ATE367392T1 - Indolderivate mit verbesserter antipsychotischer wirkung - Google Patents
Indolderivate mit verbesserter antipsychotischer wirkungInfo
- Publication number
- ATE367392T1 ATE367392T1 AT04741649T AT04741649T ATE367392T1 AT E367392 T1 ATE367392 T1 AT E367392T1 AT 04741649 T AT04741649 T AT 04741649T AT 04741649 T AT04741649 T AT 04741649T AT E367392 T1 ATE367392 T1 AT E367392T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- sub
- receptors
- indole derivatives
- relates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Light Guides In General And Applications Therefor (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2003/005789 WO2004106298A1 (en) | 2003-05-30 | 2003-05-30 | Indole derivatives with an improved antipsychotic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE367392T1 true ATE367392T1 (de) | 2007-08-15 |
Family
ID=33483768
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04741649T ATE367392T1 (de) | 2003-05-30 | 2004-05-26 | Indolderivate mit verbesserter antipsychotischer wirkung |
Country Status (10)
Country | Link |
---|---|
US (1) | US20070066608A1 (de) |
JP (1) | JP2006528957A (de) |
AT (1) | ATE367392T1 (de) |
AU (1) | AU2004242802A1 (de) |
CA (1) | CA2525282A1 (de) |
DE (1) | DE602004007658T2 (de) |
DK (1) | DK1636239T3 (de) |
ES (1) | ES2289533T3 (de) |
PT (1) | PT1636239E (de) |
WO (2) | WO2004106298A1 (de) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101676285A (zh) | 2004-03-30 | 2010-03-24 | 沃泰克斯药物股份有限公司 | 用作jak和其它蛋白激酶抑制剂的氮杂吲哚 |
JP4896476B2 (ja) * | 2005-09-16 | 2012-03-14 | 広栄化学工業株式会社 | メチルオキシメチルアミノピリジン誘導体及びその製造方法 |
CN101678022A (zh) | 2006-12-21 | 2010-03-24 | 弗特克斯药品有限公司 | 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物 |
GB0708186D0 (en) * | 2007-04-27 | 2007-06-06 | Merck Sharp & Dohme | Therapeutic compounds |
AU2009335709A1 (en) | 2008-12-19 | 2011-07-14 | Supernus Pharmaceuticals, Inc. | Method of treatment of aggression |
NZ619259A (en) | 2009-06-17 | 2015-07-31 | Vertex Pharma | Inhibitors of influenza viruses replication |
WO2011044134A1 (en) * | 2009-10-05 | 2011-04-14 | Albany Molecular Research, Inc. | Epiminocycloalkyl(b)indole derivatives as serotonin sub-type 6 (5-ht6) modulators and uses thereof |
EP3572074B1 (de) | 2010-03-31 | 2021-01-06 | Supernus Pharmaceuticals, Inc. | Stabilisierte formulierungen aus molindone |
CN103492381A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
AU2012207335A1 (en) | 2011-01-19 | 2013-07-25 | Albany Molecular Research, Inc. | Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
CA2930297C (en) | 2013-11-13 | 2022-04-05 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
CN105849100B (zh) | 2013-11-13 | 2019-07-16 | 沃泰克斯药物股份有限公司 | 流感病毒复制抑制剂 |
JP6704416B2 (ja) | 2015-05-13 | 2020-06-03 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤を調製する方法 |
JP6857617B2 (ja) | 2015-05-13 | 2021-04-14 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | インフルエンザウイルスの複製の阻害剤 |
EP3551176A4 (de) * | 2016-12-06 | 2020-06-24 | Merck Sharp & Dohme Corp. | Antidiabetische heterocyclische verbindungen |
KR20220137085A (ko) | 2020-02-04 | 2022-10-11 | 마인드셋 파마 인크. | Cns 장애의 치료를 위한 세로토닌성 사이키델릭 작용제로서의 3-피롤리딘-인돌 유도체 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2421900A1 (fr) * | 1977-03-17 | 1979-11-02 | Sauba Lab | Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques |
TW446706B (en) * | 1995-02-07 | 2001-07-21 | Janssen Pharmaceutica Nv | Vasoconstrictive substituted 2,3-dihydro-1,4-dioxinopyridines, a pharmaceutical composition containing them, their intermediates and a process for their preparation |
TW546299B (en) * | 1999-01-07 | 2003-08-11 | Wyeth Corp | 3,4-dihydro-2H-benzo[1,4]oxazinyl-methyl-[3-(1H-indol-3-yl)-alkyl]-amines |
US6313126B1 (en) * | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
AU2494300A (en) * | 1999-01-07 | 2000-07-24 | American Home Products Corporation | 3,4-dihydro-2h-benzo(1,4)oxazine derivatives |
EP1381600A1 (de) * | 2001-04-24 | 2004-01-21 | Wyeth, A Corporation of the State of Delaware | Azaheterocyclylmethyldeivate von 2,3-dihydro-1,4-benzodioxan als antidepressiva |
US6656950B2 (en) * | 2001-04-25 | 2003-12-02 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of 1,4-dioxino[2,3-b]pyridine |
-
2003
- 2003-05-30 WO PCT/EP2003/005789 patent/WO2004106298A1/en active Application Filing
-
2004
- 2004-05-26 JP JP2006530219A patent/JP2006528957A/ja not_active Withdrawn
- 2004-05-26 CA CA002525282A patent/CA2525282A1/en not_active Abandoned
- 2004-05-26 ES ES04741649T patent/ES2289533T3/es not_active Expired - Lifetime
- 2004-05-26 AU AU2004242802A patent/AU2004242802A1/en not_active Abandoned
- 2004-05-26 PT PT04741649T patent/PT1636239E/pt unknown
- 2004-05-26 DE DE602004007658T patent/DE602004007658T2/de not_active Expired - Fee Related
- 2004-05-26 DK DK04741649T patent/DK1636239T3/da active
- 2004-05-26 AT AT04741649T patent/ATE367392T1/de not_active IP Right Cessation
- 2004-05-26 WO PCT/EP2004/050922 patent/WO2004106346A1/en active IP Right Grant
- 2004-05-26 US US10/556,931 patent/US20070066608A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
PT1636239E (pt) | 2007-09-24 |
DE602004007658T2 (de) | 2008-04-10 |
WO2004106298A1 (en) | 2004-12-09 |
DE602004007658D1 (de) | 2007-08-30 |
AU2004242802A1 (en) | 2004-12-09 |
US20070066608A1 (en) | 2007-03-22 |
JP2006528957A (ja) | 2006-12-28 |
DK1636239T3 (da) | 2007-10-29 |
CA2525282A1 (en) | 2004-12-09 |
ES2289533T3 (es) | 2008-02-01 |
WO2004106346A1 (en) | 2004-12-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE367392T1 (de) | Indolderivate mit verbesserter antipsychotischer wirkung | |
WO2006079637A8 (en) | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5ht2 inhibitors in the treatment of cns disorders | |
MX2007012883A (es) | Derivados de dihidrobenzofurano y usos de los mismos. | |
MX2007012936A (es) | Derivados de dihidrobenzofurano y usos de los mismos. | |
MX2007013021A (es) | Derivados de benzofuranil-alcanamina y usos de los mismos como agonistas de 5-ht2c. | |
IL177291A0 (en) | Fused heterocyclic compounds and their use as metabotropic glutamate receptor antagonists | |
ATE475640T1 (de) | Antagonisten des opioidrezeptors | |
EA200300519A1 (ru) | Соединения производных бензотиофена, способ их получения и применения | |
WO2007088276A3 (fr) | Derives de sulfonamides, leur preparation et leur application en therapeutique | |
MY125295A (en) | 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives | |
ATE443707T1 (de) | Isoxazolin-indol-derivate mit verbesserter antipsychotischer und anxiolytischer aktivität | |
NO20025640D0 (no) | Substituerte 1-aminoalkyl-laktamer og deres anvendelse som muscarin-reseptor-antagonister | |
TW200612899A (en) | Novel tetracyclic tetrahydrofuran derivatives | |
ATE318266T1 (de) | 3-substituierte chinolin-4- carbonsäureamidderivate als nk-3- und nk-2- rezeptorantagonisten | |
EA200501148A1 (ru) | Пиридилоксиметильные и бензизоксазольные азабициклические производные | |
WO2006061392A3 (en) | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives | |
EA200702626A1 (ru) | Новые замещённые тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена и их применение в качестве лекарственного средства | |
MXPA05010483A (es) | Cromenonindoles. | |
MY123686A (en) | Indole derivatives and their use as 5ht2a ligands | |
WO2002066473A8 (en) | 8’4-’3-(5-fluoro-1h-indol-3yl) propyl!-1-piperazynyl!-2-methyl-2h-1,4-benzoxazin -3 (4h)- one methanesulfonate with high affinity for the dopamine d 2 receptor and the serotonin reuptake site | |
WO2006000555A3 (en) | Novel unsaturated tetracyclic tetrahydrofuran derivatives | |
DE602004016177D1 (de) | Methylindole und methylpyrrolopyridine als alpha-1-adrenerge agonisten | |
PL375259A1 (en) | Derivatives of pyridinalkyl-amonoalkyl-1h-indole inhibiting receptors 5-ht and recapture of serotonin which can be used as antidepressant and anxiolitic | |
ATE460411T1 (de) | Neue tetracyclische tetrahydrofuran-derivate mit cyclischer aminseitenkette | |
EA200702530A1 (ru) | Некоторые тетрациклические производные тетрагидрофурана, содержащие в боковой цепи циклическую аминогруппу |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1636239 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |