS61191683A (ja) 1986-08-26
JPH0653736B2 (ja) 1994-07-20
AU576131B2 (en) 1988-08-11
IE852841L (en) 1986-06-10
FI854821A0 (fi) 1985-12-04
NO159653B (no) 1988-10-17
EP0186367B1 (en) 1993-03-03
ATE86252T1 (de) 1993-03-15
KR860004882A (ko) 1986-07-14
FI84719B (fi) 1991-09-30
ES549768A0 (es) 1986-04-16
DK568885A (da) 1986-06-11
CN1005974B (zh) 1989-12-06
NO159653C (no) 1989-01-25
CA1259317A (en) 1989-09-12
IE58554B1 (en) 1993-10-06
PT81637A (en) 1986-01-01
CN85109061A (zh) 1987-01-21
KR890000292B1 (ko) 1989-03-13
DK568885D0 (da) 1985-12-09

Similar Documents

Publication Publication Date Title
NO854941L (no) Fremgangsmaate for fremstilling av terapeutisk aktive, sure indol-derivater.
AU549927B2 (en) 2-oxindole-1-carboxamide derivatives
ES539446A0 (es) Un procedimiento para preparar un derivado de dihidropiridazinona
AU586187B2 (en) 7-``2-(dialkylamino)ethyl``-4-hydroxy-1, 3-benzimidazol-2- ones
NO167286C (no) Fremgangsmaate for fremstilling av terapeutisk aktive benzotiazepin-derivater.
NO169442C (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive prolinderivater og lignende forbindelser
NZ216741A (en) 6-oxo-1,6-dihydropyridazines and pharmaceutical compositions
FR2598914B1 (fr) Composition prophylactique et curative pour l'arteriosclerose