DK16487D0 - Vacciner til oral indgift - Google Patents
Vacciner til oral indgiftInfo
- Publication number
- DK16487D0 DK16487D0 DK016487A DK16487A DK16487D0 DK 16487 D0 DK16487 D0 DK 16487D0 DK 016487 A DK016487 A DK 016487A DK 16487 A DK16487 A DK 16487A DK 16487 D0 DK16487 D0 DK 16487D0
- Authority
- DK
- Denmark
- Prior art keywords
- vaccines
- oral administration
- oral
- administration
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0006—Contraceptive vaccins; Vaccines against sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPH056685 | 1985-05-15 | ||
| AUPH056685 | 1985-05-15 | ||
| AUPH310485 | 1985-10-25 | ||
| AUPH310485 | 1985-10-25 | ||
| AU8600135 | 1986-05-14 | ||
| PCT/AU1986/000135 WO1986006635A1 (en) | 1985-05-15 | 1986-05-14 | Oral vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK16487D0 true DK16487D0 (da) | 1987-01-14 |
| DK16487A DK16487A (da) | 1987-03-16 |
| DK171846B1 DK171846B1 (da) | 1997-06-30 |
Family
ID=25642944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK016487A DK171846B1 (da) | 1985-05-15 | 1987-01-14 | Et kompleks, en fremgangsmåde til fremstilling af dette kompleks, en transformant vært, et rekombinant DNA-molekyle og et medikament for den specifikke stimulering af serum og sekretoriske antistoffer via mucøs tilstedeværelse af antigener |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0222835B2 (da) |
| JP (1) | JP2761849B2 (da) |
| CN (1) | CN86103835A (da) |
| CA (1) | CA1340555C (da) |
| DE (1) | DE3650082T3 (da) |
| DK (1) | DK171846B1 (da) |
| ES (1) | ES8900006A1 (da) |
| FI (1) | FI870140A0 (da) |
| HK (1) | HK29896A (da) |
| IL (1) | IL78775A (da) |
| NZ (1) | NZ216162A (da) |
| WO (1) | WO1986006635A1 (da) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8601940D0 (sv) * | 1986-04-25 | 1986-04-25 | Kabigen Ab | Preparation of fused proteins, antibodies and processes therefor |
| US4822611A (en) * | 1986-12-09 | 1989-04-18 | Immunotec, Inc. | Oral hyposensitization in the treatment of allergies |
| US5112749A (en) * | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| US5135918A (en) * | 1988-03-21 | 1992-08-04 | Broncorp | Method for decreasing reaginic antibody levels |
| WO1990002187A1 (en) * | 1988-08-30 | 1990-03-08 | Applied Research Systems Ars Holding N.V. | Recombinant fusion proteins for altering hormone secretion |
| JPH04501801A (ja) * | 1988-09-06 | 1992-04-02 | ワシントン ユニバーシティ | トランスジェニック植物による経口的免疫化 |
| US6043057A (en) * | 1988-09-16 | 2000-03-28 | Vitec Aktiebolag | Recombinant systems for expression of the cholera B-sub-unit with the aid of foreign promoters and/or leader peptides |
| FR2636842B1 (fr) * | 1988-09-27 | 1994-06-10 | Liege Universite Etat | Proteine de fusion d'une sequence derivee de la sous-unite b de la toxine cholerique et d'un antigene heterologue doue de proprietes immunogenes, compositions de vaccins les contenant et acides nucleiques recombinants contenant une sequence de nucleotides codant pour ladite proteine de fusion |
| WO1990006366A1 (en) * | 1988-12-07 | 1990-06-14 | University Of Leicester | Heat-labile toxin b subunit fusion proteins |
| AU5088690A (en) * | 1989-01-06 | 1990-08-01 | Regents Of The University Of California, The | Keratoconjunctivitis cytotoxin and methods for its use and production |
| US6413523B1 (en) * | 1989-06-02 | 2002-07-02 | The United States Of America As Represented By The Secretary Of The Navy | Pharmaceutical composition of escherichia coli heat-labile enterotoxin adjuvant and methods of use |
| DE69005572T2 (de) * | 1989-09-08 | 1994-04-07 | Takeda Chemical Industries Ltd | Fusionsproteine und Herstellung davon. |
| US5032405A (en) * | 1989-09-27 | 1991-07-16 | Warner-Lambert Company | Oral pharmaceutical composition for acid sensitive proteinaceous agents |
| US5378815A (en) * | 1989-10-20 | 1995-01-03 | National Research Council Canada | Process for indirect targeted immunocytolysis |
| CA2050425A1 (en) * | 1990-09-03 | 1992-03-04 | Yoshiaki Uda | Pharmaceutical composition and its mucous use |
| US5241053A (en) * | 1990-09-05 | 1993-08-31 | Takeda Chemical Industries, Ltd. | Fused proteins comprising glycoprotein gD of HSV-1 and LTB |
| WO1992010936A1 (en) * | 1990-12-21 | 1992-07-09 | Microcarb, Inc. | ADHESIN-OLIGOSACCHARIDE CONJUGATE VACCINE FOR $i(HAEMOPHILUS INFLUENZAE) |
| US5843463A (en) * | 1990-12-21 | 1998-12-01 | Antexbiologics, Inc. | Adhesin-oligosaccharide conjugate vaccine for Haemophilus influenzae |
| PT501882E (pt) * | 1991-03-01 | 2000-12-29 | Merial Sas | Processo de imunoneutralizacao anti-lhrm de animais domesticos machos nao castrados e peptido para esse fim |
| DK0531497T3 (da) * | 1991-04-02 | 1998-03-23 | Biotech Australia Pty Ltd | Orale indgivelsessystemer til mikropartikler |
| GB9112553D0 (en) * | 1991-06-11 | 1991-07-31 | Wellcome Found | Fusion proteins |
| ZA934199B (en) * | 1992-06-18 | 1994-01-10 | Akzo Nv | Carrier system against gnrh |
| DE69305313T3 (de) * | 1992-12-22 | 2001-06-21 | The University Of Cincinnati, Cincinnati | Orale Verabreichung von immunologischen aktiven Biomolekülen und anderen therapeutischen Proteinen |
| US5681571A (en) * | 1993-10-08 | 1997-10-28 | Duotol Ab | Immunological tolerance-inducing agent |
| US5688506A (en) * | 1994-01-27 | 1997-11-18 | Aphton Corp. | Immunogens against gonadotropin releasing hormone |
| US6030613A (en) * | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US6485726B1 (en) | 1995-01-17 | 2002-11-26 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US6086875A (en) * | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
| EP0805628B1 (en) * | 1995-01-17 | 2003-05-02 | Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
| AU6505796A (en) * | 1995-07-26 | 1997-02-26 | Maxim Pharmaceuticals | Mucosal delivery of polynucleotides |
| DE19534579C2 (de) * | 1995-09-18 | 2000-06-08 | Max Planck Gesellschaft | Nucleinsäure-Moleküle codierend Proteine, die die Adhäsion von Neisseria-Zellen an humane Zellen vermitteln |
| US6942861B2 (en) | 1996-04-19 | 2005-09-13 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Histidine-tagged intimin and methods of using intimin to stimulate an immune response and as an antigen carrier with targeting capability |
| AU722327B2 (en) | 1996-04-19 | 2000-07-27 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Method of stimulating an immune response by administration of host organisms that express intimin alone or as a fusion protein with one or more other antigens |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| US7914791B1 (en) | 1998-05-08 | 2011-03-29 | Trident Pharmaceuticals, Inc. | Vaccine |
| US7087236B1 (en) | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
| PT1035133E (pt) | 1999-02-17 | 2005-05-31 | Pfizer Prod Inc | Proteinas de fusao compreendendo veiculos que podem induzir uma dupla resposta imune |
| FR2791895B1 (fr) * | 1999-03-23 | 2001-06-15 | Pasteur Merieux Serums Vacc | Utilisation de trehalose pour stabiliser un vaccin liquide |
| JP2003512441A (ja) * | 1999-10-22 | 2003-04-02 | アメリカ合衆国 | 極性上皮細胞層を横断するタンパク質の送達 |
| AU2471201A (en) * | 1999-10-26 | 2001-06-06 | Chiron Corporation | Plant lectins as mucosal adjuvants |
| US6863896B1 (en) | 1999-10-26 | 2005-03-08 | Chiron Corporation | Plant lectins as mucosal adjuvants |
| JP2001335510A (ja) * | 2000-05-23 | 2001-12-04 | Masanori Baba | エイズワクチン |
| US9296795B2 (en) * | 2003-03-07 | 2016-03-29 | Wyeth Holdings, Llc. | Polysaccharide-staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections |
| AU2005263334C1 (en) * | 2004-07-20 | 2011-01-20 | Symphogen A/S | A procedure for structural characterization of a recombinant polyclonal protein or a polyclonal cell line |
| JP2008515808A (ja) | 2004-10-04 | 2008-05-15 | トリニティ バイオシステムズ インコーポレーテッド | 針不用の高分子送達のための方法及び組成物 |
| JP5361386B2 (ja) * | 2005-10-07 | 2013-12-04 | イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・エルレ・エルレ | マトリックスメタロプロテイナーゼ11ワクチン |
| WO2007067596A2 (en) | 2005-12-05 | 2007-06-14 | Trinity Biosystems, Inc. | Methods and compositions for needleless delivery of antibodies |
| EP3011969A1 (en) | 2006-03-07 | 2016-04-27 | Vaxinnate Corporation | Compositions that include hemagglutinin, methods of making and methods of use thereof |
| WO2009128952A2 (en) | 2008-04-18 | 2009-10-22 | Vaxinnate Corporation | Compositions of papillomavirus proteins and methods of use |
| TWI505834B (zh) | 2009-06-22 | 2015-11-01 | Wyeth Llc | 組合物及製備金黃色葡萄球菌血清型5及8莢膜多醣結合物之免疫原性組合物之方法 |
| BRPI1015567A2 (pt) | 2009-06-22 | 2021-08-31 | Wyeth Llc | Composições imunogênicas de antígenos de staphylococcus aureus |
| CN101921726B (zh) * | 2010-07-27 | 2012-08-22 | 浙江大学 | 一种口服免疫阻断鸡抑制素作用的转化子及其应用 |
| CN102178699B (zh) * | 2011-04-20 | 2013-03-20 | 威海康博尔生物药业有限公司 | 一种用于增强人体免疫力、促进生长发育的制剂 |
| US8932598B2 (en) | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| US10617650B2 (en) | 2015-10-16 | 2020-04-14 | Merck Sharp & Dohme Corp. | Process for preparing formulations for gastrointestinal-targeted therapies |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2547224A1 (de) * | 1974-11-01 | 1976-05-13 | Sandoz Ag | Organische verbindungen, ihre verwendung und herstellung |
| FR2306684A1 (fr) * | 1975-04-11 | 1976-11-05 | Crinex Lab | Nouvelle composition a action immunostimulante |
| GB1553664A (en) * | 1975-06-12 | 1979-09-26 | Unilever Ltd | Antigenic compositions |
| GR68404B (da) * | 1979-06-01 | 1981-12-29 | Univ California | |
| JPS5639022A (en) * | 1979-09-05 | 1981-04-14 | Hayashibara Biochem Lab Inc | Preparation of vaccine |
| CA1198385A (en) * | 1980-03-17 | 1985-12-24 | Leonard P. Guarente | Optimal polypeptide production |
| EP0049945A3 (en) * | 1980-09-15 | 1982-12-01 | Bactex Incorporated | Determining a hierarchy of piliated organisms and a vaccine prepared from such organisms |
| GB2094314A (en) * | 1981-02-05 | 1982-09-15 | Wellcome Found | Recombinant DNA |
| WO1982003088A1 (en) * | 1981-03-09 | 1982-09-16 | Corp Cetus | Vaccines |
| US4593002A (en) * | 1982-01-11 | 1986-06-03 | Salk Institute Biotechnology/Industrial Associates, Inc. | Viruses with recombinant surface proteins |
| CA1203164A (en) * | 1982-03-09 | 1986-04-15 | Thomas J. Mckearn | Antibody conjugates |
| IT1203672B (it) * | 1982-05-12 | 1989-02-15 | Harvard College | Proteina ibrida comprendente frammenti proteici collegati da legami peptidici e relativo gene di fusione composizione contenente tale proteina |
| US4496538A (en) * | 1982-07-06 | 1985-01-29 | Connaught Laboratories, Inc. | Haemophilus influenzae b polysaccharide-diphtheria toxoid conjugate vaccine |
| EP0116201B1 (en) * | 1983-01-12 | 1992-04-22 | Chiron Corporation | Secretory expression in eukaryotes |
| DK219084D0 (da) * | 1984-05-02 | 1984-05-02 | Frederik Carl Peter Lindberg | Antigen |
| WO1985004654A1 (en) * | 1984-04-06 | 1985-10-24 | Scripps Clinic And Research Foundation | A peptide vaccine or diagnostic, and a polypeptide useful therefor |
| US4808700A (en) * | 1984-07-09 | 1989-02-28 | Praxis Biologics, Inc. | Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers |
| EP0177343B1 (en) * | 1984-10-05 | 1992-07-22 | Genentech, Inc. | Dna, cell cultures and methods for the secretion of heterologous proteins and periplasmic protein recovery |
| NZ213759A (en) * | 1984-10-19 | 1989-01-27 | Genentech Inc | Lhrh-ctp protein conjugates influencing prolactin fsh and lh release |
| US4556555A (en) * | 1985-01-25 | 1985-12-03 | North Carolina State University | Process for the immunological neutering of animals |
-
1986
- 1986-05-13 IL IL78775A patent/IL78775A/xx not_active IP Right Cessation
- 1986-05-14 EP EP86903134A patent/EP0222835B2/en not_active Expired - Lifetime
- 1986-05-14 FI FI870140A patent/FI870140A0/fi not_active Application Discontinuation
- 1986-05-14 WO PCT/AU1986/000135 patent/WO1986006635A1/en not_active Ceased
- 1986-05-14 NZ NZ216162A patent/NZ216162A/en unknown
- 1986-05-14 DE DE3650082T patent/DE3650082T3/de not_active Expired - Fee Related
- 1986-05-14 ES ES554969A patent/ES8900006A1/es not_active Expired
- 1986-05-15 CN CN198686103835A patent/CN86103835A/zh active Pending
- 1986-05-15 CA CA000509225A patent/CA1340555C/en not_active Expired - Fee Related
-
1987
- 1987-01-14 DK DK016487A patent/DK171846B1/da not_active IP Right Cessation
-
1995
- 1995-01-05 JP JP7015505A patent/JP2761849B2/ja not_active Expired - Lifetime
-
1996
- 1996-02-15 HK HK29896A patent/HK29896A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2761849B2 (ja) | 1998-06-04 |
| HK29896A (en) | 1996-02-23 |
| EP0222835B1 (en) | 1994-09-28 |
| DE3650082T2 (de) | 1995-05-04 |
| FI870140L (fi) | 1987-01-14 |
| EP0222835A4 (en) | 1988-02-01 |
| AU594059B2 (en) | 1990-03-01 |
| FI870140A7 (fi) | 1987-01-14 |
| DE3650082T3 (de) | 2000-12-21 |
| DK16487A (da) | 1987-03-16 |
| IL78775A (en) | 1992-06-21 |
| WO1986006635A1 (en) | 1986-11-20 |
| ES8900006A1 (es) | 1988-10-16 |
| FI870140A0 (fi) | 1987-01-14 |
| IL78775A0 (en) | 1986-08-31 |
| EP0222835B2 (en) | 2000-04-19 |
| NZ216162A (en) | 1989-04-26 |
| JPH07213290A (ja) | 1995-08-15 |
| DE3650082D1 (de) | 1994-11-03 |
| EP0222835A1 (en) | 1987-05-27 |
| DK171846B1 (da) | 1997-06-30 |
| CN86103835A (zh) | 1987-04-08 |
| CA1340555C (en) | 1999-05-25 |
| ES554969A0 (es) | 1988-10-16 |
| AU5861286A (en) | 1986-12-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AHB | Application shelved due to non-payment | ||
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |