NO842084L - Fremgangsmaate ved fremstilling av optisk aktive carbazolderivater - Google Patents
Fremgangsmaate ved fremstilling av optisk aktive carbazolderivaterInfo
- Publication number
- NO842084L NO842084L NO842084A NO842084A NO842084L NO 842084 L NO842084 L NO 842084L NO 842084 A NO842084 A NO 842084A NO 842084 A NO842084 A NO 842084A NO 842084 L NO842084 L NO 842084L
- Authority
- NO
- Norway
- Prior art keywords
- general formula
- derivatives
- derivative
- carbazole
- procedure
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/14—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by free hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/16—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by esterified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19833319027 DE3319027A1 (de) | 1983-05-26 | 1983-05-26 | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
Publications (3)
Publication Number | Publication Date |
---|---|
NO842084L true NO842084L (no) | 1984-11-27 |
NO164537B NO164537B (no) | 1990-07-09 |
NO164537C NO164537C (no) | 1990-10-17 |
Family
ID=6199873
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO842084A NO164537C (no) | 1983-05-26 | 1984-05-25 | Analogifremgangsmaate ved fremstilling av terapeutisk aktive r(+)- og s(-)-carbazolderivater, og r(-)- og s(+)-4-(2,3-epoxypropoxy)-carbazol for anvendelse ved fremgangsmaaten. |
Country Status (20)
Country | Link |
---|---|
US (4) | US4697022A (no) |
EP (1) | EP0127099B1 (no) |
JP (2) | JPS59222473A (no) |
KR (1) | KR860001761B1 (no) |
AT (1) | ATE27273T1 (no) |
AU (1) | AU551116B2 (no) |
CA (1) | CA1259071A (no) |
DE (2) | DE3319027A1 (no) |
DK (2) | DK169331B1 (no) |
ES (1) | ES8502683A1 (no) |
FI (1) | FI80018C (no) |
GR (1) | GR81577B (no) |
HU (1) | HU193011B (no) |
IE (1) | IE57533B1 (no) |
IL (1) | IL71876A (no) |
NO (1) | NO164537C (no) |
NZ (1) | NZ208254A (no) |
PH (1) | PH22749A (no) |
PT (1) | PT78633B (no) |
ZA (1) | ZA843976B (no) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4657929A (en) * | 1983-10-25 | 1987-04-14 | Fisons Plc | Compounds |
DE3540149A1 (de) * | 1985-11-13 | 1987-05-14 | Boehringer Mannheim Gmbh | Verwendung von 1-(benztriazol-4-yloxy)3-(2-(2-methoxyphenoxy) -ethylamino)-2-propanol als antiglaukommittel, optisch aktive r und s isomere dieser substanz, verfahren zur herstellung derselben sowie arzneimittel, die diese substanzen enthalten |
ES2050425T3 (es) * | 1988-12-26 | 1994-05-16 | Kowa Co | Produccion de un eter glicidilico. |
WO1994020096A1 (en) * | 1993-03-05 | 1994-09-15 | Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beckman Corporation Limited | Method of employing carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
US5308862A (en) * | 1993-03-05 | 1994-05-03 | Boehringer Mannheim Pharmaceuticals Corporation - Smithkline Beecham Corp., Ltd. Partnership No. 1 | Use of, and method of treatment using, carbazolyl-(4)-oxypropanolamine compounds for inhibition of smooth muscle cell proliferation |
US5629345A (en) * | 1993-07-23 | 1997-05-13 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
US5965620A (en) * | 1993-07-23 | 1999-10-12 | Vide Pharmaceuticals | Methods and compositions for ATP-sensitive K+ channel inhibition for lowering intraocular pressure |
US5760069A (en) | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
ZA967892B (en) * | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
US6075040A (en) | 1996-09-05 | 2000-06-13 | Eli Lilly And Company | Selective β3 adrenergic agonists |
WO1998002157A1 (de) * | 1996-07-13 | 1998-01-22 | Roche Diagnostics Gmbh | Topisch einsetzbare pharmazeutische formulierungen enthaltend als wirkstoff ein carbazolyl-(4)-oxy-propanolamin-derivat |
ES2171839T3 (es) | 1996-09-05 | 2002-09-16 | Lilly Co Eli | Analogos de carbazol como agonistas adrenergicos selectivos de beta3. |
US6730326B2 (en) | 1997-07-22 | 2004-05-04 | Roche Diagnostics Gmbh | Thermodynamically stable modification of 1-(4-carbazolyl-oxy-3[2-(2-methoxyphenoxy)-ethylamino]-2-propanol process for its preparation and pharmaceutical compositions containing it |
EP0893440A1 (en) * | 1997-07-22 | 1999-01-27 | Roche Diagnostics GmbH | Thermodynamically stable modification of 1-(4-carbazolyloxy)-3-[2-(2-methoxyphenoxy)ethylamino]-2-propanole, process for its preparation and pharmaceutical compositions containing it |
ZA989365B (en) * | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
HU227441B1 (en) * | 1997-11-24 | 2011-06-28 | Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag | Process for producing carvedilol, enantiomers and salts thereof |
CO5011072A1 (es) | 1997-12-05 | 2001-02-28 | Lilly Co Eli | Etanolaminas pirazinil substituidas como agfonistas de los receptores |
US6664284B2 (en) * | 1998-07-23 | 2003-12-16 | Roche Diagnostics Gmbh | Stabilized carvedilol injection solution |
WO2001074356A1 (en) * | 2000-04-03 | 2001-10-11 | F. Hoffmann-La Roche Ag | Concentrated solutions of carvedilol |
US20010036959A1 (en) * | 2000-04-03 | 2001-11-01 | Gabel Rolf Dieter | Carvedilol-hydrophilic solutions |
CN1245974C (zh) * | 2000-06-28 | 2006-03-22 | 特瓦制药工业有限公司 | 卡维地洛 |
KR100342659B1 (en) | 2000-12-15 | 2002-07-04 | Rstech Co Ltd | Chiral polymer salene catalyst and process for preparing chiral compounds from racemic epoxide using the same |
BR0212927A (pt) * | 2001-09-28 | 2004-10-13 | Hoffmann La Roche | Formas pseudopolimórficas de carvedilol |
US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
CA2472377A1 (en) | 2002-01-15 | 2003-07-24 | Teva Pharmaceutical Industries Ltd. | Crystalline solids of carvedilol and processes for their preparation |
WO2003092622A2 (en) * | 2002-04-30 | 2003-11-13 | Sb Pharmco Puerto Rico Inc. | Carvedilol monocitrate monohydrate |
EP1539140A4 (en) * | 2002-06-27 | 2005-12-07 | Sb Pharmco Inc | CARVEDILOLHYDOBROMID |
CN103288714A (zh) * | 2002-06-27 | 2013-09-11 | 史密斯克莱.比奇曼(科克)有限公司 | 卡维地洛磷酸盐和/或其溶剂合物相应的组合物和/或治疗方法 |
SK285547B6 (sk) * | 2002-11-08 | 2007-03-01 | Zentiva, A. S. | Spôsob prípravy Carvedilolu |
EP1615888A1 (en) * | 2003-04-21 | 2006-01-18 | Matrix Laboratories Ltd | Process for the preparation of carvedilol form-ii |
US7482471B2 (en) * | 2003-06-20 | 2009-01-27 | Sun Pharmaceutical Industries Limited | Process for preparation of 1-[9H-carbazol-4-yloxy]-3-[{2-(2-(-methoxy)phenoxy)-ethyl}-amino]-propan-2-ol |
US7750036B2 (en) * | 2003-11-25 | 2010-07-06 | Sb Pharmco Puerto Rico Inc. | Carvedilol salts, corresponding compositions, methods of delivery and/or treatment |
CA2547137A1 (en) * | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods |
WO2005051325A2 (en) * | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Carvedilol compositions methods of treatment and delivery |
CA2560353A1 (en) | 2004-02-23 | 2005-09-01 | Cadila Healthcare Limited | Process for manufacture of racemic carvedilol |
WO2005115981A2 (en) * | 2004-04-22 | 2005-12-08 | Usv Limited | A process for the preparation of 1-(9h-carbazol-4-yloxy)-3-2-(-methoxyphenoxy)-ethyl amino-propan-2-ol |
GB0411273D0 (en) * | 2004-05-20 | 2004-06-23 | Cipla Ltd | Process and product |
ATE445601T1 (de) * | 2004-12-09 | 2009-10-15 | Zach System Spa | Verfahren zur herstellung von carvedilol und seinen enantiomeren |
US20070043099A1 (en) * | 2005-06-09 | 2007-02-22 | Igor Lifshitz | Crystalline forms of carvedilol and processes for their preparation |
WO2007077111A1 (en) * | 2005-12-30 | 2007-07-12 | F. Hoffmann-La Roche Ag | Compounds and methods for carbazole synthesis |
WO2008002683A2 (en) * | 2006-06-28 | 2008-01-03 | Teva Pharmaceutical Industries Ltd. | Polymorphous forms of carvedilol phosphate |
WO2008038301A1 (en) * | 2006-09-26 | 2008-04-03 | Morepen Laboratories Limited | A process for the preparation of carvedilol |
WO2008105794A1 (en) * | 2007-02-26 | 2008-09-04 | Teva Pharmaceutical Industries Ltd. | Process for the purification of carvedilol or its salts thereof |
CN102285910B (zh) * | 2011-07-04 | 2013-06-19 | 南京工业大学 | 一种制备(s)-卡维地洛的方法 |
CN102617368B (zh) * | 2012-02-27 | 2014-07-09 | 华中科技大学 | 一种α/β受体双重抑制剂及其盐的制备方法 |
US10749118B2 (en) | 2014-06-26 | 2020-08-18 | Samsung Display Co., Ltd. | Heterocyclic compound and organic light-emitting device including the same |
US20230381139A1 (en) * | 2020-09-17 | 2023-11-30 | Uti Limited Partnership | Methods of treating and/or preventing alzheimer’s disease with r-carvedilol |
CN116041248B (zh) * | 2023-04-03 | 2023-06-06 | 成都摩诃大龙医药科技有限公司 | 一种具有抗癌活性的咔唑衍生物及其制备方法和应用 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
GB1369580A (en) * | 1972-08-18 | 1974-10-09 | Boehringer Mannheim Gmbh | Tricyclic diphenylamine derivatives |
GB1458392A (en) * | 1973-11-09 | 1976-12-15 | Ici Ltd | Optically-active 1-aryloxy-2,3-epoxypropane derivatives |
US4202978A (en) * | 1978-02-08 | 1980-05-13 | Hoffmann-La Roche Inc. | (S)-1-[2-(4-(2-Hydroxy-s-(1-alkylaminopropoxy)phenylalkyl]-4-phenylpiperazines |
CH641147A5 (de) * | 1979-01-17 | 1984-02-15 | Sandoz Ag | 3-amino-2-hydroxypropoxyaryl-derivat, seine herstellung und dieses enthaltende heilmittel. |
DE3011808A1 (de) * | 1980-03-27 | 1981-10-01 | Cassella Ag, 6000 Frankfurt | Verfahren zur herstellung von n-hydroxyalkylcarbazol |
US4400383A (en) * | 1981-12-11 | 1983-08-23 | Burroughs Wellcome Co. | Treatment of anxiety |
DE3300933A1 (de) * | 1983-01-13 | 1984-07-19 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verwendung von d,l- und d-carazolol als antiglaukommittel sowie arzneimittel, die diese stoffe enthalten |
-
1983
- 1983-05-26 DE DE19833319027 patent/DE3319027A1/de not_active Withdrawn
-
1984
- 1984-05-19 AT AT84105747T patent/ATE27273T1/de not_active IP Right Cessation
- 1984-05-19 DE DE8484105747T patent/DE3463768D1/de not_active Expired
- 1984-05-19 EP EP84105747A patent/EP0127099B1/de not_active Expired
- 1984-05-21 US US06/612,255 patent/US4697022A/en not_active Expired - Lifetime
- 1984-05-22 FI FI842046A patent/FI80018C/fi not_active IP Right Cessation
- 1984-05-22 AU AU28480/84A patent/AU551116B2/en not_active Expired
- 1984-05-23 NZ NZ208254A patent/NZ208254A/xx unknown
- 1984-05-23 CA CA000454948A patent/CA1259071A/en not_active Expired
- 1984-05-23 JP JP59102778A patent/JPS59222473A/ja active Granted
- 1984-05-24 DK DK255184A patent/DK169331B1/da not_active IP Right Cessation
- 1984-05-24 KR KR1019840002847A patent/KR860001761B1/ko not_active IP Right Cessation
- 1984-05-24 IE IE1295/84A patent/IE57533B1/en not_active IP Right Cessation
- 1984-05-24 PT PT78633A patent/PT78633B/pt unknown
- 1984-05-24 GR GR74808A patent/GR81577B/el unknown
- 1984-05-25 ES ES532838A patent/ES8502683A1/es not_active Expired
- 1984-05-25 ZA ZA843976A patent/ZA843976B/xx unknown
- 1984-05-25 HU HU842038A patent/HU193011B/hu unknown
- 1984-05-25 PH PH30721A patent/PH22749A/en unknown
- 1984-05-25 NO NO842084A patent/NO164537C/no not_active IP Right Cessation
- 1984-05-26 IL IL71876A patent/IL71876A/xx not_active IP Right Cessation
-
1987
- 1987-05-13 US US07/049,673 patent/US4824963A/en not_active Expired - Lifetime
-
1989
- 1989-01-19 US US07/299,750 patent/US4985454A/en not_active Expired - Lifetime
-
1991
- 1991-01-28 US US07/631,641 patent/US5071868A/en not_active Expired - Lifetime
-
1992
- 1992-09-25 JP JP4256343A patent/JPH0613508B2/ja not_active Expired - Lifetime
-
1993
- 1993-08-06 DK DK091393A patent/DK169333B1/da not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK1K | Patent expired |