DK1636239T3 - Indolderivater med en forbedret antipsykotisk aktivitet - Google Patents
Indolderivater med en forbedret antipsykotisk aktivitetInfo
- Publication number
- DK1636239T3 DK1636239T3 DK04741649T DK04741649T DK1636239T3 DK 1636239 T3 DK1636239 T3 DK 1636239T3 DK 04741649 T DK04741649 T DK 04741649T DK 04741649 T DK04741649 T DK 04741649T DK 1636239 T3 DK1636239 T3 DK 1636239T3
- Authority
- DK
- Denmark
- Prior art keywords
- sup
- sub
- receptors
- indole derivatives
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Light Guides In General And Applications Therefor (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2003/005789 WO2004106298A1 (en) | 2003-05-30 | 2003-05-30 | Indole derivatives with an improved antipsychotic activity |
PCT/EP2004/050922 WO2004106346A1 (en) | 2003-05-30 | 2004-05-26 | Indole derivatives with an improved antipsychotic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1636239T3 true DK1636239T3 (da) | 2007-10-29 |
Family
ID=33483768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04741649T DK1636239T3 (da) | 2003-05-30 | 2004-05-26 | Indolderivater med en forbedret antipsykotisk aktivitet |
Country Status (10)
Country | Link |
---|---|
US (1) | US20070066608A1 (es) |
JP (1) | JP2006528957A (es) |
AT (1) | ATE367392T1 (es) |
AU (1) | AU2004242802A1 (es) |
CA (1) | CA2525282A1 (es) |
DE (1) | DE602004007658T2 (es) |
DK (1) | DK1636239T3 (es) |
ES (1) | ES2289533T3 (es) |
PT (1) | PT1636239E (es) |
WO (2) | WO2004106298A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2403252C2 (ru) | 2004-03-30 | 2010-11-10 | Вертекс Фармасьютикалз Инкорпорейтед | Азаиндолы, полезные в качестве ингибиторов jak и других протеинкиназ |
JP4896476B2 (ja) * | 2005-09-16 | 2012-03-14 | 広栄化学工業株式会社 | メチルオキシメチルアミノピリジン誘導体及びその製造方法 |
AU2007338754A1 (en) | 2006-12-21 | 2008-07-03 | Vertex Pharmaceuticals Incorporated | 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors |
GB0708186D0 (en) * | 2007-04-27 | 2007-06-06 | Merck Sharp & Dohme | Therapeutic compounds |
JP5783908B2 (ja) | 2008-12-19 | 2015-09-24 | スパーナス ファーマシューティカルズ インコーポレイテッド | 攻撃性を治療する方法 |
RS57869B1 (sr) | 2009-06-17 | 2018-12-31 | Vertex Pharma | Inhibitori replikacije virusa gripa |
WO2011044134A1 (en) * | 2009-10-05 | 2011-04-14 | Albany Molecular Research, Inc. | Epiminocycloalkyl(b)indole derivatives as serotonin sub-type 6 (5-ht6) modulators and uses thereof |
WO2011123497A1 (en) | 2010-03-31 | 2011-10-06 | Supernus Pharmaceuticals Inc. | Stabilized formulations of cns compounds |
RU2013132681A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
WO2012099952A2 (en) | 2011-01-19 | 2012-07-26 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-ht6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
RS57541B1 (sr) | 2013-11-13 | 2018-10-31 | Vertex Pharma | Postupci za pripremu inhibitora replikacije virusa gripa |
ES2741444T3 (es) | 2013-11-13 | 2020-02-11 | Vertex Pharma | Inhibidores de la replicación de virus de la gripe |
EP3294735B8 (en) | 2015-05-13 | 2022-01-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
EP3551176A4 (en) * | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | ANTIDIABETIC HETEROCYCLIC COMPOUNDS |
IL295374A (en) | 2020-02-04 | 2022-10-01 | Mindset Pharma Inc | 3-pyrrolidine indole derivatives as serotonergic psychedelics for the treatment of central nervous system disorders |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2421900A1 (fr) * | 1977-03-17 | 1979-11-02 | Sauba Lab | Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques |
TW446706B (en) * | 1995-02-07 | 2001-07-21 | Janssen Pharmaceutica Nv | Vasoconstrictive substituted 2,3-dihydro-1,4-dioxinopyridines, a pharmaceutical composition containing them, their intermediates and a process for their preparation |
AU2494300A (en) * | 1999-01-07 | 2000-07-24 | American Home Products Corporation | 3,4-dihydro-2h-benzo(1,4)oxazine derivatives |
US6313126B1 (en) * | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
TW546299B (en) * | 1999-01-07 | 2003-08-11 | Wyeth Corp | 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines |
WO2002085896A1 (en) * | 2001-04-24 | 2002-10-31 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-benzodioxan |
US6656950B2 (en) * | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
-
2003
- 2003-05-30 WO PCT/EP2003/005789 patent/WO2004106298A1/en active Application Filing
-
2004
- 2004-05-26 AT AT04741649T patent/ATE367392T1/de not_active IP Right Cessation
- 2004-05-26 AU AU2004242802A patent/AU2004242802A1/en not_active Abandoned
- 2004-05-26 WO PCT/EP2004/050922 patent/WO2004106346A1/en active IP Right Grant
- 2004-05-26 ES ES04741649T patent/ES2289533T3/es not_active Expired - Lifetime
- 2004-05-26 JP JP2006530219A patent/JP2006528957A/ja not_active Withdrawn
- 2004-05-26 DK DK04741649T patent/DK1636239T3/da active
- 2004-05-26 CA CA002525282A patent/CA2525282A1/en not_active Abandoned
- 2004-05-26 US US10/556,931 patent/US20070066608A1/en not_active Abandoned
- 2004-05-26 PT PT04741649T patent/PT1636239E/pt unknown
- 2004-05-26 DE DE602004007658T patent/DE602004007658T2/de not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2289533T3 (es) | 2008-02-01 |
DE602004007658T2 (de) | 2008-04-10 |
ATE367392T1 (de) | 2007-08-15 |
WO2004106298A1 (en) | 2004-12-09 |
PT1636239E (pt) | 2007-09-24 |
JP2006528957A (ja) | 2006-12-28 |
DE602004007658D1 (de) | 2007-08-30 |
AU2004242802A1 (en) | 2004-12-09 |
CA2525282A1 (en) | 2004-12-09 |
WO2004106346A1 (en) | 2004-12-09 |
US20070066608A1 (en) | 2007-03-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1636239T3 (da) | Indolderivater med en forbedret antipsykotisk aktivitet | |
MX2007012883A (es) | Derivados de dihidrobenzofurano y usos de los mismos. | |
EA200701583A1 (ru) | Гетероциклические тетрациклические производные гидрофурана в качестве ингибиторов 5нт2 в терапии расстройств цнс | |
JP5833804B2 (ja) | Nos阻害活性を有する置換インドール化合物 | |
MX2007012936A (es) | Derivados de dihidrobenzofurano y usos de los mismos. | |
MX2007013021A (es) | Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c. | |
IL177291A0 (en) | Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists | |
ATE449082T1 (de) | (3,4-dihydro-chinazolin-2-yl)-(2-aryloxy-ethyl) amine mit aktivität am 5-ht-rezeptor | |
SK287018B6 (sk) | Deriváty fenylpiperazínov, spôsob ich prípravy, farmaceutická kompozícia s ich obsahom a ich použitie | |
EA200300519A1 (ru) | Соединения производных бензотиофена, способ их получения и применения | |
ATE443707T1 (de) | Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität | |
MY125295A (en) | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives | |
ATE318266T1 (de) | 3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonisten | |
SK9232001A3 (en) | Amide and urea derivatives as 5-ht reuptake inhibitors and as 5-ht1b/1d ligands | |
TW200612899A (en) | Novel tetracyclic tetrahydrofuran derivatives | |
DE60111464D1 (de) | Azabicycloalkan-Derivate zur Verwendung als Inhibitoren der Serotonin-Wiederaufnahme und als 5HT2a Antagonisten | |
WO2006061392A3 (en) | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives | |
RS20050892A (en) | Imidazole derivatives as glutamate receptor antagonists | |
EA200702626A1 (ru) | Новые замещённые тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена и их применение в качестве лекарственного средства | |
RU2007125691A (ru) | Бенздиоксановые производные пиперазина с комбинацией сродства к допаминовым-d2 рецепторам и участкам обратного захвата серотонина | |
KR100859107B1 (ko) | 도파민 d2 수용체 및 세로토닌 재흡수 부위에 대한친화도가 높은8-{4-[3-(5-플루오로-1h-인돌-3-일)-프로필]-피페라진-1-일}-2-메틸-4h-벤조[1,4]옥사진-3-온 메실레이트 | |
MY123686A (en) | Indole derivatives and their use as 5ht2a ligands | |
MXPA05010483A (es) | Cromenonindoles. | |
DE602004016177D1 (de) | Methylindole und methylpyrrolopyridine als alpha-1-adrenerge agonisten | |
JP2009545555A (ja) | 置換インダニルスルホンアミド化合物、それらの調製、および薬剤としての使用 |