DK172954B1 - Lægemiddel med antitumorvirkning samt fremgangsmåder til fremstilling deraf - Google Patents
Lægemiddel med antitumorvirkning samt fremgangsmåder til fremstilling deraf Download PDFInfo
- Publication number
- DK172954B1 DK172954B1 DK198703931A DK393187A DK172954B1 DK 172954 B1 DK172954 B1 DK 172954B1 DK 198703931 A DK198703931 A DK 198703931A DK 393187 A DK393187 A DK 393187A DK 172954 B1 DK172954 B1 DK 172954B1
- Authority
- DK
- Denmark
- Prior art keywords
- hexadecylphosphocholine
- optionally
- weight
- drug
- mixture
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3542893 | 1985-12-04 | ||
DE3542893 | 1985-12-04 | ||
DE3606631 | 1986-02-28 | ||
DE3606631 | 1986-02-28 | ||
PCT/EP1986/000705 WO1987003480A2 (en) | 1985-12-04 | 1986-12-04 | Medicament with anti-tumoral action containing hexadecylphosphocholine |
EP8600705 | 1986-12-04 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK393187D0 DK393187D0 (da) | 1987-07-28 |
DK393187A DK393187A (da) | 1987-07-28 |
DK172954B1 true DK172954B1 (da) | 1999-10-18 |
Family
ID=25838509
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198703931A DK172954B1 (da) | 1985-12-04 | 1987-07-28 | Lægemiddel med antitumorvirkning samt fremgangsmåder til fremstilling deraf |
DK398587A DK398587A (da) | 1985-12-04 | 1987-07-30 | Antitumorvirksomt laegemiddel |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK398587A DK398587A (da) | 1985-12-04 | 1987-07-30 | Antitumorvirksomt laegemiddel |
Country Status (15)
Country | Link |
---|---|
US (2) | US4837023A (pt) |
EP (4) | EP0230575A3 (pt) |
JP (2) | JPH0637393B2 (pt) |
AT (2) | ATE75608T1 (pt) |
CA (2) | CA1338627C (pt) |
DE (4) | DE3641491A1 (pt) |
DK (2) | DK172954B1 (pt) |
ES (2) | ES2032755T3 (pt) |
FI (2) | FI873364A0 (pt) |
GR (2) | GR3002487T3 (pt) |
HU (2) | HU208143B (pt) |
IE (2) | IE59778B1 (pt) |
NO (2) | NO174877C (pt) |
PT (2) | PT83873B (pt) |
WO (2) | WO1987003478A2 (pt) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5916884A (en) * | 1985-12-04 | 1999-06-29 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften | Compositions containing a mixture of phosphorus compounds and alkylglycerols |
CA2001401A1 (en) * | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Quaternary amine containing ether or ester lipid derivatives and therapeutic compositions |
ATE137973T1 (de) * | 1989-08-10 | 1996-06-15 | Sandoz Ag | Phospholipide zur behandlung der multiplen sklerose |
US5182271A (en) * | 1989-08-10 | 1993-01-26 | Sandoz Ltd. | Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis |
US5290769A (en) * | 1989-09-27 | 1994-03-01 | Asta Pharma Aktiengesellschaft | Use of hexadecylphosphocholine for the treatment of psoriasis |
EP0916343A1 (de) * | 1989-09-27 | 1999-05-19 | ASTA Medica Aktiengesellschaft | Verwendung von Alkylphosphorsäure-Verbindungen zur Bekämpfung von Psoriasis-Erkrankungen |
DE4111105A1 (de) * | 1991-04-05 | 1992-10-08 | Max Planck Gesellschaft | Neue erucyl-, brassidyl- und nervonylderivate |
US5506217A (en) * | 1991-04-25 | 1996-04-09 | The University Of British Columbia | Phosphonates as anti-cancer agents |
US5369097A (en) * | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
ES2108715T3 (es) * | 1991-07-04 | 1998-01-01 | Asta Medica Ag | Procedimiento para la preparacion de alquilfosfocolinas y purificacion de las mismas. |
DE4132344A1 (de) * | 1991-09-27 | 1993-04-01 | Max Planck Gesellschaft | Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis |
US6254879B1 (en) | 1991-09-27 | 2001-07-03 | Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. | Methods of treating protozoal diseases |
US5298655A (en) * | 1991-09-27 | 1994-03-29 | Merck & Co., Inc. | Farnesyl pyrophosphate analogs |
DE4222910A1 (de) * | 1992-07-11 | 1994-01-13 | Asta Medica Ag | Neue Phospholipidderivate |
US6172050B1 (en) | 1992-07-11 | 2001-01-09 | Asta Medica Aktiengesellschaft | Phospholipid derivatives |
DE4235911A1 (de) * | 1992-10-23 | 1994-04-28 | Asta Medica Ag | Stabilisierte Hexadecylphosphocholinlösungen in Glycerinalkylethern |
DE69431596D1 (de) * | 1993-06-10 | 2002-11-28 | Wake Forest University Winston | (phospho)lipide zum bekämpfen einer hepatitis b-infektion |
US6551623B1 (en) | 1993-09-09 | 2003-04-22 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
EP0717631B1 (en) | 1993-09-09 | 2003-07-09 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
US7135584B2 (en) * | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
AU3216695A (en) * | 1994-08-29 | 1996-03-22 | University Of North Carolina At Chapel Hill, The | Lipid analogs for treating viral infections |
US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
WO1996024598A1 (en) * | 1995-02-10 | 1996-08-15 | The University Of British Columbia | [4-hexadecyl-3-methoxy-butyl] phosphonic acid and its protein conjugates useful as anti-cancer agents |
AU711294B2 (en) | 1995-03-16 | 1999-10-07 | Erin Mills Biotech Inc. | Immunomodulating compositions from bile for the treatment of immune system disorders |
KR100499190B1 (ko) * | 1996-03-29 | 2006-04-17 | 교와 핫꼬 고교 가부시끼가이샤 | 육모제 |
US20040101569A1 (en) * | 1996-05-16 | 2004-05-27 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
US6121245A (en) * | 1997-01-29 | 2000-09-19 | Firshein; Richard N. | Method of treating cancer using alkylglycerols in conjunction with chemotherapy |
SE9701912D0 (sv) * | 1997-05-22 | 1997-05-22 | Interhealth Ab | Pharmaceutical composition and use thereof |
US7582678B2 (en) * | 1997-07-09 | 2009-09-01 | D-Pharm Limited | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain |
ATE215817T1 (de) * | 1998-01-22 | 2002-04-15 | Zentaris Ag | Feste miltefosin enthaltende arzneimittel zur oralen verabreichung bei der behandlung von leishmaniasis |
US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
IL137672A0 (en) | 2000-08-03 | 2001-10-31 | Dpharm Ltd | Derivatives of branched-chain lipophilic molecules and uses thereof |
US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
EP1397326A2 (en) * | 2001-05-29 | 2004-03-17 | Koninklijke Philips Electronics N.V. | Metal-ceramic bond |
WO2003021959A1 (en) * | 2001-08-31 | 2003-03-13 | Thomson Licensing Sa | Sequence counter for an audio visual stream |
BR0215680A (pt) * | 2002-04-26 | 2005-02-01 | Rudolf Perl | Composição farmacêutica oral estável |
US20050187191A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Louis S. | Methods and compositions for the treatment of respiratory syncytial virus |
CA2632449A1 (en) | 2005-12-19 | 2007-06-28 | Aeterna Zentaris Gmbh | Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof |
ES2391226T3 (es) * | 2006-12-20 | 2012-11-22 | Alphaptose Gmbh | Forma farmacéutica tópica que comprende compuestos de glicerol tri-sustituido |
JP2011057647A (ja) * | 2009-09-14 | 2011-03-24 | Adeka Corp | 化粧料 |
CN103732231B (zh) | 2011-06-24 | 2020-04-10 | 格里生物公司 | 炎性病症的预防和治疗 |
CN102491994B (zh) * | 2011-12-07 | 2014-10-15 | 宁波九胜创新医药科技有限公司 | 一种胆碱磷酸烷基酯的制备方法 |
CN114712504A (zh) * | 2014-12-09 | 2022-07-08 | Gri生物有限公司 | 炎性病况的预防和治疗 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3225227A1 (de) * | 1982-07-06 | 1984-01-12 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids |
JPS5984824A (ja) * | 1982-11-08 | 1984-05-16 | Takeda Chem Ind Ltd | 抗腫瘍剤 |
US4690935A (en) * | 1983-03-31 | 1987-09-01 | Wayne State University | Inhibition of tumor growth and metastasis with calcium channel blocker compounds |
-
1986
- 1986-12-03 IE IE317786A patent/IE59778B1/en not_active IP Right Cessation
- 1986-12-03 CA CA000524478A patent/CA1338627C/en not_active Expired - Fee Related
- 1986-12-03 CA CA000524479A patent/CA1280369C/en not_active Expired - Lifetime
- 1986-12-03 IE IE317686A patent/IE59777B1/en not_active IP Right Cessation
- 1986-12-04 PT PT83873A patent/PT83873B/pt unknown
- 1986-12-04 DE DE19863641491 patent/DE3641491A1/de not_active Withdrawn
- 1986-12-04 DE DE8686906829T patent/DE3679908D1/de not_active Expired - Lifetime
- 1986-12-04 DE DE19863641379 patent/DE3641379A1/de not_active Withdrawn
