WO2007067711A3 - Certain chemical entities, compositions, and methods for modulating trpv1 - Google Patents

Certain chemical entities, compositions, and methods for modulating trpv1 Download PDF

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Publication number
WO2007067711A3
WO2007067711A3 PCT/US2006/046769 US2006046769W WO2007067711A3 WO 2007067711 A3 WO2007067711 A3 WO 2007067711A3 US 2006046769 W US2006046769 W US 2006046769W WO 2007067711 A3 WO2007067711 A3 WO 2007067711A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical entities
compositions
methods
trpv1
certain chemical
Prior art date
Application number
PCT/US2006/046769
Other languages
French (fr)
Other versions
WO2007067711A2 (en
Inventor
Jose S Mendoza
Carl Nicholas Hodge
John K Dickson Jr
Original Assignee
Amphora Discovery Corp
Jose S Mendoza
Carl Nicholas Hodge
John K Dickson Jr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amphora Discovery Corp, Jose S Mendoza, Carl Nicholas Hodge, John K Dickson Jr filed Critical Amphora Discovery Corp
Publication of WO2007067711A2 publication Critical patent/WO2007067711A2/en
Publication of WO2007067711A3 publication Critical patent/WO2007067711A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Provided are chemical entities chosen from compounds of Formula (I) and pharmaceutically or cosmetically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof. The chemical entities modulate TRPV1 and are useful in the treatment of at least one disease or disorder modulated by TRPV1 activity.
PCT/US2006/046769 2005-12-08 2006-12-05 Certain chemical entities, compositions, and methods for modulating trpv1 WO2007067711A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74901905P 2005-12-08 2005-12-08
US60/749,019 2005-12-08
US83469506P 2006-07-31 2006-07-31
US60/834,695 2006-07-31

Publications (2)

Publication Number Publication Date
WO2007067711A2 WO2007067711A2 (en) 2007-06-14
WO2007067711A3 true WO2007067711A3 (en) 2009-05-14

Family

ID=38123502

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/046769 WO2007067711A2 (en) 2005-12-08 2006-12-05 Certain chemical entities, compositions, and methods for modulating trpv1

Country Status (1)

Country Link
WO (1) WO2007067711A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216298B (en) * 2008-09-16 2014-04-16 Csir公司 Imidazopyridines and imidazopyrimidines as HIV-1 reverse transcriptase inhibitors

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ES2395583T3 (en) * 2007-05-10 2013-02-13 Ge Healthcare Limited IMIDAZOL (1,2-A) PIRIDINES and compounds related to activity against CB2 cannabinoid receptors
DE102007040336A1 (en) * 2007-08-27 2009-03-05 Johann Wolfgang Goethe-Universität Frankfurt am Main New inhibitors of 5-lipoxygenase and their uses
JP5643112B2 (en) 2008-01-28 2014-12-17 アモーレパシフィック コーポレイションＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ Novel compounds as vanilloid receptors, isomers or pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing the same
CN102137851B (en) 2008-07-02 2014-08-27 株式会社爱茉莉太平洋 Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist and pharmaceutical compositions containing the same
US8481740B2 (en) * 2009-04-07 2013-07-09 University Of The Witwatersrand, Johannesburg Imidazo[1,2 a] pyridine-6-carboxamide derivatives, their use for the treatment of colon cancer and their method of manufacture
WO2012018932A2 (en) * 2010-08-03 2012-02-09 The Regents Of The University Of California Compounds and compositions for mitigating tissue damage and lethality
JP2014510768A (en) * 2011-04-11 2014-05-01 グラクソ グループ リミテッド N-cyclobutylimidazopyridine methylamine as a TRPV1 antagonist
RU2015118985A (en) 2012-11-14 2017-01-10 Ф. Хоффманн-Ля Рош Аг IMIDAZOPYRIDINE DERIVATIVES
US20170107216A1 (en) 2015-10-19 2017-04-20 Incyte Corporation Heterocyclic compounds as immunomodulators
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US20170342060A1 (en) 2016-05-26 2017-11-30 Incyte Corporation Heterocyclic compounds as immunomodulators
BR112018076534A2 (en) 2016-06-20 2019-04-02 Incyte Corporation heterocyclic compounds as immunomodulators
ES2930092T3 (en) 2016-07-14 2022-12-07 Incyte Corp Heterocyclic compounds as immunomodulators
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EP3558985B1 (en) 2016-12-22 2022-09-07 Incyte Corporation Benzooxazole derivatives as immunomodulators
EP3558989B1 (en) 2016-12-22 2021-04-14 Incyte Corporation Triazolo[1,5-a]pyridine derivatives as immunomodulators
MA47120A (en) 2016-12-22 2021-04-28 Incyte Corp PYRIDINE DERIVATIVES USED AS IMMUNOMODULATORS
MY197501A (en) 2016-12-22 2023-06-19 Incyte Corp Tetrahydro imidazo[4,5-c]pyridine derivatives as pd-l1 internalization inducers
CR20200520A (en) 2018-03-30 2021-03-09 Incyte Corp Heterocyclic compounds as immunomodulators
EP3790877B1 (en) 2018-05-11 2023-03-01 Incyte Corporation Tetrahydro-imidazo[4,5-c]pyridine derivatives as pd-l1 immunomodulators
TW202115059A (en) 2019-08-09 2021-04-16 美商英塞特公司 Salts of a pd-1/pd-l1 inhibitor
TW202126652A (en) 2019-09-30 2021-07-16 美商英塞特公司 Pyrido[3,2-d]pyrimidine compounds as immunomodulators
AU2020385113A1 (en) 2019-11-11 2022-05-19 Incyte Corporation Salts and crystalline forms of a PD-1/PD-L1 inhibitor
WO2022099018A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process of preparing a pd-1/pd-l1 inhibitor
CA3200844A1 (en) 2020-11-06 2022-05-12 Incyte Corporation Process for making a pd-1/pd-l1 inhibitor and salts and crystalline forms thereof
TW202233615A (en) 2020-11-06 2022-09-01 美商英塞特公司 Crystalline form of a pd-1/pd-l1 inhibitor

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6156180A (en) * 1984-08-23 1986-03-20 Fujisawa Pharmaceut Co Ltd Imidazo-heterocyclic compound

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6156180A (en) * 1984-08-23 1986-03-20 Fujisawa Pharmaceut Co Ltd Imidazo-heterocyclic compound

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ADHIKARY P.K. ET AL.: "Synthesis and antihypertensive activity of some imidazoindole derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 19, no. 11, 1976, pages 1352 - 1354 *
ALMIRANTE ET AL.: "Derivatives of Imidazole. I. Synthesis and reactions of Imidazo[1,2- a]pyridines with analgesic, Antiinflammatory, Antipyretic, and Anticonvulsant activity", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, 1965, pages 305 - 312 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102216298B (en) * 2008-09-16 2014-04-16 Csir公司 Imidazopyridines and imidazopyrimidines as HIV-1 reverse transcriptase inhibitors

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Publication number Publication date
WO2007067711A2 (en) 2007-06-14

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