ES8706717A1 - Metodo de preparar esteroides - Google Patents
Metodo de preparar esteroidesInfo
- Publication number
- ES8706717A1 ES8706717A1 ES535643A ES535643A ES8706717A1 ES 8706717 A1 ES8706717 A1 ES 8706717A1 ES 535643 A ES535643 A ES 535643A ES 535643 A ES535643 A ES 535643A ES 8706717 A1 ES8706717 A1 ES 8706717A1
- Authority
- ES
- Spain
- Prior art keywords
- steroids
- containing same
- compositions containing
- therapeutic compositions
- hyperglycemic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
- C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
- C07J1/0025—Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
- C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class
- C07J53/002—Carbocyclic rings fused
- C07J53/004—3 membered carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
METODO DE PREPARAR ESTEROIDES. CONSISTE EN PROTEGER LOS GRUPOS REACTIVOS DEL MATERIAL DE PARTIDA, EFECTUAR REACCIONES DE SUSTITUCION DE ANILLO EN UN DISOLVENTE ORGANICO A PRESION ATMOSFERICA Y A UNA TEMPERATURA ENTRE -80GC Y LA DE REFLUJO DE LA MEZCLA DE REACCION, Y ELIMINAR CUALESQUIERA GRUPOS PROTECTORES OPCIONALMENTE AÑADIDOS, PARA PRODUCIR ESTEROIDES DE FORMULA (I) DONDE R1, R2, R3, R4, R5, R6, R7 Y R8 SE ELIGEN CADA UNO DEL GRUPO FORMADO POR HIDROGENO, ALQUILO, ALQUENILO, HALOGENO E HIDROXILO; Y N ES UN ENTERO DE 1 A 2. TIENEN APLICACIONES FARMACEUTICAS COMO AGENTES ANTICANCER Y ANTIOBESIDAD. *FORMULA*
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US51955083A | 1983-08-02 | 1983-08-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES535643A0 ES535643A0 (es) | 1987-07-01 |
ES8706717A1 true ES8706717A1 (es) | 1987-07-01 |
Family
ID=24068794
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535643A Expired ES8706717A1 (es) | 1983-08-02 | 1984-08-02 | Metodo de preparar esteroides |
Country Status (10)
Country | Link |
---|---|
EP (2) | EP0133995B1 (es) |
JP (1) | JPS6069096A (es) |
AU (1) | AU582122B2 (es) |
CA (1) | CA1314870C (es) |
DE (1) | DE3485647D1 (es) |
DK (1) | DK375384A (es) |
ES (1) | ES8706717A1 (es) |
GR (1) | GR80020B (es) |
IE (1) | IE72193B1 (es) |
IL (1) | IL72566A (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5804576A (en) * | 1983-08-02 | 1998-09-08 | Research Corporation Technologies, Inc. | Derivatives of 5-androsten-17-ones and 5-androstan-17-ones |
US5714481A (en) * | 1983-08-02 | 1998-02-03 | Research Corporation Technologies, Inc. | Derivatives of 5-androsten-17 ones and 5-androstan-17-ones |
US5157031A (en) * | 1983-08-02 | 1992-10-20 | Research Corporation Technologies, Inc. | Method for prophylaxis of obesity |
US5656621A (en) * | 1983-08-02 | 1997-08-12 | Research Corporation Tech., Inc. | Steroids useful as anti-cancer and anti-obesity agents |
AU598201B2 (en) * | 1985-08-02 | 1990-06-21 | Research Corporation | Steroids useful as anti-cancer, anti-obesity, anti-hyperglycemic, anti-autoimmune and anti-hypercholesterolemic agents |
PT84911B (pt) * | 1986-05-21 | 1990-02-08 | Research Corp | Processo para a preparacao de esteroides uteis como agentes anti-cancerigenos e anti-obesidade |
NL194728C (nl) * | 1987-04-16 | 2003-01-07 | Hollis Eden Pharmaceuticals | Farmaceutisch preparaat geschikt voor de profylaxe of therapie van een retrovirale infectie of een complicatie of gevolg daarvan. |
JPS63267722A (ja) * | 1987-04-27 | 1988-11-04 | Daiichi Yakuhin Sangyo Kk | 抗肥満症剤 |
US4897390A (en) * | 1987-07-21 | 1990-01-30 | Ruhe Rodney C | Novel anti-obesity compounds and method of use |
JPS6440428A (en) * | 1987-08-07 | 1989-02-10 | Daiichi Yakuhin Sangyo Kk | Antihyperlipemia |
US5175154A (en) * | 1987-11-25 | 1992-12-29 | Research Corporation Technologies, Inc. | 5 α-pregnan-20-ones and 5-pregnen-20-ones and related compounds |
US5001119A (en) * | 1987-11-25 | 1991-03-19 | Schwartz Arthur G | 16-substituted androstanes and 16-substituted androstenes |
US4898694A (en) * | 1987-11-25 | 1990-02-06 | Schwartz Arthur G | 17-Hydroxy-steroids |
US5028631A (en) * | 1987-11-25 | 1991-07-02 | Schwartz Arthur G | Homoandrostan-17-one and homoandrosten-17-ones |
US5753237A (en) * | 1989-09-25 | 1998-05-19 | University Of Utah Research Foundation | Method for augmenting immunological responses |
AU652130B2 (en) * | 1989-09-25 | 1994-08-18 | University Of Utah Research Foundation | Use of steroid hormones in compositions for inducing T cell lymphokine production |
US5585371A (en) * | 1990-08-29 | 1996-12-17 | Humanetics Corporation | Treatment of immune system with Δ5-androstenes |
DE69133158T2 (de) * | 1990-08-29 | 2003-07-17 | Humanetics Corp | Behandlungsverfahren zur förderung des gewichtsverlustes unter verwendung eines substituierten delta-5-androstens |
US5424463A (en) * | 1990-08-29 | 1995-06-13 | Humanetics Corporation | Δ5-androstenes useful for promoting weight maintenance or weight loss and treatment process |
JPH0684398B2 (ja) * | 1990-08-31 | 1994-10-26 | 雪印乳業株式会社 | 新規なアンドロステン誘導体及びそれを用いる6‐アルキルカルボニルオキシ‐14α‐ヒドロキシ‐アンドロスト‐4,6‐ジエン‐3,17‐ジオンの製造法 |
JP3862295B2 (ja) * | 1993-09-30 | 2006-12-27 | 独立行政法人理化学研究所 | 抗肥満剤 |
US5736537A (en) * | 1995-09-12 | 1998-04-07 | Estee Lauder, Inc. | Dehydroep:androsterone sailcylate useful against skin atrophy |
US6667299B1 (en) | 2000-03-16 | 2003-12-23 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical compositions and treatment methods |
PT1163256E (pt) * | 1999-03-23 | 2004-07-30 | Hollis Eden Pharmaceuticals | Hemi-hidrato de 16-alfa-bromoepiandrosterona |
EP1422234A3 (en) * | 1999-03-23 | 2010-12-08 | Harbor BioSciences, Inc. | Immunomodulatory steroids, in particular the hemihydrate of 16.alpha.-bromoepiandrosterone |
CA2670236C (en) | 1999-09-30 | 2012-06-05 | Hollis-Eden Pharmaceuticals, Inc. | Therapeutic treatment of androgen receptor driven conditions |
WO2011138460A1 (en) * | 2010-05-07 | 2011-11-10 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Progesterone receptor antagonists and uses thereof |
CN105339382A (zh) * | 2013-05-21 | 2016-02-17 | 雷迪博士实验室有限公司 | 脱氢表雄酮及其中间体的制备方法 |
CA2953917C (en) * | 2013-07-01 | 2021-10-19 | The Research Foundation For The State University Of New York | Ship inhibition to combat obesity |
EP3157529B1 (en) | 2014-06-17 | 2021-08-04 | The Research Foundation for The State University of New York | Ship inhibition to induce activation of natural killer cells |
ES2970792T3 (es) * | 2019-10-09 | 2024-05-30 | Windtree Therapeutics Inc | Derivados de androstano con actividad como estimuladores puros o predominantemente puros de SERCA2A para el tratamiento de la insuficiencia cardíaca |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2833793A (en) * | 1957-09-30 | 1958-05-06 | Searle & Co | 17-oxygenated derivatives of 5-androstene-1, 3-diol |
US2911418A (en) * | 1959-01-02 | 1959-11-03 | Searle & Co | 16-halo 17-oxygenated androst-5-en-3-ols and esters |
FR1355505A (fr) * | 1959-02-03 | 1964-03-20 | Upjohn Co | Procédé de préparation de 6-fluoro stéroïdes de la série de l'androstène |
GB876009A (en) * | 1959-11-26 | 1961-08-30 | Upjohn Co | Improvements in or relating to steroids and the manufacture thereof |
