DK165839C - Tigogenin-cellobiosidforbindelser, farmaceutiske praeparater, der indeholder forbindelserne, anvendelse af forbindelserne til fremstilling af et farmaceutisk praeparat samt fremgangsmaade til fremstilling af forbindelserne - Google Patents
Tigogenin-cellobiosidforbindelser, farmaceutiske praeparater, der indeholder forbindelserne, anvendelse af forbindelserne til fremstilling af et farmaceutisk praeparat samt fremgangsmaade til fremstilling af forbindelserneInfo
- Publication number
- DK165839C DK165839C DK361084A DK361084A DK165839C DK 165839 C DK165839 C DK 165839C DK 361084 A DK361084 A DK 361084A DK 361084 A DK361084 A DK 361084A DK 165839 C DK165839 C DK 165839C
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- compounds
- pharmaceutical
- procedure
- tigogenin cellobioside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0016—Details of inhalators; Constructional features thereof with inhalation check valves located downstream of the dispenser, i.e. traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0086—Inhalation chambers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Vascular Medicine (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Cephalosporin Compounds (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US60229884 | 1984-04-20 | ||
US06/602,298 US4602005A (en) | 1982-05-17 | 1984-04-20 | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis |
Publications (4)
Publication Number | Publication Date |
---|---|
DK361084D0 DK361084D0 (da) | 1984-07-23 |
DK361084A DK361084A (da) | 1985-10-21 |
DK165839B DK165839B (da) | 1993-01-25 |
DK165839C true DK165839C (da) | 1993-06-21 |
Family
ID=24410793
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK361084A DK165839C (da) | 1984-04-20 | 1984-07-23 | Tigogenin-cellobiosidforbindelser, farmaceutiske praeparater, der indeholder forbindelserne, anvendelse af forbindelserne til fremstilling af et farmaceutisk praeparat samt fremgangsmaade til fremstilling af forbindelserne |
DK014892A DK166213C (da) | 1984-04-20 | 1992-02-06 | Tigogenin-cellobiosid-heptaacetatforbindelser og fremgangsmaade til fremstilling heraf |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK014892A DK166213C (da) | 1984-04-20 | 1992-02-06 | Tigogenin-cellobiosid-heptaacetatforbindelser og fremgangsmaade til fremstilling heraf |
Country Status (16)
Country | Link |
---|---|
US (1) | US4602005A (da) |
EP (1) | EP0159431B1 (da) |
JP (1) | JPS60224697A (da) |
KR (1) | KR940002114B1 (da) |
AT (1) | ATE42959T1 (da) |
AU (1) | AU580005B2 (da) |
CA (1) | CA1246544A (da) |
DE (1) | DE3478114D1 (da) |
DK (2) | DK165839C (da) |
ES (1) | ES8601233A1 (da) |
FI (2) | FI82253C (da) |
HU (1) | HUT37802A (da) |
IE (1) | IE58015B1 (da) |
NO (1) | NO842990L (da) |
NZ (1) | NZ208961A (da) |
ZA (1) | ZA845690B (da) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4602005A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis |
US4865850A (en) * | 1986-09-08 | 1989-09-12 | See/Shell Biotechnology, Inc. | Dietary fat reduction |
US5010185A (en) * | 1989-06-13 | 1991-04-23 | Pfizer Inc. | Processes for tigogenin beta-cellobioside |
US5091192A (en) * | 1990-01-16 | 1992-02-25 | Natur-All Systems, Inc. | Bile salts permanently bound to insoluble cellulose as a dietary supplement |
CA2079544A1 (en) * | 1991-10-04 | 1993-04-05 | Adam Weislaw Mazur | Cholesterol lowering compounds |
AU2753292A (en) * | 1991-10-04 | 1993-05-03 | Procter & Gamble Company, The | Cholesterol lowering compounds and process for making them |
HUT67035A (en) * | 1991-11-25 | 1995-01-30 | Pfizer | New process for the production of steroidal glycosides derivatives |
US5294703A (en) * | 1992-05-01 | 1994-03-15 | Eastman Kodak Company | Process for preparing α-D-cellobiose octaacetate |
RU94046294A (ru) * | 1992-06-26 | 1996-10-10 | Пфайзер Инк. (US) | Стероидные гликозиды для лечения гиперхолестеринэмии |
JP2578399B2 (ja) * | 1992-06-26 | 1997-02-05 | ファイザー インク. | ステロイド−β−O−セロビオシドヘプタアルカノエートの製造方法 |
