DK568885D0 - Sure indolforbindelser og deres anvendelse som antiallergiske midler - Google Patents

Sure indolforbindelser og deres anvendelse som antiallergiske midler

Info

Publication number
DK568885D0
DK568885D0 DK568885A DK568885A DK568885D0 DK 568885 D0 DK568885 D0 DK 568885D0 DK 568885 A DK568885 A DK 568885A DK 568885 A DK568885 A DK 568885A DK 568885 D0 DK568885 D0 DK 568885D0
Authority
DK
Denmark
Prior art keywords
carbon atoms
radical
substituted
compounds
amino group
Prior art date
Application number
DK568885A
Other languages
English (en)
Other versions
DK568885A (da
DK174104B1 (da
Inventor
David T Connor
Paul C Unangst
S Russell Stabler
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of DK568885D0 publication Critical patent/DK568885D0/da
Publication of DK568885A publication Critical patent/DK568885A/da
Application granted granted Critical
Publication of DK174104B1 publication Critical patent/DK174104B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
DK198505688A 1984-12-10 1985-12-09 1-Tetrazol-5-yl-1H-indol-carboxamidderivater, fremgangsmåde til fremstilling deraf samt lægemidde indeholdende forbindelserne DK174104B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68011684A 1984-12-10 1984-12-10
US68011684 1984-12-10
US78811185 1985-10-21
US06/788,111 US4675332A (en) 1984-12-10 1985-10-21 Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents

Publications (3)

Publication Number Publication Date
DK568885D0 true DK568885D0 (da) 1985-12-09
DK568885A DK568885A (da) 1986-06-11
DK174104B1 DK174104B1 (da) 2002-06-17

Family

ID=27102395

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198505688A DK174104B1 (da) 1984-12-10 1985-12-09 1-Tetrazol-5-yl-1H-indol-carboxamidderivater, fremgangsmåde til fremstilling deraf samt lægemidde indeholdende forbindelserne

Country Status (18)

