DE602004032118D1 - Aminophosphonsäurederivate, deren additionssalze und s1p-rezeptormodulatoren - Google Patents
Aminophosphonsäurederivate, deren additionssalze und s1p-rezeptormodulatorenInfo
- Publication number
- DE602004032118D1 DE602004032118D1 DE602004032118T DE602004032118T DE602004032118D1 DE 602004032118 D1 DE602004032118 D1 DE 602004032118D1 DE 602004032118 T DE602004032118 T DE 602004032118T DE 602004032118 T DE602004032118 T DE 602004032118T DE 602004032118 D1 DE602004032118 D1 DE 602004032118D1
- Authority
- DE
- Germany
- Prior art keywords
- acid derivatives
- receptor modulators
- phosphonic acid
- additional salts
- amino phosphonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- PTMHPRAIXMAOOB-UHFFFAOYSA-N phosphoramidic acid Chemical class NP(O)(O)=O PTMHPRAIXMAOOB-UHFFFAOYSA-N 0.000 title abstract 2
- 102000011011 Sphingosine 1-phosphate receptors Human genes 0.000 abstract 1
- 108050001083 Sphingosine 1-phosphate receptors Proteins 0.000 abstract 1
- YCBQMUQISIMBKU-UHFFFAOYSA-N [2-amino-5-[2-chloro-4-(3-phenylmethoxyphenyl)sulfanylphenyl]-2-methylpentyl]phosphonic acid Chemical compound C1=C(Cl)C(CCCC(N)(C)CP(O)(O)=O)=CC=C1SC1=CC=CC(OCC=2C=CC=CC=2)=C1 YCBQMUQISIMBKU-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
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- A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
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- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3826—Acyclic unsaturated acids
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- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
- C07F9/3882—Arylalkanephosphonic acids
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- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4015—Esters of acyclic unsaturated acids
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- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4056—Esters of arylalkanephosphonic acids
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/653—Five-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Vascular Medicine (AREA)
- Neurology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003039269 | 2003-02-18 | ||
PCT/JP2004/001783 WO2004074297A1 (ja) | 2003-02-18 | 2004-02-18 | アミノホスホン酸誘導体とその付加塩及びs1p受容体調節剤 |
Publications (1)
Publication Number | Publication Date |
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DE602004032118D1 true DE602004032118D1 (de) | 2011-05-19 |
Family
ID=32905163
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004032118T Expired - Lifetime DE602004032118D1 (de) | 2003-02-18 | 2004-02-18 | Aminophosphonsäurederivate, deren additionssalze und s1p-rezeptormodulatoren |
Country Status (17)
Country | Link |
---|---|
US (2) | US7456157B2 (de) |
EP (2) | EP2172472B1 (de) |
JP (1) | JP4564918B2 (de) |
KR (1) | KR101005171B1 (de) |
CN (1) | CN100344638C (de) |
AT (1) | ATE504590T1 (de) |
AU (1) | AU2004213297B2 (de) |
BR (1) | BRPI0407658A (de) |
CA (1) | CA2515574C (de) |
CY (1) | CY1111529T1 (de) |
DE (1) | DE602004032118D1 (de) |
DK (1) | DK1602660T3 (de) |
ES (1) | ES2360394T3 (de) |
MX (1) | MXPA05008760A (de) |
PT (1) | PT1602660E (de) |
SI (1) | SI1602660T1 (de) |
WO (1) | WO2004074297A1 (de) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2617711A1 (de) * | 2002-09-19 | 2013-07-24 | Kyorin Pharmaceutical Co., Ltd. | Aminoalkoholderivate, Salze davon und Immunsuppressiva |
KR101005171B1 (ko) * | 2003-02-18 | 2011-01-04 | 교린 세이야꾸 가부시키 가이샤 | 아미노포스폰산 유도체와 그 부가염 및 s1p 수용체조절제 |
WO2005041899A2 (en) | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
EP1772145B1 (de) | 2004-07-16 | 2011-03-23 | Kyorin Pharmaceutical Co., Ltd. | Verfahren zur effektiven anwendung eines medikaments und verfahren zur prävention von nebenwirkungen |
US20060223866A1 (en) * | 2004-08-13 | 2006-10-05 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
