DK172077B1 - 6-Fluor-7-(4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinolin-3-carboxylsyre-derivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse forbindelser - Google Patents

6-Fluor-7-(4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinolin-3-carboxylsyre-derivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse forbindelser Download PDF

Info

Publication number
DK172077B1
DK172077B1 DK616388A DK616388A DK172077B1 DK 172077 B1 DK172077 B1 DK 172077B1 DK 616388 A DK616388 A DK 616388A DK 616388 A DK616388 A DK 616388A DK 172077 B1 DK172077 B1 DK 172077B1
Authority
DK
Denmark
Prior art keywords
methyl
oxo
compound
compounds
piperazinyl
Prior art date
Application number
DK616388A
Other languages
Danish (da)
English (en)
Other versions
DK616388D0 (da
DK616388A (da
Inventor
Masahiro Kise
Masahiko Kitano
Masakuni Ozaki
Kenji Kazuno
Masahito Matsuda
Ichiro Shirahase
Jun Segawa
Original Assignee
Nippon Shinyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Shinyaku Co Ltd filed Critical Nippon Shinyaku Co Ltd
Publication of DK616388D0 publication Critical patent/DK616388D0/da
Publication of DK616388A publication Critical patent/DK616388A/da
Application granted granted Critical
Publication of DK172077B1 publication Critical patent/DK172077B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Dental Preparations (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)
DK616388A 1987-11-07 1988-11-04 6-Fluor-7-(4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinolin-3-carboxylsyre-derivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse forbindelser DK172077B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP28155087 1987-11-07
JP28155087 1987-11-07

Publications (3)

Publication Number Publication Date
DK616388D0 DK616388D0 (da) 1988-11-04
DK616388A DK616388A (da) 1989-05-08
DK172077B1 true DK172077B1 (da) 1997-10-13

Family

ID=17640743

Family Applications (1)

Application Number Title Priority Date Filing Date
DK616388A DK172077B1 (da) 1987-11-07 1988-11-04 6-Fluor-7-(4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinolin-3-carboxylsyre-derivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse forbindelser

Country Status (14)

Country Link
US (1) US5086049A (zh)
EP (1) EP0315828B1 (zh)
JP (1) JPH0751579B2 (zh)
KR (1) KR950011747B1 (zh)
CN (1) CN1024194C (zh)
AT (1) ATE74608T1 (zh)
CA (1) CA1316925C (zh)
DE (1) DE3869907D1 (zh)
DK (1) DK172077B1 (zh)
ES (1) ES2031569T3 (zh)
FI (1) FI88618C (zh)
IL (1) IL88303A (zh)
NO (1) NO177934C (zh)
ZA (1) ZA888186B (zh)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3869906D1 (de) * 1987-11-07 1992-05-14 Nippon Shinyaku Co Ltd Chinolincarbonsaeure-derivate.
AU6641190A (en) * 1989-11-17 1991-06-13 Nippon Shinyaku Co. Ltd. Quinolinecarboxylic acid derivative
EP0551518A4 (en) * 1990-10-03 1993-09-22 Nippon Shinyaku Company, Limited Quinolinecarboxylic acid derivative
NO304832B1 (no) * 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
RU2270695C2 (ru) 1999-03-17 2006-02-27 Дайити Фармасьютикал Ко., Лтд. Фармацевтическая композиция
CN100351258C (zh) * 2003-04-30 2007-11-28 日本新药株式会社 喹啉羧酸衍生物溶剂化物的结晶
WO2004096815A1 (ja) 2003-04-30 2004-11-11 Nippon Shinyaku Co. Ltd. キノリンカルボン酸誘導体溶媒和物の結晶
JPWO2005073239A1 (ja) * 2004-01-30 2008-01-10 日本新薬株式会社 キノリンカルボン酸誘導体の精製方法
CN1321997C (zh) * 2004-03-03 2007-06-20 刘玉辉 一种稳定的噻丁啶喹啉羧酸盐在制备抗感染药物中的应用
CN100360539C (zh) * 2005-09-23 2008-01-09 广州白云山制药股份有限公司广州白云山化学制药厂 普卢利沙星的制备方法
WO2007082472A1 (en) * 2006-01-18 2007-07-26 Guangzhou Baiyunshan Pharmaceutical Co., Ltd. Guangzhou Baiyunshan Pharmaceutical Factory Anti-infective quinolone compound, preparation method thereof and use thereof
CN101003540A (zh) * 2006-01-18 2007-07-25 广州白云山制药股份有限公司广州白云山制药总厂 一种抗感染化合物和用途
US20100113783A1 (en) * 2007-03-14 2010-05-06 Ranbaxy Laboratories Limited Process for the preparation of crystals of prulifloxacin
WO2008111016A1 (en) * 2007-03-14 2008-09-18 Ranbaxy Laboratories Limited Process for the preparation of pure prulifloxacin
WO2009093268A1 (en) * 2008-01-23 2009-07-30 Ind-Swift Laboratories Limited Process for the preparation of highly pure prulifloxacin
CN101565428B (zh) * 2009-06-02 2011-06-29 重庆科瑞制药有限责任公司 普卢利沙星的制备方法
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
CN102093393B (zh) * 2009-12-15 2014-03-26 南京长澳医药科技有限公司 一种制备普卢利沙星及其中间产物的方法
CN101768172B (zh) * 2010-01-13 2012-04-18 海南皇隆制药股份有限公司 用于抗感染的普卢利沙星的光学活性化合物和制备方法
CN102198135B (zh) * 2010-03-22 2013-05-08 北京联木医药技术发展有限公司 一种新型稳定的普卢利沙星盐酸盐在制备抗感染药物中的应用
IN2012MN02925A (zh) * 2010-06-30 2015-05-22 Cipla Ltd
CN114751873A (zh) * 2022-04-25 2022-07-15 扬州市普林斯医药科技有限公司 一种1-(2,3-二氯苯基)哌嗪的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57203067A (en) * 1981-06-10 1982-12-13 Kanebo Ltd Novel quinolinecarboxylic acid derivatives, their preparations, and antibacterial agent comprising them as active ingredient
JPS59227887A (ja) * 1983-06-09 1984-12-21 Nippon Shinyaku Co Ltd ナフチリジン誘導体
US4659734A (en) * 1983-08-15 1987-04-21 Nippon Shinyaku Co., Ltd. Olinecarboxylic acid derivatives
DE3504643A1 (de) * 1985-02-12 1986-08-14 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-1,4-dihydro-4-oxo-7-(4-(2-oxo-1,3-dioxol-4-yl-methyl)-1-piperazinyl)-3-chinolin carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3542002A1 (de) * 1985-11-28 1987-06-04 Bayer Ag 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS63107990A (ja) * 1986-05-14 1988-05-12 Nippon Shinyaku Co Ltd キノリンカルボン酸誘導体
EP0312794B1 (en) * 1987-09-22 1993-05-19 Nippon Shinyaku Company, Limited Thiazetidine derivatives
DE3869906D1 (de) * 1987-11-07 1992-05-14 Nippon Shinyaku Co Ltd Chinolincarbonsaeure-derivate.

Also Published As

Publication number Publication date
US5086049A (en) 1992-02-04
KR890008150A (ko) 1989-07-10
FI88618B (fi) 1993-02-26
AU608911B2 (en) 1991-04-18
ATE74608T1 (de) 1992-04-15
DK616388D0 (da) 1988-11-04
ES2031569T3 (es) 1992-12-16
FI885128A (fi) 1989-05-08
CA1316925C (en) 1993-04-27
ZA888186B (en) 1989-07-26
JPH0751579B2 (ja) 1995-06-05
FI885128A0 (fi) 1988-11-07
NO177934C (no) 1995-12-20
FI88618C (fi) 1993-06-10
IL88303A (en) 1993-05-13
DK616388A (da) 1989-05-08
NO177934B (no) 1995-09-11
KR950011747B1 (en) 1995-10-09
CN1024194C (zh) 1994-04-13
DE3869907D1 (de) 1992-05-14
IL88303A0 (en) 1989-06-30
CN1033055A (zh) 1989-05-24
EP0315828A1 (en) 1989-05-17
JPH01294680A (ja) 1989-11-28
NO884958D0 (no) 1988-11-07
AU2467388A (en) 1989-05-11
EP0315828B1 (en) 1992-04-08
NO884958L (no) 1989-05-08

Similar Documents

Publication Publication Date Title
DK172077B1 (da) 6-Fluor-7-(4-(5-methyl-2-oxo-1,3-dioxolen-4-yl)methyl-1-piperazinyl)-4-oxo-4H-(1,3)thiazeto(3,2-a)quinolin-3-carboxylsyre-derivater, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse forbindelser
FR2555584A1 (fr) Derives de l'acide fluoro-6-dihydro-1,4-oxo-4-piperazinyl substitue-7-quinoline-carboxylique-3 et procede pour leur preparation et compositions pharmaceutiques a action anti-bacteriennes a base desdits derives
US4499091A (en) 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents
EP0375658A1 (en) Quinoline derivatives and processes for preparation thereof
US4429127A (en) Quinoline carboxylic acid derivative
US4472406A (en) Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
EP0090424B1 (en) New quinolone compounds and preparation thereof
EP0178388A1 (en) Quinolinecarboxylic acid derivatives
US4439436A (en) 1,3-Dioxolo(4,5-G)quinoline compounds
EP0549857A1 (en) Antibacterial quinolone carboxylic acid derivatives
EP0364943B1 (en) Benzoheterocyclic compounds
JPH02131483A (ja) ベンゾヘテロ環化合物
KR930003611B1 (ko) 퀴놀론 카복실산 유도체의 제조방법
EP0221541A2 (en) Quinolonecarboxylic acid derivatives and their preparation
KR0174373B1 (ko) 7-(4-아미노메틸-4-알킬-3-알킬옥심)피롤리딘 치환체를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법
JP2666320B2 (ja) 抗菌化合物
KR100222081B1 (ko) 7-[3-아미노메틸-4-(z)-치환된 옥심]피롤리딘 치환체를 갖는 퀴놀린 카복실산 유도체
US4567269A (en) Intermediates for the preparation of 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acids
KR0134941B1 (ko) 7-아지도피롤리딘 치환체를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법
KR940009786B1 (ko) 새로운 퀴놀론계 항균제
KR0120278B1 (ko) 7-(4-아미노-3-옥심)피롤리딘 치환체를 갖는 신규 퀴놀린 카르복실산 유도체 및 그의 제조방법
JP2621204B2 (ja) 抗菌化合物
JPH0616678A (ja) キノリンカルボン酸誘導体
KR19980076903A (ko) 신규한 퀴놀론카르복실산 유도체
JPH03130286A (ja) 選択毒性を示す哺乳動物用抗菌薬としての１，４―ジヒドロ―４―オキソ―３―キノリン誘導体

Legal Events

Date Code Title Description
PUP Patent expired