- 1986-12-04 US US07/097,960 patent/US4837023A/en not_active Expired - Lifetime
- 1986-12-04 EP EP86116860A patent/EP0230575A3/de active Pending
- 1986-12-04 HU HU87831A patent/HU208143B/hu not_active IP Right Cessation
- 1986-12-04 EP EP87900101A patent/EP0248062B1/de not_active Expired - Lifetime
- 1986-12-04 PT PT83872A patent/PT83872B/pt not_active IP Right Cessation
- 1986-12-04 HU HU865560A patent/HU203201B/hu unknown
- 1986-12-04 AT AT87900101T patent/ATE75608T1/de not_active IP Right Cessation
- 1986-12-04 EP EP86906829A patent/EP0248047B1/de not_active Expired - Lifetime
- 1986-12-04 ES ES198686906829T patent/ES2032755T3/es not_active Expired - Lifetime
- 1986-12-04 WO PCT/EP1986/000706 patent/WO1987003478A2/de active IP Right Grant
- 1986-12-04 AT AT86906829T patent/ATE64529T1/de active
- 1986-12-04 ES ES198787900101T patent/ES2038215T3/es not_active Expired - Lifetime
- 1986-12-04 EP EP86116858A patent/EP0225608A3/de active Pending
- 1986-12-04 DE DE19375061C patent/DE19375061I2/de active Active
- 1986-12-04 JP JP50634086A patent/JPH0637393B2/ja not_active Expired - Lifetime
- 1986-12-04 WO PCT/EP1986/000705 patent/WO1987003480A2/de active IP Right Grant
-
1987
- 1987-07-28 DK DK198703931A patent/DK172954B1/da not_active IP Right Cessation
- 1987-07-30 DK DK398587A patent/DK398587A/da not_active Application Discontinuation
- 1987-08-03 FI FI873364A patent/FI873364A0/fi not_active Application Discontinuation
- 1987-08-03 FI FI873363A patent/FI873363A0/fi not_active Application Discontinuation
- 1987-08-03 NO NO873243A patent/NO174877C/no not_active IP Right Cessation
- 1987-08-03 NO NO873244A patent/NO175620C/no not_active IP Right Cessation
-
1989
- 1989-02-27 US US07/316,413 patent/US5049552A/en not_active Expired - Lifetime
-
1991
- 1991-08-16 GR GR91401135T patent/GR3002487T3/el unknown
-
1992
- 1992-07-15 GR GR920401514T patent/GR3005168T3/el unknown
-
1995
- 1995-07-24 JP JP7187517A patent/JP2857084B2/ja not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK172954B1 (da) | Lægemiddel med antitumorvirkning samt fremgangsmåder til fremstilling deraf | |
US20060241086A1 (en) | Calcium salt of myo-inositol 1,6:2,3:4,5 tripyrophosphate as an allosteric effector of hemoglobin | |
DE3042117A1 (de) | Gynosaponine, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate | |
CN109771431A (zh) | 和厚朴酚衍生物的新用途 | |
US20140179635A1 (en) | Tumor eradication by inositol-tripyrophosphate | |
JPH02191220A (ja) | イノシトールトリホスフェートを含有するリポ蛋白質の異常レベルに対する医薬 | |
KR19980703829A (ko) | 바이러스 및 암 성장 억제용, 엔-클로로페닐카르바메이트및 엔-클로로페닐티오카르바메이트 함유 약학 조성물 | |
JPH04505760A (ja) | Aztの副作用および毒性からの保護方法 | |
US4068003A (en) | Method of medical treatment of myasthenia | |
KR101893812B1 (ko) | 13가지 글리세리드를 포함한 의이인오일, 제제 및 그 응용 | |
AU709068B2 (en) | Pharmaceutical compositions containing cyclosporine and a carrier comprising at least an ester of alpha-glycerophosphoric acid | |
US6254879B1 (en) | Methods of treating protozoal diseases | |
KR0183448B1 (ko) | 진세노사이드 Rg5를 함유하는 항암제 조성물 | |
US5916884A (en) | Compositions containing a mixture of phosphorus compounds and alkylglycerols | |
US6475520B1 (en) | Pharmaceutical composition with low toxicity for anti-inflammation and anti-exudation | |
CN114191427B (zh) | 一种用于抑制血小板活化的药物及其应用 | |
JP7447013B2 (ja) | 1,2-ナフトキノン誘導体化合物を含む固形癌または血液癌の予防または治療用薬学組成物 | |
CN107441036A (zh) | 一种抗癌重楼注射剂的制备工艺 | |
EP1513539B1 (de) | Verwendung von amphiphilen nucleosid-phosphonoameisensäure-derivaten zur behandlung von viralen infektionskrankheiten | |
KR20040036092A (ko) | 진세노사이드 Rh2 및 Rg3 항암 조성물 | |
DD281961A5 (de) | Verfahren zur herstellung eines antitumorwirksamen arzneimittels | |
US20020173489A1 (en) | Compositions containing a mixture of phosphorous compounds and alkylglycerols | |
JPH01211528A (ja) | 抗hiv剤 | |
JPS62187410A (ja) | Atp増強組成物 | |
MXPA99009817A (es) | Composiciones farmaceuticas de arglabina y derivados de arglabina. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |