DK168708B1 - Fremgangsmåde til fremstilling af N7-amidinosubstituerede mitomycin C-derivater - Google Patents

Fremgangsmåde til fremstilling af N7-amidinosubstituerede mitomycin C-derivater Download PDF

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Publication number
DK168708B1
DK168708B1 DK193786A DK193786A DK168708B1 DK 168708 B1 DK168708 B1 DK 168708B1 DK 193786 A DK193786 A DK 193786A DK 193786 A DK193786 A DK 193786A DK 168708 B1 DK168708 B1 DK 168708B1
Authority
DK
Denmark
Prior art keywords
mitomycin
process according
amino
lower alkyl
chloride
Prior art date
Application number
DK193786A
Other languages
Danish (da)
English (en)
Other versions
DK193786A (da
DK193786D0 (da
Inventor
Takushi Kaneko
Henry S L Wong
Original Assignee
Squibb Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb Bristol Myers Co filed Critical Squibb Bristol Myers Co
Publication of DK193786D0 publication Critical patent/DK193786D0/da
Publication of DK193786A publication Critical patent/DK193786A/da
Application granted granted Critical
Publication of DK168708B1 publication Critical patent/DK168708B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK193786A 1985-04-29 1986-04-28 Fremgangsmåde til fremstilling af N7-amidinosubstituerede mitomycin C-derivater DK168708B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72865085 1985-04-29
US06/728,650 US4652644A (en) 1985-04-29 1985-04-29 Process for preparation of N7 -amidino substituted mitomycin C derivatives

Publications (3)

Publication Number Publication Date
DK193786D0 DK193786D0 (da) 1986-04-28
DK193786A DK193786A (da) 1986-10-30
DK168708B1 true DK168708B1 (da) 1994-05-24

Family

ID=24927725

Family Applications (1)

Application Number Title Priority Date Filing Date
DK193786A DK168708B1 (da) 1985-04-29 1986-04-28 Fremgangsmåde til fremstilling af N7-amidinosubstituerede mitomycin C-derivater

Country Status (21)

Country Link
US (1) US4652644A (ko)
KR (1) KR910002080B1 (ko)
CN (1) CN1020731C (ko)
AR (1) AR242210A1 (ko)
AT (1) AT394724B (ko)
CA (1) CA1247617A (ko)
CS (1) CS271331B2 (ko)
DD (1) DD258011A5 (ko)
DK (1) DK168708B1 (ko)
ES (1) ES8706685A1 (ko)
FI (1) FI83519C (ko)
GR (1) GR861152B (ko)
HU (1) HU194243B (ko)
IT (1) IT1208605B (ko)
LU (1) LU86411A1 (ko)
NO (1) NO164543C (ko)
OA (1) OA08243A (ko)
PT (1) PT82471B (ko)
SU (1) SU1436881A3 (ko)
YU (1) YU45778B (ko)
ZW (1) ZW5386A1 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6354380A (ja) * 1986-08-26 1988-03-08 Kyowa Hakko Kogyo Co Ltd マイトマイシン誘導体
JPH0867676A (ja) * 1994-03-30 1996-03-12 Eisai Kagaku Kk 保護アミノチアゾリル酢酸誘導体
JP3202960B2 (ja) * 1998-02-17 2001-08-27 大塚化学株式会社 ハロゲン化剤及び水酸基のハロゲン化方法
CN104478885B (zh) * 2014-12-12 2017-08-01 常州大学 9‑氨基‑9a‑烯丙基苯并吡咯里西啶生物碱的制备方法
CN104710426B (zh) * 2014-12-12 2017-08-01 常州大学 苯并吡咯里西啶生物碱及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1135270B (it) * 1980-04-12 1986-08-20 Erba Farmitalia 3-amidino-ansamicine
US4487769A (en) * 1982-06-04 1984-12-11 Bristol-Myers Company Amidines
US4567256A (en) * 1983-05-09 1986-01-28 Bristol-Myers Company Amidine process

Also Published As

Publication number Publication date
ZW5386A1 (en) 1986-10-01
YU70086A (en) 1987-12-31
KR910002080B1 (ko) 1991-04-03
NO164543C (no) 1990-10-17
AR242210A1 (es) 1993-03-31
IT8620228A0 (it) 1986-04-28
US4652644A (en) 1987-03-24
DK193786A (da) 1986-10-30
FI83519B (fi) 1991-04-15
FI83519C (fi) 1991-07-25
KR860008201A (ko) 1986-11-12
SU1436881A3 (ru) 1988-11-07
NO164543B (no) 1990-07-09
CN1020731C (zh) 1993-05-19
GR861152B (en) 1986-09-02
CN86101611A (zh) 1986-12-17
CA1247617A (en) 1988-12-28
CS311786A2 (en) 1989-12-13
ATA101886A (de) 1991-11-15
LU86411A1 (fr) 1986-11-05
PT82471B (pt) 1988-10-14
ES554469A0 (es) 1987-07-01
CS271331B2 (en) 1990-09-12
YU45778B (sh) 1992-07-20
PT82471A (en) 1986-05-01
HU194243B (en) 1988-01-28
ES8706685A1 (es) 1987-07-01
HUT40665A (en) 1987-01-28
FI861720A (fi) 1986-10-30
AT394724B (de) 1992-06-10
FI861720A0 (fi) 1986-04-24
OA08243A (fr) 1987-10-30
DK193786D0 (da) 1986-04-28
DD258011A5 (de) 1988-07-06
IT1208605B (it) 1989-07-10
NO861652L (no) 1986-10-30

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed