DK167768B1 - Fluorescerende mono- eller polyamider af en aminodicarboxylsyre og en tetrapyrrolforbindelse indeholdende mindst en carboxylgruppe samt terapeutisk praeparat indeholdende disse forbindelser - Google Patents
Fluorescerende mono- eller polyamider af en aminodicarboxylsyre og en tetrapyrrolforbindelse indeholdende mindst en carboxylgruppe samt terapeutisk praeparat indeholdende disse forbindelser Download PDFInfo
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- DK167768B1 DK167768B1 DK326785A DK326785A DK167768B1 DK 167768 B1 DK167768 B1 DK 167768B1 DK 326785 A DK326785 A DK 326785A DK 326785 A DK326785 A DK 326785A DK 167768 B1 DK167768 B1 DK 167768B1
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- acid
- methanol
- chlorine
- compound
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
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- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
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- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0036—Porphyrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Pyrrole Compounds (AREA)
- Rolls And Other Rotary Bodies (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/631,925 US4675338A (en) | 1984-07-18 | 1984-07-18 | Tetrapyrrole therapeutic agents |
| US63192584 | 1984-07-18 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK326785D0 DK326785D0 (da) | 1985-07-18 |
| DK326785A DK326785A (da) | 1986-01-19 |
| DK167768B1 true DK167768B1 (da) | 1993-12-13 |
Family
ID=24533344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK326785A DK167768B1 (da) | 1984-07-18 | 1985-07-18 | Fluorescerende mono- eller polyamider af en aminodicarboxylsyre og en tetrapyrrolforbindelse indeholdende mindst en carboxylgruppe samt terapeutisk praeparat indeholdende disse forbindelser |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US4675338A (ja) |
| EP (1) | EP0168832B1 (ja) |
| JP (2) | JPH0689000B2 (ja) |
| AT (1) | ATE94547T1 (ja) |
| AU (1) | AU579387B2 (ja) |
| CA (1) | CA1262862A (ja) |
| DE (1) | DE3587579T2 (ja) |
| DK (1) | DK167768B1 (ja) |
| HK (1) | HK135994A (ja) |
| NO (1) | NO169290C (ja) |
| SG (1) | SG103194G (ja) |
Families Citing this family (99)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4649151A (en) * | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
| US4675338A (en) * | 1984-07-18 | 1987-06-23 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| JPS61186385A (ja) * | 1985-02-13 | 1986-08-20 | Sato Yakugaku Kenkyusho:Kk | デユウテロポルフイリン誘導体及びその塩 |
| JPS625986A (ja) * | 1985-04-30 | 1987-01-12 | Nippon Petrochem Co Ltd | 新規なテトラピロ−ル化合物 |
| US4656186A (en) * | 1985-04-30 | 1987-04-07 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| JPH0764728B2 (ja) * | 1985-04-30 | 1995-07-12 | 日本石油化学株式会社 | 新規なテトラピロ−ル医薬用組成物 |
| US5066274A (en) * | 1985-04-30 | 1991-11-19 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole therapeutic agents |
| US4977177A (en) * | 1985-04-30 | 1990-12-11 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole polyaminomonocarboxylic acid therapeutic agents |
| AU603999B2 (en) * | 1985-10-23 | 1990-12-06 | Photochemical Co., Ltd. | Porphyrin derivatives, and their production and use |
| US5534506A (en) * | 1986-01-02 | 1996-07-09 | University Of Toledo | Use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US5216012A (en) * | 1986-01-02 | 1993-06-01 | University Of Toledo | Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US5051415A (en) * | 1986-01-02 | 1991-09-24 | The University Of Toledo | Production and use of purpurins, chlorins and purpurin- and chlorin-containing compositions |
| US4772681A (en) * | 1986-01-17 | 1988-09-20 | Hamari Chemicals, Ltd. | Porphyrin derivatives |
| US4877872A (en) * | 1986-06-24 | 1989-10-31 | The University Of Toledo | Production and use of dimers of hematoporophyrin, purpurins, chlorines and purpurin- and chlorin-complexes |
| US5095030A (en) * | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US4883790A (en) * | 1987-01-20 | 1989-11-28 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| US5283255A (en) * | 1987-01-20 | 1994-02-01 | The University Of British Columbia | Wavelength-specific cytotoxic agents |
| US4920143A (en) * | 1987-04-23 | 1990-04-24 | University Of British Columbia | Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents |
| US5171749A (en) * | 1987-01-20 | 1992-12-15 | University Of British Columbia | Wavelength-specific cytotoxic agents |
| JPH0629196B2 (ja) * | 1987-12-01 | 1994-04-20 | 甲子郎 梅村 | 超音波による腫瘍治療用生理作用増強剤 |
| US5004811A (en) * | 1987-12-24 | 1991-04-02 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole aminocarboxylic acids |
| US5109016A (en) * | 1988-05-23 | 1992-04-28 | Georgia State University Foundation, Inc. | Method for inhibiting infection or replication of human immunodeficiency virus with porphyrin and phthalocyanine antiviral compositions |
| US5192788A (en) * | 1988-05-23 | 1993-03-09 | Georgia State University Foundation, Inc. | Porphyrin antiviral compositions |
| US4925736A (en) * | 1988-07-06 | 1990-05-15 | Long Island Jewish Medical Center | Topical hematoporphyrin |
| DE3827940A1 (de) * | 1988-08-13 | 1990-03-01 | Schering Ag | 13,17-propionsaeure- und propionsaeurederivat- substituierte porphyrin-komplexverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| US4959356A (en) * | 1989-05-26 | 1990-09-25 | The United States Of America As Represented By The United States Department Of Energy | Porphyrins for boron neutron capture therapy |
| US4997639A (en) * | 1989-11-27 | 1991-03-05 | Nippon Petrochemicals Company, Limited | Method for detecting cholesterol deposited in bodies of mammals |
| US5238940A (en) * | 1990-03-22 | 1993-08-24 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
| US5053423A (en) * | 1990-03-22 | 1991-10-01 | Quadra Logic Technologies Inc. | Compositions for photodynamic therapy |
| EP0553116A1 (en) * | 1990-10-05 | 1993-08-04 | Queen's University At Kingston | Porphyrin derivatives |
| US5219878A (en) * | 1990-10-05 | 1993-06-15 | Queen's University | Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents |
| JP3154742B2 (ja) * | 1991-04-30 | 2001-04-09 | 日本石油化学株式会社 | 哺乳類の動脈硬化症治療剤 |
| US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
| US5658892A (en) * | 1993-01-15 | 1997-08-19 | The General Hospital Corporation | Compound delivery using high-pressure impulse transients |
| US5614502A (en) * | 1993-01-15 | 1997-03-25 | The General Hospital Corporation | High-pressure impulse transient drug delivery for the treatment of proliferative diseases |
| JP3565442B2 (ja) * | 1993-04-22 | 2004-09-15 | 新日本石油化学株式会社 | 哺乳類の関節炎の診断剤および／または治療剤 |
| US5492924A (en) * | 1993-09-24 | 1996-02-20 | Fox Chase Cancer Center | Phorbine derivatives and their use in the diagnosis and therapy of cancer |
| US5474910A (en) * | 1993-10-15 | 1995-12-12 | Alfano; Robert R. | Method and device for detecting biological molecules and/or microorganisms within a desired area or space |
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| WO2007056498A2 (en) * | 2005-11-07 | 2007-05-18 | Light Sciences Oncology, Inc | Light delivery apparatus |
| WO2007103427A2 (en) * | 2006-03-06 | 2007-09-13 | Wang Xiang H | Medical use of bilirubin and its structural analogues |
| CN100408581C (zh) * | 2006-04-30 | 2008-08-06 | 中国人民解放军总医院 | 3-(1-烷氧基乙基)-8-乙基-2,7,12,15,18-五甲基-13-羧酸-17-丙酸、其合成方法和光动力治疗药物 |
| CN100369914C (zh) * | 2006-04-30 | 2008-02-20 | 中国人民解放军总医院 | 3-烯基-8-乙基-2,7,12,15,18-五甲基-13-羧酸-17-丙酸氨基酸酰胺、其合成方法及光动力治疗药物 |
| US8198312B2 (en) * | 2006-06-30 | 2012-06-12 | Light Sciences Oncology, Inc. | Compositions and methods of making a photoactive agent |
| US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
| FR2914302A1 (fr) * | 2007-03-30 | 2008-10-03 | Sanofi Pasteur Sa | Procede de preparation de derives de porphyrine, telle que la protoporphyrine (ix) et intermediaire de synthese |
| US7911053B2 (en) * | 2007-04-19 | 2011-03-22 | Marvell World Trade Ltd. | Semiconductor packaging with internal wiring bus |
| US8318794B2 (en) * | 2008-11-25 | 2012-11-27 | Science Group Pty. Ltd. | Method of use of porphyrins in preparing a medicament for sonodynamic therapy and a method of sonodynamic therapy using porphyrins |
| CN102724951A (zh) | 2009-11-09 | 2012-10-10 | 阿勒根公司 | 用于刺激毛发生长的组合物和方法 |
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Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4393071A (en) * | 1975-03-17 | 1983-07-12 | Naoharu Fujii | Method of treating gastric, mammary, lung and uterus tumors |
| JPS53112900A (en) * | 1977-03-14 | 1978-10-02 | Ajinomoto Co Inc | Porphyrin derivative |
| JPS58201791A (ja) * | 1982-05-19 | 1983-11-24 | Katsuo Unno | ヘマトポルフイリン誘導体 |
| JPS60500132A (ja) * | 1982-09-27 | 1985-01-31 | ヘルス・リサーチ・インコーポレーテッド | 腫瘍の診断および治療のための精製されたヘマトポルフイリン誘導体ならびにその方法 |
| US4649151A (en) * | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
| JPS60158686A (ja) * | 1984-01-27 | 1985-08-20 | Matsushita Electric Ind Co Ltd | 半導体レ−ザ |
| JPS60158687A (ja) * | 1984-01-27 | 1985-08-20 | Matsushita Electric Ind Co Ltd | 半導体レ−ザ |
| US4693885A (en) * | 1984-07-18 | 1987-09-15 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
| US4675338A (en) * | 1984-07-18 | 1987-06-23 | Nippon Petrochemicals Co., Ltd. | Tetrapyrrole therapeutic agents |
-
1984
- 1984-07-18 US US06/631,925 patent/US4675338A/en not_active Expired - Lifetime
-
1985
- 1985-07-18 AU AU45158/85A patent/AU579387B2/en not_active Expired
- 1985-07-18 AT AT85108987T patent/ATE94547T1/de not_active IP Right Cessation
- 1985-07-18 NO NO852871A patent/NO169290C/no not_active IP Right Cessation
- 1985-07-18 JP JP60158687A patent/JPH0689000B2/ja not_active Expired - Lifetime
- 1985-07-18 DE DE85108987T patent/DE3587579T2/de not_active Expired - Lifetime
- 1985-07-18 DK DK326785A patent/DK167768B1/da not_active IP Right Cessation
- 1985-07-18 EP EP85108987A patent/EP0168832B1/en not_active Expired - Lifetime
- 1985-07-18 CA CA000487040A patent/CA1262862A/en not_active Expired
- 1985-07-18 JP JP60158686A patent/JPH0688902B2/ja not_active Expired - Lifetime
-
1994
- 1994-07-26 SG SG103194A patent/SG103194G/en unknown
- 1994-12-01 HK HK135994A patent/HK135994A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| SG103194G (en) | 1994-10-28 |
| CA1262862C (en) | 1989-11-14 |
| EP0168832B1 (en) | 1993-09-15 |
| JPH0689000B2 (ja) | 1994-11-09 |
| DE3587579D1 (de) | 1993-10-21 |
| NO169290C (no) | 1992-06-03 |
| US4675338A (en) | 1987-06-23 |
| NO852871L (no) | 1986-01-20 |
| HK135994A (en) | 1994-12-09 |
| DK326785D0 (da) | 1985-07-18 |
| JPS61129163A (ja) | 1986-06-17 |
| DE3587579T2 (de) | 1994-02-17 |
| EP0168832A3 (en) | 1988-05-04 |
| JPS6183186A (ja) | 1986-04-26 |
| DK326785A (da) | 1986-01-19 |
| ATE94547T1 (de) | 1993-10-15 |
| AU579387B2 (en) | 1988-11-24 |
| CA1262862A (en) | 1989-11-14 |
| AU4515885A (en) | 1986-03-27 |
| JPH0688902B2 (ja) | 1994-11-09 |
| NO169290B (no) | 1992-02-24 |
| EP0168832A2 (en) | 1986-01-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PUP | Patent expired |