DK171599B1 - 3-Aryl-5-alkylthio-4H-1,2,4-thiazoler, samt fremstilling og anvendelse deraf - Google Patents

3-Aryl-5-alkylthio-4H-1,2,4-thiazoler, samt fremstilling og anvendelse deraf Download PDF

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Publication number
DK171599B1
DK171599B1 DK035488A DK35488A DK171599B1 DK 171599 B1 DK171599 B1 DK 171599B1 DK 035488 A DK035488 A DK 035488A DK 35488 A DK35488 A DK 35488A DK 171599 B1 DK171599 B1 DK 171599B1
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DK
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Prior art keywords
methyl
triazole
phenyl
alkyl
compound
Prior art date
Application number
DK035488A
Other languages
Danish (da)
English (en)
Other versions
DK35488A (da
DK35488D0 (da
Inventor
John M Kane
Francis P Miller
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK35488D0 publication Critical patent/DK35488D0/da
Publication of DK35488A publication Critical patent/DK35488A/da
Application granted granted Critical
Publication of DK171599B1 publication Critical patent/DK171599B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK035488A 1987-01-27 1988-01-26 3-Aryl-5-alkylthio-4H-1,2,4-thiazoler, samt fremstilling og anvendelse deraf DK171599B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US706387A 1987-01-27 1987-01-27
US706387 1987-01-27
US07/126,191 US4900743A (en) 1987-01-27 1987-12-04 3-aryl-5-alkylthio-4H-1,2,4-triazoles
US12619187 1987-12-04

Publications (3)

Publication Number Publication Date
DK35488D0 DK35488D0 (da) 1988-01-26
DK35488A DK35488A (da) 1988-07-28
DK171599B1 true DK171599B1 (da) 1997-02-17

Family

ID=26676435

Family Applications (1)

Application Number Title Priority Date Filing Date
DK035488A DK171599B1 (da) 1987-01-27 1988-01-26 3-Aryl-5-alkylthio-4H-1,2,4-thiazoler, samt fremstilling og anvendelse deraf

Country Status (19)

Country Link
US (1) US4900743A (zh)
EP (1) EP0276793B1 (zh)
JP (1) JP2537651B2 (zh)
KR (1) KR960007166B1 (zh)
CN (1) CN1023480C (zh)
AR (1) AR244682A1 (zh)
AU (1) AU601013B2 (zh)
CA (1) CA1312605C (zh)
DE (1) DE3881712T2 (zh)
DK (1) DK171599B1 (zh)
ES (1) ES2058144T3 (zh)
FI (1) FI91526C (zh)
HU (1) HU205747B (zh)
IE (1) IE61188B1 (zh)
IL (1) IL85185A (zh)
NO (1) NO166642C (zh)
NZ (1) NZ223260A (zh)
PH (1) PH24513A (zh)
PT (1) PT86623B (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1989006125A1 (en) * 1987-12-31 1989-07-13 Smithkline Beckman Corporation 4-aralkyl-5-substituted-1,2,4-triazole-5-thiols
AU644500B2 (en) * 1990-12-20 1993-12-09 Merrell Dow Pharmaceuticals Inc. 3-aryl-5-alkylthio-4h-1,2,4-triazoles for treatment of hyperreflexia due to spinal trauma
DE4339412A1 (de) * 1993-11-18 1995-05-24 Bayer Ag Verfahren und neue Zwischenprodukte zur Herstellung von Triazolinonen
AR032653A1 (es) * 2001-02-09 2003-11-19 Telik Inc Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos.
CN1736381B (zh) * 2005-08-11 2010-09-08 沈阳药科大学 吗啉甲基萘满酮用于制备平滑肌解痉剂的用途
US20110295016A1 (en) * 2008-12-12 2011-12-01 Astrazeneca Ab A new process for preparing 4-[4-methyl-5-(cl-10alkylthio/c5-10aryl-cl-6alkylthio)-4h-1,2,4-triazol-3-yl]pyridines

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU193891B (en) * 1984-02-07 1987-12-28 Gyogyszerkutato Intezet Process for production of new derivatives of 1,2,4-triasole

Also Published As

Publication number Publication date
FI880282A (fi) 1988-07-28
ES2058144T3 (es) 1994-11-01
DK35488A (da) 1988-07-28
FI91526C (fi) 1994-07-11
FI91526B (fi) 1994-03-31
CA1312605C (en) 1993-01-12
CN1023480C (zh) 1994-01-12
PT86623B (pt) 1993-01-29
NO880337L (no) 1988-07-28
IL85185A0 (en) 1988-07-31
PT86623A (pt) 1988-02-01
EP0276793A3 (en) 1988-09-21
KR880008999A (ko) 1988-09-13
IL85185A (en) 1996-03-31
NO166642C (no) 1991-08-21
CN88100346A (zh) 1988-11-02
DE3881712T2 (de) 1993-12-23
US4900743A (en) 1990-02-13
NZ223260A (en) 1991-07-26
JPS63201176A (ja) 1988-08-19
AU601013B2 (en) 1990-08-30
AU1072888A (en) 1988-07-28
FI880282A0 (fi) 1988-01-22
AR244682A1 (es) 1993-11-30
EP0276793B1 (en) 1993-06-16
PH24513A (en) 1990-07-18
NO880337D0 (no) 1988-01-26
IE61188B1 (en) 1994-10-19
NO166642B (no) 1991-05-13
DK35488D0 (da) 1988-01-26
HUT47257A (en) 1989-02-28
JP2537651B2 (ja) 1996-09-25
EP0276793A2 (en) 1988-08-03
DE3881712D1 (de) 1993-07-22
HU205747B (en) 1992-06-29
KR960007166B1 (ko) 1996-05-29

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B1 Patent granted (law 1993)
PBP Patent lapsed

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