DK167978B1 - Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse - Google Patents
Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse Download PDFInfo
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- DK167978B1 DK167978B1 DK106287A DK106287A DK167978B1 DK 167978 B1 DK167978 B1 DK 167978B1 DK 106287 A DK106287 A DK 106287A DK 106287 A DK106287 A DK 106287A DK 167978 B1 DK167978 B1 DK 167978B1
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- DK
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- Prior art keywords
- serine
- glycero
- groups
- group
- general formula
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- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical class OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- 239000010773 plant oil Substances 0.000 description 1
- 239000003495 polar organic solvent Substances 0.000 description 1
- 229920001515 polyalkylene glycol Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 150000003354 serine derivatives Chemical class 0.000 description 1
- 150000003355 serines Chemical class 0.000 description 1
- 125000003808 silyl group Chemical group [H][Si]([H])([H])[*] 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- RZWQDAUIUBVCDD-UHFFFAOYSA-M sodium;benzenethiolate Chemical compound [Na+].[S-]C1=CC=CC=C1 RZWQDAUIUBVCDD-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DD27823085A DD238978A1 (de) | 1985-07-03 | 1985-07-03 | Verfahren zur herstellung von 2-o-alkyl-i-des oxy-1-halogenglycero-3-phospho-l-serinen |
| DD27823085 | 1985-07-03 | ||
| DD27823185 | 1985-07-03 | ||
| DD27823185A DD238979A1 (de) | 1985-07-03 | 1985-07-03 | Verfahren zur herstellung von o-alkylglycerophosphoserin-analogen |
| DD27856085A DD239208B1 (de) | 1985-07-15 | 1985-07-15 | Verfahren zur herstellung von 1-o-alkyl-2-o-trifluoralkylglycerophospho-l-serinen |
| DD27856185A DD239209A1 (de) | 1985-07-15 | 1985-07-15 | Verfahren zur herstellung von o-alkylsubstituierten glycero- sowie desoxyglycerophospho-serinen |
| DD27856185 | 1985-07-15 | ||
| DD27856285A DD239405A1 (de) | 1985-07-15 | 1985-07-15 | Verfahren zur herstellung von trifluoralkyl-glycerophospho-l-serinen |
| DD27856085 | 1985-07-15 | ||
| DD27856285 | 1985-07-15 | ||
| EP8600390 | 1986-07-02 | ||
| PCT/EP1986/000390 WO1987000173A1 (en) | 1985-07-03 | 1986-07-02 | Derivatives of glycero-3(2)-phospho-l-serine and pharmaceutical preparations containing them |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK106287A DK106287A (da) | 1987-03-02 |
| DK106287D0 DK106287D0 (da) | 1987-03-02 |
| DK167978B1 true DK167978B1 (da) | 1994-01-10 |
Family
ID=27509737
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK106287A DK167978B1 (da) | 1985-07-03 | 1987-03-02 | Glycero-3(2)-phospho-l-serin-derivater og salte deraf, fremgangsmaade til fremstilling af saadanne forbindelser og farmaceutiske praeparater indeholdende disse |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0229128B1 (fi) |
| JP (1) | JPH0751588B2 (fi) |
| DE (1) | DE3671630D1 (fi) |
| DK (1) | DK167978B1 (fi) |
| FI (1) | FI82473C (fi) |
| HU (1) | HU198076B (fi) |
| NO (1) | NO169171C (fi) |
| WO (1) | WO1987000173A1 (fi) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1249063B (it) * | 1991-05-28 | 1995-02-11 | Fidia Spa | Impiego di derivati fosfolipidici per la preparazione di composizioni farmaceutiche aventi attivita' immunosoppressiva |
| ES2034885B1 (es) * | 1991-07-10 | 1994-03-01 | Menarini Lab | Procedimiento para la preparacion de cetoalquilglicerofosfolipidos. |
| DE4229877C2 (de) * | 1992-09-04 | 1994-09-15 | Max Delbrueck Centrum | Phospho- bzw. Phosphono-(N-acyl)-serine und ihre Herstellung |
| IT1311929B1 (it) * | 1999-04-28 | 2002-03-20 | Chemi Spa | Procedimento per la preparazione di fosfatidilserine. |
| WO2005077963A1 (fr) * | 2004-01-16 | 2005-08-25 | Institut Superieur Agricole De Beauvais | DErivEs de saccharides et d'itols possEdant un groupement O-alkyle ou un groupement O-alkyle et un groupement O-n-butanoyle. Applications comme mEdicaments dans les pathologies prolifEratives tumorales ou bEnignes. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1123142B (it) * | 1979-09-14 | 1986-04-30 | Lpb Ist Farm | Uso di glicerilfosforil derivati nella terapia di dislipemie ed epatiti,e composizioni farmaceutiche relative |
| DD222595A1 (de) * | 1984-01-24 | 1985-05-22 | Zi F Molekularbiologie | Verfahren zur herstellung von 1-0-alkyl-2-0-(2,2,2-trifluorethyl)glycero-3-phosphocholinen |
-
1986
- 1986-07-02 JP JP61503925A patent/JPH0751588B2/ja not_active Expired - Lifetime
- 1986-07-02 DE DE8686904150T patent/DE3671630D1/de not_active Expired - Fee Related
- 1986-07-02 EP EP86904150A patent/EP0229128B1/de not_active Expired - Lifetime
- 1986-07-02 WO PCT/EP1986/000390 patent/WO1987000173A1/de active IP Right Grant
- 1986-07-03 HU HU862805A patent/HU198076B/hu not_active IP Right Cessation
-
1987
- 1987-02-20 FI FI870732A patent/FI82473C/fi not_active IP Right Cessation
- 1987-02-27 NO NO87870834A patent/NO169171C/no unknown
- 1987-03-02 DK DK106287A patent/DK167978B1/da active
Also Published As
| Publication number | Publication date |
|---|---|
| EP0229128B1 (de) | 1990-05-30 |
| HUT43861A (en) | 1987-12-28 |
| FI82473C (fi) | 1991-03-11 |
| WO1987000173A1 (en) | 1987-01-15 |
| DE3671630D1 (de) | 1990-07-05 |
| DK106287A (da) | 1987-03-02 |
| NO870834D0 (no) | 1987-02-27 |
| FI870732A (fi) | 1987-02-20 |
| DK106287D0 (da) | 1987-03-02 |
| JPH0751588B2 (ja) | 1995-06-05 |
| NO870834L (no) | 1987-02-27 |
| HU198076B (en) | 1989-07-28 |
| EP0229128A1 (de) | 1987-07-22 |
| FI82473B (fi) | 1990-11-30 |
| FI870732A0 (fi) | 1987-02-20 |
| NO169171C (no) | 1992-05-20 |
| NO169171B (no) | 1992-02-10 |
| JPS63500658A (ja) | 1988-03-10 |
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