WO2008011487A3 - L-benzyl-l-hydr0xy-2, 3-diamin0-propyl amines and 3-benzyl-3-hydroxy-2-amino-propionicacid amides for chronic pain - Google Patents
L-benzyl-l-hydr0xy-2, 3-diamin0-propyl amines and 3-benzyl-3-hydroxy-2-amino-propionicacid amides for chronic pain Download PDFInfo
- Publication number
- WO2008011487A3 WO2008011487A3 PCT/US2007/073818 US2007073818W WO2008011487A3 WO 2008011487 A3 WO2008011487 A3 WO 2008011487A3 US 2007073818 W US2007073818 W US 2007073818W WO 2008011487 A3 WO2008011487 A3 WO 2008011487A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- benzyl
- diamin0
- propionicacid
- hydr0xy
- amides
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Abstract
Disclosed herein are methods of treating a patient suffering from one or more types of chronic pain using the following compounds:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80779606P | 2006-07-19 | 2006-07-19 | |
US60/807,796 | 2006-07-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008011487A2 WO2008011487A2 (en) | 2008-01-24 |
WO2008011487A3 true WO2008011487A3 (en) | 2008-05-15 |
Family
ID=38740306
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/073818 WO2008011487A2 (en) | 2006-07-19 | 2007-07-18 | L-benzyl-l-hydr0xy-2, 3-diamin0-propyl amines and 3-benzyl-3-hydroxy-2-amino-propionicacid amides for chronic pain |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008011487A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9532976B2 (en) | 2004-11-10 | 2017-01-03 | Genzyme Corporation | Method of lowering blood glucose |
US9556155B2 (en) | 2006-05-09 | 2017-01-31 | Genzyme Corporation | Methods of treating fatty liver disease |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008011483A2 (en) * | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Methods for treating chronic pain using 1- (hetero) aryl-1-hydroxy 2,3-diamino-propyl amines and related compounds |
US9314466B2 (en) * | 2007-03-06 | 2016-04-19 | Allergan, Inc. | Methods for treating cognitive disorders using 1-benzyl-1-hydroxy-2,3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds |
US8304447B2 (en) | 2007-05-31 | 2012-11-06 | Genzyme Corporation | 2-acylaminopropoanol-type glucosylceramide synthase inhibitors |
SG184721A1 (en) | 2007-10-05 | 2012-10-30 | Genzyme Corp | Method of treating polycystic kidney diseases with ceramide derivatives |
WO2009117150A2 (en) * | 2008-03-20 | 2009-09-24 | Genzyme Corporation | Method of treating lupus with ceramide derivatives |
US8389517B2 (en) | 2008-07-28 | 2013-03-05 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
EP3078373A1 (en) | 2008-10-03 | 2016-10-12 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitor |
AU2010295698A1 (en) * | 2009-09-16 | 2012-04-12 | Allergan, Inc. | Compositions and methods for treating disorders of gastrointestinal motility |
WO2011034912A1 (en) * | 2009-09-16 | 2011-03-24 | Allergan, Inc. | Compositions and methods for treating spasticity |
JP6537500B2 (en) | 2013-09-20 | 2019-07-03 | ビオマリン プハルマセウトイカル インコーポレイテッド | Glucosylceramide synthase inhibitors for the treatment of diseases |
CN109096243B (en) * | 2018-07-26 | 2020-06-26 | 南京昊绿生物科技有限公司 | Synthesis process of deuterated ibrutinostat racemate |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0720852A1 (en) * | 1993-08-13 | 1996-07-10 | Seikagaku Corporation | Remedy for nervous diseases |
WO2005063275A1 (en) * | 2003-12-23 | 2005-07-14 | Musc Foundaton For Research Development | Methods and compositions for the prevention and treatment of inflammatory diseases or conditions |
WO2006036512A2 (en) * | 2004-09-28 | 2006-04-06 | Allergan, Inc. | Unsubstituted and substituted 4-benzyl-1,3-dihydro-imidazole-2-thiones acting as specific or selective alpha2 adrenergic agonists and methods for using the same |
WO2006081252A2 (en) * | 2005-01-26 | 2006-08-03 | Allergan, Inc. | Use of 1-benzyl-1-hydr0xy-2, 3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds as analgesics |
-
2007
- 2007-07-18 WO PCT/US2007/073818 patent/WO2008011487A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0720852A1 (en) * | 1993-08-13 | 1996-07-10 | Seikagaku Corporation | Remedy for nervous diseases |
WO2005063275A1 (en) * | 2003-12-23 | 2005-07-14 | Musc Foundaton For Research Development | Methods and compositions for the prevention and treatment of inflammatory diseases or conditions |
WO2006036512A2 (en) * | 2004-09-28 | 2006-04-06 | Allergan, Inc. | Unsubstituted and substituted 4-benzyl-1,3-dihydro-imidazole-2-thiones acting as specific or selective alpha2 adrenergic agonists and methods for using the same |
WO2006081252A2 (en) * | 2005-01-26 | 2006-08-03 | Allergan, Inc. | Use of 1-benzyl-1-hydr0xy-2, 3-diamino-propyl amines, 3-benzyl-3-hydroxy-2-amino-propionic acid amides and related compounds as analgesics |
Non-Patent Citations (1)
Title |
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PANNU R ET AL: "A novel role of lactosylceramide in the regulation of lipopolysaccharide/interferon-gamma-mediated inducible nitric oxide synthase gene expression: implications for neuroinflammatory diseases", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 24, no. 26, 30 June 2004 (2004-06-30), pages 5942 - 5954, XP002993267, ISSN: 0270-6474 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9532976B2 (en) | 2004-11-10 | 2017-01-03 | Genzyme Corporation | Method of lowering blood glucose |
US9556155B2 (en) | 2006-05-09 | 2017-01-31 | Genzyme Corporation | Methods of treating fatty liver disease |
Also Published As
Publication number | Publication date |
---|---|
WO2008011487A2 (en) | 2008-01-24 |
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