DK1589956T3 - Transdermal granisetron - Google Patents

Transdermal granisetron

Info

Publication number
DK1589956T3
DK1589956T3 DK04708393T DK04708393T DK1589956T3 DK 1589956 T3 DK1589956 T3 DK 1589956T3 DK 04708393 T DK04708393 T DK 04708393T DK 04708393 T DK04708393 T DK 04708393T DK 1589956 T3 DK1589956 T3 DK 1589956T3
Authority
DK
Denmark
Prior art keywords
granisetron
transdermal
transdermal granisetron
skin
substantially increase
Prior art date
Application number
DK04708393T
Other languages
English (en)
Inventor
Peter Altenschoepfer
Adam Charles Watkinson
Original Assignee
Strakan Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9952502&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1589956(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Strakan Int Ltd filed Critical Strakan Int Ltd
Application granted granted Critical
Publication of DK1589956T3 publication Critical patent/DK1589956T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/70Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061Polyacrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/04Antipruritics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36Opioid-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/02Antidotes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Rheumatology (AREA)
  • Psychology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK04708393T 2003-02-05 2004-02-05 Transdermal granisetron DK1589956T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0302662.2A GB0302662D0 (en) 2003-02-05 2003-02-05 Transdermal granisetron
PCT/GB2004/000403 WO2004069141A2 (en) 2003-02-05 2004-02-05 Transdermal granisetron

Publications (1)

Publication Number Publication Date
DK1589956T3 true DK1589956T3 (da) 2007-10-01

Family

ID=9952502

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04708393T DK1589956T3 (da) 2003-02-05 2004-02-05 Transdermal granisetron

Country Status (33)

Country Link
US (3) US7608282B2 (da)
EP (1) EP1589956B1 (da)
JP (2) JP4146486B2 (da)
KR (1) KR100893158B1 (da)
CN (3) CN102526043A (da)
AT (1) ATE368454T1 (da)
AU (1) AU2004210181B2 (da)
BR (1) BRPI0407280A (da)
CA (1) CA2515094C (da)
CR (1) CR7923A (da)
CY (1) CY1106811T1 (da)
DE (1) DE602004007888T2 (da)
DK (1) DK1589956T3 (da)
EC (1) ECSP055953A (da)
ES (1) ES2287695T3 (da)
GB (1) GB0302662D0 (da)
GE (1) GEP20084390B (da)
HK (1) HK1082199A1 (da)
HR (1) HRP20050695B1 (da)
IL (1) IL169881A (da)
IS (1) IS7997A (da)
MA (1) MA27616A1 (da)
MX (1) MXPA05008343A (da)
NO (1) NO331441B1 (da)
NZ (1) NZ541103A (da)
PL (1) PL218351B1 (da)
PT (1) PT1589956E (da)
RS (1) RS51696B (da)
RU (1) RU2355387C2 (da)
SI (1) SI1589956T1 (da)
UA (1) UA83362C2 (da)
WO (1) WO2004069141A2 (da)
ZA (1) ZA200506128B (da)

