NO882357L - Substituerte purinarabinocider og fremgangsmaate for deresfremstilling. - Google Patents

Substituerte purinarabinocider og fremgangsmaate for deresfremstilling.

Info

Publication number
NO882357L
NO882357L NO882357A NO882357A NO882357L NO 882357 L NO882357 L NO 882357L NO 882357 A NO882357 A NO 882357A NO 882357 A NO882357 A NO 882357A NO 882357 L NO882357 L NO 882357L
Authority
NO
Norway
Prior art keywords
preparation
purinarabinocides
procedures
substituted
prophylaxis
Prior art date
Application number
NO882357A
Other languages
English (en)
Other versions
NO882357D0 (no
NO172543B (no
NO172543C (no
Inventor
Thomas Anthony Krenitsky
George Walter Koszalka
Lynda Addington Jones
Devron Randolph Averett
Allan Ray Moorman
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of NO882357D0 publication Critical patent/NO882357D0/no
Publication of NO882357L publication Critical patent/NO882357L/no
Publication of NO172543B publication Critical patent/NO172543B/no
Publication of NO172543C publication Critical patent/NO172543C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines Containing Plant Substances (AREA)
NO882357A 1987-05-30 1988-05-27 Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte purinarabinosider NO172543C (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878712745A GB8712745D0 (en) 1987-05-30 1987-05-30 Antiviral compounds

Publications (4)

Publication Number Publication Date
NO882357D0 NO882357D0 (no) 1988-05-27
NO882357L true NO882357L (no) 1988-12-01
NO172543B NO172543B (no) 1993-04-26
NO172543C NO172543C (no) 1993-08-04

Family

ID=10618179

Family Applications (2)

Application Number Title Priority Date Filing Date
NO882357A NO172543C (no) 1987-05-30 1988-05-27 Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte purinarabinosider
NO2007016C NO2007016I2 (no) 1987-05-30 2007-12-21 Nelarabin eller et farmasoytisk akseptabelt salt derav ( nelarabin=9-(beta-D-arabinofuranosyl-2-amino-6-metoksy-9H-purin)

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2007016C NO2007016I2 (no) 1987-05-30 2007-12-21 Nelarabin eller et farmasoytisk akseptabelt salt derav ( nelarabin=9-(beta-D-arabinofuranosyl-2-amino-6-metoksy-9H-purin)

Country Status (31)

