DK172954B1 - Lægemiddel med antitumorvirkning samt fremgangsmåder til fremstilling deraf - Google Patents
Lægemiddel med antitumorvirkning samt fremgangsmåder til fremstilling deraf Download PDFInfo
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- DK172954B1 DK172954B1 DK198703931A DK393187A DK172954B1 DK 172954 B1 DK172954 B1 DK 172954B1 DK 198703931 A DK198703931 A DK 198703931A DK 393187 A DK393187 A DK 393187A DK 172954 B1 DK172954 B1 DK 172954B1
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- hexadecylphosphocholine
- optionally
- weight
- drug
- mixture
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-M methyl sulfate(1-) Chemical compound COS([O-])(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-M 0.000 description 1
- 230000011987 methylation Effects 0.000 description 1
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- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- QTNLALDFXILRQO-UHFFFAOYSA-N nonadecane-1,2,3-triol Chemical compound CCCCCCCCCCCCCCCCC(O)C(O)CO QTNLALDFXILRQO-UHFFFAOYSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000010606 normalization Methods 0.000 description 1
- NBAGCCUHRNLKBE-UHFFFAOYSA-N octadecan-2-yloxy-oxido-oxophosphanium Chemical compound C(CCCCCCCCCCCCCCC)C(C)OP(=O)=O NBAGCCUHRNLKBE-UHFFFAOYSA-N 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 238000009116 palliative therapy Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 230000026731 phosphorylation Effects 0.000 description 1
- 238000006366 phosphorylation reaction Methods 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000007142 ring opening reaction Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 231100000456 subacute toxicity Toxicity 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 238000011521 systemic chemotherapy Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- BETUMLXGYDBOLV-UHFFFAOYSA-N tetradecyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCOP([O-])(=O)OCC[N+](C)(C)C BETUMLXGYDBOLV-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000012905 visible particle Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
- A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/08—Ethers or acetals acyclic, e.g. paraformaldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2458—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Electrically Operated Instructional Devices (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Respiratory Apparatuses And Protective Means (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3542893 | 1985-12-04 | ||
| DE3542893 | 1985-12-04 | ||
| DE3606631 | 1986-02-28 | ||
| DE3606631 | 1986-02-28 | ||
| EP8600705 | 1986-12-04 | ||
| PCT/EP1986/000705 WO1987003480A2 (fr) | 1985-12-04 | 1986-12-04 | Medicament a effet anti-tumoral contenant de l'hexadecylphosphocholine |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK393187A DK393187A (da) | 1987-07-28 |
| DK393187D0 DK393187D0 (da) | 1987-07-28 |
| DK172954B1 true DK172954B1 (da) | 1999-10-18 |
Family
ID=25838509
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK198703931A DK172954B1 (da) | 1985-12-04 | 1987-07-28 | Lægemiddel med antitumorvirkning samt fremgangsmåder til fremstilling deraf |
| DK398587A DK398587A (da) | 1985-12-04 | 1987-07-30 | Antitumorvirksomt laegemiddel |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK398587A DK398587A (da) | 1985-12-04 | 1987-07-30 | Antitumorvirksomt laegemiddel |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US4837023A (fr) |
| EP (4) | EP0248062B1 (fr) |
| JP (2) | JPH0637393B2 (fr) |
| AT (2) | ATE64529T1 (fr) |
| CA (2) | CA1338627C (fr) |
| DE (4) | DE3679908D1 (fr) |
| DK (2) | DK172954B1 (fr) |
| ES (2) | ES2032755T3 (fr) |
| FI (2) | FI873363A (fr) |
| GR (2) | GR3002487T3 (fr) |
| HU (2) | HU203201B (fr) |
| IE (2) | IE59777B1 (fr) |
| NO (2) | NO175620C (fr) |
| PT (2) | PT83872B (fr) |
| WO (2) | WO1987003480A2 (fr) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916884A (en) * | 1985-12-04 | 1999-06-29 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften | Compositions containing a mixture of phosphorus compounds and alkylglycerols |
