WO1987003480A3 - Medicament a effet anti-tumoral contenant de l'hexadecylphosphocholine - Google Patents

Medicament a effet anti-tumoral contenant de l'hexadecylphosphocholine Download PDF

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Publication number
WO1987003480A3
WO1987003480A3 PCT/EP1986/000705 EP8600705W WO8703480A3 WO 1987003480 A3 WO1987003480 A3 WO 1987003480A3 EP 8600705 W EP8600705 W EP 8600705W WO 8703480 A3 WO8703480 A3 WO 8703480A3
Authority
WO
WIPO (PCT)
Prior art keywords
medicament
pct
action containing
hexadecylphosphocholine
tumoral
Prior art date
Application number
PCT/EP1986/000705
Other languages
German (de)
English (en)
Other versions
WO1987003480A2 (fr
Inventor
Hansjoerg Eibl
Original Assignee
Max Planck Gesellschaft
Eibl Hans Joerg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Max Planck Gesellschaft, Eibl Hans Joerg filed Critical Max Planck Gesellschaft
Priority to AT86906829T priority Critical patent/ATE64529T1/de
Priority to JP50634086A priority patent/JPH0637393B2/ja
Priority to HU865560A priority patent/HU203201B/hu
Priority to DE8686906829T priority patent/DE3679908D1/de
Priority to DE19375061C priority patent/DE19375061I2/de
Publication of WO1987003480A2 publication Critical patent/WO1987003480A2/fr
Priority to DK198703931A priority patent/DK172954B1/da
Priority to NO873243A priority patent/NO174877C/no
Priority to FI873363A priority patent/FI873363A0/fi
Publication of WO1987003480A3 publication Critical patent/WO1987003480A3/fr
Priority to GR91401135T priority patent/GR3002487T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Electrically Operated Instructional Devices (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)

Abstract

Médicament cytotoxyque contenant comme substance active de l'hexadecylphohsphocholine.
PCT/EP1986/000705 1985-12-04 1986-12-04 Medicament a effet anti-tumoral contenant de l'hexadecylphosphocholine WO1987003480A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AT86906829T ATE64529T1 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
JP50634086A JPH0637393B2 (ja) 1985-12-04 1986-12-04 抗腫瘍作用を有する薬剤
HU865560A HU203201B (en) 1985-12-04 1986-12-04 Process for producing antitumoural pharmaceutical composition having synergetic effect
DE8686906829T DE3679908D1 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
DE19375061C DE19375061I2 (de) 1985-12-04 1986-12-04 Hexadecylphosphocolin enthaltende arzneimittel mit antitumorwirkung.
DK198703931A DK172954B1 (da) 1985-12-04 1987-07-28 Lægemiddel med antitumorvirkning samt fremgangsmåder til fremstilling deraf
NO873243A NO174877C (no) 1985-12-04 1987-08-03 Fremgangsmåte for fremstilling av et legemiddel med antitumorvirkning
FI873363A FI873363A0 (fi) 1985-12-04 1987-08-03 Foerfarande foer framstaellning av laekemedel med antitumoeraktivitet.
GR91401135T GR3002487T3 (en) 1985-12-04 1991-08-16 Medicament with anti-tumoral action containing hexadecylphosphocholine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE3542893 1985-12-04
DEP3542893.7 1985-12-04
DE3606631 1986-02-28
DEP3606631.1 1986-02-28

Publications (2)

Publication Number Publication Date
WO1987003480A2 WO1987003480A2 (fr) 1987-06-18
WO1987003480A3 true WO1987003480A3 (fr) 1988-02-25

Family

ID=25838509

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/EP1986/000705 WO1987003480A2 (fr) 1985-12-04 1986-12-04 Medicament a effet anti-tumoral contenant de l'hexadecylphosphocholine
PCT/EP1986/000706 WO1987003478A2 (fr) 1985-12-04 1986-12-04 Medicaments

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/EP1986/000706 WO1987003478A2 (fr) 1985-12-04 1986-12-04 Medicaments

Country Status (15)

Country Link
US (2) US4837023A (fr)
EP (4) EP0230575A3 (fr)
JP (2) JPH0637393B2 (fr)
AT (2) ATE64529T1 (fr)
CA (2) CA1280369C (fr)
DE (4) DE3679908D1 (fr)
DK (2) DK172954B1 (fr)
ES (2) ES2038215T3 (fr)
FI (2) FI873363A0 (fr)
GR (2) GR3002487T3 (fr)
HU (2) HU208143B (fr)
IE (2) IE59778B1 (fr)
NO (2) NO175620C (fr)
PT (2) PT83872B (fr)
WO (2) WO1987003480A2 (fr)

Families Citing this family (43)

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Publication number Priority date Publication date Assignee Title
US5916884A (en) * 1985-12-04 1999-06-29 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing a mixture of phosphorus compounds and alkylglycerols
CA2001401A1 (fr) * 1988-10-25 1990-04-25 Claude Piantadosi Derives d'ether ou d'ester lipidique contenant une amine quaternaire et composes therapeutiques
US5182271A (en) * 1989-08-10 1993-01-26 Sandoz Ltd. Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis
EP0412941B1 (fr) * 1989-08-10 1996-05-15 Sandoz Ltd. Phospholipides pour le traitement de la sclérose multiple
EP0419998A3 (en) * 1989-09-27 1991-10-23 Asta Pharma Aktiengesellschaft Use of alkylphosphonic acid derivatives for the treatment of psoriasis
US5290769A (en) * 1989-09-27 1994-03-01 Asta Pharma Aktiengesellschaft Use of hexadecylphosphocholine for the treatment of psoriasis
DE4111105A1 (de) * 1991-04-05 1992-10-08 Max Planck Gesellschaft Neue erucyl-, brassidyl- und nervonylderivate
US5506217A (en) * 1991-04-25 1996-04-09 The University Of British Columbia Phosphonates as anti-cancer agents
US5369097A (en) * 1991-04-25 1994-11-29 The University Of British Columbia Phosphonates as anti-cancer agents
DE59208905D1 (de) * 1991-07-04 1997-10-23 Asta Medica Ag Verfahren zur Herstellung von Alkylphosphocholinen und Reinherstellung derselben
US5298655A (en) * 1991-09-27 1994-03-29 Merck & Co., Inc. Farnesyl pyrophosphate analogs
US6254879B1 (en) 1991-09-27 2001-07-03 Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. Methods of treating protozoal diseases
DE4132344A1 (de) * 1991-09-27 1993-04-01 Max Planck Gesellschaft Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis
DE4222910A1 (de) * 1992-07-11 1994-01-13 Asta Medica Ag Neue Phospholipidderivate
US6172050B1 (en) 1992-07-11 2001-01-09 Asta Medica Aktiengesellschaft Phospholipid derivatives
DE4235911A1 (de) * 1992-10-23 1994-04-28 Asta Medica Ag Stabilisierte Hexadecylphosphocholinlösungen in Glycerinalkylethern
EP0702556B1 (fr) * 1993-06-10 2002-10-23 Wake Forest University (phospho)lipides contre l'infection a virus de l'hepatite b
US6551623B1 (en) 1993-09-09 2003-04-22 Lorus Therapeutics Inc. Immunomodulating compositions from bile
NZ273258A (en) 1993-09-09 2000-01-28 Lorus Therapeutics Inc Immunomodulator composition with components less than 3000 D that are extractable from bile, stimulate monocytes and macrophages and modulate TNF
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
AU3216695A (en) * 1994-08-29 1996-03-22 University Of North Carolina At Chapel Hill, The Lipid analogs for treating viral infections
US5574025A (en) * 1994-10-26 1996-11-12 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
WO1996024598A1 (fr) * 1995-02-10 1996-08-15 The University Of British Columbia Acide [4-hexadecyl-3-methoxy-butyl] phosphonique et ses conjugues proteiques, s'utilisant comme anticancereux
JPH11501634A (ja) 1995-03-16 1999-02-09 イムテック ファーマ インコーポレイテッド 免疫系異常治療用の胆汁からの免疫調節組成物
KR100499190B1 (ko) * 1996-03-29 2006-04-17 교와 핫꼬 고교 가부시끼가이샤 육모제
US20040101569A1 (en) * 1996-05-16 2004-05-27 Lorus Therapeutics Inc. Immunomodulating compositions from bile
US6121245A (en) * 1997-01-29 2000-09-19 Firshein; Richard N. Method of treating cancer using alkylglycerols in conjunction with chemotherapy
SE9701912D0 (sv) * 1997-05-22 1997-05-22 Interhealth Ab Pharmaceutical composition and use thereof
US7582678B2 (en) * 1997-07-09 2009-09-01 D-Pharm Limited Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
DE69804865T2 (de) * 1998-01-22 2002-11-07 Zentaris Ag Feste miltefosin enthaltende arzneimittel zur oralen verabreichung bei der behandlung von leishmaniasis
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
IL137672A0 (en) 2000-08-03 2001-10-31 Dpharm Ltd Derivatives of branched-chain lipophilic molecules and uses thereof
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
WO2002096826A2 (fr) * 2001-05-29 2002-12-05 Koninklijke Philips Electronics N.V. Liaison metal-ceramique
WO2003021959A1 (fr) * 2001-08-31 2003-03-13 Thomson Licensing Sa Compteur de sequences destine a un flux audio continu
WO2003090757A1 (fr) * 2002-04-26 2003-11-06 Rudolf Perl Compositions pharmaceutiques de derives phospholipidiques
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
JP5232009B2 (ja) 2005-12-19 2013-07-10 エテルナ ツェンタリス ゲゼルシャフト ミット ベシュレンクテル ハフツング 低減された細胞毒性を有するアルキルリン脂質誘導体並びにそれらの使用
US8637688B2 (en) * 2006-12-20 2014-01-28 Julia Diederichs Topical dosage form comprising tri-substituted glycerol compounds
JP2011057647A (ja) * 2009-09-14 2011-03-24 Adeka Corp 化粧料
BR112013033309B1 (pt) 2011-06-24 2022-07-05 Gri Bio, Inc Uso de tazaroteno e método in vitro para inibição de ativação de células nkt tipo i
CN102491994B (zh) * 2011-12-07 2014-10-15 宁波九胜创新医药科技有限公司 一种胆碱磷酸烷基酯的制备方法
JP2017537984A (ja) * 2014-12-09 2017-12-21 ジーアールアイ バイオ， インコーポレイテッド 炎症性病態の予防および治療

