DK171670B1 - Anvendelse af puriderivater til fremstilling af et lægemiddel til behandling eller forebyggelse af humane virale infektioner forårsaget af VZV, hidtil ukendt 9-beta-D-arabinofuranosyl-2-amino-6-methoxy-9H-purin og derivater heraf, fremgangsmåde til fremstilling af en sådan purinforbindelse og farmaceutisk præparat indeholdende den, samt farmaceutisk acceptabel ester af 9-beta-D-arabino-furanosyl-6 - Google Patents

Anvendelse af puriderivater til fremstilling af et lægemiddel til behandling eller forebyggelse af humane virale infektioner forårsaget af VZV, hidtil ukendt 9-beta-D-arabinofuranosyl-2-amino-6-methoxy-9H-purin og derivater heraf, fremgangsmåde til fremstilling af en sådan purinforbindelse og farmaceutisk præparat indeholdende den, samt farmaceutisk acceptabel ester af 9-beta-D-arabino-furanosyl-6 Download PDF

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Publication number
DK171670B1
DK171670B1 DK289788A DK289788A DK171670B1 DK 171670 B1 DK171670 B1 DK 171670B1 DK 289788 A DK289788 A DK 289788A DK 289788 A DK289788 A DK 289788A DK 171670 B1 DK171670 B1 DK 171670B1
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DK
Denmark
Prior art keywords
purine
methoxy
arabinofuranosyl
ester
salt
Prior art date
Application number
DK289788A
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Danish (da)
English (en)
Other versions
DK289788A (da
DK289788D0 (da
Inventor
Thomas Anthony Krenitsky
George Walter Koszalka
Lynda Addington Jones
Devron Randolph Averett
Allan Ray Moorman
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Wellcome Found
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Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of DK289788D0 publication Critical patent/DK289788D0/da
Publication of DK289788A publication Critical patent/DK289788A/da
Application granted granted Critical
Publication of DK171670B1 publication Critical patent/DK171670B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK289788A 1987-05-30 1988-05-27 Anvendelse af puriderivater til fremstilling af et lægemiddel til behandling eller forebyggelse af humane virale infektioner forårsaget af VZV, hidtil ukendt 9-beta-D-arabinofuranosyl-2-amino-6-methoxy-9H-purin og derivater heraf, fremgangsmåde til fremstilling af en sådan purinforbindelse og farmaceutisk præparat indeholdende den, samt farmaceutisk acceptabel ester af 9-beta-D-arabino-furanosyl-6 DK171670B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB878712745A GB8712745D0 (en) 1987-05-30 1987-05-30 Antiviral compounds
GB8712745 1987-05-30

Publications (3)

Publication Number Publication Date
DK289788D0 DK289788D0 (da) 1988-05-27
DK289788A DK289788A (da) 1988-12-01
DK171670B1 true DK171670B1 (da) 1997-03-10

Family

ID=10618179

Family Applications (1)

Application Number Title Priority Date Filing Date
DK289788A DK171670B1 (da) 1987-05-30 1988-05-27 Anvendelse af puriderivater til fremstilling af et lægemiddel til behandling eller forebyggelse af humane virale infektioner forårsaget af VZV, hidtil ukendt 9-beta-D-arabinofuranosyl-2-amino-6-methoxy-9H-purin og derivater heraf, fremgangsmåde til fremstilling af en sådan purinforbindelse og farmaceutisk præparat indeholdende den, samt farmaceutisk acceptabel ester af 9-beta-D-arabino-furanosyl-6

Country Status (31)

Country Link
US (2) US5424295A (nl)
EP (1) EP0294114B1 (nl)
JP (1) JP2667873B2 (nl)
KR (1) KR970009474B1 (nl)
CN (1) CN1020107C (nl)
AT (1) ATE142636T1 (nl)
AU (1) AU622403B2 (nl)
CA (1) CA1330990C (nl)
CS (1) CS277006B6 (nl)
CY (2) CY2001A (nl)
DD (2) DD293962A5 (nl)
DE (2) DE122008000003I2 (nl)
DK (1) DK171670B1 (nl)
ES (1) ES2091750T3 (nl)
FI (1) FI89805C (nl)
GB (1) GB8712745D0 (nl)
GR (1) GR3021257T3 (nl)
HK (1) HK78497A (nl)
HU (2) HU205001B (nl)
IL (1) IL86531A (nl)
LU (1) LU91370I2 (nl)
MC (1) MC1935A1 (nl)
MY (1) MY103567A (nl)
NL (1) NL300302I2 (nl)
NO (2) NO172543C (nl)
NZ (1) NZ224813A (nl)
PH (1) PH27292A (nl)
PL (1) PL157684B1 (nl)
PT (1) PT87592B (nl)
SA (1) SA99200688A (nl)
ZA (2) ZA883829B (nl)

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GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
US7307166B1 (en) * 1987-10-28 2007-12-11 Wellstat Therapeutics Corporation Oxpurine nucleosides and their congeners, and acyl, derivatives thereof, for improvement of hematopoiesis
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
GB8919607D0 (en) 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
KR910007655A (ko) * 1989-10-03 1991-05-30 엠. 피. 잭슨 치료용 뉴클레오시드
US5206351A (en) * 1990-06-15 1993-04-27 Ash Stevens, Inc. Process for the preparation of 2-amino (2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)adenine
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
US5283331A (en) * 1990-12-20 1994-02-01 Nippon Kayaku Kabushiki Kaisha 2-halogeno-oxetanocin A and phosphoric ester thereof
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
US5961987A (en) * 1996-10-31 1999-10-05 University Of Iowa Research Foundation Ocular protein stimulants
JP3619017B2 (ja) 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
US6653318B1 (en) 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
AU2001238516B2 (en) * 2000-02-18 2005-08-04 Southern Research Institute Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H- purin-6-amine
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
JP3421330B2 (ja) * 2000-11-02 2003-06-30 持田製薬株式会社 ビダラビン注射用乾燥製剤
JP4493337B2 (ja) * 2001-11-27 2010-06-30 アナディス ファーマシューティカルズ インク ３−β−Ｄ−リボフラノシルチアゾロ［４，５−ｄ］ピリミジンヌクレオシド及びその使用
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
WO2004028481A2 (en) * 2002-09-30 2004-04-08 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
PT1824482E (pt) * 2004-12-17 2014-05-13 Anadys Pharmaceuticals Inc Compostos 3h-oxazolo e 3h-tiazolo[4,5-d]pirimidin-2-ona 3,5- -di-substituídos e 3,5,7-tri-substituídos e seus pró- -fármacos
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
SG152296A1 (en) 2005-11-21 2009-05-29 Anadys Pharmaceuticals Inc Novel process for the preparation of 5-amino-3h-thiazolo[4,5-d]pyrimidin-2- one
CA2655904C (en) * 2006-06-22 2014-11-18 Anadys Pharmaceuticals, Inc. Prodrugs of 5-amino-3-(3'-deoxy-.beta.-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
JP5225991B2 (ja) 2006-07-18 2013-07-03 アナディス ファーマシューティカルズ インク チアゾロ［４，５−ｄ］ピリミジンのカーボネート及びカルバメートプロドラッグ
CN101092441A (zh) * 2007-07-17 2007-12-26 北京本草天源药物研究院 一种奈拉滨的合成方法
US7846912B2 (en) * 2007-09-13 2010-12-07 Protia, Llc Deuterium-enriched nelarabine
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
CN103665076B (zh) * 2012-08-30 2018-01-09 上海阳帆医药科技有限公司 奈拉滨的制备方法
CN104892709B (zh) * 2015-06-04 2018-01-19 新乡学院 一种合成奈拉滨的方法
WO2018133835A1 (en) * 2017-01-20 2018-07-26 National Institute Of Biological Sciences, Beijing Nucleoside analogue regulating mammalian circadian rhythm
WO2022258014A1 (zh) * 2021-06-09 2022-12-15 正大天晴药业集团股份有限公司 用于制备奈拉滨的重组基因工程菌及其应用

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BE759011A (fr) * 1969-11-17 1971-05-17 Wellcome Found Aminopurines
US3758684A (en) * 1971-09-07 1973-09-11 Burroughs Wellcome Co Treating dna virus infections with amino purine derivatives
US4055717A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
US4055718A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(2-O-Acyl-β-D-arabinofuranosyl)-adenine compounds and method for their production
US4048432A (en) * 1976-05-17 1977-09-13 Parke, Davis & Company 9-(3,5-Di-O-acyl-β-D-arabinofuranosyl)adenine compounds and method for their production
JPS6053941B2 (ja) * 1977-08-10 1985-11-28 日本電気株式会社 バイアスライト駆動方式
JPS5515716A (en) * 1978-07-18 1980-02-04 Ajinomoto Co Inc Production of purine arabinoside
US4371613A (en) * 1977-08-10 1983-02-01 Ajinomoto Company Incorporated Method for producing purine arabinosides
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
EP0199451B1 (en) * 1985-03-16 1996-03-06 The Wellcome Foundation Limited Therapeutic nucleosides
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds

Also Published As

Publication number Publication date
MC1935A1 (fr) 1989-05-19
HK78497A (en) 1997-06-20
CY2008001I2 (el) 2009-11-04
ATE142636T1 (de) 1996-09-15
JPS63310831A (ja) 1988-12-19
IL86531A (en) 1993-07-08
HU895829D0 (en) 1990-01-28
IL86531A0 (en) 1988-11-15
GB8712745D0 (en) 1987-07-01
ES2091750T3 (es) 1996-11-16
NO172543C (no) 1993-08-04
ZA897598B (en) 1990-01-31
DK289788A (da) 1988-12-01
FI89805B (fi) 1993-08-13
NO882357D0 (no) 1988-05-27
EP0294114A3 (en) 1990-01-24
US5424295A (en) 1995-06-13
GR3021257T3 (en) 1997-01-31
DD282694A5 (de) 1990-09-19
CA1330990C (en) 1994-07-26
AU622403B2 (en) 1992-04-09
CY2001A (en) 1997-12-05
KR970009474B1 (ko) 1997-06-13
DE3855522D1 (de) 1996-10-17
US5539098A (en) 1996-07-23
AU1671888A (en) 1988-12-01
DE122008000003I2 (de) 2010-02-04
DE3855522T2 (de) 1997-02-06
PL272729A1 (en) 1989-02-06
HU205001B (en) 1992-03-30
NO2007016I2 (no) 2008-06-23
PH27292A (en) 1993-05-04
LU91370I2 (fr) 2007-12-10
CS8803635A2 (en) 1990-09-12
KR880013967A (ko) 1988-12-22
DK289788D0 (da) 1988-05-27
FI882511A (fi) 1988-12-01
SA99200688A (ar) 2005-12-03
NO882357L (no) 1988-12-01
NZ224813A (en) 1991-04-26
DD293962A5 (de) 1991-09-19
PL157684B1 (pl) 1992-06-30
CY2008001I1 (el) 2009-11-04
JP2667873B2 (ja) 1997-10-27
NO172543B (no) 1993-04-26
FI89805C (fi) 1993-11-25
FI882511A0 (fi) 1988-05-27
CS277006B6 (en) 1992-11-18
EP0294114B1 (en) 1996-09-11
ZA883829B (en) 1990-01-31
NO2007016I1 (no) 2008-01-14
CN1020107C (zh) 1993-03-17
CN1031233A (zh) 1989-02-22
MY103567A (en) 1993-08-28
HU199870B (en) 1990-03-28
DE122008000003I1 (de) 2008-04-17
PT87592B (pt) 1992-09-30
NL300302I1 (nl) 2008-01-02
NL300302I2 (nl) 2008-05-01
EP0294114A2 (en) 1988-12-07
HUT47129A (en) 1989-01-30
PT87592A (pt) 1989-05-31

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2007 00059

Filing date: 20071130

Expiry date: 20130527

CTFG Supplementary protection certificate (spc) issued

Free format text: PRODUCT NAME: NELARABIN OG FARMACEUTISK ACCEPTABLE SALTE DERAF

Spc suppl protection certif: CA 2007 00059

Filing date: 20071130

PUP Patent expired