DK171846B1 - Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener - Google Patents

Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener Download PDF

Info

Publication number
DK171846B1
DK171846B1 DK016487A DK16487A DK171846B1 DK 171846 B1 DK171846 B1 DK 171846B1 DK 016487 A DK016487 A DK 016487A DK 16487 A DK16487 A DK 16487A DK 171846 B1 DK171846 B1 DK 171846B1
Authority
DK
Denmark
Prior art keywords
immunogen
complex
molecule
carrier molecule
carrier
Prior art date
Application number
DK016487A
Other languages
Danish (da)
English (en)
Other versions
DK16487A (da
DK16487D0 (da
Inventor
Gregory John Russell-Jones
Henry James De Aizpurua
Peter Howe
Keith Norman Rand
Original Assignee
Biotech Australia Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25642944&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK171846(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biotech Australia Pty Ltd filed Critical Biotech Australia Pty Ltd
Publication of DK16487D0 publication Critical patent/DK16487D0/da
Publication of DK16487A publication Critical patent/DK16487A/da
Application granted granted Critical
Publication of DK171846B1 publication Critical patent/DK171846B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
DK016487A 1985-05-15 1987-01-14 Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener DK171846B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
AUPH056685 1985-05-15
AUPH056685 1985-05-15
AUPH310485 1985-10-25
AUPH310485 1985-10-25
AU8600135 1986-05-14
PCT/AU1986/000135 WO1986006635A1 (fr) 1985-05-15 1986-05-14 Vaccins oraux

Publications (3)

Publication Number Publication Date
DK16487D0 DK16487D0 (da) 1987-01-14
DK16487A DK16487A (da) 1987-03-16
DK171846B1 true DK171846B1 (da) 1997-06-30

Family

ID=25642944

Family Applications (1)

Application Number Title Priority Date Filing Date
DK016487A DK171846B1 (da) 1985-05-15 1987-01-14 Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener

Country Status (12)

Country Link
EP (1) EP0222835B2 (fr)
JP (1) JP2761849B2 (fr)
CN (1) CN86103835A (fr)
CA (1) CA1340555C (fr)
DE (1) DE3650082T3 (fr)
DK (1) DK171846B1 (fr)
ES (1) ES8900006A1 (fr)
FI (1) FI870140A0 (fr)
HK (1) HK29896A (fr)
IL (1) IL78775A (fr)
NZ (1) NZ216162A (fr)
WO (1) WO1986006635A1 (fr)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8601940D0 (sv) * 1986-04-25 1986-04-25 Kabigen Ab Preparation of fused proteins, antibodies and processes therefor
US4822611A (en) * 1986-12-09 1989-04-18 Immunotec, Inc. Oral hyposensitization in the treatment of allergies
US5112749A (en) * 1987-10-02 1992-05-12 Praxis Biologics, Inc. Vaccines for the malaria circumsporozoite protein
US5135918A (en) * 1988-03-21 1992-08-04 Broncorp Method for decreasing reaginic antibody levels
JPH03502584A (ja) * 1988-08-30 1991-06-13 アプライド・リサーチ・システムス・エー・アール・エス・ホールディング・エヌ・ブイ ホルモン分泌を変化させる組換え体融合タンパク質
WO1990002484A1 (fr) * 1988-09-06 1990-03-22 Washington University Immunisation par voie orale a l'aide de plantes transgeniques
US6043057A (en) * 1988-09-16 2000-03-28 Vitec Aktiebolag Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides
FR2636842B1 (fr) * 1988-09-27 1994-06-10 Liege Universite Etat Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion
AU4754490A (en) * 1988-12-07 1990-06-26 University Of Leicester Heat-labile toxin b subunit fusion proteins
WO1990007525A1 (fr) * 1989-01-06 1990-07-12 The Regents Of The University Of California Cytotoxine de la keratoconjonctivite et ses procedes d'utilisation et de production
US6413523B1 (en) * 1989-06-02 2002-07-02 The United States Of America As Represented By The Secretary Of The Navy Pharmaceutical composition of escherichia coli heat-labile enterotoxin adjuvant and methods of use
DE69005572T2 (de) * 1989-09-08 1994-04-07 Takeda Chemical Industries Ltd Fusionsproteine und Herstellung davon.
US5032405A (en) * 1989-09-27 1991-07-16 Warner-Lambert Company Oral pharmaceutical composition for acid sensitive proteinaceous agents
US5378815A (en) * 1989-10-20 1995-01-03 National Research Council Canada Process for indirect targeted immunocytolysis
CA2050425A1 (fr) * 1990-09-03 1992-03-04 Yoshiaki Uda Composition pharmaceutique et son utilisation avec du mucus
US5241053A (en) * 1990-09-05 1993-08-31 Takeda Chemical Industries, Ltd. Fused proteins comprising glycoprotein gD of HSV-1 and LTB
EP0565590B1 (fr) * 1990-12-21 1999-03-03 Antex Biologics, Inc. VACCIN CONJUGUE ADHESINE-OLIGOSACCHARIDE CONTRE $i(HAEMOPHILUS INFLUENZAE)
US5843463A (en) * 1990-12-21 1998-12-01 Antexbiologics, Inc. Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae
PL296623A1 (en) * 1991-03-01 1993-09-20 Rhone Merieux Method of improving organoleptic properties of male slaughter animal meat
WO1992017167A1 (fr) * 1991-04-02 1992-10-15 Biotech Australia Pty. Ltd. Systemes de liberation orale de microparticules
GB9112553D0 (en) * 1991-06-11 1991-07-31 Wellcome Found Fusion proteins
ZA934199B (en) * 1992-06-18 1994-01-10 Akzo Nv Carrier system against gnrh
DK0603992T4 (da) * 1992-12-22 2001-03-05 Univ Cincinnati Oral indgivelse af immunologisk aktive biomolekyler og andre terapeutiske proteiner
US5681571A (en) * 1993-10-08 1997-10-28 Duotol Ab Immunological tolerance-inducing agent
US5688506A (en) * 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
US6030613A (en) * 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US6086875A (en) * 1995-01-17 2000-07-11 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
US6485726B1 (en) 1995-01-17 2002-11-26 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
DK1323346T3 (da) * 1995-01-17 2006-10-30 Brigham & Womens Hospital Receptorspecifik transport af immunogener gennem epitelet
EP0840796A2 (fr) * 1995-07-26 1998-05-13 Maxim Pharmaceuticals Apport de polynucleotides dans les muqueuses
DE19534579C2 (de) * 1995-09-18 2000-06-08 Max Planck Gesellschaft Nucleinsäure-Moleküle codierend Proteine, die die Adhäsion von Neisseria-Zellen an humane Zellen vermitteln
JP2000509270A (ja) 1996-04-19 2000-07-25 ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン ヒスチジンタグ付きインチミン、ならびに免疫応答を刺激し、標的能力を有する抗原担体としてインチミンを使用する方法
JP2000510332A (ja) 1996-04-19 2000-08-15 ヘンリー エム．ジャクソン ファンデーション フォー ザ アドバンスメント オブ ミリタリー メディシン インチミンを単独で、または１以上の他の抗原との融合タンパク質として発現する宿主生物の投与による、免疫応答を刺激する方法
US6818222B1 (en) 1997-03-21 2004-11-16 Chiron Corporation Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
US7914791B1 (en) 1998-05-08 2011-03-29 Trident Pharmaceuticals, Inc. Vaccine
US7087236B1 (en) 1998-09-01 2006-08-08 Merrion Research I Limited Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof
ES2233284T3 (es) 1999-02-17 2005-06-16 Pfizer Products Inc. Proteinas de fusion que comprenden portadores que pueden inducir una bdoble respuesta inmune.
FR2791895B1 (fr) * 1999-03-23 2001-06-15 Pasteur Merieux Serums Vacc Utilisation de trehalose pour stabiliser un vaccin liquide
JP2003512441A (ja) * 1999-10-22 2003-04-02 アメリカ合衆国 極性上皮細胞層を横断するタンパク質の送達
US6863896B1 (en) 1999-10-26 2005-03-08 Chiron Corporation Plant lectins as mucosal adjuvants
WO2001034193A1 (fr) * 1999-10-26 2001-05-17 Chiron Corporation Lectines vegetales en tant qu'adjuvants des muqueuses
JP2001335510A (ja) * 2000-05-23 2001-12-04 Masanori Baba エイズワクチン
BRPI0408167B1 (pt) * 2003-03-07 2014-10-21 Wyeth Corp Conjugados de polissacarídeo-proteína veículo adesina da superfície estafilocócica para imunização contra infecções nosocomiais
PL1787126T3 (pl) * 2004-07-20 2010-03-31 Symphogen As Sposób charakteryzowania poliklonalnej linii komórkowej
AU2005296064A1 (en) 2004-10-04 2006-04-27 Trinity Biosystems, Inc. Methods and compositions for needleless delivery of macromolecules
CA2623531C (fr) * 2005-10-07 2013-12-10 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Vaccin de metalloproteinase 11 matricielle
CA2631952A1 (fr) 2005-12-05 2007-06-14 Trinity Biosystems, Inc. Procedes et compositions servant a l'apport, sans aiguille, d'anticorps
AU2007224034B2 (en) 2006-03-07 2012-03-29 Vaxinnate Corporation Compositions that include hemagglutinin, methods of making and methods of use thereof
WO2009128949A2 (fr) 2008-04-18 2009-10-22 Vaxinnate Corporation Compositions de proteines du virus de la dengue et methodes d’utilisation associees
EP3461496B1 (fr) 2009-06-22 2023-08-23 Wyeth LLC Compositions et procédés d'élaboration de compositions immunogènes conjuguées à polysaccharides capsulaires de sérotypes 5 et 8 de staphylococcus aureus
MX2012000044A (es) 2009-06-22 2012-01-30 Wyeth Llc Composiciones inmunogenicas de antigenos de staphylococcus aureus.
CN101921726B (zh) * 2010-07-27 2012-08-22 浙江大学 一种口服免疫阻断鸡抑制素作用的转化子及其应用
CN102178699B (zh) * 2011-04-20 2013-03-20 威海康博尔生物药业有限公司 一种用于增强人体免疫力、促进生长发育的制剂
US8932598B2 (en) 2012-08-28 2015-01-13 Vaxinnate Corporation Fusion proteins and methods of use
US10617650B2 (en) 2015-10-16 2020-04-14 Merck Sharp & Dohme Corp. Process for preparing formulations for gastrointestinal-targeted therapies

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2547224A1 (de) * 1974-11-01 1976-05-13 Sandoz Ag Organische verbindungen, ihre verwendung und herstellung
FR2306684A1 (fr) * 1975-04-11 1976-11-05 Crinex Lab Nouvelle composition a action immunostimulante
GB1553664A (en) * 1975-06-12 1979-09-26 Unilever Ltd Antigenic compositions
ZA802992B (en) * 1979-06-01 1981-10-28 Univ California Human pre-growth hormone
JPS5639022A (en) * 1979-09-05 1981-04-14 Hayashibara Biochem Lab Inc Preparation of vaccine
DE3153267A1 (fr) * 1980-03-17 1985-08-14
EP0049945A3 (fr) * 1980-09-15 1982-12-01 Bactex Incorporated Méthode pour la détermination de la hiérarchie des organismes piliés et vaccin préparé à partir de ces organismes
GB2094314A (en) * 1981-02-05 1982-09-15 Wellcome Found Recombinant DNA
NZ199866A (en) * 1981-03-09 1984-11-09 Cetus Corp Vaccine for prevention of gastroenteric disease:non-pathogenic strain genetically engineered to comprise genes for adhesin and/or toxoids
US4593002A (en) * 1982-01-11 1986-06-03 Salk Institute Biotechnology/Industrial Associates, Inc. Viruses with recombinant surface proteins
CA1203164A (fr) * 1982-03-09 1986-04-15 Thomas J. Mckearn Conjugats d'anticorps
ES8407097A1 (es) * 1982-05-12 1984-08-16 Harvard College Un procedimiento para obtener una proteina hibrida.
US4496538A (en) * 1982-07-06 1985-01-29 Connaught Laboratories, Inc. Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine
EP0116201B1 (fr) * 1983-01-12 1992-04-22 Chiron Corporation Expression sécrétoire en eukaryotes
DK219084D0 (da) * 1984-05-02 1984-05-02 Frederik Carl Peter Lindberg Antigen
AU582358B2 (en) * 1984-04-06 1989-03-23 Scripps Clinic And Research Foundation A peptide vaccine or diagnostic, and a polypeptide useful therefor
US4808700A (en) * 1984-07-09 1989-02-28 Praxis Biologics, Inc. Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
DE3586386T2 (de) * 1984-10-05 1993-01-14 Genentech Inc Dna, zellkulturen und verfahren zur sekretion von heterologen proteinen und periplasmische proteinrueckgewinnung.
NZ213759A (en) * 1984-10-19 1989-01-27 Genentech Inc Lhrh-ctp protein conjugates influencing prolactin fsh and lh release
US4556555A (en) * 1985-01-25 1985-12-03 North Carolina State University Process for the immunological neutering of animals

Also Published As

Publication number Publication date
AU594059B2 (en) 1990-03-01
AU5861286A (en) 1986-12-04
IL78775A (en) 1992-06-21
IL78775A0 (en) 1986-08-31
JPH07213290A (ja) 1995-08-15
JP2761849B2 (ja) 1998-06-04
FI870140A (fi) 1987-01-14
ES8900006A1 (es) 1988-10-16
FI870140A0 (fi) 1987-01-14
DE3650082T2 (de) 1995-05-04
DE3650082D1 (de) 1994-11-03
HK29896A (en) 1996-02-23
EP0222835B2 (fr) 2000-04-19
CA1340555C (fr) 1999-05-25
NZ216162A (en) 1989-04-26
DK16487A (da) 1987-03-16
DK16487D0 (da) 1987-01-14
ES554969A0 (es) 1988-10-16
CN86103835A (zh) 1987-04-08
DE3650082T3 (de) 2000-12-21
WO1986006635A1 (fr) 1986-11-20
EP0222835A4 (fr) 1988-02-01
EP0222835A1 (fr) 1987-05-27
EP0222835B1 (fr) 1994-09-28

Similar Documents

Publication Publication Date Title
DK171846B1 (da) Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener
De Aizpurua et al. Oral vaccination. Identification of classes of proteins that provoke an immune response upon oral feeding.
US6103243A (en) Oral vaccines
Ellis Vaccines: New approaches to immunological problems
US7960535B2 (en) Recombinant lipidated PsaA protein, methods of preparation and use
US20050244425A1 (en) Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability
Oaks et al. Development and evaluation of a Shigella flexneri 2a and S. sonnei bivalent invasin complex (Invaplex) vaccine
JP2012139221A (ja) 肺炎球菌感染を治療または予防するための組成物および方法
KR20010021953A (ko) Ｂ군 수막염균 포린 및 에이치.인플루엔자 다당류를포함하는 면역원성 접합체
US9011871B2 (en) Broad spectrum vaccine against typhoidal and non-typhoidal Salmonella disease
LEVINE et al. Pediatric diarrhea: the challenge of prevention
EP0682950B1 (fr) Administration mucosale d'antigènes de pneumococcus
CZ281556B6 (cs) Způsob výroby kompozitní vakcíny proti střevní infekci způsobené enterotexigenickými bakteriemi E. coli
JPH05503420A (ja) キメラタンパク質
EP0365646A1 (fr) Peptides synthetiques provenant de proteines streptococciques m et vaccins prepares a partir de ces peptides.
Lasaro et al. Prime-boost vaccine regimen confers protective immunity to human-derived enterotoxigenic Escherichia coli
AU594059C (en) Oral vaccines
Jacob et al. Identification of a 33 kDa antigen associated with an adhesive and colonizing strain of Vibrio cholerae El Tor and its role in protection
Klipstein et al. Differences in cross-protection in rats immunized with the B subunits of cholera toxin and Escherichia coli heat-labile toxin
NO870148L (no) Orale vaksiner.
JP2660511B2 (ja) 経口ワクチン
Svennerholm et al. Immunity to enterotoxin-producing bacteria
Freytag Effect of gene location on in vitro and in vivo stability, immunogenicity and expression of foreign antigens in bacterial vaccine fectors
Dickinson Construction and characterization of a non-toxic mutant of the Escherichia coli heat-labile enterotoxin effective as an oral adjuvant
Guinée et al. Infection and immunity to Vibrio cholerae, Salmonella typhimurium and Escherichia coli in a rabbit model

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment
B1 Patent granted (law 1993)
PBP Patent lapsed