WO2006122186A3 - 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia - Google Patents
1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia Download PDFInfo
- Publication number
- WO2006122186A3 WO2006122186A3 PCT/US2006/018076 US2006018076W WO2006122186A3 WO 2006122186 A3 WO2006122186 A3 WO 2006122186A3 US 2006018076 W US2006018076 W US 2006018076W WO 2006122186 A3 WO2006122186 A3 WO 2006122186A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hydroxyalkyl
- diphenyl
- hypercholestrolemia
- treating
- azetidinone derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
Abstract
The invention relates to a chemical genus of 1,4-diphenyl-3-hydroxyalkyl-2-azetidinones useful for the treatment of hypercholesterolemia and related disorders, having general formula (I).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06759488A EP1879860A2 (en) | 2005-05-10 | 2006-05-10 | 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67932605P | 2005-05-10 | 2005-05-10 | |
US60/679,326 | 2005-05-10 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006122186A2 WO2006122186A2 (en) | 2006-11-16 |
WO2006122186A3 true WO2006122186A3 (en) | 2007-03-01 |
Family
ID=37397271
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/018076 WO2006122186A2 (en) | 2005-05-10 | 2006-05-10 | 1,4-diphenyl-3-hydroxyalkyl-2-azetidinone derivatives for treating hypercholestrolemia |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP1879860A2 (en) |
WO (1) | WO2006122186A2 (en) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7842684B2 (en) | 2006-04-27 | 2010-11-30 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitor activity |
US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
US7893048B2 (en) | 2005-06-22 | 2011-02-22 | Astrazeneca Ab | 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
US8349814B2 (en) | 2006-10-10 | 2013-01-08 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US8541581B2 (en) | 2009-04-07 | 2013-09-24 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US8546564B2 (en) | 2009-04-07 | 2013-10-01 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US8957049B2 (en) | 2008-04-09 | 2015-02-17 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US9034849B2 (en) | 2010-02-03 | 2015-05-19 | Infinity Pharmaceuticals, Inc. | Fatty acid amide hydrolase inhibitors |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UY29607A1 (en) | 2005-06-20 | 2007-01-31 | Astrazeneca Ab | CHEMICAL COMPOUNDS |
MY148538A (en) | 2005-06-22 | 2013-04-30 | Astrazeneca Ab | Novel 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
BRPI0715160A2 (en) | 2006-08-08 | 2013-06-11 | Sanofi Aventis | arylamimoaryl-alkyl-substituted imidazolidine-2,4-diones, process for preparing them, drugs comprising these compounds, and their use |
WO2008061238A2 (en) * | 2006-11-16 | 2008-05-22 | Ironwood Pharmaceuticals, Inc. | Processes for production of 4-biphenylyazetidin-2-ones |
EP3150589A1 (en) | 2007-06-08 | 2017-04-05 | MannKind Corporation | Ire-1a inhibitors |
EP2025674A1 (en) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs |
DE102007063671A1 (en) | 2007-11-13 | 2009-06-25 | Sanofi-Aventis Deutschland Gmbh | New crystalline diphenylazetidinone hydrates, medicaments containing these compounds and their use |
EP2310372B1 (en) | 2008-07-09 | 2012-05-23 | Sanofi | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
EP2403848A1 (en) | 2009-03-06 | 2012-01-11 | Lipideon Biotechnology AG | Pharmaceutical hypocholesterolemic compositions |
BR112012003973A2 (en) | 2009-08-26 | 2015-09-08 | Sanofi Sa | crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
ES2552657T3 (en) | 2010-05-26 | 2015-12-01 | Satiogen Pharmaceuticals, Inc. | Inhibitors of the recycling of bile acids and satiogens for the treatment of diabetes, obesity, and inflammatory gastrointestinal conditions |
WO2011157827A1 (en) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
WO2012120053A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120056A1 (en) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683705B1 (en) | 2011-03-08 | 2015-04-22 | Sanofi | Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
CA2852957C (en) | 2011-10-28 | 2020-08-04 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
US20140243281A1 (en) | 2011-10-28 | 2014-08-28 | Lumena Pharmaceuticals, Inc. | Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases |
JP2016514684A (en) | 2013-03-15 | 2016-05-23 | ルメナ ファーマシューティカルズ エルエルシー | Bile acid recirculation inhibitors for the treatment of primary sclerosing cholangitis and inflammatory bowel disease |
BR112015023697A2 (en) | 2013-03-15 | 2017-07-18 | Lumena Pharmaceuticals Inc | recycling bile acid inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease |
EP4245367A3 (en) | 2019-02-12 | 2023-12-20 | Mirum Pharmaceuticals, Inc. | Methods for treating cholestasis |
CN112245421A (en) * | 2020-09-25 | 2021-01-22 | 北京大学 | New application of nemostat in preparation of demethylase inhibitor |
CN115068441B (en) * | 2022-06-30 | 2023-04-14 | 东北农业大学 | Water-soluble cannabidiol microcapsule and preparation method thereof |
-
2006
- 2006-05-10 WO PCT/US2006/018076 patent/WO2006122186A2/en active Application Filing
- 2006-05-10 EP EP06759488A patent/EP1879860A2/en not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
AMIT BASAK ET AL.: "PPL-catalysed hydrolysis of 3,4-disubstituted beta-lactams: Effect of chain length and stereochemistry on the enantioselectivity", TETRAHEDRON, vol. 54, no. 23, 4 June 1998 (1998-06-04), pages 6529 - 6538, XP004119596 * |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7871998B2 (en) | 2003-12-23 | 2011-01-18 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitory activity |
US7893048B2 (en) | 2005-06-22 | 2011-02-22 | Astrazeneca Ab | 2-azetidinone derivatives as cholesterol absorption inhibitors for the treatment of hyperlipidaemic conditions |
US7842684B2 (en) | 2006-04-27 | 2010-11-30 | Astrazeneca Ab | Diphenylazetidinone derivatives possessing cholesterol absorption inhibitor activity |
US8349814B2 (en) | 2006-10-10 | 2013-01-08 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US9108989B2 (en) | 2006-10-10 | 2015-08-18 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US8957049B2 (en) | 2008-04-09 | 2015-02-17 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US8541581B2 (en) | 2009-04-07 | 2013-09-24 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US8546564B2 (en) | 2009-04-07 | 2013-10-01 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
US9034849B2 (en) | 2010-02-03 | 2015-05-19 | Infinity Pharmaceuticals, Inc. | Fatty acid amide hydrolase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
WO2006122186A2 (en) | 2006-11-16 |
EP1879860A2 (en) | 2008-01-23 |
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