ATE86252T1 - Indolsaeureverbindungen und ihre anwendung als antiallergische heilmittel. - Google Patents
Indolsaeureverbindungen und ihre anwendung als antiallergische heilmittel.Info
- Publication number
- ATE86252T1 ATE86252T1 AT85308948T AT85308948T ATE86252T1 AT E86252 T1 ATE86252 T1 AT E86252T1 AT 85308948 T AT85308948 T AT 85308948T AT 85308948 T AT85308948 T AT 85308948T AT E86252 T1 ATE86252 T1 AT E86252T1
- Authority
- AT
- Austria
- Prior art keywords
- carbon atoms
- radical
- substituted
- compounds
- amino group
- Prior art date
Links
- HCUARRIEZVDMPT-UHFFFAOYSA-N Indole-2-carboxylic acid Chemical class C1=CC=C2NC(C(=O)O)=CC2=C1 HCUARRIEZVDMPT-UHFFFAOYSA-N 0.000 title 1
- 230000003266 anti-allergic effect Effects 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 12
- 125000003277 amino group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- BNJMRELGMDUDDB-UHFFFAOYSA-N $l^{1}-sulfanylbenzene Chemical compound [S]C1=CC=CC=C1 BNJMRELGMDUDDB-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- -1 phenylsulphinyl radical Chemical class 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- 125000003396 thiol group Chemical class [H]S* 0.000 abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical class [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 1
- BQIKRTGTPBOIMK-UHFFFAOYSA-N [O]C[O] Chemical compound [O]C[O] BQIKRTGTPBOIMK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Lubricants (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68011684A | 1984-12-10 | 1984-12-10 | |
| US06/788,111 US4675332A (en) | 1984-12-10 | 1985-10-21 | Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents |
| EP85308948A EP0186367B1 (de) | 1984-12-10 | 1985-12-10 | Indolsäureverbindungen und ihre Anwendung als antiallergische Heilmittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE86252T1 true ATE86252T1 (de) | 1993-03-15 |
Family
ID=27102395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85308948T ATE86252T1 (de) | 1984-12-10 | 1985-12-10 | Indolsaeureverbindungen und ihre anwendung als antiallergische heilmittel. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4675332A (de) |
| EP (1) | EP0186367B1 (de) |
| JP (1) | JPH0653736B2 (de) |
| KR (1) | KR890000292B1 (de) |
| CN (1) | CN1005974B (de) |
| AT (1) | ATE86252T1 (de) |
| AU (1) | AU576131B2 (de) |
| CA (1) | CA1259317A (de) |
| DE (1) | DE3587148T2 (de) |
| DK (1) | DK174104B1 (de) |
| ES (1) | ES8700252A1 (de) |
| FI (1) | FI84719C (de) |
| GR (1) | GR852948B (de) |
| IE (1) | IE58554B1 (de) |
| NO (1) | NO159653C (de) |
| NZ (1) | NZ214480A (de) |
| PH (1) | PH24075A (de) |
| PT (1) | PT81637B (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE64995B1 (en) * | 1987-07-14 | 1995-09-20 | Warner Lambert Co | Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome |
| IT1228893B (it) * | 1989-02-24 | 1991-07-09 | Valeas Spa | Derivati tetrazol ammidici di acidi alchenil eterociclici e loroimpiego come sostanze antiallergiche |
| LU87611A1 (fr) * | 1989-10-20 | 1991-05-07 | Oreal | Composition tinctoriale pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs amino indoliques,procedes de teinture mettant en oeuvre ces compositions et composes nouveaux |
| US5051442A (en) * | 1990-04-25 | 1991-09-24 | Merrell Dow Pharmaceuticals Inc. | 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof |
| US5095031A (en) * | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
| AU641052B2 (en) * | 1990-11-02 | 1993-09-09 | Aventisub Ii Inc. | 3-amidoindolyl derivatives |
| US5189054A (en) * | 1990-11-02 | 1993-02-23 | Merrell Dow Pharmaceuticals Inc. | 3-amidoindolyl derivatives and pharmaceutical compositions thereof |
| US5599774A (en) * | 1992-01-22 | 1997-02-04 | Imperial Chemical Industries Plc | N-arylindoles and their use as herbicides |
| US5395817A (en) * | 1992-01-22 | 1995-03-07 | Imperial Chemical Industries Plc | N-arylindoles and their use as herbicides |
| US5424329A (en) * | 1993-08-18 | 1995-06-13 | Warner-Lambert Company | Indole-2-carboxamides as inhibitors of cell adhesion |
| GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
| GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902455D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902453D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902459D0 (en) * | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| US6436965B1 (en) | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
| EP1314733A1 (de) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indol-2-carbonsäureamide als Faktor-Xa-Hemmer |
| GB0217920D0 (en) | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
| WO2003091215A1 (en) * | 2002-04-23 | 2003-11-06 | Aventis Pharmaceuticals Inc. | 3-substituted amino-1h-indole-2-carboxylic acid and 3-substituted amino-benzo’ b! thiophene-2-carboxylic acid derivatives as interieukin-4 gene expression inhibitors |
| WO2004014364A1 (en) * | 2002-08-07 | 2004-02-19 | Idenix (Cayman) Limited | Substituted phenylindoles for the treatment of hiv |
| EP1479677A1 (de) * | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Neue Indolderivate als Faktor Xa-Inhibitoren |
| WO2004108708A1 (en) * | 2003-06-05 | 2004-12-16 | Warner-Lambert Company Llc | 3-substituted indoles and derivatives thereof as therapeutic agents |
| AU2004303826A1 (en) | 2003-12-11 | 2005-07-07 | Aventis Pharmaceuticals Inc. | Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase I Epsilon |
| KR20070028553A (ko) | 2004-06-18 | 2007-03-12 | 바이올리폭스 에이비 | 염증 치료에 유용한 인돌 |
| WO2006077366A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflammation |
| US7973025B2 (en) | 2005-05-26 | 2011-07-05 | Neuron Systems, Inc. | Compositions and methods of treating retinal disease |
| CA2782015C (en) | 2009-12-11 | 2020-08-25 | Neuron Systems, Inc. | Topical ophthalmic compositions and methods for the treatment of macular degeneration |
| WO2012081893A2 (ko) * | 2010-12-13 | 2012-06-21 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
| KR20150118106A (ko) | 2012-12-20 | 2015-10-21 | 알데이라 테라퓨틱스, 아이엔씨. | 페리-카르비놀 |
| HK1217439A1 (zh) | 2013-01-23 | 2017-01-13 | Aldeyra Therapeutics, Inc. | 与毒性醛相关的疾病和治疗 |
| MX2015009444A (es) | 2013-01-25 | 2016-04-15 | Aldeyra Therapeutics Inc | Trampas novedosas en el tratamiento de la degeneracion macular. |
| MX2018002155A (es) | 2015-08-21 | 2018-06-08 | Aldeyra Therapeutics Inc | Compuestos deuterados y usos de los mismos. |
| CA3022665A1 (en) | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
| ES2968462T3 (es) | 2017-03-16 | 2024-05-09 | Aldeyra Therapeutics Inc | Sal polimórfica de 6-cloro-3-amino-2(2-hidroxiprolil) quinolina y usos de la misma |
| JP7311162B2 (ja) | 2017-10-10 | 2023-07-19 | アルデイラ セラピューティクス， インコーポレイテッド | 炎症性障害の処置 |
| US11690824B2 (en) | 2018-04-10 | 2023-07-04 | The General Hospital Corporation | Antibacterial compounds |
| WO2020033344A1 (en) | 2018-08-06 | 2020-02-13 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| US12098132B2 (en) | 2019-05-02 | 2024-09-24 | Aldeyra Therapeutics, Inc. | Process for preparation of aldehyde scavenger and intermediates |
| WO2020223685A1 (en) | 2019-05-02 | 2020-11-05 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
| CN112028815A (zh) * | 2019-06-03 | 2020-12-04 | 中国药科大学 | 吲哚类衍生物及其医药用途 |
| WO2021231792A1 (en) | 2020-05-13 | 2021-11-18 | Aldeyra Therapeutics, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3417096A (en) * | 1965-07-01 | 1968-12-17 | Bristol Myers Co | Certain 5(1-benzoyl-3-indolylmethyl) tetrazoles |
| US4316904A (en) * | 1978-06-05 | 1982-02-23 | Brown Richard E | Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic activity |
| US4432986A (en) * | 1979-06-18 | 1984-02-21 | Riker Laboratories, Inc. | Tetrazoles bonded to certain polycyclic aromatic systems and anti-allergic use thereof |
| US4333943A (en) * | 1980-04-24 | 1982-06-08 | Miles Laboratories, Inc. | Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents |
| DE3131527A1 (de) * | 1981-08-08 | 1983-02-24 | Kali-Chemie Pharma Gmbh, 3000 Hannover | 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| GB2111050B (en) * | 1981-11-19 | 1985-09-11 | Ciba Geigy Ag | N-substituted-2-pyridylindoles |
| US4567201A (en) * | 1981-11-25 | 1986-01-28 | Takeda Chemical Industries, Ltd. | Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof |
| US4436746A (en) * | 1982-09-30 | 1984-03-13 | Ciba-Geigy Corporation | Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles |
| US4511573A (en) * | 1983-05-17 | 1985-04-16 | Ciba-Geigy Corporation | 3-Substituted-2-(heteroaryl) indoles |
| US4536505A (en) * | 1983-05-17 | 1985-08-20 | Ciba-Geigy Corporation | Certain N-(pyridyl) indoles |
| EP0146243A1 (de) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase-Inhibitoren |
| US4581354A (en) * | 1984-08-06 | 1986-04-08 | Sterling Drug Inc. | 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use |
| IE58555B1 (en) * | 1984-12-10 | 1993-10-06 | Warner Almbert Company | Novel benzothiophenes and benzofurans having antiallergy activity |
-
1985
- 1985-10-21 US US06/788,111 patent/US4675332A/en not_active Expired - Lifetime
- 1985-11-13 IE IE284185A patent/IE58554B1/en not_active IP Right Cessation
- 1985-11-29 AU AU50508/85A patent/AU576131B2/en not_active Ceased
- 1985-12-04 FI FI854821A patent/FI84719C/fi not_active IP Right Cessation
- 1985-12-06 PH PH33140A patent/PH24075A/en unknown
- 1985-12-09 JP JP60275227A patent/JPH0653736B2/ja not_active Expired - Fee Related
- 1985-12-09 NO NO854941A patent/NO159653C/no unknown
- 1985-12-09 GR GR852948A patent/GR852948B/el unknown
- 1985-12-09 NZ NZ214480A patent/NZ214480A/en unknown
- 1985-12-09 DK DK198505688A patent/DK174104B1/da not_active IP Right Cessation
- 1985-12-10 EP EP85308948A patent/EP0186367B1/de not_active Expired - Lifetime
- 1985-12-10 AT AT85308948T patent/ATE86252T1/de not_active IP Right Cessation
- 1985-12-10 ES ES549768A patent/ES8700252A1/es not_active Expired
- 1985-12-10 PT PT81637A patent/PT81637B/pt not_active IP Right Cessation
- 1985-12-10 DE DE8585308948T patent/DE3587148T2/de not_active Expired - Fee Related
- 1985-12-10 CA CA000497268A patent/CA1259317A/en not_active Expired
- 1985-12-10 CN CN85109061.3A patent/CN1005974B/zh not_active Expired
- 1985-12-10 KR KR1019850009255A patent/KR890000292B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI84719C (fi) | 1992-01-10 |
| AU5050885A (en) | 1986-06-19 |
| CA1259317A (en) | 1989-09-12 |
| FI854821A7 (fi) | 1986-06-11 |
| DK568885D0 (da) | 1985-12-09 |
| DK568885A (da) | 1986-06-11 |
| CN1005974B (zh) | 1989-12-06 |
| EP0186367A2 (de) | 1986-07-02 |
| US4675332A (en) | 1987-06-23 |
| ES549768A0 (es) | 1986-04-16 |
| JPH0653736B2 (ja) | 1994-07-20 |
| FI84719B (fi) | 1991-09-30 |
| IE58554B1 (en) | 1993-10-06 |
| KR890000292B1 (ko) | 1989-03-13 |
| DE3587148D1 (de) | 1993-04-08 |
| ES8700252A1 (es) | 1986-10-16 |
| FI854821A0 (fi) | 1985-12-04 |
| EP0186367A3 (en) | 1988-01-07 |
| GR852948B (de) | 1986-04-11 |
| DE3587148T2 (de) | 1993-07-15 |
| PH24075A (en) | 1990-03-05 |
| NO854941L (no) | 1986-06-11 |
| IE852841L (en) | 1986-06-10 |
| PT81637B (pt) | 1988-02-17 |
| EP0186367B1 (de) | 1993-03-03 |
| NZ214480A (en) | 1988-05-30 |
| NO159653C (no) | 1989-01-25 |
| PT81637A (en) | 1986-01-01 |
| DK174104B1 (da) | 2002-06-17 |
| KR860004882A (ko) | 1986-07-14 |
| AU576131B2 (en) | 1988-08-11 |
| JPS61191683A (ja) | 1986-08-26 |
| NO159653B (no) | 1988-10-17 |
| CN85109061A (zh) | 1987-01-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |