WO2008011478A3 - Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds - Google Patents

Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds Download PDF

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Publication number
WO2008011478A3
WO2008011478A3 PCT/US2007/073806 US2007073806W WO2008011478A3 WO 2008011478 A3 WO2008011478 A3 WO 2008011478A3 US 2007073806 W US2007073806 W US 2007073806W WO 2008011478 A3 WO2008011478 A3 WO 2008011478A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydroxy
amino
propionic acid
acid amides
methods
Prior art date
Application number
PCT/US2007/073806
Other languages
French (fr)
Other versions
WO2008011478A2 (en
Inventor
John E Donello
Fabien J Schweighoffer
Bertrand Leblond
Original Assignee
Allergan Inc
John E Donello
Fabien J Schweighoffer
Bertrand Leblond
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc, John E Donello, Fabien J Schweighoffer, Bertrand Leblond filed Critical Allergan Inc
Publication of WO2008011478A2 publication Critical patent/WO2008011478A2/en
Publication of WO2008011478A3 publication Critical patent/WO2008011478A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using compounds of Formula 1 wherein the variables have the meaning disclosed in the specification.
PCT/US2007/073806 2006-07-19 2007-07-18 Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds WO2008011478A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80779206P 2006-07-19 2006-07-19
US60/807,792 2006-07-19

Publications (2)

Publication Number Publication Date
WO2008011478A2 WO2008011478A2 (en) 2008-01-24
WO2008011478A3 true WO2008011478A3 (en) 2008-03-20

Family

ID=38793589

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/073806 WO2008011478A2 (en) 2006-07-19 2007-07-18 Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds

Country Status (1)

Country Link
WO (1) WO2008011478A2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008519840A (en) 2004-11-10 2008-06-12 ジェンザイム・コーポレイション How to treat diabetes
EP2032134B1 (en) 2006-05-09 2015-06-24 Genzyme Corporation Methods of treating fatty liver disease comprising inhibiting glucosphingolipid synthesis
EP2594565B1 (en) 2007-05-31 2018-10-24 Genzyme Corporation 2-acylaminopropanol-type glucosylceramide synthase inhibitors
SG10201707161PA (en) 2007-10-05 2017-10-30 Genzyme Corp Method of treating polycystic kidney diseases with ceramide derivatives
US8168631B2 (en) 2008-02-05 2012-05-01 Allergan, Inc. 3-(4-fluorophenyl)-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic activity
WO2009117150A2 (en) * 2008-03-20 2009-09-24 Genzyme Corporation Method of treating lupus with ceramide derivatives
JP2011529500A (en) 2008-07-28 2011-12-08 ジェンザイム コーポレーション Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular diseases
US8309593B2 (en) 2008-10-03 2012-11-13 Genzyme Corporation 2-acylaminopropoanol-type glucosylceramide synthase inhibitors
ES2440068T3 (en) * 2009-09-16 2014-01-27 Allergan, Inc. Compounds for use in the treatment of seizure disorders
JP2013505246A (en) 2009-09-16 2013-02-14 アラーガン インコーポレイテッド Compounds and methods for treating spasticity
JP2013505247A (en) * 2009-09-16 2013-02-14 アラーガン インコーポレイテッド Compositions and methods for treating gastrointestinal motility disorders
DK3033327T3 (en) * 2013-08-15 2018-04-16 Allergan Inc (-) - (2R, 3S) -2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L) - (+) - tartrate salt, PROCEDURE FOR MANUFACTURING AND USING THEREOF

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995016786A1 (en) * 1993-12-17 1995-06-22 Dsm N.V. Phenylserine amides and the preparation of phenylserines/phenylserine amides
WO2003045928A1 (en) * 2001-11-26 2003-06-05 Genzyme Corporation Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors
WO2006081280A1 (en) * 2005-01-26 2006-08-03 Allergan, Inc. 3-heterocyclyl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immunostimulant activity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995016786A1 (en) * 1993-12-17 1995-06-22 Dsm N.V. Phenylserine amides and the preparation of phenylserines/phenylserine amides
WO2003045928A1 (en) * 2001-11-26 2003-06-05 Genzyme Corporation Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors
US20030153768A1 (en) * 2001-11-26 2003-08-14 Genzyme Corporation Diastereoselective synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
WO2006081280A1 (en) * 2005-01-26 2006-08-03 Allergan, Inc. 3-heterocyclyl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immunostimulant activity
WO2006081252A2 (en) * 2005-01-26 2006-08-03 Allergan, Inc. Use of 1-benzyl-1-hydr0xy-2, 3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds as analgesics
WO2006081273A1 (en) * 2005-01-26 2006-08-03 Allergan, Inc. 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroayryl-3-hydroxy-2-amino-propionic acid amides and related compounds having analgesic and/or immunostimulant activity

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BIXLER R L ET AL: "Synthesis of beta-/4-pyridyl)-DL-analine and of beta-/4-pyridyl-1-oxide)-DL-, D-, and L-analine", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY. EASTON, US, vol. 23, April 1958 (1958-04-01), pages 575 - 584, XP002380699, ISSN: 0022-3263 *
DATABASE CA [online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; KASTRON, YA. A. ET AL: "Reaction of ethyl .beta.-furylglycidate with ammonia", XP002462452, retrieved from STN Database accession no. 1966:19065 *
LATVIJAS PSR ZINATNU AKADEMIJAS VESTIS, KIMIJAS SERIJA , (4), 471-7 CODEN: LZAKAM; ISSN: 0002-3248, 1965 *
THE MERCK DIVISISION: "The Merk Index", 2001, MERCK, XP002462479 *

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