DK165837C - Analogifremgangsmaade til fremstilling af lokalt anti-inflammatorisk aktive 17alfa-carbonat-androst-4-en-3-on-17beta-carboxylsyreestere, der in vivo nedbrydes til ikke toksiske metabolitter - Google Patents

Analogifremgangsmaade til fremstilling af lokalt anti-inflammatorisk aktive 17alfa-carbonat-androst-4-en-3-on-17beta-carboxylsyreestere, der in vivo nedbrydes til ikke toksiske metabolitter

Info

Publication number
DK165837C
DK165837C DK302181A DK302181A DK165837C DK 165837 C DK165837 C DK 165837C DK 302181 A DK302181 A DK 302181A DK 302181 A DK302181 A DK 302181A DK 165837 C DK165837 C DK 165837C
Authority
DK
Denmark
Prior art keywords
metabolet
inflammatorally
17alfa
deviced
17beta
Prior art date
Application number
DK302181A
Other languages
Danish (da)
English (en)
Other versions
DK165837B (da
DK302181A (da
Inventor
Nicholas Stephen Bodor
Original Assignee
Bodor Nicholas S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bodor Nicholas S filed Critical Bodor Nicholas S
Publication of DK302181A publication Critical patent/DK302181A/da
Publication of DK165837B publication Critical patent/DK165837B/da
Application granted granted Critical
Publication of DK165837C publication Critical patent/DK165837C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK302181A 1980-07-10 1981-07-08 Analogifremgangsmaade til fremstilling af lokalt anti-inflammatorisk aktive 17alfa-carbonat-androst-4-en-3-on-17beta-carboxylsyreestere, der in vivo nedbrydes til ikke toksiske metabolitter DK165837C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16845380A 1980-07-10 1980-07-10
US16845380 1980-07-10
US26578581A 1981-05-21 1981-05-21
US26578581 1981-05-21

Publications (3)

Publication Number Publication Date
DK302181A DK302181A (da) 1982-01-11
DK165837B DK165837B (da) 1993-01-25
DK165837C true DK165837C (da) 1993-06-21

Family

ID=26864131

Family Applications (1)

Application Number Title Priority Date Filing Date
DK302181A DK165837C (da) 1980-07-10 1981-07-08 Analogifremgangsmaade til fremstilling af lokalt anti-inflammatorisk aktive 17alfa-carbonat-androst-4-en-3-on-17beta-carboxylsyreestere, der in vivo nedbrydes til ikke toksiske metabolitter

Country Status (17)

Country Link
KR (2) KR860000266B1 (enrdf_load_stackoverflow)
AT (1) AT379816B (enrdf_load_stackoverflow)
AU (1) AU540898B2 (enrdf_load_stackoverflow)
CA (1) CA1174667A (enrdf_load_stackoverflow)
CH (1) CH648856A5 (enrdf_load_stackoverflow)
DE (1) DE3126732C2 (enrdf_load_stackoverflow)
DK (1) DK165837C (enrdf_load_stackoverflow)
ES (2) ES8300785A1 (enrdf_load_stackoverflow)
FI (1) FI71748C (enrdf_load_stackoverflow)
FR (1) FR2486529A1 (enrdf_load_stackoverflow)
GB (1) GB2079755B (enrdf_load_stackoverflow)
IT (1) IT1205446B (enrdf_load_stackoverflow)
NL (1) NL192343C (enrdf_load_stackoverflow)
NO (1) NO163285C (enrdf_load_stackoverflow)
PH (1) PH25874A (enrdf_load_stackoverflow)
PT (1) PT73348B (enrdf_load_stackoverflow)
SE (1) SE449106B (enrdf_load_stackoverflow)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2137206B (en) * 1980-02-15 1985-04-03 Glaxo Group Ltd Androstane 17-carbothioc acid derivatives
JPS6041607A (ja) * 1983-08-12 1985-03-05 Otsuka Pharmaceut Co Ltd 軟膏基剤
IL78144A0 (en) * 1985-04-04 1986-07-31 Draco Ab Novel androstane-17beta-carboxylic acid esters
SE8501693D0 (sv) * 1985-04-04 1985-04-04 Draco Ab Novel 16,17-acetalsubstituted androstane-17beta-carboxylic acid esters
WO1989003390A1 (en) * 1987-10-13 1989-04-20 Bodor Nicholas S Soft steroids having anti-inflammatory activity
DE4025342A1 (de) * 1990-08-10 1992-02-13 Hoechst Ag In 17-stellung substituierte corticoid-17-alkylcarbonate, verfahren zu deren herstellung und diese enthaltende arzneimittel
EP0998484B1 (en) * 1997-06-30 2004-03-03 Glaxo Group Limited Method of identifying compounds having reduced systemic effects
CA2634715A1 (en) 2000-08-05 2002-02-14 Glaxo Group Limited 6.alpha.,9.alpha.-difluoro-17.alpha.-[(2-furanylcarboxyl)oxy}-11.beta.-hydroxy-16.alpha-methyl-3-oxo-androsta-1,4-diene-17.beta.carbothioic acids-fluoromethyl ester as an anti-inflammatory agent
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
US6750210B2 (en) 2000-08-05 2004-06-15 Smithkline Beecham Corporation Formulation containing novel anti-inflammatory androstane derivative
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6759398B2 (en) 2000-08-05 2004-07-06 Smithkline Beecham Corporation Anti-inflammatory androstane derivative
US6858593B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6777400B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
US6787532B2 (en) 2000-08-05 2004-09-07 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivatives
UA77656C2 (en) 2001-04-07 2007-01-15 Glaxo Group Ltd S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
CA2445839A1 (en) 2001-04-30 2002-11-07 Glaxo Group Limited Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
UA82323C2 (uk) * 2002-08-09 2008-04-10 Меда Фарма Гмбх & Ко. Кг Нова комбінація глюкокортикоїду та pde-інгібітору для лікування респіраторних захворювань, алергічних захворювань, астми та хронічних обструктивних легеневих захворювань
GB0316290D0 (en) 2003-07-11 2003-08-13 Glaxo Group Ltd Novel compounds
ATE517908T1 (de) 2005-01-10 2011-08-15 Glaxo Group Ltd Androstan-17-alpha-carbonat-derivate zur verwendung bei der behandlung allergischer und entzündlicher zustände
TWI374147B (en) * 2006-01-27 2012-10-11 Sun Pharma Advance Res Company Ltd Novel 11β-hydroxyandrosta-4-ene-3-ones
US7687484B2 (en) * 2006-05-25 2010-03-30 Bodor Nicholas S Transporter enhanced corticosteroid activity
US7691811B2 (en) * 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
CN101942001B (zh) * 2010-08-24 2013-02-06 山东省医药工业研究所 一种氯替泼诺的提纯方法
CN103183714A (zh) * 2011-12-29 2013-07-03 山东方明药业集团股份有限公司 一种氯替泼诺的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1384372A (en) * 1971-01-20 1975-02-19 Glaxo Lab Ltd Dereivatives of 17alpha-hydroxyandrost-4-ene-17beta-carboxylic acids
GB1438940A (en) * 1972-07-19 1976-06-09 Glaxo Lab Ltd 17beta-haloalkoxycarbonyl-17alpha-oxysteroids
GB1514476A (en) * 1974-08-30 1978-06-14 Glaxo Lab Ltd Alkyl and haloalkyl androst-4-ene and androsta-1,4-diene-17beta-carboxylates
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
IT1114534B (it) * 1978-02-08 1986-01-27 Glaxo Group Ltd Steroide anti-infiammatorio della serie dell'androstano composizioni che lo contengono e procedimento per produrlo
US4188385A (en) * 1978-04-05 1980-02-12 Syntex (U.S.A.) Inc. Thioetianic acid derivatives
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung

Also Published As

Publication number Publication date
DK165837B (da) 1993-01-25
FR2486529B1 (enrdf_load_stackoverflow) 1985-01-04
NO812344L (no) 1982-01-11
IT1205446B (it) 1989-03-23
ES8306767A1 (es) 1983-06-16
DE3126732A1 (de) 1982-03-25
AU7259181A (en) 1982-01-14
NL192343B (nl) 1997-02-03
NL192343C (nl) 1997-06-04
ES504340A0 (es) 1982-12-01
IT8105186A0 (it) 1981-07-09
ES8300785A1 (es) 1982-12-01
KR850002759A (ko) 1985-05-15
KR830006327A (ko) 1983-09-24
SE449106B (sv) 1987-04-06
FI71748B (fi) 1986-10-31
CH648856A5 (de) 1985-04-15
PT73348A (en) 1981-08-01
NL8103315A (nl) 1982-02-01
FI812175L (fi) 1982-01-11
NO163285C (no) 1990-05-02
CA1174667A (en) 1984-09-18
ATA307081A (de) 1985-07-15
GB2079755B (en) 1985-01-30
NO163285B (no) 1990-01-22
FI71748C (fi) 1987-02-09
ES514633A0 (es) 1983-06-16
DK302181A (da) 1982-01-11
AT379816B (de) 1986-03-10
FR2486529A1 (fr) 1982-01-15
DE3126732C2 (de) 1987-04-30
AU540898B2 (en) 1984-12-06
SE8104132L (sv) 1982-01-11
KR860000452B1 (ko) 1986-04-26
PH25874A (en) 1991-12-02
KR860000266B1 (ko) 1986-03-22
PT73348B (en) 1982-09-23
GB2079755A (en) 1982-01-27

Similar Documents

Publication Publication Date Title
DK165837C (da) Analogifremgangsmaade til fremstilling af lokalt anti-inflammatorisk aktive 17alfa-carbonat-androst-4-en-3-on-17beta-carboxylsyreestere, der in vivo nedbrydes til ikke toksiske metabolitter
DK158971C (da) Fremgangsmaade til fremstilling af et pulverformet praeparat, som kan rekonstitueres med vand til dannelse af en farmaceutisk suspension af mikrokapsler indeholdende bacampicillinsyreadditionssalt i et vandigt suspensionsmedium
NO159928C (no) Fremgangsmaate til fremstilling av optisk aktive 1-,4-dihydropyridinkarboksylsyreestere.
DK147735C (da) Analogifremgangsmaade til fremstilling af 3-oxo-androst-4-en-17beta-thiocarboxylsyreestere
DK189881A (da) Fremgangsmaade til fremstilling af aminocyklopentanalkensyrer eller estere deraf
AR228452A1 (es) Medio para comprobar la presencia de enzimas esteroliticas y/o proteoliticas y procedimiento para preparar esteres fenoxiamino acidos
DK153542C (da) Analogifremgangsmaade til fremstilling af ornithin- eller argininsalte af forgrenede alfa-keto-syrer
FI791088A7 (fi) 4-halogeeni-3-oksoandrost-4-eenien 17 - tiokarboksyylihappoestereitä.
FI832407A7 (fi) Malonihappoesterien epimerisointi.
DK149630C (da) Analogifremgangsmaade til fremstilling af tripeptidamider eller -estere eller fysiologisk acceptable syreadditionssalte deraf
DK98684D0 (da) Fremgangsmade til fremstilling af fedtsyreestere af ascorbinsyre
DK576784A (da) Fremgangsmaade til fremstilling af optisk aktive 3-aminocarboxylsyreestere
ES393914A0 (es) Procedimiento de preparacion de nuevos derivados de acido fenilacetico, racemicos, u opticamente activos
DK153279A (da) 1,3-dibenzoesyreestere af 17alfa-ethynyl-7alfa-methyl-1,3,5(10)-oestratrien-1,3,17beta-trioler samt fremgangsmaade til fremstilling deraf
NO840350L (no) Fremgangsmaate til racematoppdeling av optisk aktive bicykliske imino-alfa-karboksylsyreestere, og anvendelsen av de saaledes dannede forbindelser til fremstilling av karboksyalkyldipeptider
DK280285D0 (da) Fremgangsmaade til fremstilling af ascorbinsyre
DK537181A (da) Herbicidt virkende 5-amino-1-phenylpyrazol-4-carboxylsyreestere
NO854414L (no) Fremgangsmaate for fremstilling av kinkonidinsaltet av d-2-(6-metoksy-2-naftyl)-propionsyre.
FI814059A7 (fi) Propionihappoesterit.
DK429779A (da) Fremgangsmaade til fremstilling af cyklopropancarboxylsyreestere
DK208981A (da) Fremgangsmaade til fremstilling af benzoxazol- eller benzothiazol-2-carboxylsyreestere eller syreadditionssalte eller konjugatsalte deraf
DK161177A (da) Elektrokemisk reduktion af imidazolcarboxylsyreestere
DK372279A (da) Fremgangsmaade til fremstilling af aminsalte af sure 0,dialkylthiophosphorsyreestere
IT7825104A0 (it) Esteri 3-ureido-fenilici dell'acido carbanilico, procedimento per preparare questi composti e mezzi erbicidi che li contengono.
DK234677A (da) Fremgangsmade til fremstilling af 2,2-dimethyl-3-(2i,2i-dihalogenvinyl)-cyclopropan-1-carboxylsyreestere

Legal Events

Date Code Title Description
PUP Patent expired