Country Link
US (2) US5424295A (no)
EP (1) EP0294114B1 (no)
JP (1) JP2667873B2 (no)
KR (1) KR970009474B1 (no)
CN (1) CN1020107C (no)
AT (1) ATE142636T1 (no)
AU (1) AU622403B2 (no)
CA (1) CA1330990C (no)
CS (1) CS277006B6 (no)
CY (2) CY2001A (no)
DD (2) DD282694A5 (no)
DE (2) DE3855522T2 (no)
DK (1) DK171670B1 (no)
ES (1) ES2091750T3 (no)
FI (1) FI89805C (no)
GB (1) GB8712745D0 (no)
GR (1) GR3021257T3 (no)
HK (1) HK78497A (no)
HU (2) HU199870B (no)
IL (1) IL86531A (no)
LU (1) LU91370I2 (no)
MC (1) MC1935A1 (no)
MY (1) MY103567A (no)
NL (1) NL300302I2 (no)
NO (2) NO172543C (no)
NZ (1) NZ224813A (no)
PH (1) PH27292A (no)
PL (1) PL157684B1 (no)
PT (1) PT87592B (no)
SA (1) SA99200688A (no)
ZA (2) ZA883829B (no)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds
US6054441A (en) * 1987-10-28 2000-04-25 Pro-Neuron, Inc. Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis
DD293498A5 (de) * 1989-07-20 1991-09-05 Zi Fuer Molekularbiologie Der Adw,De Verfahren zur herstellung eines mittels fuer die behandlung oder prophylaxe von hepatits-infektionen bei mensch und tier
US6337209B1 (en) 1992-02-26 2002-01-08 Glaxo Wellcome Inc. Molecular constructs containing a carcinoembryonic antigen regulatory sequence
GB8919607D0 (en) 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
KR910007655A (ko) * 1989-10-03 1991-05-30 엠. 피. 잭슨 치료용 뉴클레오시드
US5206351A (en) * 1990-06-15 1993-04-27 Ash Stevens, Inc. Process for the preparation of 2-amino (2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl)adenine
GB9015914D0 (en) * 1990-07-19 1990-09-05 Wellcome Found Heterocyclic compounds
US5283331A (en) * 1990-12-20 1994-02-01 Nippon Kayaku Kabushiki Kaisha 2-halogeno-oxetanocin A and phosphoric ester thereof
GB9104165D0 (en) * 1991-02-27 1991-04-17 Wellcome Found Novel entities for hiv therapy
US5961987A (en) * 1996-10-31 1999-10-05 University Of Iowa Research Foundation Ocular protein stimulants
JP3619017B2 (ja) 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
US6653318B1 (en) * 1999-07-21 2003-11-25 Yale University 5-(E)-Bromovinyl uracil analogues and related pyrimidine nucleosides as anti-viral agents and methods of use
JP4555536B2 (ja) * 2000-02-18 2010-10-06 サザン・リサーチ・インスティテュート ２−クロロ−９−（２−デオキシ−２−フルオロ−β−Ｄ−アラビノフラノシル）−９Ｈ−プリン−６−アミンの合成方法
US6753322B2 (en) * 2000-06-06 2004-06-22 Pfizer Inc 2-aminocarbonyl-9H-purine derivatives
JP3421330B2 (ja) * 2000-11-02 2003-06-30 持田製薬株式会社 ビダラビン注射用乾燥製剤
UA79764C2 (en) 2001-11-27 2007-07-25 Anadys Pharmaceuticals Inc 3-?-D-RIBOFURANOSYLTHIAZOLO[4,5-d]PYRIDIMINE NUCLEOSIDES AND USES THEREOF
US7321033B2 (en) * 2001-11-27 2008-01-22 Anadys Pharmaceuticals, Inc. 3-B-D-ribofuranosylthiazolo [4,5-d] pyrimidine nucleosides and uses thereof
PL376043A1 (en) * 2002-09-30 2005-12-12 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis c virus infection
US7560544B2 (en) 2004-12-17 2009-07-14 Anadys Pharmaceuticals, Inc. 3,5-Disubsitituted and 3,5,7-trisubstituted-3H-oxazolo and 3H-thiazolo[4,5-d]pyrimidin-2-one compounds and prodrugs thereof
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
JP5117391B2 (ja) 2005-11-21 2013-01-16 アナディス ファーマシューティカルズ インク ５−アミノ−３Ｈ−チアゾロ［４，５−ｄ］ピリミジン−２−オンを調製するための新規な方法
EP2034834B1 (en) * 2006-06-22 2011-01-26 Anadys Pharmaceuticals, Inc. Prodrugs of 5-amino-3-(3'-deoxy-beta-d-ribofuranosyl)-thiazolo[4,5-d]pyrimidin-2,7-dione
DE602007012881D1 (en) 2006-07-18 2011-04-14 Anadys Pharmaceuticals Inc Carbonat- und carbamat-prodrugs von thiazolo ä4,5-dü-pyrimidinen
CN101092441A (zh) * 2007-07-17 2007-12-26 北京本草天源药物研究院 一种奈拉滨的合成方法
US7846912B2 (en) * 2007-09-13 2010-12-07 Protia, Llc Deuterium-enriched nelarabine
CN101768197A (zh) * 2008-12-29 2010-07-07 北京德众万全药物技术开发有限公司 一种奈拉滨的制备方法
CN103665076B (zh) * 2012-08-30 2018-01-09 上海阳帆医药科技有限公司 奈拉滨的制备方法
CN104892709B (zh) * 2015-06-04 2018-01-19 新乡学院 一种合成奈拉滨的方法
WO2018133835A1 (en) * 2017-01-20 2018-07-26 National Institute Of Biological Sciences, Beijing Nucleoside analogue regulating mammalian circadian rhythm
WO2022258014A1 (zh) * 2021-06-09 2022-12-15 正大天晴药业集团股份有限公司 用于制备奈拉滨的重组基因工程菌及其应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE759011A (fr) * 1969-11-17 1971-05-17 Wellcome Found Aminopurines
US3758684A (en) * 1971-09-07 1973-09-11 Burroughs Wellcome Co Treating dna virus infections with amino purine derivatives
US4055717A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(3-O-Acyl-β-D-arabinofuranosyl)adenine compounds, 9-(2,3-di-O-acyl-β-D-arabinofuranosyl)-adenine compounds, and method for their production
US4048432A (en) * 1976-05-17 1977-09-13 Parke, Davis & Company 9-(3,5-Di-O-acyl-β-D-arabinofuranosyl)adenine compounds and method for their production
US4055718A (en) * 1976-05-17 1977-10-25 Parke, Davis & Company 9-(2-O-Acyl-β-D-arabinofuranosyl)-adenine compounds and method for their production
JPS6053941B2 (ja) * 1977-08-10 1985-11-28 日本電気株式会社 バイアスライト駆動方式
US4371613A (en) * 1977-08-10 1983-02-01 Ajinomoto Company Incorporated Method for producing purine arabinosides
JPS5515716A (en) * 1978-07-18 1980-02-04 Ajinomoto Co Inc Production of purine arabinoside
GB1573777A (en) * 1977-11-03 1980-08-28 Wellcome Found 9-d-arabinonucleosides and an enzymatic process for their preparation
US4495180A (en) * 1982-06-21 1985-01-22 Merck & Co., Inc. Prodrugs of Ara-A an antiviral agent
JPS58225097A (ja) * 1982-06-23 1983-12-27 Yamasa Shoyu Co Ltd ヌクレオシド５′−アルキルもしくはアルケニルりん酸
CA1285935C (en) * 1985-03-16 1991-07-09 Janet Lister Rideout Therapeutic nucleosides
GB8712745D0 (en) * 1987-05-30 1987-07-01 Wellcome Found Antiviral compounds

Also Published As

Publication number Publication date
NO882357D0 (no) 1988-05-27
MC1935A1 (fr) 1989-05-19
ZA883829B (en) 1990-01-31
DK289788D0 (da) 1988-05-27
KR970009474B1 (ko) 1997-06-13
HUT47129A (en) 1989-01-30
NL300302I1 (nl) 2008-01-02
EP0294114B1 (en) 1996-09-11
SA99200688A (ar) 2005-12-03
NO2007016I2 (no) 2008-06-23
HU205001B (en) 1992-03-30
CS8803635A2 (en) 1990-09-12
EP0294114A3 (en) 1990-01-24
CY2001A (en) 1997-12-05
PL272729A1 (en) 1989-02-06
PH27292A (en) 1993-05-04
CN1020107C (zh) 1993-03-17
CN1031233A (zh) 1989-02-22
CA1330990C (en) 1994-07-26
IL86531A0 (en) 1988-11-15
AU622403B2 (en) 1992-04-09
DK289788A (da) 1988-12-01
DK171670B1 (da) 1997-03-10
PL157684B1 (pl) 1992-06-30
HU199870B (en) 1990-03-28
DE3855522T2 (de) 1997-02-06
CY2008001I2 (el) 2009-11-04
NO172543B (no) 1993-04-26
DE122008000003I1 (de) 2008-04-17
PT87592A (pt) 1989-05-31
FI89805C (fi) 1993-11-25
IL86531A (en) 1993-07-08
EP0294114A2 (en) 1988-12-07
US5539098A (en) 1996-07-23
HK78497A (en) 1997-06-20
PT87592B (pt) 1992-09-30
ES2091750T3 (es) 1996-11-16
FI882511A (fi) 1988-12-01
CS277006B6 (en) 1992-11-18
JP2667873B2 (ja) 1997-10-27
DE3855522D1 (de) 1996-10-17
JPS63310831A (ja) 1988-12-19
DE122008000003I2 (de) 2010-02-04
DD282694A5 (de) 1990-09-19
FI882511A0 (fi) 1988-05-27
AU1671888A (en) 1988-12-01
LU91370I2 (fr) 2007-12-10
HU895829D0 (en) 1990-01-28
NO2007016I1 (no) 2008-01-14
CY2008001I1 (el) 2009-11-04
ZA897598B (en) 1990-01-31
NZ224813A (en) 1991-04-26
US5424295A (en) 1995-06-13
GR3021257T3 (en) 1997-01-31
FI89805B (fi) 1993-08-13
KR880013967A (ko) 1988-12-22
DD293962A5 (de) 1991-09-19
MY103567A (en) 1993-08-28
NL300302I2 (nl) 2008-05-01
GB8712745D0 (en) 1987-07-01
ATE142636T1 (de) 1996-09-15
NO172543C (no) 1993-08-04

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Legal Events

Date Code Title Description
SPCF Filing of supplementary protection certificate

Free format text: PRODUCT NAME: ATRIANCE - NELARABIN; NAT. REG. NO/DATE: EU107403001 20070904; FIRST REG. NO/DATE: EU , EU107403001 20070822

Spc suppl protection certif: 2007016

Filing date: 20071221

MK1K Patent expired
SPCG Granted supplementary protection certificate

Free format text: PRODUCT NAME: ATRIANCE - NELARABIN; NAT. REG. NO/DATE: EU107403001 20070904; FIRST REG. NO/DATE: EU , EU107403001 20070822

Spc suppl protection certif: 2007016

Filing date: 20071221

Extension date: 20130527

SPCX Expiry of an spc

Spc suppl protection certif: 2007016

Effective date: 20130527