DK1602660T3 - Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer - Google Patents
Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorerInfo
- Publication number
- DK1602660T3 DK1602660T3 DK04712184.3T DK04712184T DK1602660T3 DK 1602660 T3 DK1602660 T3 DK 1602660T3 DK 04712184 T DK04712184 T DK 04712184T DK 1602660 T3 DK1602660 T3 DK 1602660T3
- Authority
- DK
- Denmark
- Prior art keywords
- acid derivatives
- receptor modulators
- aminophosphonic acid
- addition salts
- aminophosphonic
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/3804—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se) not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003039269 | 2003-02-18 | ||
PCT/JP2004/001783 WO2004074297A1 (ja) | 2003-02-18 | 2004-02-18 | アミノホスホン酸誘導体とその付加塩及びs1p受容体調節剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1602660T3 true DK1602660T3 (da) | 2011-05-23 |
Family
ID=32905163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04712184.3T DK1602660T3 (da) | 2003-02-18 | 2004-02-18 | Aminophosphonsyrederivater, additionssalte deraf og S1P-receptormodulatorer |
Country Status (17)
Country | Link |
---|---|
US (2) | US7456157B2 (da) |
EP (2) | EP2172472B1 (da) |
JP (1) | JP4564918B2 (da) |
KR (1) | KR101005171B1 (da) |
CN (1) | CN100344638C (da) |
AT (1) | ATE504590T1 (da) |
AU (1) | AU2004213297B2 (da) |
BR (1) | BRPI0407658A (da) |
CA (1) | CA2515574C (da) |
CY (1) | CY1111529T1 (da) |
DE (1) | DE602004032118D1 (da) |
DK (1) | DK1602660T3 (da) |
ES (1) | ES2360394T3 (da) |
MX (1) | MXPA05008760A (da) |
PT (1) | PT1602660E (da) |
SI (1) | SI1602660T1 (da) |
WO (1) | WO2004074297A1 (da) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2498944C (en) | 2002-09-19 | 2011-05-17 | Yasushi Kohno | Amino alcohol derivatives, salts thereof and immunosuppressive agents |
KR101005171B1 (ko) * | 2003-02-18 | 2011-01-04 | 교린 세이야꾸 가부시키 가이샤 | 아미노포스폰산 유도체와 그 부가염 및 s1p 수용체조절제 |
US7638637B2 (en) | 2003-11-03 | 2009-12-29 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
PL1772145T3 (pl) * | 2004-07-16 | 2011-08-31 | Kyorin Seiyaku Kk | Sposób skutecznego stosowania leku i sposób dotyczący zapobiegania efektom ubocznym |
WO2006020951A1 (en) | 2004-08-13 | 2006-02-23 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (s1p) receptor activity |
US20060223866A1 (en) * | 2004-08-13 | 2006-10-05 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
KR101181090B1 (ko) * | 2004-10-12 | 2012-09-07 | 교린 세이야꾸 가부시키 가이샤 | 2-아미노-2-[2-[4-(3-벤질옥시페닐티오)-2-클로로페닐]에틸]-1,3-프로판디올 염산염 또는 그 수화물의 제조방법 및 그 제조 중간체 |
WO2006063033A2 (en) | 2004-12-06 | 2006-06-15 | University Of Virginia Patent Foundation | Aryl amide sphingosine 1-phosphate analogs |
KR101476591B1 (ko) * | 2005-09-09 | 2014-12-24 | 노파르티스 아게 | 자가면역성 질환의 치료 |
PT1932522E (pt) * | 2005-10-07 | 2012-06-26 | Kyorin Seiyaku Kk | Agente terapêutico para doenças do fígado contendo, como princípio activo, um derivado de 2- amino-1,3-propanodiol |
RU2008134702A (ru) | 2006-01-27 | 2010-03-10 | Юниверсити Оф Вирждиния Пэтент Фаундейшн (Us) | Способ лечения невропатической боли |
TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
CA2641718A1 (en) | 2006-02-09 | 2007-08-16 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
JP2009545630A (ja) * | 2006-08-04 | 2009-12-24 | プリーシス・ファーマシューティカルズ・インコーポレイテッド | 化合物 |
NZ574011A (en) * | 2006-08-08 | 2011-10-28 | Kyorin Seiyaku Kk | Aminophosphoric acid ester derivative and s1p receptor modulator containing the same as active ingredient |
MY146775A (en) | 2006-08-08 | 2012-09-28 | Kyorin Seiyaku Kk | Amino alcohol derivative and immunosuppressive agent having same as an active ingredient |
AU2007323540A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
JP2010510251A (ja) | 2006-11-21 | 2010-04-02 | ユニバーシティ オブ バージニア パテント ファンデーション | スフィンゴシン=1−燐酸受容体活性を有するベンゾシクロヘプチルアナログ |
CA2669102A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Tetralin analogs having sphingosine 1-phosphate agonist activity |
WO2009048993A2 (en) | 2007-10-12 | 2009-04-16 | Novartis Ag | Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators |
TW200946105A (en) | 2008-02-07 | 2009-11-16 | Kyorin Seiyaku Kk | Therapeutic agent or preventive agent for inflammatory bowel disease containing amino alcohol derivative as active ingredient |
EP3059226A1 (en) * | 2008-03-24 | 2016-08-24 | Kyorin Pharmaceutical Co., Ltd. | 2-amino-2-[2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-ethyl]-1,3-propanediol hydrochloride crystal |
CN103396346A (zh) * | 2008-05-19 | 2013-11-20 | 杏林制药株式会社 | 光学活性氨基醇衍生物的制备方法 |
RU2505288C2 (ru) | 2008-05-20 | 2014-01-27 | Киорин Фармасьютикал Ко., Лтд. | Средства поддержания индуцированной ремиссии |
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- 2004-02-18 CA CA2515574A patent/CA2515574C/en not_active Expired - Fee Related
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- 2004-02-18 MX MXPA05008760A patent/MXPA05008760A/es active IP Right Grant
- 2004-02-18 SI SI200431656T patent/SI1602660T1/sl unknown
- 2004-02-18 DK DK04712184.3T patent/DK1602660T3/da active
- 2004-02-18 US US10/545,790 patent/US7456157B2/en active Active
- 2004-02-18 PT PT04712184T patent/PT1602660E/pt unknown
- 2004-02-18 BR BRPI0407658-3A patent/BRPI0407658A/pt not_active Application Discontinuation
- 2004-02-18 DE DE602004032118T patent/DE602004032118D1/de not_active Expired - Lifetime
- 2004-02-18 ES ES04712184T patent/ES2360394T3/es not_active Expired - Lifetime
- 2004-02-18 AU AU2004213297A patent/AU2004213297B2/en not_active Ceased
- 2004-02-18 EP EP04712184A patent/EP1602660B1/en not_active Expired - Lifetime
- 2004-02-18 CN CNB200480004551XA patent/CN100344638C/zh not_active Expired - Fee Related
- 2004-02-18 AT AT04712184T patent/ATE504590T1/de active
- 2004-02-18 WO PCT/JP2004/001783 patent/WO2004074297A1/ja active Application Filing
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Publication number | Publication date |
---|---|
US7759326B2 (en) | 2010-07-20 |
DE602004032118D1 (de) | 2011-05-19 |
EP1602660A4 (en) | 2008-03-19 |
EP2172472B1 (en) | 2012-12-26 |
EP2172472A2 (en) | 2010-04-07 |
KR20050109069A (ko) | 2005-11-17 |
BRPI0407658A (pt) | 2006-02-21 |
AU2004213297A1 (en) | 2004-09-02 |
CN100344638C (zh) | 2007-10-24 |
SI1602660T1 (sl) | 2011-06-30 |
ES2360394T3 (es) | 2011-06-03 |
JPWO2004074297A1 (ja) | 2006-06-01 |
AU2004213297B2 (en) | 2009-03-19 |
ATE504590T1 (de) | 2011-04-15 |
EP1602660B1 (en) | 2011-04-06 |
WO2004074297A1 (ja) | 2004-09-02 |
CA2515574C (en) | 2012-03-13 |
CY1111529T1 (el) | 2015-08-05 |
US7456157B2 (en) | 2008-11-25 |
EP2172472A3 (en) | 2010-06-30 |
EP1602660A1 (en) | 2005-12-07 |
PT1602660E (pt) | 2011-06-15 |
MXPA05008760A (es) | 2006-03-21 |
CA2515574A1 (en) | 2004-09-02 |
KR101005171B1 (ko) | 2011-01-04 |
JP4564918B2 (ja) | 2010-10-20 |
US20080275008A1 (en) | 2008-11-06 |
CN1751054A (zh) | 2006-03-22 |
US20060160771A1 (en) | 2006-07-20 |
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