| CA2001401A1 (fr) * | 1988-10-25 | 1990-04-25 | Claude Piantadosi | Derives d'ether ou d'ester lipidique contenant une amine quaternaire et composes therapeutiques |
| US5182271A (en) * | 1989-08-10 | 1993-01-26 | Sandoz Ltd. | Thioether, keto-ester and alkyl phospholipids useful in treating multiple sclerosis |
| DE69026991T2 (de) * | 1989-08-10 | 1997-01-16 | Sandoz Ag | Phospholipide zur Behandlung der multiplen Sklerose |
| EP0916343A1 (fr) * | 1989-09-27 | 1999-05-19 | ASTA Medica Aktiengesellschaft | utilisation de composés alkyl phosphoriques dans le traitement de maladies psoriatiques |
| US5290769A (en) * | 1989-09-27 | 1994-03-01 | Asta Pharma Aktiengesellschaft | Use of hexadecylphosphocholine for the treatment of psoriasis |
| DE4111105A1 (de) * | 1991-04-05 | 1992-10-08 | Max Planck Gesellschaft | Neue erucyl-, brassidyl- und nervonylderivate |
| US5506217A (en) * | 1991-04-25 | 1996-04-09 | The University Of British Columbia | Phosphonates as anti-cancer agents |
| US5369097A (en) * | 1991-04-25 | 1994-11-29 | The University Of British Columbia | Phosphonates as anti-cancer agents |
| EP0521297B1 (fr) * | 1991-07-04 | 1997-09-17 | ASTA Medica Aktiengesellschaft | Procédé de préparation d'alkylphosphocholines et purification de celles-ci |
| US6254879B1 (en) | 1991-09-27 | 2001-07-03 | Max-Planck-Gessellschaft zun Förderung der Wissenschaften e.V. | Methods of treating protozoal diseases |
| US5298655A (en) * | 1991-09-27 | 1994-03-29 | Merck & Co., Inc. | Farnesyl pyrophosphate analogs |
| DE4132344A1 (de) * | 1991-09-27 | 1993-04-01 | Max Planck Gesellschaft | Verfahren zur herstellung eines arzneimittels zur oralen oder topischen verabreichung bei der behandlung von leishmaniasis |
| DE4222910A1 (de) * | 1992-07-11 | 1994-01-13 | Asta Medica Ag | Neue Phospholipidderivate |
| US6172050B1 (en) | 1992-07-11 | 2001-01-09 | Asta Medica Aktiengesellschaft | Phospholipid derivatives |
| DE4235911A1 (de) * | 1992-10-23 | 1994-04-28 | Asta Medica Ag | Stabilisierte Hexadecylphosphocholinlösungen in Glycerinalkylethern |
| EP0702556B1 (fr) * | 1993-06-10 | 2002-10-23 | Wake Forest University | (phospho)lipides contre l'infection a virus de l'hepatite b |
| US6551623B1 (en) | 1993-09-09 | 2003-04-22 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
| JP4708511B2 (ja) | 1993-09-09 | 2011-06-22 | エリン・ミルズ・バイオテック・インコーポレーテッド | 胆汁由来免疫調節組成物 |
| AU3216695A (en) * | 1994-08-29 | 1996-03-22 | University Of North Carolina At Chapel Hill, The | Lipid analogs for treating viral infections |
| US7135584B2 (en) * | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
| US5574025A (en) * | 1994-10-26 | 1996-11-12 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferases |
| WO1996024598A1 (fr) * | 1995-02-10 | 1996-08-15 | The University Of British Columbia | Acide [4-hexadecyl-3-methoxy-butyl] phosphonique et ses conjugues proteiques, s'utilisant comme anticancereux |
| CN1182368A (zh) | 1995-03-16 | 1998-05-20 | 伊姆特克药物公司 | 来源于胆汁的治疗免疫系统紊乱的免疫调节组合物 |
| KR100499190B1 (ko) * | 1996-03-29 | 2006-04-17 | 교와 핫꼬 고교 가부시끼가이샤 | 육모제 |
| US20040101569A1 (en) * | 1996-05-16 | 2004-05-27 | Lorus Therapeutics Inc. | Immunomodulating compositions from bile |
| US6121245A (en) * | 1997-01-29 | 2000-09-19 | Firshein; Richard N. | Method of treating cancer using alkylglycerols in conjunction with chemotherapy |
| SE9701912D0 (sv) * | 1997-05-22 | 1997-05-22 | Interhealth Ab | Pharmaceutical composition and use thereof |
| US7582678B2 (en) * | 1997-07-09 | 2009-09-01 | D-Pharm Limited | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain |
| TR200001717T2 (tr) * | 1998-01-22 | 2000-11-21 | Asta Medica Aktiengesellschaft | Leishmaniasis tedavisinde miltefosin ihtiva eden ve ağızdan alınan katı farmasötik bileşimler. |
| US7026469B2 (en) * | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| IL137672A0 (en) | 2000-08-03 | 2001-10-31 | Dpharm Ltd | Derivatives of branched-chain lipophilic molecules and uses thereof |
| US7309696B2 (en) | 2000-10-19 | 2007-12-18 | Wake Forest University | Compositions and methods for targeting cancer cells |
| KR20030041130A (ko) * | 2001-05-29 | 2003-05-23 | 코닌클리케 필립스 일렉트로닉스 엔.브이. | 금속-세라믹 접착 |
| US7551837B2 (en) * | 2001-08-31 | 2009-06-23 | Thomson Licensing | Sequence counter for an audio visual stream |
| AU2002346284A1 (en) * | 2002-04-26 | 2003-11-10 | Rudolf Perl | Pharmaceutical compositions of phospholipid derivatives |
| US20050187191A1 (en) * | 2004-02-20 | 2005-08-25 | Kucera Louis S. | Methods and compositions for the treatment of respiratory syncytial virus |
| AU2006328479B2 (en) | 2005-12-19 | 2012-03-08 | Aeterna Zentaris Gmbh | Alkyl phospholipid derivatives with reduced cytotoxicity and uses thereof |
| WO2008074573A1 (fr) * | 2006-12-20 | 2008-06-26 | Alphaptose Gmbh | Forme posologique topique comprenant des composés de glycérol trisubstitué |
| JP2011057647A (ja) * | 2009-09-14 | 2011-03-24 | Adeka Corp | 化粧料 |
| CA2840272C (fr) | 2011-06-24 | 2020-09-15 | Glycoregimmune, Inc. | Prevention et traitement d'etats inflammatoires |
| CN102491994B (zh) * | 2011-12-07 | 2014-10-15 | 宁波九胜创新医药科技有限公司 | 一种胆碱磷酸烷基酯的制备方法 |
| JP2017537984A (ja) * | 2014-12-09 | 2017-12-21 | ジーアールアイ バイオ， インコーポレイテッド | 炎症性病態の予防および治療 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3225227A1 (de) * | 1982-07-06 | 1984-01-12 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Derivate des n.n-bis-(2-chlor-aethyl)-phosphorsaeureamids |
| JPS5984824A (ja) * | 1982-11-08 | 1984-05-16 | Takeda Chem Ind Ltd | 抗腫瘍剤 |
| US4690935A (en) * | 1983-03-31 | 1987-09-01 | Wayne State University | Inhibition of tumor growth and metastasis with calcium channel blocker compounds |
-
1986
- 1986-12-03 CA CA000524478A patent/CA1338627C/fr not_active Expired - Fee Related
- 1986-12-03 CA CA000524479A patent/CA1280369C/fr not_active Expired - Lifetime
- 1986-12-03 IE IE317686A patent/IE59777B1/en not_active IP Right Cessation
- 1986-12-03 IE IE317786A patent/IE59778B1/en not_active IP Right Cessation
- 1986-12-04 DE DE8686906829T patent/DE3679908D1/de not_active Expired - Lifetime
- 1986-12-04 US US07/097,960 patent/US4837023A/en not_active Expired - Lifetime
- 1986-12-04 EP EP87900101A patent/EP0248062B1/fr not_active Expired - Lifetime
- 1986-12-04 AT AT86906829T patent/ATE64529T1/de active
- 1986-12-04 ES ES198686906829T patent/ES2032755T3/es not_active Expired - Lifetime
- 1986-12-04 WO PCT/EP1986/000705 patent/WO1987003480A2/fr active IP Right Grant
- 1986-12-04 PT PT83872A patent/PT83872B/pt not_active IP Right Cessation
- 1986-12-04 DE DE19375061C patent/DE19375061I2/de active Active
- 1986-12-04 PT PT83873A patent/PT83873B/pt unknown
- 1986-12-04 EP EP86116860A patent/EP0230575A3/fr active Pending
- 1986-12-04 WO PCT/EP1986/000706 patent/WO1987003478A2/fr active IP Right Grant
- 1986-12-04 AT AT87900101T patent/ATE75608T1/de not_active IP Right Cessation
- 1986-12-04 ES ES198787900101T patent/ES2038215T3/es not_active Expired - Lifetime
- 1986-12-04 HU HU865560A patent/HU203201B/hu unknown
- 1986-12-04 JP JP50634086A patent/JPH0637393B2/ja not_active Expired - Lifetime
- 1986-12-04 HU HU87831A patent/HU208143B/hu not_active IP Right Cessation
- 1986-12-04 DE DE19863641379 patent/DE3641379A1/de not_active Withdrawn
- 1986-12-04 EP EP86116858A patent/EP0225608A3/fr active Pending
- 1986-12-04 EP EP86906829A patent/EP0248047B1/fr not_active Expired - Lifetime
- 1986-12-04 DE DE19863641491 patent/DE3641491A1/de not_active Withdrawn
-
1987
- 1987-07-28 DK DK198703931A patent/DK172954B1/da not_active IP Right Cessation
- 1987-07-30 DK DK398587A patent/DK398587A/da not_active Application Discontinuation
- 1987-08-03 NO NO873244A patent/NO175620C/no not_active IP Right Cessation
- 1987-08-03 FI FI873363A patent/FI873363A/fi not_active Application Discontinuation
- 1987-08-03 NO NO873243A patent/NO174877C/no not_active IP Right Cessation
- 1987-08-03 FI FI873364A patent/FI873364A/fi not_active Application Discontinuation
-
1989
- 1989-02-27 US US07/316,413 patent/US5049552A/en not_active Expired - Lifetime
-
1991
- 1991-08-16 GR GR91401135T patent/GR3002487T3/el unknown
-
1992
- 1992-07-15 GR GR920401514T patent/GR3005168T3/el unknown
-
1995
- 1995-07-24 JP JP7187517A patent/JP2857084B2/ja not_active Expired - Fee Related
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