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US20060263421A1 (en) * 2005-05-18 2006-11-23 Abeille Pharmaceuticals Inc Transdermal Method and Patch for Nausea
NZ563946A (en) * 2005-06-03 2012-02-24 Acrux Dds Pty Ltd Testosterone containing non-occlusive transdermal drug delivery composition for application to the arm pit / axilla
CN100464752C (zh) * 2005-11-01 2009-03-04 中国人民解放军第二军医大学 格拉司琼巴布剂及其制法
EP1842541A1 (en) * 2006-03-29 2007-10-10 G.I.M.-Gesellschaft Für Innovative Medizin Gmbh Nfg Ohg Plant components and extracts and uses thereof
WO2008115599A1 (en) * 2007-03-21 2008-09-25 Alza Corporation Apparatus and method for transdermal delivery of a 5-hydroxytrytamine antagonist
US20080242696A1 (en) * 2007-03-27 2008-10-02 Chemagis Ltd. Crystalline granisetron base and production process therefor
JP2008297277A (ja) * 2007-06-01 2008-12-11 Taiyo Yakuhin Kogyo Kk 注射剤の安定化法
KR100929560B1 (ko) * 2008-01-09 2009-12-03 에코 퍼시픽 엘티디 그라니세트론을 함유한 매트릭스 형태의 경피 흡수제
CN101721394B (zh) * 2008-10-29 2013-04-17 大连理工大学 一种格拉司琼和/或其盐酸盐贴剂
TW201021856A (en) 2008-12-01 2010-06-16 Genovate Biotechnology Co Ltd Antiemetic patch
CN101716163B (zh) * 2009-12-24 2013-07-31 沈阳药科大学 一种来曲唑靶向定位缓释透皮贴剂及其制备方法
CN101836949A (zh) * 2010-02-11 2010-09-22 上海现代药物制剂工程研究中心有限公司 含有止吐活性药物的透皮凝胶制剂及制备方法
US20110288115A1 (en) * 2010-05-24 2011-11-24 Avmedis Llc Treatment of vagally-mediated spectrum disorders
CN102293761B (zh) * 2010-06-22 2014-01-08 浙江省医学科学院 含止吐剂成份的透皮吸收贴剂
CN102462672B (zh) * 2010-11-17 2013-12-04 汪晴 一种雷莫司琼透皮贴剂及其制备方法
CN102178660B (zh) * 2011-04-19 2012-08-08 上海现代药物制剂工程研究中心有限公司 微孔型盐酸格拉司琼透皮贴膜及其制法
US9205060B2 (en) 2011-07-07 2015-12-08 Teikoku Seiyaku Co., Ltd. Adhesive skin patch containing serotonin receptor antagonist drug
CN106176742A (zh) * 2011-08-01 2016-12-07 江苏康倍得药业股份有限公司 适于透皮给药的含格拉司琼的药物组合物及其制备与应用
WO2014051055A1 (ja) * 2012-09-28 2014-04-03 東レ株式会社 キヌクリジンウレア誘導体及びその医薬用途
ES2943157T3 (es) 2014-04-30 2023-06-09 Sorrento Therapeutics Inc Aparato de administración transdérmica de fármacos
CN105520921B (zh) * 2015-01-09 2018-12-25 中国科学院理化技术研究所 一种含有格拉司琼的长效透皮贴剂
WO2018115001A1 (en) 2016-12-20 2018-06-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine
BR112019012573A2 (pt) 2016-12-20 2019-11-19 Lts Lohmann Therapie Systeme Ag sistema terapêutico transdérmico que contém asenapina e polissiloxano ou poli-isobutileno
ES2881783T3 (es) 2017-06-26 2021-11-30 Lts Lohmann Therapie Systeme Ag Sistema terapéutico transdérmico que contiene asenapina y polímero de acrílico y silicona
CN112704672A (zh) 2018-06-20 2021-04-27 罗曼治疗系统股份公司 含有阿塞那平的透皮治疗系统
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Also Published As

Publication number Publication date
CR7923A (es) 2008-10-29
IL169881A0 (en) 2007-07-04
RS51696B (en) 2011-10-31
HRP20050695A2 (en) 2006-02-28
CN102416009A (zh) 2012-04-18
NZ541103A (en) 2007-01-26
PL379027A1 (pl) 2006-06-26
US20120258164A1 (en) 2012-10-11
WO2004069141A3 (en) 2004-10-07
US20100008974A1 (en) 2010-01-14
JP4146486B2 (ja) 2008-09-10
AU2004210181A2 (en) 2004-08-19
ECSP055953A (es) 2006-01-16
KR20050116365A (ko) 2005-12-12
JP2006516601A (ja) 2006-07-06
IS7997A (is) 2005-08-24
HK1082199A1 (en) 2006-06-02
PT1589956E (pt) 2007-08-23
KR100893158B1 (ko) 2009-04-16
CA2515094A1 (en) 2004-08-19
JP2008195738A (ja) 2008-08-28
CN102416009B (zh) 2013-09-11
US7608282B2 (en) 2009-10-27
CN102526043A (zh) 2012-07-04
ATE368454T1 (de) 2007-08-15
DE602004007888D1 (en) 2007-09-13
AU2004210181A1 (en) 2004-08-19
GB0302662D0 (en) 2003-03-12
EP1589956B1 (en) 2007-08-01
RS20050600A (en) 2007-12-31
GEP20084390B (en) 2008-06-10
BRPI0407280A (pt) 2006-01-31
HRP20050695B1 (hr) 2013-11-08
WO2004069141B1 (en) 2004-12-23
EP1589956A2 (en) 2005-11-02
UA83362C2 (uk) 2008-07-10
NO331441B1 (no) 2012-01-02
ES2287695T3 (es) 2007-12-16
AU2004210181B2 (en) 2009-11-19
MA27616A1 (fr) 2005-11-01
NO20053663L (no) 2005-11-04
ZA200506128B (en) 2006-12-27
DE602004007888T2 (de) 2008-04-17
MXPA05008343A (es) 2006-01-31
CA2515094C (en) 2008-12-09
RU2005127599A (ru) 2006-01-20
CN1747724A (zh) 2006-03-15
RU2355387C2 (ru) 2009-05-20
SI1589956T1 (sl) 2007-10-31
CY1106811T1 (el) 2012-05-23
PL218351B1 (pl) 2014-11-28
WO2004069141A2 (en) 2004-08-19
US20060177493A1 (en) 2006-08-10
NO20053663D0 (no) 2005-07-28
IL169881A (en) 2011-12-29

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