US3148198A (en) * | 1960-09-06 | 1964-09-08 | Searle & Co | 3, 17-bisoxygenated 16alpha, 16beta-difluoroandrostenes and process |
US3018298A (en) * | 1961-03-14 | 1962-01-23 | Searle & Co | 17-oxygenated 3alpha-halo-5alpha-androstan-2beta-ols and derivatives thereof |
GB989503A (en) * | 1962-08-29 | 1965-04-22 | British Drug Houses Ltd | 6,16-disubstituted androstenes and process for the preparation thereof |
DE1239306B (de) * | 1963-05-11 | 1967-04-27 | Vismara Francesco Spa | Verfahren zur Herstellung von Ketosteroiden, die in alpha-Stellung zur Ketogruppe eine gegebenenfalls substituierte Allylgruppe tragen |
US3166578A (en) * | 1963-11-12 | 1965-01-19 | Searle & Co | (optionally 17-alkylated) 17-oxygenated 5alpha-androst-2-en-4-ones and intermediatesthereto |
BE666194A (es) * | 1964-06-30 | |||
US3357888A (en) * | 1965-04-07 | 1967-12-12 | Upjohn Co | 4, 7-dimethyl androstene derivatives |
BE754111A (fr) * | 1969-07-29 | 1971-01-29 | Upjohn Co | Nouveaux 7alpha- et 7beta-methyl-3alpha,5alpha- cycloandrostanes et composes analogues 19-nor et leur procede de preparation |
JPS5031155B2 (es) * | 1972-05-29 | 1975-10-07 | ||
US3976691A (en) * | 1972-12-11 | 1976-08-24 | E. I. Du Pont De Nemours And Company | Dialkylaminosulfur trifluorides as fluorinating agents |
GB1550343A (en) * | 1975-07-16 | 1979-08-15 | Gist Brocades Nv | Androstane derivatives |
DE2705917C3 (de) * | 1977-02-09 | 1980-05-08 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 3 ß , 16 ß -Dihydroxy-5-androsten- 17-on durch mikrobiologische Hydrolyse |
DE2757157C3 (de) * | 1977-12-19 | 1980-10-09 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von 16 a -alkylierten Steroiden |
EP0014971B1 (de) * | 1979-02-16 | 1982-06-16 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Verfahren zur Herstellung von 1-alpha-Hydroxydehydroepiandrosteron |
IE53463B1 (en) * | 1981-06-15 | 1988-11-23 | Akzo Nv | Mono-and bisquaternary ammonium derivatives of 2 beta,16 beta-d-amino-5 alpha-androstane derivatives and pharmaceutical preparations containing same |
-
1984
- 1984-08-02 EP EP84109185A patent/EP0133995B1/en not_active Expired - Lifetime
- 1984-08-02 GR GR80020A patent/GR80020B/el unknown
- 1984-08-02 AU AU31456/84A patent/AU582122B2/en not_active Expired
- 1984-08-02 EP EP19900122171 patent/EP0423842A3/en not_active Withdrawn
- 1984-08-02 JP JP59163758A patent/JPS6069096A/ja not_active Withdrawn
- 1984-08-02 ES ES535643A patent/ES8706717A1/es not_active Expired
- 1984-08-02 CA CA000460267A patent/CA1314870C/en not_active Expired - Fee Related
- 1984-08-02 DE DE8484109185T patent/DE3485647D1/de not_active Expired - Lifetime
- 1984-08-02 IL IL72566A patent/IL72566A/xx not_active IP Right Cessation
- 1984-08-02 DK DK375384A patent/DK375384A/da not_active Application Discontinuation
- 1984-08-02 IE IE199184A patent/IE72193B1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK375384A (da) | 1985-02-03 |
IE841991L (en) | 1985-02-02 |
EP0133995B1 (en) | 1992-04-15 |
ES535643A0 (es) | 1987-07-01 |
EP0133995A2 (en) | 1985-03-13 |
IE72193B1 (en) | 1997-03-26 |
AU3145684A (en) | 1985-10-03 |
DK375384D0 (da) | 1984-08-02 |
JPS6069096A (ja) | 1985-04-19 |
GR80020B (en) | 1984-12-11 |
IL72566A (en) | 1988-08-31 |
EP0133995A3 (en) | 1985-11-27 |
IL72566A0 (en) | 1984-11-30 |
EP0423842A3 (en) | 1991-08-07 |
CA1314870C (en) | 1993-03-23 |
DE3485647D1 (de) | 1992-05-21 |
EP0423842A2 (en) | 1991-04-24 |
AU582122B2 (en) | 1989-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20040414 |