ATE165367T1 - Cholesterinsenkende verbindungen und verfahren zu ihrer herstellung - Google Patents
Cholesterinsenkende verbindungen und verfahren zu ihrer herstellungInfo
- Publication number
- ATE165367T1 ATE165367T1 AT92921189T AT92921189T ATE165367T1 AT E165367 T1 ATE165367 T1 AT E165367T1 AT 92921189 T AT92921189 T AT 92921189T AT 92921189 T AT92921189 T AT 92921189T AT E165367 T1 ATE165367 T1 AT E165367T1
- Authority
- AT
- Austria
- Prior art keywords
- hydroxymethylhexose
- sterol
- cholesterol
- production
- hexaacylated
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 229930182558 Sterol Natural products 0.000 abstract 3
- 150000003432 sterols Chemical class 0.000 abstract 3
- 235000003702 sterols Nutrition 0.000 abstract 3
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 230000037213 diet Effects 0.000 abstract 1
- 235000005911 diet Nutrition 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229930182490 saponin Natural products 0.000 abstract 1
- 150000007949 saponins Chemical class 0.000 abstract 1
- 235000017709 saponins Nutrition 0.000 abstract 1
- FTVLMFQEYACZNP-UHFFFAOYSA-N trimethylsilyl trifluoromethanesulfonate Chemical compound C[Si](C)(C)OS(=O)(=O)C(F)(F)F FTVLMFQEYACZNP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003648 triterpenes Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77170991A | 1991-10-04 | 1991-10-04 | |
| US77166891A | 1991-10-04 | 1991-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE165367T1 true ATE165367T1 (de) | 1998-05-15 |
Family
ID=27118506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92921189T ATE165367T1 (de) | 1991-10-04 | 1992-09-29 | Cholesterinsenkende verbindungen und verfahren zu ihrer herstellung |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0607245B1 (de) |
| JP (1) | JPH06511250A (de) |
| AT (1) | ATE165367T1 (de) |
| AU (1) | AU2753292A (de) |
| DE (1) | DE69225233T2 (de) |
| ES (1) | ES2114948T3 (de) |
| GR (1) | GR3026698T3 (de) |
| PT (1) | PT100922B (de) |
| WO (1) | WO1993007167A1 (de) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5629295A (en) * | 1992-06-26 | 1997-05-13 | Pfizer Inc. | Steroidal glycosides for treating hypercholesterolemia |
| EP0696292A1 (de) * | 1993-04-28 | 1996-02-14 | Pfizer Inc. | Spirostanyl-glycosid-kristall-monohydrat |
| US5502038A (en) * | 1993-06-21 | 1996-03-26 | Medical Research Foundation Of Oregon | Cholesterol sequestrant glycosides that inhibit intestinal cholesterol absorption |
| ES2074006B1 (es) * | 1993-07-05 | 1996-03-16 | Pfizer | Glicosidos esteroidales para tratar hipercolesterolemia. |
| US6150336A (en) * | 1995-05-29 | 2000-11-21 | Pfizer Inc. | Steroidal glycosides |
| US5756470A (en) * | 1996-10-29 | 1998-05-26 | Schering Corporation | Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents |
| CA2389670A1 (en) * | 1999-11-01 | 2001-05-10 | Forbes Medi-Tech Inc. | Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| SI1355644T1 (sl) | 2001-01-26 | 2006-10-31 | Schering Corp | Uporaba substituiranih azetidinonskih spojin za zdravljenje sitosterolemije |
| IL156445A0 (en) | 2001-01-26 | 2004-01-04 | Schering Corp | Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| FI20010780A0 (fi) | 2001-04-12 | 2001-04-12 | Raisio Benecol Oy | Parannetut koostumukset |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| DK1429756T3 (da) | 2001-09-21 | 2007-03-19 | Schering Corp | Behandling af xanthoma med azetidinonderivater som sterolabsorptionsinhibitorer |
| US20040092499A1 (en) | 2002-11-06 | 2004-05-13 | Schering Corporation | Methods and therapeutic combinations for the treatment of autoimmune disorders |
| ATE418551T1 (de) | 2003-03-07 | 2009-01-15 | Schering Corp | Substituierte azetidinon-derivate, deren pharmazeutische formulierungen und deren verwendung zur behandlung von hypercholesterolemia |
| WO2004081002A1 (en) | 2003-03-07 | 2004-09-23 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| CN1756755A (zh) | 2003-03-07 | 2006-04-05 | 先灵公司 | 取代的2－吖丁啶酮化合物、其制剂及其治疗高胆甾醇血症的用途 |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| KR101426180B1 (ko) | 2009-11-02 | 2014-07-31 | 화이자 인코포레이티드 | 디옥사-비시클로［3.2.1］옥탄-2,3,4-트리올 유도체 |
| EP3145934B1 (de) | 2014-05-19 | 2020-11-11 | Pfizer Inc | Substituierte 6,8-dioxabicyclo[3.2.1]octane-2,3-diol-verbindungen als zielsubstanzen für asgpr |
| KR20170123345A (ko) | 2015-03-20 | 2017-11-07 | 오르후스 우니베르시테트 | 지질단백질 대사 장애의 치료를 위한 pcsk9의 억제제 |
| EP3515455B1 (de) | 2016-09-20 | 2021-04-14 | Aarhus Universitet | Verbindungen zur behandlung von störungen des lipoproteinstoffwechsels |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4602005A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Tigogenin cellobioside for treating hypercholesterolemia and atherosclerosis |
| US5041541A (en) * | 1988-05-05 | 1991-08-20 | The Procter & Gamble Company | Functional sugar substituted with reduced calories |
-
1992
- 1992-09-29 AT AT92921189T patent/ATE165367T1/de not_active IP Right Cessation
- 1992-09-29 EP EP92921189A patent/EP0607245B1/de not_active Expired - Lifetime
- 1992-09-29 JP JP50700993A patent/JPH06511250A/ja active Pending
- 1992-09-29 DE DE69225233T patent/DE69225233T2/de not_active Expired - Fee Related
- 1992-09-29 AU AU27532/92A patent/AU2753292A/en not_active Abandoned
- 1992-09-29 WO PCT/US1992/008290 patent/WO1993007167A1/en not_active Ceased
- 1992-09-29 ES ES92921189T patent/ES2114948T3/es not_active Expired - Lifetime
- 1992-10-01 PT PT100922A patent/PT100922B/pt not_active IP Right Cessation
-
1998
- 1998-04-23 GR GR980400751T patent/GR3026698T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT100922A (pt) | 1993-10-29 |
| AU2753292A (en) | 1993-05-03 |
| ES2114948T3 (es) | 1998-06-16 |
| DE69225233T2 (de) | 1998-11-19 |
| DE69225233D1 (de) | 1998-05-28 |
| PT100922B (pt) | 1999-08-31 |
| EP0607245A1 (de) | 1994-07-27 |
| WO1993007167A1 (en) | 1993-04-15 |
| GR3026698T3 (en) | 1998-07-31 |
| EP0607245B1 (de) | 1998-04-22 |
| JPH06511250A (ja) | 1994-12-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |