DK169331B1 - Fremgangsmåde til fremstilling af optisk aktive R(+)-carbazolderivater, nye R(+)-carbazolderivater, samt lægemidler, der indeholder disse forbindelser - Google Patents
Fremgangsmåde til fremstilling af optisk aktive R(+)-carbazolderivater, nye R(+)-carbazolderivater, samt lægemidler, der indeholder disse forbindelser Download PDFInfo
- Publication number
- DK169331B1 DK169331B1 DK255184A DK255184A DK169331B1 DK 169331 B1 DK169331 B1 DK 169331B1 DK 255184 A DK255184 A DK 255184A DK 255184 A DK255184 A DK 255184A DK 169331 B1 DK169331 B1 DK 169331B1
- Authority
- DK
- Denmark
- Prior art keywords
- group
- lower alkyl
- pharmacologically acceptable
- carbazole
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3319027 | 1983-05-26 | ||
DE19833319027 DE3319027A1 (de) | 1983-05-26 | 1983-05-26 | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
Publications (3)
Publication Number | Publication Date |
---|---|
DK255184D0 DK255184D0 (da) | 1984-05-24 |
DK255184A DK255184A (da) | 1984-11-27 |
DK169331B1 true DK169331B1 (da) | 1994-10-10 |
Family
ID=6199873
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK255184A DK169331B1 (da) | 1983-05-26 | 1984-05-24 | Fremgangsmåde til fremstilling af optisk aktive R(+)-carbazolderivater, nye R(+)-carbazolderivater, samt lægemidler, der indeholder disse forbindelser |
DK091393A DK169333B1 (da) | 1983-05-26 | 1993-08-06 | Fremgangsmåde til fremstilling af optisk aktive S(-)-carbazolderivater, nye S(-)-carbazolderivater, samt lægemidler, der indeholder disse forbindelser |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK091393A DK169333B1 (da) | 1983-05-26 | 1993-08-06 | Fremgangsmåde til fremstilling af optisk aktive S(-)-carbazolderivater, nye S(-)-carbazolderivater, samt lægemidler, der indeholder disse forbindelser |
Country Status (20)
Country | Link |
---|---|
US (4) | US4697022A (fr) |
EP (1) | EP0127099B1 (fr) |
JP (2) | JPS59222473A (fr) |
KR (1) | KR860001761B1 (fr) |
AT (1) | ATE27273T1 (fr) |
AU (1) | AU551116B2 (fr) |
CA (1) | CA1259071A (fr) |
DE (2) | DE3319027A1 (fr) |
DK (2) | DK169331B1 (fr) |
ES (1) | ES8502683A1 (fr) |
FI (1) | FI80018C (fr) |
GR (1) | GR81577B (fr) |
HU (1) | HU193011B (fr) |
IE (1) | IE57533B1 (fr) |
IL (1) | IL71876A (fr) |
NO (1) | NO164537C (fr) |
NZ (1) | NZ208254A (fr) |
PH (1) | PH22749A (fr) |
PT (1) | PT78633B (fr) |
ZA (1) | ZA843976B (fr) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4657929A (en) * | 1983-10-25 | 1987-04-14 | Fisons Plc | Compounds |
DE3540149A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten |
US5359097A (en) * | 1988-12-26 | 1994-10-25 | Kowa Company Ltd. | Process for preparation of glycidyl ether |
WO1994020096A1 (fr) * | 1993-03-05 | 1994-09-15 | Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beckman Corporation Limited | Procede d'utilisation de carbazolyle-(4)-oxypropanolamine pour inhiber la proliferation de cellules de muscles lisses |
US5308862A (en) * | 1993-03-05 | 1994-05-03 | Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 | Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
US6075040A (en) * | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
WO1998002157A1 (fr) * | 1996-07-13 | 1998-01-22 | Roche Diagnostics Gmbh | Formulations pharmaceutiques pour utilisation topique contenant comme principe actif un derive de carbazolyl-(4)-oxy-propanolamine |
ATE215369T1 (de) | 1996-09-05 | 2002-04-15 | Lilly Co Eli | Carbazolanaloge als selektive beta3-adrenergische agonisten |
US6730326B2 (en) | 1997-07-22 | 2004-05-04 | Roche Diagnostics Gmbh | Thermodynamically stable modification of 1-(4-carbazolyl-oxy-3[2-(2-methoxyphenoxy)-ethylamino]-2-propanol process for its preparation and pharmaceutical compositions containing it |
EP0893440A1 (fr) * | 1997-07-22 | 1999-01-27 | Roche Diagnostics GmbH | Une modification thermodynamique stabilisée de 1-(4-carbazolyloxy)-3[2-(2-methoxyphenoxy)ethylamino]- 2-propanole, un procédé pour sa préparation et une composition pharmaceutique qui la contient |
ZA989365B (en) * | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
HU227441B1 (en) * | 1997-11-24 | 2011-06-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing carvedilol, enantiomers and salts thereof |
CO5011072A1 (es) * | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
US6664284B2 (en) * | 1998-07-23 | 2003-12-16 | Roche Diagnostics Gmbh | Stabilized carvedilol injection solution |
US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
ES2227206T3 (es) * | 2000-04-03 | 2005-04-01 | F. Hoffmann-La Roche Ag | Soluciones concentradas de carvedilol. |
PL365694A1 (en) | 2000-06-28 | 2005-01-10 | Teva Pharmaceutical Industries Ltd. | Carvedilol |
KR100342659B1 (en) | 2000-12-15 | 2002-07-04 | Rstech Co Ltd | Chiral polymer salene catalyst and process for preparing chiral compounds from racemic epoxide using the same |
BR0212927A (pt) * | 2001-09-28 | 2004-10-13 | Hoffmann La Roche | Formas pseudopolimórficas de carvedilol |
US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
US6710184B2 (en) | 2002-01-15 | 2004-03-23 | Teva Pharmaceutical Industries Ltd. | Crystalline solids of carvedilol and processes for their preparation |
EP1499310A4 (fr) * | 2002-04-30 | 2005-12-07 | Sb Pharmco Inc | Monocitrate monohydrate de carvedilol |
AU2003251627A1 (en) * | 2002-06-27 | 2004-01-19 | Sb Pharmco Puerto Rico Inc. | Carvedilol hydrobromide |
MXPA04012923A (es) * | 2002-06-27 | 2005-03-31 | Sb Pharmco Inc | Sales de fosfato de carvedilol y/o solvatos de las mismas, composiciones correspondientes y/o metodos de tratamiento. |
SK285547B6 (sk) | 2002-11-08 | 2007-03-01 | Zentiva, A. S. | Spôsob prípravy Carvedilolu |
WO2004094378A1 (fr) * | 2003-04-21 | 2004-11-04 | Matrix Laboratories Ltd | Procede de fabrication de carvedilol, forme-ii |
WO2004113296A1 (fr) * | 2003-06-20 | 2004-12-29 | Sun Pharmaceutical Industries Limited | Procede de preparation de 1-[9h-carbazol-4-yloxy]- 3-[{2-(2-(-(methoxy)phenoxy)-ethyl}-amino]-propane-2-ol |
JP2007512372A (ja) * | 2003-11-25 | 2007-05-17 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール塩、対応する組成物、送達および/または治療方法 |
EP1691789B1 (fr) * | 2003-11-25 | 2017-12-20 | SmithKline Beecham (Cork) Limited | Base libre de carvedilol, ses sels, formes anhydres ou solvates, compositions pharmaceutiques correspondantes, formulations a liberation controlee, et procedes de traitement ou d'administration |
WO2005051325A2 (fr) * | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Base libre de carvedilol, ses sels, formes anhydres ou solvats, compositions pharmaceutiques correspondantes, formulations a liberation controlee, et methodes de traitement ou d'administration |
EP1723107A2 (fr) | 2004-02-23 | 2006-11-22 | Cadila Healthcare Ltd. | Procede de preparation de carvedilol racemique |
US20070191456A1 (en) * | 2004-04-22 | 2007-08-16 | Tarur Venkatasubramanian R | Novel process for the preparation of 1-(9h-carbazol-4-yloxy)-3-[[2-(-methoxyphenoxy)-ethyl] amino]-propan-2-ol |
GB0411273D0 (en) * | 2004-05-20 | 2004-06-23 | Cipla Ltd | Process and product |
DK1838670T3 (da) * | 2004-12-09 | 2010-03-01 | Zach System Spa | Fremgangsmåde til fremstilling af carvedilol og dets enantiomere |
US20070043099A1 (en) * | 2005-06-09 | 2007-02-22 | Igor Lifshitz | Crystalline forms of carvedilol and processes for their preparation |
WO2007077111A1 (fr) * | 2005-12-30 | 2007-07-12 | F. Hoffmann-La Roche Ag | Composés et méthodes pour la synthèse de carbazole |
WO2008002683A2 (fr) * | 2006-06-28 | 2008-01-03 | Teva Pharmaceutical Industries Ltd. | Carvédilol phosphate |
WO2008038301A1 (fr) * | 2006-09-26 | 2008-04-03 | Morepen Laboratories Limited | Procédé pour la préparation de carvédilol |
EP2114881A1 (fr) * | 2007-02-26 | 2009-11-11 | Teva Pharmaceutical Industries Ltd. | Procédé de purification du carvédilol ou de ses sels |
CN102285910B (zh) * | 2011-07-04 | 2013-06-19 | 南京工业大学 | 一种制备(s)-卡维地洛的方法 |
CN102617368B (zh) * | 2012-02-27 | 2014-07-09 | 华中科技大学 | 一种α/β受体双重抑制剂及其盐的制备方法 |
US10749118B2 (en) | 2014-06-26 | 2020-08-18 | Samsung Display Co., Ltd. | Heterocyclic compound and organic light-emitting device including the same |
US20230381139A1 (en) * | 2020-09-17 | 2023-11-30 | Uti Limited Partnership | Methods of treating and/or preventing alzheimer’s disease with r-carvedilol |
CN116041248B (zh) * | 2023-04-03 | 2023-06-06 | 成都摩诃大龙医药科技有限公司 | 一种具有抗癌活性的咔唑衍生物及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB1369580A (en) * | 1972-08-18 | 1974-10-09 | Boehringer Mannheim Gmbh | Tricyclic diphenylamine derivatives |
GB1458392A (en) * | 1973-11-09 | 1976-12-15 | Ici Ltd | Optically-active 1-aryloxy-2,3-epoxypropane derivatives |
US4202978A (en) * | 1978-02-08 | 1980-05-13 | Hoffmann-La Roche Inc. | (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines |
CH641147A5 (de) * | 1979-01-17 | 1984-02-15 | Sandoz Ag | 3-amino-2-hydroxypropoxyaryl-derivat, seine herstellung und dieses enthaltende heilmittel. |
DE3011808A1 (de) * | 1980-03-27 | 1981-10-01 | Cassella Ag, 6000 Frankfurt | Verfahren zur herstellung von n-hydroxyalkylcarbazol |
US4400383A (en) * | 1981-12-11 | 1983-08-23 | Burroughs Wellcome Co. | Treatment of anxiety |
DE3300933A1 (de) * | 1983-01-13 | 1984-07-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von d,l- und d-carazolol als antiglaukommittel sowie arzneimittel, die diese stoffe enthalten |
-
1983
- 1983-05-26 DE DE19833319027 patent/DE3319027A1/de not_active Withdrawn
-
1984
- 1984-05-19 EP EP84105747A patent/EP0127099B1/fr not_active Expired
- 1984-05-19 AT AT84105747T patent/ATE27273T1/de not_active IP Right Cessation
- 1984-05-19 DE DE8484105747T patent/DE3463768D1/de not_active Expired
- 1984-05-21 US US06/612,255 patent/US4697022A/en not_active Expired - Lifetime
- 1984-05-22 AU AU28480/84A patent/AU551116B2/en not_active Expired
- 1984-05-22 FI FI842046A patent/FI80018C/fi not_active IP Right Cessation
- 1984-05-23 NZ NZ208254A patent/NZ208254A/xx unknown
- 1984-05-23 CA CA000454948A patent/CA1259071A/fr not_active Expired
- 1984-05-23 JP JP59102778A patent/JPS59222473A/ja active Granted
- 1984-05-24 PT PT78633A patent/PT78633B/pt unknown
- 1984-05-24 KR KR1019840002847A patent/KR860001761B1/ko not_active IP Right Cessation
- 1984-05-24 IE IE1295/84A patent/IE57533B1/en not_active IP Right Cessation
- 1984-05-24 GR GR74808A patent/GR81577B/el unknown
- 1984-05-24 DK DK255184A patent/DK169331B1/da not_active IP Right Cessation
- 1984-05-25 ZA ZA843976A patent/ZA843976B/xx unknown
- 1984-05-25 PH PH30721A patent/PH22749A/en unknown
- 1984-05-25 NO NO842084A patent/NO164537C/no not_active IP Right Cessation
- 1984-05-25 ES ES532838A patent/ES8502683A1/es not_active Expired
- 1984-05-25 HU HU842038A patent/HU193011B/hu unknown
- 1984-05-26 IL IL71876A patent/IL71876A/xx not_active IP Right Cessation
-
1987
- 1987-05-13 US US07/049,673 patent/US4824963A/en not_active Expired - Lifetime
-
1989
- 1989-01-19 US US07/299,750 patent/US4985454A/en not_active Expired - Lifetime
-
1991
- 1991-01-28 US US07/631,641 patent/US5071868A/en not_active Expired - Lifetime
-
1992
- 1992-09-25 JP JP4256343A patent/JPH0613508B2/ja not_active Expired - Lifetime
-
1993
- 1993-08-06 DK DK091393A patent/DK169333B1/da not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK169331B1 (da) | Fremgangsmåde til fremstilling af optisk aktive R(+)-carbazolderivater, nye R(+)-carbazolderivater, samt lægemidler, der indeholder disse forbindelser | |
NO163618B (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive aryloksy- og aryltio-hydroksypropyl-piperazin-acetanilider. | |
FR2581993A1 (fr) | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique | |
EP0060897B1 (fr) | Derives de l'ester 1,4-dihydropyridine-3,5-dicarboxylique | |
JPS5919539B2 (ja) | 3,4−ジヒドロカルボスチリル誘導体 | |
EP0054304B1 (fr) | Dérivés de l'alcoylènedioxybenzène, leurs sels d'addition et leur procédé de préparation | |
US4187313A (en) | 2-Aminoethyl-1,4-benzodioxans | |
US4147869A (en) | 3,4-Dihydrocarbostyril derivatives and process for preparing the same | |
KR920000762B1 (ko) | 벤조티아진 유도체의 제조방법 | |
DK166878B (da) | Fluorallylaminer og pharmakologisk acceptable syreadditionssalte deraf samt pharmaceutisk praeparat indeholdende disse forbindelser | |
IE921771A1 (en) | New 2-amino-5-cyano-1,4-dihydropyridines, processes for¹their preparation and their use in medicaments | |
EP0116825B1 (fr) | Dérivés d'aryloxypropanolamines, leur procédé de préparation, compositions pharmaceutiques et leur utilisation thérapeutique | |
EP0009075A1 (fr) | Pyridyloxypropanolamines et leurs esters, leur procédé de préparation et les compositions pharmaceutiques les contenant | |
KR20010022147A (ko) | 아미노시클로알칸 화합물 | |
EP0005091B1 (fr) | Nouvelles pipérazines monosubstituées, leurs procédés de préparation et les compositions pharmaceutiques les renfermant | |
CA1300157C (fr) | Composes de type dihydropyridine a effets pharmacologiques uniques, et procede pour leur production | |
Zelesko et al. | Cardiac-slowing amidines containing the 3-thioindole group. Potential antianginal agents | |
JPS62249969A (ja) | N−ジヒドロインドリルエチル−スルホンアミド類 | |
CA1257279A (fr) | R- et s-4-(2,3-epoxypropoxy)-carbazoles | |
KR790001364B1 (ko) | 황함유 복소환 화합물의 제조방법 | |
HU201749B (en) | Process for producing ether and thioether derivatives and pharmaceutical compositions comprising such compounds as active ingredient | |
EP0658555A1 (fr) | Dérivés de la pyridazinone, procédés de production et utilisation | |
JP2588193B2 (ja) | ベンゾジオキソ−ル誘導体 | |
KR820000521B1 (ko) | 페닐에탄올아민 유도체의 제조 방법 | |
JPS5927339B2 (ja) | 3,4−ジヒドロカルボスチリル誘導体 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B1 | Patent granted (law 1993) | ||
PUP | Patent expired |