DK164941C - Gaerhybridvektor, transformeret gaercelle samt fremgangsmaade til fremstilling af vaevsplasminogenaktivitor (tpa) - Google Patents
Gaerhybridvektor, transformeret gaercelle samt fremgangsmaade til fremstilling af vaevsplasminogenaktivitor (tpa)Info
- Publication number
- DK164941C DK164941C DK551084A DK551084A DK164941C DK 164941 C DK164941 C DK 164941C DK 551084 A DK551084 A DK 551084A DK 551084 A DK551084 A DK 551084A DK 164941 C DK164941 C DK 164941C
- Authority
- DK
- Denmark
- Prior art keywords
- gercelle
- tpa
- transformed
- plasminogen activator
- tissue plasminogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C12N15/69—Increasing the copy number of the vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
- C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838331045A GB8331045D0 (en) | 1983-11-21 | 1983-11-21 | Synthesis of fibrinolytic agents by yeast |
| GB8331045 | 1983-11-21 | ||
| GB848423112A GB8423112D0 (en) | 1983-11-21 | 1984-09-13 | Synthesis of fibrino lytic agents by yeast |
| GB8423112 | 1984-09-13 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| DK551084D0 DK551084D0 (da) | 1984-11-20 |
| DK551084A DK551084A (da) | 1985-05-22 |
| DK164941B DK164941B (da) | 1992-09-14 |
| DK164941C true DK164941C (da) | 1993-02-01 |
Family
ID=26287024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK551084A DK164941C (da) | 1983-11-21 | 1984-11-20 | Gaerhybridvektor, transformeret gaercelle samt fremgangsmaade til fremstilling af vaevsplasminogenaktivitor (tpa) |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0143081B1 (fi) |
| JP (1) | JPS6119489A (fi) |
| KR (1) | KR930002889B1 (fi) |
| AU (1) | AU595478B2 (fi) |
| DD (1) | DD229151A5 (fi) |
| DE (1) | DE3479520D1 (fi) |
| DK (1) | DK164941C (fi) |
| ES (1) | ES8609471A1 (fi) |
| FI (1) | FI86746C (fi) |
| GR (1) | GR80966B (fi) |
| HU (1) | HU201115B (fi) |
| IE (1) | IE57699B1 (fi) |
| IL (1) | IL73568A (fi) |
| NO (1) | NO844618L (fi) |
| NZ (1) | NZ210266A (fi) |
| PH (1) | PH22337A (fi) |
| PT (1) | PT79518B (fi) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL68366A (en) * | 1982-04-15 | 1990-08-31 | Genentech Inc | Process for expressing a gene encoding a protein comprising the enzymatic portion of human urokinase in a microorganism or cell culture |
| US7138505B1 (en) | 1984-01-12 | 2006-11-21 | Novartis Vaccines And Diagnostics, Inc. | Factor VIII:C nucleic acid molecules |
| JPS61502655A (ja) * | 1984-07-09 | 1986-11-20 | インテグレ−テッド・ジェネティックス・インコ−ポレ−テッド | 酵母クロ−ニングビヒクル |
| DK175327B1 (da) * | 1984-10-01 | 2004-08-23 | Integrated Genetics Inc | Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA) |
| JPS624233A (ja) * | 1985-07-01 | 1987-01-10 | Toyobo Co Ltd | 組織性プラスミノ−ゲン活性化因子の製造法 |
| JPS6229975A (ja) * | 1985-08-01 | 1987-02-07 | Mitsui Toatsu Chem Inc | 粗ｔＰＡの精製法 |
| GB8521496D0 (en) * | 1985-08-29 | 1985-10-02 | Ciba Geigy Ag | Repressible yeast promoters |
| EP0216573B1 (en) * | 1985-09-18 | 1990-11-22 | Green Cross Corporation | Yeast promoter and method of producing heterologous proteins |
| USH2055H1 (en) * | 1985-09-20 | 2002-12-03 | Zymogenetics, Inc. | Expression of tissue-type plasminogen activator in bacteria |
| GB8530631D0 (en) | 1985-12-12 | 1986-01-22 | Ciba Geigy Ag | Thrombin inhibitors |
| MY101203A (en) * | 1985-12-12 | 1991-08-17 | Ucp Gen Pharma Ag | Production of thrombin iinhibitors. |
| US5106741A (en) * | 1985-12-20 | 1992-04-21 | The Upjohn Company | Tissue plasminogen activator (TPA) analogs |
| US4898825A (en) * | 1986-05-07 | 1990-02-06 | Mitsui Toatsu Chemicals, Incorporated | Methods for purification of single-chain and double-chain tissue plasminogen activator |
| ZA872534B (en) * | 1986-05-08 | 1987-11-25 | Phillips Petroleum Co | Yeast production of streptokinase |
| PT84991B (pt) * | 1986-06-06 | 1990-03-08 | Genentech Inc | Processo para a producao de actividador do plasminogenio biologicamente activo |
| JPS6463378A (en) * | 1986-08-11 | 1989-03-09 | Mitsui Toatsu Chemicals | Separation of single stranded tpa and double standard tpa |
| GB8621118D0 (en) * | 1986-09-01 | 1986-10-08 | Whitbread & Co Plc | Stabilised polypeptides |
| EP0263072B1 (en) | 1986-10-03 | 1994-03-23 | Ciba-Geigy Ag | Novel lymphokine related peptides |
| PT86162B (pt) * | 1986-11-21 | 1990-11-20 | Smithkline Beecham Corp | Expressao de proteina recombinante |
| ZA879286B (en) | 1986-12-16 | 1988-10-26 | Smith Kline Rit | New plasminogen activators |
| US5149533A (en) * | 1987-06-04 | 1992-09-22 | Zymogenetics, Inc. | Modified t-PA with kringle-/replaced by another kringle |
| US5089409A (en) * | 1989-09-28 | 1992-02-18 | Monsanto Company | Method of increasing specific activity of t-pa |
| US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
| SG49862A1 (en) * | 1993-08-04 | 2002-03-19 | Ucp Gen Pharma Ag | High molecular weight desulphatohirudin |
| EP0801682B1 (en) | 1995-02-09 | 2001-10-24 | Novartis AG | Process for the production of proteins |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775622A (en) * | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| IL68561A (en) * | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
| GB2125047B (en) * | 1982-08-09 | 1986-02-19 | Ciba Geigy Ag | Yeast hybrid vectors and their use for the production of polypeptides |
| EP0174835A1 (en) * | 1984-09-11 | 1986-03-19 | The Upjohn Company | Human tissue plasminogen activator and recombinant DNA compounds |
| DK175327B1 (da) * | 1984-10-01 | 2004-08-23 | Integrated Genetics Inc | Replicerbar ekspressionsvektor og rekombinant DNA-molekyle, som indkoder aktiv human livmodervævsplasminogen-aktivator, pattedyrscelle transformeret med vektoren og fremgangsmåde til fremstilling af aktiv human vævsplasminogen-aktivator (TPA) |
-
1984
- 1984-11-19 EP EP84810564A patent/EP0143081B1/en not_active Expired
- 1984-11-19 DD DD84269628A patent/DD229151A5/de not_active IP Right Cessation
- 1984-11-19 DE DE8484810564T patent/DE3479520D1/de not_active Expired
- 1984-11-19 FI FI844544A patent/FI86746C/fi not_active IP Right Cessation
- 1984-11-19 PH PH31460A patent/PH22337A/en unknown
- 1984-11-19 PT PT79518A patent/PT79518B/pt not_active IP Right Cessation
- 1984-11-19 GR GR80966A patent/GR80966B/el unknown
- 1984-11-20 NZ NZ210266A patent/NZ210266A/xx unknown
- 1984-11-20 JP JP59243529A patent/JPS6119489A/ja active Pending
- 1984-11-20 HU HU844309A patent/HU201115B/hu not_active IP Right Cessation
- 1984-11-20 NO NO844618A patent/NO844618L/no unknown
- 1984-11-20 IL IL73568A patent/IL73568A/xx unknown
- 1984-11-20 AU AU35719/84A patent/AU595478B2/en not_active Ceased
- 1984-11-20 IE IE2965/84A patent/IE57699B1/en not_active IP Right Cessation
- 1984-11-20 DK DK551084A patent/DK164941C/da not_active IP Right Cessation
- 1984-11-21 KR KR1019840007284A patent/KR930002889B1/ko active IP Right Grant
- 1984-11-21 ES ES537828A patent/ES8609471A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| KR930002889B1 (ko) | 1993-04-12 |
| IE842965L (en) | 1985-05-21 |
| HUT36185A (en) | 1985-08-28 |
| DK551084D0 (da) | 1984-11-20 |
| AU3571984A (en) | 1986-03-20 |
| ES537828A0 (es) | 1986-07-16 |
| DK164941B (da) | 1992-09-14 |
| PT79518B (pt) | 1986-12-12 |
| EP0143081B1 (en) | 1989-08-23 |
| IL73568A0 (en) | 1985-02-28 |
| NO844618L (no) | 1985-05-22 |
| FI844544A0 (fi) | 1984-11-19 |
| KR850003733A (ko) | 1985-06-26 |
| NZ210266A (en) | 1988-11-29 |
| AU595478B2 (en) | 1990-04-05 |
| DK551084A (da) | 1985-05-22 |
| JPS6119489A (ja) | 1986-01-28 |
| FI86746B (fi) | 1992-06-30 |
| ES8609471A1 (es) | 1986-07-16 |
| EP0143081A3 (en) | 1987-01-07 |
| IE57699B1 (en) | 1993-03-10 |
| PT79518A (en) | 1984-12-01 |
| HU201115B (en) | 1990-09-28 |
| FI844544L (fi) | 1985-05-22 |
| EP0143081A2 (en) | 1985-05-29 |
| GR80966B (en) | 1985-03-15 |
| FI86746C (fi) | 1992-10-12 |
| IL73568A (en) | 1992-07-15 |
| DE3479520D1 (en) | 1989-09-28 |
| DD229151A5 (de) | 1985-10-30 |
| PH22337A (en) | 1988-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PBP | Patent lapsed |