Country Link
US (1) US4675332A (da)
EP (1) EP0186367B1 (da)
JP (1) JPH0653736B2 (da)
KR (1) KR890000292B1 (da)
CN (1) CN1005974B (da)
AT (1) ATE86252T1 (da)
AU (1) AU576131B2 (da)
CA (1) CA1259317A (da)
DE (1) DE3587148T2 (da)
DK (1) DK174104B1 (da)
ES (1) ES8700252A1 (da)
FI (1) FI84719C (da)
GR (1) GR852948B (da)
IE (1) IE58554B1 (da)
NO (1) NO159653C (da)
NZ (1) NZ214480A (da)
PH (1) PH24075A (da)
PT (1) PT81637B (da)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE64995B1 (en) * 1987-07-14 1995-09-20 Warner Lambert Co Novel benzothiophenes having antiallergic activity and both novel and other selected benzothiophenes having activity for treating acute respiratory distress syndrome
IT1228893B (it) * 1989-02-24 1991-07-09 Valeas Spa Derivati tetrazol ammidici di acidi alchenil eterociclici e loroimpiego come sostanze antiallergiche
LU87611A1 (fr) * 1989-10-20 1991-05-07 Oreal Composition tinctoriale pour fibres keratiniques contenant des precurseurs de colorants par oxydation et des coupleurs amino indoliques,procedes de teinture mettant en oeuvre ces compositions et composes nouveaux
US5051442A (en) * 1990-04-25 1991-09-24 Merrell Dow Pharmaceuticals Inc. 3-indolyl thioacetate derivatives and NMDA receptor antagonistic use thereof
US5095031A (en) * 1990-08-20 1992-03-10 Abbott Laboratories Indole derivatives which inhibit leukotriene biosynthesis
CA2054339C (en) * 1990-11-02 2002-12-24 Francesco G. Salituro 3-amidoindolyl derivatives
US5189054A (en) * 1990-11-02 1993-02-23 Merrell Dow Pharmaceuticals Inc. 3-amidoindolyl derivatives and pharmaceutical compositions thereof
US5599774A (en) * 1992-01-22 1997-02-04 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5395817A (en) * 1992-01-22 1995-03-07 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
US5424329A (en) * 1993-08-18 1995-06-13 Warner-Lambert Company Indole-2-carboxamides as inhibitors of cell adhesion
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9902453D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902459D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902455D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
US6436965B1 (en) 2000-03-02 2002-08-20 Merck Frosst Canada & Co. PDE IV inhibiting amides, compositions and methods of treatment
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
JP4497930B2 (ja) * 2002-04-23 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド インターロイキン−４遺伝子発現抑制剤としての３−置換アミノ−１Ｈ−インドール−２−カルボン酸および３−置換アミノ−ベンゾ（ｂ）チオフェン−２−カルボン酸誘導体
GB0217920D0 (en) * 2002-04-23 2002-09-11 Aventis Pharm Prod Inc Interleukin-4 Gene Expression inhibitors
EP1545510A4 (en) * 2002-08-07 2006-11-15 Idenix Cayman Ltd SUBSTITUTED PHENYLINDOLE FOR THE TREATMENT OF HIV
EP1479677A1 (en) 2003-05-19 2004-11-24 Aventis Pharma Deutschland GmbH New indole derivatives as factor xa inhibitors
EP1644360A1 (en) * 2003-06-05 2006-04-12 Warner-Lambert Company LLC 3-substituted indoles and derivatives thereof as therapeutic agents
PL1747220T3 (pl) 2003-12-11 2009-09-30 Aventis Pharma Inc Podstawione 1H-pirolo[3,2-b, 3,2-c i 2,3-c]pirydyno-2-karboksyamidy oraz pokrewne analogi jako inhibitory kinazy kazeinowej l epsilon
AU2005254782A1 (en) 2004-06-18 2005-12-29 Biolipox Ab Indoles useful in the treatment of inflammation
DE602005026867D1 (de) 2005-01-19 2011-04-21 Biolipox Ab Entzündungshemmende indol-derivate
US8940764B2 (en) 2005-05-26 2015-01-27 Aldexa Therapeutics, Inc. Compositions and methods of treating retinal disease
CA2782015C (en) 2009-12-11 2020-08-25 Neuron Systems, Inc. Topical ophthalmic compositions and methods for the treatment of macular degeneration
WO2012081893A2 (ko) * 2010-12-13 2012-06-21 한국화학연구원 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
AU2013361314A1 (en) 2012-12-20 2015-07-02 Aldeyra Therapeutics, Inc. Peri-carbinols
CN111135171B (zh) 2013-01-23 2023-09-08 奥尔德拉医疗公司 与毒性醛相关的疾病和治疗
AU2014209585A1 (en) 2013-01-25 2015-07-23 Aldeyra Therapeutics, Inc. Novel traps in the treatment of macular degeneration
WO2017035077A1 (en) 2015-08-21 2017-03-02 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
CA3022665A1 (en) 2016-05-09 2017-11-16 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
CA3054811A1 (en) 2017-03-16 2018-09-20 Aldeyra Therapeutics, Inc. Polymorphic compounds and uses thereof
CN111356451A (zh) 2017-10-10 2020-06-30 奥尔德拉医疗公司 炎性病症的治疗
US11690824B2 (en) 2018-04-10 2023-07-04 The General Hospital Corporation Antibacterial compounds
CN112714762A (zh) 2018-08-06 2021-04-27 奥尔德拉医疗公司 多晶型化合物及其用途
CN112028815A (zh) * 2019-06-03 2020-12-04 中国药科大学 吲哚类衍生物及其医药用途

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3417096A (en) * 1965-07-01 1968-12-17 Bristol Myers Co Certain 5(1-benzoyl-3-indolylmethyl) tetrazoles
US4316904A (en) * 1978-06-05 1982-02-23 Brown Richard E Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic activity
US4432986A (en) * 1979-06-18 1984-02-21 Riker Laboratories, Inc. Tetrazoles bonded to certain polycyclic aromatic systems and anti-allergic use thereof
US4333943A (en) * 1980-04-24 1982-06-08 Miles Laboratories, Inc. Ethyl 3-(3-indolyl)-3-(5-tetrazolyl) propionate compounds used as anti-hypertensive agents
DE3131527A1 (de) * 1981-08-08 1983-02-24 Kali-Chemie Pharma Gmbh, 3000 Hannover 1-phenyl-2-aminocarbonylindol-verbindungen sowie verfahren und zwischenprodukte zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
GB2111050B (en) * 1981-11-19 1985-09-11 Ciba Geigy Ag N-substituted-2-pyridylindoles
US4567201A (en) * 1981-11-25 1986-01-28 Takeda Chemical Industries, Ltd. Diphenoxypropane derivatives and compositions of antiasthmatic and antiinflammatory agents thereof
US4436746A (en) * 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4536505A (en) * 1983-05-17 1985-08-20 Ciba-Geigy Corporation Certain N-(pyridyl) indoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4581354A (en) * 1984-08-06 1986-04-08 Sterling Drug Inc. 3-arylcarbonyl- and 3-cycloalkylcarbonyl-1-aminoalkyl-1H-indoles, compositions and use
IE58555B1 (en) * 1984-12-10 1993-10-06 Warner Almbert Company Novel benzothiophenes and benzofurans having antiallergy activity

Also Published As

Publication number Publication date
ATE86252T1 (de) 1993-03-15
FI84719B (fi) 1991-09-30
CA1259317A (en) 1989-09-12
KR860004882A (ko) 1986-07-14
GR852948B (da) 1986-04-11
EP0186367A2 (en) 1986-07-02
JPS61191683A (ja) 1986-08-26
EP0186367B1 (en) 1993-03-03
DE3587148D1 (de) 1993-04-08
FI84719C (fi) 1992-01-10
IE58554B1 (en) 1993-10-06
CN85109061A (zh) 1987-01-21
KR890000292B1 (ko) 1989-03-13
DK568885A (da) 1986-06-11
NO159653B (no) 1988-10-17
US4675332A (en) 1987-06-23
JPH0653736B2 (ja) 1994-07-20
ES8700252A1 (es) 1986-10-16
DK174104B1 (da) 2002-06-17
DE3587148T2 (de) 1993-07-15
IE852841L (en) 1986-06-10
AU576131B2 (en) 1988-08-11
PT81637B (pt) 1988-02-17
FI854821A0 (fi) 1985-12-04
NZ214480A (en) 1988-05-30
PT81637A (en) 1986-01-01
NO159653C (no) 1989-01-25
AU5050885A (en) 1986-06-19
FI854821A (fi) 1986-06-11
PH24075A (en) 1990-03-05
EP0186367A3 (en) 1988-01-07
ES549768A0 (es) 1986-04-16
CN1005974B (zh) 1989-12-06
NO854941L (no) 1986-06-11

Similar Documents

Publication Publication Date Title
DK568885A (da) Sure indolforbindelser og deres anvendelse som antiallergiske midler
FI944394A (fi) Kinuklidiinijohdannaisia P-aineen antagonisteina
ES539446A0 (es) Un procedimiento para preparar un derivado de dihidropiridazinona
PT87361A (pt) Process for preparing dihydropyridines
DK527984A (da) 11-substituerede 5h,11h-pyrrolo(2,1-c)(1,4)benzoxazepiner eller farmaceutisk acceptable salte deraf, deres fremstilling og mellemprodukter hertil samt deres anvendelse som antipsychotika og analgetika
ES552044A0 (es) Un procedimiento para la preparacion de oxindol-carboxamidas triciclicas
MX11866A (es) Nuevas cicloalquilamidas y procedimiento para su preparacion.
DK0902684T3 (da) Hexahydro-pyrido (4,3-B) indolderivater som antipsykotiske lægemidler
DK407885A (da) 7-(2-(dialkylamino)ethyl)-4-hydroxy-1,3-benzimidazol-2-oner
NO167286C (no) Fremgangsmaate for fremstilling av terapeutisk aktive benzotiazepin-derivater.
NO853551L (no) Fremgangsmaate ved fremstilling av prolinderivater og lignende forbindelser med antihypertensiv aktivitet.
NZ332687A (en) use of 1-methyl-carbapenem derivatives as anti-helicobacter pylori agents
DK96086A (da) 8-thiotetrahydroquinolinderivater, deres fremstilling og anvendelse som laegemidler
DK573981A (da) Fremgangsmaade til fremstilling af cis-c-3",c4"-carbonatderivater af o-demethyl-oleandomycin og mellemprodukter herfor
DK316986A (da) Kemiske forbindelser, som er phosphodiesterase type iii inhibitorer
DE3781044T2 (de) Prophylaktische und heilende zusammensetzung enthaltende eine 8-chlorbenzothiazepin-verbindung und dessen verwendung.

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK