DE3068924D1 - Heparin fragments having a selective anticoagulation activity and process for their preparation - Google Patents

Heparin fragments having a selective anticoagulation activity and process for their preparation

Info

Publication number
DE3068924D1
DE3068924D1 DE8080850002T DE3068924T DE3068924D1 DE 3068924 D1 DE3068924 D1 DE 3068924D1 DE 8080850002 T DE8080850002 T DE 8080850002T DE 3068924 T DE3068924 T DE 3068924T DE 3068924 D1 DE3068924 D1 DE 3068924D1
Authority
DE
Germany
Prior art keywords
heparin fragments
preparation
anticoagulation activity
selective
sulphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8080850002T
Other languages
English (en)
Inventor
Ulf Per Fredrik Lindahl
Gudrun Elisabet Backstrom
John Yngve Lennart Thunberg
Lars-Ake Fransson
Lars-Olov Andersson
Erik Yngve Holmer
Inga Helena Sandberg
Ewa Gunilla Soderstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Kabi AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20336970&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3068924(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kabi AB filed Critical Kabi AB
Application granted granted Critical
Publication of DE3068924D1 publication Critical patent/DE3068924D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
DE8080850002T 1979-01-08 1980-01-07 Heparin fragments having a selective anticoagulation activity and process for their preparation Expired DE3068924D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE7900164 1979-01-08

Publications (1)

Publication Number Publication Date
DE3068924D1 true DE3068924D1 (en) 1984-09-20

Family

ID=20336970

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8080850002T Expired DE3068924D1 (en) 1979-01-08 1980-01-07 Heparin fragments having a selective anticoagulation activity and process for their preparation

Country Status (11)

Country Link
US (1) US4303651A (de)
EP (1) EP0014184B2 (de)
JP (1) JPS6344764B2 (de)
AT (1) ATE8998T1 (de)
CA (1) CA1136620A (de)
DE (1) DE3068924D1 (de)
DK (1) DK160764C (de)
NL (1) NL930104I2 (de)
NO (1) NO150801C (de)
SU (1) SU1209033A3 (de)
WO (1) WO1980001383A1 (de)

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FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
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US4692435A (en) * 1978-11-06 1987-09-08 Choay, S.A. Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
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JPH0258920B2 (de) * 1980-10-09 1990-12-11 Boehringer Mannheim Gmbh
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2535324A1 (fr) * 1982-10-27 1984-05-04 Choay Sa Station perfectionnee pour l'epuration d'eaux usees
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
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FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
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US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
FR2614026B1 (fr) * 1987-04-16 1992-04-17 Sanofi Sa Heparines de bas poids moleculaire, a structure reguliere, leur preparation et leurs applications biologiques
EP0337327A1 (de) * 1988-04-09 1989-10-18 Bioiberica, S.A. Verfahren zur Herstellung von neuen Oligosaccharid-Fragmenten durch kontrollierte chemische Depolymerisation von Heparin
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
AU7742591A (en) * 1990-04-06 1991-10-30 Washington University Anticoagulant oligosaccharides
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
US5665379A (en) * 1990-09-28 1997-09-09 Pharmacia & Upjohn Aktiebolag Lipid particle forming matrix, preparation and use thereof
FI921689A (fi) * 1991-04-16 1992-10-17 Seikagagu Kogyo Kabushiki Kais Oligosackarid med affinitet foer fibroblasttillvaextfaktor och foerfarande foer framstaellning av denna
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
GB9206291D0 (en) * 1992-03-23 1992-05-06 Cancer Res Campaign Tech Oligosaccharides having growth factor binding affinity
DE4217916C2 (de) * 1992-05-30 1995-05-18 Job Prof Dr Med Harenberg N-Alkylamin- und N-Arylalkylaminderivate von Heparin, Verfahren zu ihrer Herstellung und ihrer Verwendung
GB9306255D0 (en) * 1993-03-25 1993-05-19 Cancer Res Campaign Tech Heparan sulphate oligosaccharides having hepatocyte growth factor binding affinity
SE9302135D0 (sv) * 1993-06-18 1993-06-18 Kabi Pharmacia Ab New pharmaceutical composition
DE69623840D1 (de) * 1995-03-31 2002-10-31 Hamilton Civic Hospitals Res Zusammensetzung zur Hemmung der Thromboseentstehung
SK286024B6 (sk) * 1996-11-27 2008-01-07 Aventis Pharmaceuticals Inc. Farmaceutický prostriedok a použitie tohto prostriedku na prípravu liečiva
WO1998055515A1 (en) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors
WO2000065521A2 (en) 1999-04-23 2000-11-02 Massachusetts Institute Of Technology System and method for polymer notation
BR0012202A (pt) * 1999-06-30 2002-04-02 Hamilton Civic Hospitals Res Composições de heparina de peso molecular médio (mmwh), método de tratamento de uma condição trombótica, método de prevenção da formação de um trombo, método de inibição da formação de trombos, composição farmacêutica, método de tratamento de trombose venosa profunda, método de prevenção de embolia pulmonar, método de preparação e usos de uma composição de mmwh
JP2002097143A (ja) * 2000-07-18 2002-04-02 Koyo Chemical Kk 血流改善剤及び血栓予防治療剤または食品
AU2001291549A1 (en) * 2000-09-08 2002-03-22 Hamilton Civic Hospitals Research Development Inc. Antithrombotic compositions
JP2006096668A (ja) * 2002-11-08 2006-04-13 Ono Pharmaceut Co Ltd エラスターゼ阻害剤と血液凝固系および／または線溶系酵素阻害剤との組み合わせからなる医薬
US6933372B2 (en) 2003-03-07 2005-08-23 Warner-Lambert Company Method to produce a solid form of heparin
BRPI0410844A (pt) * 2003-06-05 2006-06-27 Centelion fator de crescimento de fibroblasto de codificação de plasmìdeo para o tratamento de defeitos angiogênicos associados com hipercolesterolemia ou diabetes
ITMI20031679A1 (it) * 2003-08-29 2005-02-28 Opocrin Spa Processo per la produzione di eparine a basso peso
US20050096294A1 (en) * 2003-10-31 2005-05-05 Takashi Komai Novel anti-coagulant
EP1582531A1 (de) 2004-03-24 2005-10-05 Aventis Pharma S.A. Verfahren zur Oxydierung nicht-fraktionierten Heparins und die Detektion der Anwesenheit oder Abwesenheit von Glykoserin in Heparin und in von Heparin abgeleiteten Produkten
ATE552004T1 (de) 2005-11-30 2012-04-15 Istituto G Ronzoni Oral verabreichbare heparinderivate
US8569262B2 (en) 2007-11-02 2013-10-29 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
EP2205642B1 (de) * 2007-11-02 2016-01-27 Momenta Pharmaceuticals, Inc. Nicht gerinnungshemmende polysaccharidzusammensetzungen
US8592393B2 (en) * 2007-11-02 2013-11-26 Momenta Pharmaceuticals, Inc. Polysaccharide compositions and methods of use for the treatment and prevention of disorders associated with progenitor cell mobilization
CA2724840A1 (en) * 2008-05-20 2009-11-26 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
ES2340902B1 (es) * 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
JP5982361B2 (ja) 2010-04-16 2016-08-31 モメンタ ファーマシューティカルズ インコーポレイテッド 組織標的化方法
US10017585B2 (en) 2010-06-17 2018-07-10 Momenta Pharmaceuticals, Inc. Methods and compositions for promoting hair growth
ES2656613T3 (es) * 2011-12-19 2018-02-27 Dilafor Ab Glicosaminoglicanos no anticoagulantes que comprenden unidades de repetición de disacáridos y su uso médico
WO2013095215A1 (en) 2011-12-19 2013-06-27 Dilaforette Ab Low anticoagulant heparins
EP3003324A4 (de) 2013-05-28 2017-01-25 Momenta Pharmaceuticals, Inc. Pharmazeutische zusammensetzungen
RU2612813C1 (ru) * 2015-12-07 2017-03-13 Павел Андреевич Канаев Способ получения гепарина
WO2019159092A1 (en) 2018-02-14 2019-08-22 Biological E Limited Improved process for the preparation of dalteparin sodium
WO2022015794A1 (en) 2020-07-14 2022-01-20 Optimvia, Llc Methods for synthesizing non-anticoagulant heparan sulfate
AU2020310172A1 (en) 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides

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US3135660A (en) * 1956-11-09 1964-06-02 Riker Laboratories Inc Method for purifying sulfated carbohydrates with oxidizing agents
US3066076A (en) * 1958-12-15 1962-11-27 Fo We Forschungs Und Verwertun Soluble heparin product and process for preparing same
FR2100735B1 (de) * 1970-06-08 1974-08-30 Mar Pha Etu Expl Marques
DE2148011C3 (de) * 1970-10-05 1978-11-09 Aminkemi Ab Verfahren zum Herstellen nichtthrombogener Kunststoffoberflächen
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
GB1399824A (en) * 1971-08-16 1975-07-02 Mar Pha Etu Expl Marques Heparin esters
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche

Also Published As

Publication number Publication date
DK380280A (da) 1980-09-05
CA1136620A (en) 1982-11-30
US4303651A (en) 1981-12-01
WO1980001383A1 (en) 1980-07-10
EP0014184A3 (en) 1980-10-01
DK160764C (da) 1991-09-23
SU1209033A3 (ru) 1986-01-30
EP0014184B2 (de) 1989-10-18
JPS56500066A (de) 1981-01-22
NO150801C (no) 1984-12-27
DK160764B (da) 1991-04-15
NL930104I1 (nl) 1993-10-01
ATE8998T1 (de) 1984-09-15
EP0014184A2 (de) 1980-08-06
NO802626L (no) 1980-09-05
JPS6344764B2 (de) 1988-09-06
NL930104I2 (nl) 1997-02-03
NO150801B (no) 1984-09-10
EP0014184B1 (de) 1984-08-15

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Legal Events

Date Code Title Description
8366 Restricted maintained after opposition proceedings
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA AB, STOCKHOLM, SE

8328 Change in the person/name/address of the agent

Free format text: TER MEER-MUELLER-STEINMEISTER & PARTNER, PATENTANWAELTE, 81679 MUENCHEN

8328 Change in the person/name/address of the agent

Free format text: DERZEIT KEIN VERTRETER BESTELLT

8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN AB, STOCKHOLM, SE