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108565A2 (fr) * 1982-11-08 1984-05-16 Takeda Chemical Industries, Ltd. Phospholipides, leur production et leur utilisation
EP0123850A2 (fr) * 1983-03-31 1984-11-07 The Board Of Governors Of Wayne State University Inhibition de la croissance de tumeurs et de la métastase avec des bloqueurs de canaux de calcium

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
DE3225227A1 (de) * 1982-07-06 1984-01-12 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108565A2 (fr) * 1982-11-08 1984-05-16 Takeda Chemical Industries, Ltd. Phospholipides, leur production et leur utilisation
EP0123850A2 (fr) * 1983-03-31 1984-11-07 The Board Of Governors Of Wayne State University Inhibition de la croissance de tumeurs et de la métastase avec des bloqueurs de canaux de calcium

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
Agents and Actions, Vol. 11, No. 6-7, 1981, published by Birkhauser (Basel, CH), H. BEKEMEIER et al.: "Effect Oflysolecithin on Blood Vessel Reactivity and of some Ethers and Esters of Glycerophosphocholine and Phosphocholine, Respectively, on Aggregation of Rat Platelets", pages 563-565, see 564, table 2 *
Cancer Research, Vol. 32, No. 1, January 1972, K. ANDO et al.: "Antitumor activity of Glyceryl Ethers", pages 125-129, see the whole document *
Dialog Information Services, File 5: Biosis Previews 69-87, W.J. ZELLER et al.: "Comparative activity of Hexadecylphosphocholine in Transplanted and Autochthonous Mammary Tumors", see Abstract No. 0017070067, & 14th International Cancer Congress, Budapest, Hungary, Aug. 21-27, 1986. Abstracts, Lectures, Symposia and Free Communications, Vols. 1,2,3 late Abstracts, and Register. XVI +479P. *
J. Cancer Res. Clin. Oncol. Vol. 111, suppl. 1986, M.R. BERGER et al.: "Alkylphosphocholines as Anticancer Agents" page S 24, Abstract NCy 21, see the Abstract *
J. Cancer Res. Clin. Oncol. Vol. 111, suppl., 1986, H. EIBL et al.: "Hexadecylphosphocholine, a new Antineoplastic Agent: Cytotoxic Properties in Leukaemic Cells", pages S 24, Abstract NCy 22, see the whole Abstract *
J. Cancer, Res. Clin. Oncol., Vol. 111, suppl., 1986, C. MUSCHIOL et al.: "Anticancer activity of new Alkyllysophospholipidderivatives", page S 22, Abstract NCy, see the whole document *
Klinische Wochenschrift, Vol. 63, No. 12, 1985, Springler-Verlag (DE), C. UNGER et al.: "Blut-Hirnschranke und Penetration von Zytostatika", pages 565-571, see the whole document *

Also Published As

Publication number Publication date
HUT44431A (en) 1988-03-28
HUT44441A (en) 1988-03-28
NO873243D0 (no) 1987-08-03
DE3641379A1 (de) 1987-09-03
DE19375061I2 (de) 2008-11-20
EP0230575A3 (fr) 1987-12-02
IE59778B1 (en) 1994-04-06
FI873364A0 (fi) 1987-08-03
NO175620B (fr) 1994-08-01
CA1280369C (fr) 1991-02-19
PT83872A (de) 1987-01-01
HU203201B (en) 1991-06-28
EP0225608A2 (fr) 1987-06-16
FI873363A (fi) 1987-08-03
DK393187D0 (da) 1987-07-28
FI873363A0 (fi) 1987-08-03
EP0248062A1 (fr) 1987-12-09
WO1987003478A2 (fr) 1987-06-18
NO873243L (no) 1987-10-02
WO1987003478A3 (fr) 1987-09-24
DK172954B1 (da) 1999-10-18
IE863176L (en) 1987-06-04
US4837023A (en) 1989-06-06
GR3005168T3 (fr) 1993-05-24
IE863177L (en) 1987-06-04
EP0248047A1 (fr) 1987-12-09
PT83872B (pt) 1989-01-17
JPH0859677A (ja) 1996-03-05
CA1338627C (fr) 1996-10-01
NO873244L (no) 1987-10-01
DE3641491A1 (de) 1987-09-17
ES2038215T3 (es) 1993-07-16
NO873244D0 (no) 1987-08-03
FI873364A (fi) 1987-08-03
NO175620C (no) 1994-11-09
ATE64529T1 (de) 1991-07-15
DK393187A (da) 1987-07-28
GR3002487T3 (en) 1992-12-30
EP0230575A2 (fr) 1987-08-05
DK398587D0 (da) 1987-07-30
WO1987003480A2 (fr) 1987-06-18
IE59777B1 (en) 1994-04-06
HU208143B (en) 1993-08-30
EP0248047B1 (fr) 1991-06-19
NO174877C (no) 1994-07-27
PT83873A (de) 1987-01-01
ES2032755T3 (es) 1993-03-01
JPH0637393B2 (ja) 1994-05-18
JPS63501719A (ja) 1988-07-14
NO174877B (no) 1994-04-18
DK398587A (da) 1987-07-30
EP0225608A3 (fr) 1987-10-28
DE3679908D1 (de) 1991-07-25
US5049552A (en) 1991-09-17
ATE75608T1 (de) 1992-05-15
PT83873B (pt) 1989-01-17
EP0248062B1 (fr) 1992-05-06
JP2857084B2 (ja) 1999-02-10

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Free format text: IN PAT.BUL.13/87,UNDER INID (54) TITLE REPLACE"MEDICAMENT WITH ANTI-TUMORAL ACTION CONTAINING HEXADECYLPHOSPHOCHOLINE" BY "HEXADECYLPHOSPHOCHOLINE-CONTAINING MEDICAMENT WITH ANTI-TUMOUR ACTION"

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