NZ252006A (en) * | 1992-06-26 | 1995-10-26 | Pfizer | Preparation of 1-o-steroidal peracyl-beta-glycosides |
US5530107A (en) * | 1992-10-15 | 1996-06-25 | Pfizer Inc. | Method for making steroidal peracyl glycosides |
PL311278A1 (en) * | 1993-04-28 | 1996-02-05 | Pfizer | Crystalline glycosidal spirostantil monohydrate |
US5502038A (en) * | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
WO1995000158A1 (en) * | 1993-06-25 | 1995-01-05 | Bio-Sphere Technology | Dietary supplement incorporating beta-sitosterol and pectin |
ES2074006B1 (es) * | 1993-07-05 | 1996-03-16 | Pfizer | Glicosidos esteroidales para tratar hipercolesterolemia. |
AU7948494A (en) * | 1993-12-28 | 1995-07-17 | Pfizer Inc. | Steroidal glycosides |
US5607841A (en) * | 1994-06-20 | 1997-03-04 | Lipinski; Boguslaw | Preparation and proteolytic degradation of a macromolecular protein complex from fibrinogen |
EP0782451A1 (en) * | 1994-09-20 | 1997-07-09 | Pfizer Inc. | Combination of a cholesterol absorption inhibitor and a cholesterol synthesis inhibitor |
WO1996038466A1 (en) * | 1995-05-29 | 1996-12-05 | Pfizer Inc. | Steroidal glycosides |
US5698527A (en) * | 1995-08-08 | 1997-12-16 | Merck & Co., Inc. | Steroidal glycosides as antihyperlipidemic agents |
US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
GB9923076D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
ID26989A (id) * | 1998-03-26 | 2001-02-22 | Phytopharm Plc | Smilagenin dan anzurogenin-d untuk pengobatan penyakit alzheimer |
GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB9923077D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
GB0000228D0 (en) * | 2000-01-06 | 2000-03-01 | Phytopharm Plc | Fluoro substituted sapogenins and their use |
US6982251B2 (en) * | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
AU2002247019C1 (en) * | 2001-01-26 | 2017-05-11 | Organon Llc | Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
KR20080067717A (ko) * | 2001-01-26 | 2008-07-21 | 쉐링 코포레이션 | 스테롤 흡수 억제제와 혈액 조절제를 포함하는 혈관 질환의치료 또는 예방용 약제학적 조성물 |
CZ20032031A3 (cs) * | 2001-01-26 | 2003-12-17 | Schering Corporation | Farmaceutický prostředek |
CZ305202B6 (cs) * | 2001-01-26 | 2015-06-10 | Merck Sharp & Dohme Corp. | Farmaceutický prostředek |
DK1363668T3 (da) * | 2001-01-26 | 2007-11-05 | Schering Corp | Kombinationer af galdesyrekompleksdanner(e) og sterolabsorptionsinhibitor(er) og behandling af vaskulære indikationer |
US7071181B2 (en) * | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
AR034204A1 (es) * | 2001-01-26 | 2004-02-04 | Schering Corp | Composiciones y combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y el uso de los mismos para preparar medicamentos para el tratamiento para indicaciones vasculares |
GB0107822D0 (en) * | 2001-03-28 | 2001-05-23 | Phytopharm Plc | Sapogenin derivatives their synthesis and use methods based upon their use |
ES2275007T3 (es) * | 2001-05-25 | 2007-06-01 | Schering Corporation | Uso de derivados de azetidinona sustitudos en el tratamiento de la enfermedad de alzeimer. |
US7056906B2 (en) * | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
US20030119808A1 (en) * | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
HUP0401501A3 (en) * | 2001-09-21 | 2012-02-28 | Schering Corp | Treating or preventing vascular inflammation using pharmaceutical compositions containing sterol absorption inhibitor(s) |
JP2005504091A (ja) * | 2001-09-21 | 2005-02-10 | シェーリング コーポレイション | ステロール吸収阻害剤としてアゼチジノンを用いる黄色腫の処置 |
US7053080B2 (en) * | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
KR101130212B1 (ko) * | 2002-03-27 | 2012-04-13 | 파이토팜 피엘씨 | 사포게닌 및 그 유도체의 치료 방법 및 사용법 |
US20050130948A1 (en) * | 2002-03-27 | 2005-06-16 | Daryl Rees | Therapeutic methods and uses of sapogenins and their derivatives |
EP1560579A1 (en) * | 2002-11-06 | 2005-08-10 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of autoimmune disorders |
WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
US7208486B2 (en) | 2003-03-07 | 2007-04-24 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
JP2006519869A (ja) * | 2003-03-07 | 2006-08-31 | シェーリング コーポレイション | 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用 |
US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
EP1680189A2 (en) * | 2003-11-05 | 2006-07-19 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
GB0329667D0 (en) * | 2003-12-22 | 2004-01-28 | King S College London | Core 2 GlcNAc-T inhibitor |
WO2005063790A1 (en) * | 2003-12-31 | 2005-07-14 | Council Of Scientific & Industrial Research | Isolation of tigogenin pentaglycoside from chlorophytum nimonii |
US7160866B2 (en) | 2004-03-22 | 2007-01-09 | Council Of Scientific And Industrial Research | Isolation of tigogenin pentaglycoside from Chlorophytum nimonii |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2759171A1 (de) * | 1977-12-31 | 1979-07-12 | Roecar Holdings Nv | Arzneimittel mit wirkung als prostaglandinsynthetaseninhibitor |
DE2926463A1 (de) * | 1978-07-05 | 1980-01-24 | Roecar Holdings Nv | Spiroketaline und ihre verwendung |
US4260603A (en) * | 1979-01-02 | 1981-04-07 | Pegel Karl H | Sterol glycoside with activity as prostaglandin synthetase inhibitor |
US4242502A (en) * | 1979-04-20 | 1980-12-30 | United States Of America | Enhancement of cholesterol combining properties of saponins |
US4602005A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis |
US4602003A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia |
-
1984
- 1984-04-20 US US06/602,298 patent/US4602005A/en not_active Expired - Lifetime
- 1984-07-20 NZ NZ208961A patent/NZ208961A/en unknown
- 1984-07-23 DE DE8484304993T patent/DE3478114D1/de not_active Expired
- 1984-07-23 IE IE190484A patent/IE58015B1/en not_active IP Right Cessation
- 1984-07-23 AT AT84304993T patent/ATE42959T1/de not_active IP Right Cessation
- 1984-07-23 ES ES534553A patent/ES8601233A1/es not_active Expired
- 1984-07-23 AU AU30977/84A patent/AU580005B2/en not_active Ceased
- 1984-07-23 FI FI842935A patent/FI82253C/fi not_active IP Right Cessation
- 1984-07-23 NO NO842990A patent/NO842990L/no unknown
- 1984-07-23 EP EP84304993A patent/EP0159431B1/en not_active Expired
- 1984-07-23 KR KR1019840004369A patent/KR940002114B1/ko not_active IP Right Cessation
- 1984-07-23 ZA ZA845690A patent/ZA845690B/xx unknown
- 1984-07-23 JP JP59153899A patent/JPS60224697A/ja active Granted
- 1984-07-23 DK DK361084A patent/DK165839C/da not_active IP Right Cessation
- 1984-07-23 HU HU842837A patent/HUT37802A/hu unknown
- 1984-07-23 CA CA000459491A patent/CA1246544A/en not_active Expired
-
1990
- 1990-02-02 FI FI900531A patent/FI87792C/fi not_active IP Right Cessation
-
1992
- 1992-02-06 DK DK014892A patent/DK166213C/da not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH0456840B2 (da) | 1992-09-09 |
KR940002114B1 (ko) | 1994-03-17 |
JPS60224697A (ja) | 1985-11-09 |
EP0159431A2 (en) | 1985-10-30 |
ES534553A0 (es) | 1985-11-16 |
FI82253B (fi) | 1990-10-31 |
EP0159431A3 (en) | 1986-01-08 |
IE841904L (en) | 1985-10-20 |
DK166213C (da) | 1993-08-16 |
KR850007432A (ko) | 1985-12-04 |
HUT37802A (en) | 1986-02-28 |
ES8601233A1 (es) | 1985-11-16 |
NZ208961A (en) | 1988-01-08 |
FI842935A (fi) | 1985-10-21 |
DK14892A (da) | 1992-02-06 |
CA1246544A (en) | 1988-12-13 |
DK166213B (da) | 1993-03-22 |
AU3097784A (en) | 1985-10-24 |
DK361084A (da) | 1985-10-21 |
EP0159431B1 (en) | 1989-05-10 |
US4602005A (en) | 1986-07-22 |
FI900531A0 (fi) | 1990-02-02 |
ZA845690B (en) | 1986-03-26 |
FI87792B (fi) | 1992-11-13 |
DK14892D0 (da) | 1992-02-06 |
IE58015B1 (en) | 1993-06-16 |
DE3478114D1 (en) | 1989-06-15 |
FI87792C (fi) | 1993-02-25 |
FI842935A0 (fi) | 1984-07-23 |
AU580005B2 (en) | 1988-12-22 |
DK361084D0 (da) | 1984-07-23 |
DK165839B (da) | 1993-01-25 |
ATE42959T1 (de) | 1989-05-15 |
FI82253C (fi) | 1991-02-11 |
NO842990L (no) | 1985-10-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PBP | Patent lapsed | ||
PBP | Patent lapsed |