DK160764C - Analogifremgangsmaade til fremstilling af terapeutisk aktive heparinfragmenter - Google Patents

Analogifremgangsmaade til fremstilling af terapeutisk aktive heparinfragmenter

Info

Publication number
DK160764C
DK160764C DK380280A DK380280A DK160764C DK 160764 C DK160764 C DK 160764C DK 380280 A DK380280 A DK 380280A DK 380280 A DK380280 A DK 380280A DK 160764 C DK160764 C DK 160764C
Authority
DK
Denmark
Prior art keywords
preparation
infrastructs
therapeutically active
analogy procedure
active hearing
Prior art date
Application number
DK380280A
Other languages
Danish (da)
English (en)
Other versions
DK160764B (da
DK380280A (da
Inventor
Ulf Per Fredrik Lindahl
Gudrun Elisabet Baeckstroem
John Yngve Lennart Thunberg
Lars-Aake Fransson
Lars-Olov Andersson
Erik Yngve Holmer
Inga Helena Sandberg
Ewa Gunilla Soederstroem
Original Assignee
Kabi Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20336970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK160764(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kabi Ab filed Critical Kabi Ab
Publication of DK380280A publication Critical patent/DK380280A/da
Publication of DK160764B publication Critical patent/DK160764B/da
Application granted granted Critical
Publication of DK160764C publication Critical patent/DK160764C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)
DK380280A 1979-01-08 1980-09-05 Analogifremgangsmaade til fremstilling af terapeutisk aktive heparinfragmenter DK160764C (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE7900164 1979-01-08
SE7900164 1979-01-08
SE8000005 1980-01-07
PCT/SE1980/000005 WO1980001383A1 (fr) 1979-01-08 1980-01-07 Fragments d'heparine ayant une activite selective d'anticoagulation

Publications (3)

Publication Number Publication Date
DK380280A DK380280A (da) 1980-09-05
DK160764B DK160764B (da) 1991-04-15
DK160764C true DK160764C (da) 1991-09-23

Family

ID=20336970

Family Applications (1)

Application Number Title Priority Date Filing Date
DK380280A DK160764C (da) 1979-01-08 1980-09-05 Analogifremgangsmaade til fremstilling af terapeutisk aktive heparinfragmenter

Country Status (11)

Country Link
US (1) US4303651A (fr)
EP (1) EP0014184B2 (fr)
JP (1) JPS6344764B2 (fr)
AT (1) ATE8998T1 (fr)
CA (1) CA1136620A (fr)
DE (1) DE3068924D1 (fr)
DK (1) DK160764C (fr)
NL (1) NL930104I2 (fr)
NO (1) NO150801C (fr)
SU (1) SU1209033A3 (fr)
WO (1) WO1980001383A1 (fr)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
US4500519A (en) * 1978-11-06 1985-02-19 Choay S.A. Mucopolysaccharides having biological properties, preparation and method of use
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4438261A (en) 1980-05-19 1984-03-20 Riker Laboratories, Inc. Anticoagulant substance
CA1171375A (fr) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides ayant un pouvoir anticoagulant selectif
EP0049877B1 (fr) * 1980-10-09 1984-05-23 Roche Diagnostics GmbH Procédé et réactif pour la détermination de l'antithrombine-BM
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2535324A1 (fr) * 1982-10-27 1984-05-04 Choay Sa Station perfectionnee pour l'epuration d'eaux usees
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
DE3265781D1 (en) 1981-05-21 1985-10-03 Akzo Nv New anti-thromboticum based on polysacharides, method for its preparation and pharmaceutical compositions
US4396762A (en) * 1981-08-24 1983-08-02 Massachusetts Institute Of Technology Heparinase derived anticoagulants
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
CA1265132A (fr) * 1982-01-15 1990-01-30 Mahmoud Nassr Processus de synthese organique d'oligosaccharides et de leurs derives
US4539398A (en) * 1982-01-22 1985-09-03 Riker Laboratories, Inc. Affinity fractionation of heparin on immobilized Concanavalin A
ZA829463B (en) * 1982-07-19 1983-10-26 Hepar Ind Inc Process for manufacturing low molecular weight heparins by depolymerization of normal heparin
FR2538404B1 (fr) * 1982-12-28 1985-08-23 Anic Spa
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
GB8614189D0 (en) * 1986-06-11 1986-07-16 Leo Pharm Prod Ltd Pharmaceutical composition
US4942156A (en) * 1986-08-20 1990-07-17 Hepar Industries, Inc. Low molecular weight heparin derivatives having improved anti-Xa specificity
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0337327A1 (fr) * 1988-04-09 1989-10-18 Bioiberica, S.A. Procédé de préparation de fractions oligosaccharides par une dépolymérisation chimique réglée d'héparine
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
AU7742591A (en) * 1990-04-06 1991-10-30 Washington University Anticoagulant oligosaccharides
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5665379A (en) * 1990-09-28 1997-09-09 Pharmacia & Upjohn Aktiebolag Lipid particle forming matrix, preparation and use thereof
NO921495L (no) * 1991-04-16 1992-10-19 Seikagaku Kogyo Co Ltd Oligosakkarid og fremgangsmaate for dets fremstilling
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
GB9206291D0 (en) * 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
DE4217916C2 (de) * 1992-05-30 1995-05-18 Job Prof Dr Med Harenberg N-Alkylamin- und N-Arylalkylaminderivate von Heparin, Verfahren zu ihrer Herstellung und ihrer Verwendung
GB9306255D0 (en) * 1993-03-25 1993-05-19 Cancer Res Campaign Tech Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity
SE9302135D0 (sv) * 1993-06-18 1993-06-18 Kabi Pharmacia Ab New pharmaceutical composition
EP0735050B1 (fr) * 1995-03-31 2002-09-25 Hamilton Civic Hospitals Research Development, Inc. Compositions pour inhibiter la thrombogénèse
AP1390A (en) * 1996-11-27 2005-04-15 Aventis Pharmaceuticals Products Inc Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound.
WO1998055515A1 (fr) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Heparine de faible poids moleculaire modifiee inhibant les facteurs de coagulation associes au caillot
CA2643162C (fr) 1999-04-23 2018-01-02 Massachusetts Institute Of Technology Systeme et procede d'identification et de sequencage de polymeres, et d'analyse de leur composition par comparaison des proprietes
KR20020032444A (ko) * 1999-06-30 2002-05-03 잭 허쉬 응괴 연관된 응고 인자를 억제하는 헤파린 조성물
JP2002097143A (ja) * 2000-07-18 2002-04-02 Koyo Chemical Kk 血流改善剤及び血栓予防治療剤または食品
MXPA03001986A (es) * 2000-09-08 2004-03-19 Hamilton Civic Hospitals Res Composiciones antitromboticas.
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
US6933372B2 (en) 2003-03-07 2005-08-23 Warner-Lambert Company Method to produce a solid form of heparin
JP2006526592A (ja) * 2003-06-05 2006-11-24 センテリオン 血管由来の欠損に関連する高コレステロール血症または糖尿病の治療のための、線維芽細胞成長因子をコードするプラスミド
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US20050096294A1 (en) * 2003-10-31 2005-05-05 Takashi Komai Novel anti-coagulant
EP1582531A1 (fr) 2004-03-24 2005-10-05 Aventis Pharma S.A. Procédé d'oxydation d'héparines non-fractionnées et la détection de la présence ou de l'absence de glycosérine dans l'héparine et les produits dérivés de l'héparine.
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2205642B1 (fr) * 2007-11-02 2016-01-27 Momenta Pharmaceuticals, Inc. Compositions de polysaccharides non anticoagulants
US8592393B2 (en) 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2283045A1 (fr) * 2008-05-20 2011-02-16 Crystal Clear Partnership Séparation de polysaccharides par un gradient de densité de charge
ES2340902B1 (es) * 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
WO2011130697A2 (fr) 2010-04-16 2011-10-20 Momenta Pharmaceuticals, Inc. Ciblage tissulaire
WO2011159770A2 (fr) 2010-06-17 2011-12-22 Momenta Pharmaceuticals, Inc. Procédés et compositions pour moduler la croissance capillaire
WO2013095215A1 (fr) 2011-12-19 2013-06-27 Dilaforette Ab Héparines anticoagulantes de faible poids moléculaire
ME02994B (fr) 2011-12-19 2018-10-20 Dilafor Ab Nouveau glycosaminoglycan faiblement anticoagulant comprenant des unites disaccharides repetees et son utilisation medicale
US10016449B2 (en) 2013-05-28 2018-07-10 Momenta Pharmaceuticals, Inc. Pharmaceutical compositions
RU2612813C1 (ru) * 2015-12-07 2017-03-13 Павел Андреевич Канаев Способ получения гепарина
CN111727204B (zh) 2018-02-14 2023-01-31 生物E有限公司 用于制备达肝素钠的改进方法
BR112022000255A8 (pt) 2019-07-09 2022-03-22 Optimvia Llc Métodos para sintetizar polissacarídeos anticoagulantes
EP4182452A1 (fr) 2020-07-14 2023-05-24 Optimvia, LLC Procédés de synthèse de sulfate d'héparane non anticoagulant

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US3135660A (en) * 1956-11-09 1964-06-02 Riker Laboratories Inc Method for purifying sulfated carbohydrates with oxidizing agents
US3066076A (en) * 1958-12-15 1962-11-27 Fo We Forschungs Und Verwertun Soluble heparin product and process for preparing same
US3835112A (en) * 1970-06-08 1974-09-10 Etude Et D Exploit De Marques Heparin esters
DE2148011C3 (de) * 1970-10-05 1978-11-09 Aminkemi Ab Verfahren zum Herstellen nichtthrombogener Kunststoffoberflächen
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
GB1399824A (en) * 1971-08-16 1975-07-02 Mar Pha Etu Expl Marques Heparin esters
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche

Also Published As

Publication number Publication date
NL930104I2 (nl) 1997-02-03
NO150801C (no) 1984-12-27
NL930104I1 (nl) 1993-10-01
ATE8998T1 (de) 1984-09-15
JPS56500066A (fr) 1981-01-22
EP0014184A2 (fr) 1980-08-06
DK160764B (da) 1991-04-15
NO150801B (no) 1984-09-10
SU1209033A3 (ru) 1986-01-30
EP0014184A3 (en) 1980-10-01
DK380280A (da) 1980-09-05
NO802626L (no) 1980-09-05
CA1136620A (fr) 1982-11-30
WO1980001383A1 (fr) 1980-07-10
JPS6344764B2 (fr) 1988-09-06
EP0014184B1 (fr) 1984-08-15
EP0014184B2 (fr) 1989-10-18
DE3068924D1 (en) 1984-09-20
US4303651A (en) 1981-12-01

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