US7241812B2 (en) | 2004-08-13 | 2007-07-10 | Praecis Pharmaceuticals, Inc. | Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity |
JP4792400B2 (ja) * | 2004-10-12 | 2011-10-12 | 杏林製薬株式会社 | 2−アミノ−2−[2−[4−(3−ベンジルオキシフェニルチオ)−2−クロロフェニル]エチル]−1,3−プロパンジオール塩酸塩又はその水和物の製造方法及びその製造中間体 |
EP1827606A2 (de) | 2004-12-06 | 2007-09-05 | University Of Virginia Patent Foundation | Arylamid-sphingosin-1-phosphat-analoga |
PT2295049E (pt) | 2005-09-09 | 2015-03-02 | Novartis Ag | Tratamento de doenças auto-imunes |
WO2007043433A1 (ja) * | 2005-10-07 | 2007-04-19 | Kyorin Pharmaceutical Co., Ltd. | 2-アミノ-1,3-プロパンジオール誘導体を有効成分とする肝臓疾患治療剤および肝臓疾患治療方法 |
AU2007209961A1 (en) | 2006-01-27 | 2007-08-09 | University Of Virginia Patent Foundation | Method for treatment of neuropathic pain |
TWI389683B (zh) * | 2006-02-06 | 2013-03-21 | Kyorin Seiyaku Kk | A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient |
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WO2008019090A2 (en) * | 2006-08-04 | 2008-02-14 | Praecis Pharmaceuticals Incorporated | Agonists of the sphingosine-1-phosphate receptor |
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-
2004
- 2004-02-18 KR KR1020057015237A patent/KR101005171B1/ko not_active IP Right Cessation
- 2004-02-18 AT AT04712184T patent/ATE504590T1/de active
- 2004-02-18 DE DE602004032118T patent/DE602004032118D1/de not_active Expired - Lifetime
- 2004-02-18 CA CA2515574A patent/CA2515574C/en not_active Expired - Fee Related
- 2004-02-18 DK DK04712184.3T patent/DK1602660T3/da active
- 2004-02-18 PT PT04712184T patent/PT1602660E/pt unknown
- 2004-02-18 EP EP09178067A patent/EP2172472B1/de not_active Expired - Lifetime
- 2004-02-18 EP EP04712184A patent/EP1602660B1/de not_active Expired - Lifetime
- 2004-02-18 US US10/545,790 patent/US7456157B2/en active Active
- 2004-02-18 BR BRPI0407658-3A patent/BRPI0407658A/pt not_active Application Discontinuation
- 2004-02-18 WO PCT/JP2004/001783 patent/WO2004074297A1/ja active Application Filing
- 2004-02-18 CN CNB200480004551XA patent/CN100344638C/zh not_active Expired - Fee Related
- 2004-02-18 AU AU2004213297A patent/AU2004213297B2/en not_active Ceased
- 2004-02-18 JP JP2005502730A patent/JP4564918B2/ja not_active Expired - Fee Related
- 2004-02-18 SI SI200431656T patent/SI1602660T1/sl unknown
- 2004-02-18 MX MXPA05008760A patent/MXPA05008760A/es active IP Right Grant
- 2004-02-18 ES ES04712184T patent/ES2360394T3/es not_active Expired - Lifetime
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2008
- 2008-06-16 US US12/213,187 patent/US7759326B2/en not_active Expired - Fee Related
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- 2011-06-06 CY CY20111100542T patent/CY1111529T1/el unknown
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Publication number | Publication date |
---|---|
MXPA05008760A (es) | 2006-03-21 |
EP1602660A1 (de) | 2005-12-07 |
JPWO2004074297A1 (ja) | 2006-06-01 |
CA2515574C (en) | 2012-03-13 |
EP1602660B1 (de) | 2011-04-06 |
EP2172472A2 (de) | 2010-04-07 |
US7456157B2 (en) | 2008-11-25 |
US20060160771A1 (en) | 2006-07-20 |
AU2004213297B2 (en) | 2009-03-19 |
EP2172472B1 (de) | 2012-12-26 |
JP4564918B2 (ja) | 2010-10-20 |
US7759326B2 (en) | 2010-07-20 |
KR101005171B1 (ko) | 2011-01-04 |
ES2360394T3 (es) | 2011-06-03 |
CN1751054A (zh) | 2006-03-22 |
SI1602660T1 (sl) | 2011-06-30 |
WO2004074297A1 (ja) | 2004-09-02 |
CA2515574A1 (en) | 2004-09-02 |
BRPI0407658A (pt) | 2006-02-21 |
ATE504590T1 (de) | 2011-04-15 |
PT1602660E (pt) | 2011-06-15 |
AU2004213297A1 (en) | 2004-09-02 |
EP2172472A3 (de) | 2010-06-30 |
CY1111529T1 (el) | 2015-08-05 |
EP1602660A4 (de) | 2008-03-19 |
CN100344638C (zh) | 2007-10-24 |
US20080275008A1 (en) | 2008-11-06 |
DK1602660T3 (da) | 2011-05-23 |
KR20050109069A (ko) | 2005-11-17 |
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