DK1589005T3 - Fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre - Google Patents

Fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre

Info

Publication number
DK1589005T3
DK1589005T3 DK05290381T DK05290381T DK1589005T3 DK 1589005 T3 DK1589005 T3 DK 1589005T3 DK 05290381 T DK05290381 T DK 05290381T DK 05290381 T DK05290381 T DK 05290381T DK 1589005 T3 DK1589005 T3 DK 1589005T3
Authority
DK
Denmark
Prior art keywords
ivabradine
synthesis
pharmaceutically acceptable
addition salts
acceptable acid
Prior art date
Application number
DK05290381T
Other languages
Danish (da)
English (en)
Inventor
Jean-Michel Lerestif
Jean-Pierre Lecouve
Jean-Claude Souvie
Daniel Brigot
Stephane Horvath
Marie-Noelle Auguste
Gerard Damien
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34941959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1589005(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK1589005T3 publication Critical patent/DK1589005T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • E—FIXED CONSTRUCTIONS
    • E01—CONSTRUCTION OF ROADS, RAILWAYS, OR BRIDGES
    • E01C—CONSTRUCTION OF, OR SURFACES FOR, ROADS, SPORTS GROUNDS, OR THE LIKE; MACHINES OR AUXILIARY TOOLS FOR CONSTRUCTION OR REPAIR
    • E01C11/00—Details of pavings
    • E01C11/16—Reinforcements
    • E01C11/165—Reinforcements particularly for bituminous or rubber- or plastic-bound pavings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Architecture (AREA)
  • Civil Engineering (AREA)
  • Structural Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK05290381T 2004-04-13 2005-02-21 Fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre DK1589005T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0403830A FR2868777B1 (fr) 2004-04-13 2004-04-13 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
DK1589005T3 true DK1589005T3 (da) 2007-07-30

Family

ID=34941959

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05290381T DK1589005T3 (da) 2004-04-13 2005-02-21 Fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre

Country Status (43)

Country Link
US (2) US7176197B2 (xx)
EP (1) EP1589005B1 (xx)
JP (2) JP4515934B2 (xx)
KR (1) KR100677019B1 (xx)
CN (1) CN1305856C (xx)
AP (1) AP1821A (xx)
AR (1) AR047745A1 (xx)
AT (1) ATE358123T1 (xx)
AU (1) AU2005200861B2 (xx)
BR (1) BRPI0500585B8 (xx)
CA (1) CA2496723C (xx)
CO (1) CO5670092A1 (xx)
CR (2) CR7691A (xx)
CU (1) CU23465B7 (xx)
CY (1) CY1106597T1 (xx)
DE (1) DE602005000765T2 (xx)
DK (1) DK1589005T3 (xx)
EA (1) EA007745B1 (xx)
EC (1) ECSP055610A (xx)
ES (1) ES2285651T3 (xx)
FR (1) FR2868777B1 (xx)
GE (1) GEP20074138B (xx)
HK (1) HK1080362B (xx)
HR (1) HRP20070246T5 (xx)
IL (1) IL167013A (xx)
MA (1) MA27600A1 (xx)
ME (1) ME01396B (xx)
MX (1) MXPA05003694A (xx)
MY (1) MY141194A (xx)
NI (1) NI200500031A (xx)
NO (1) NO329807B1 (xx)
NZ (1) NZ538326A (xx)
OA (1) OA12913A (xx)
PL (1) PL1589005T3 (xx)
PT (1) PT1589005E (xx)
RS (1) RS50511B (xx)
SA (1) SA05260016B1 (xx)
SG (1) SG116575A1 (xx)
SI (1) SI1589005T1 (xx)
UA (1) UA80834C2 (xx)
UY (1) UY28759A1 (xx)
WO (1) WO2005110993A1 (xx)
ZA (1) ZA200501466B (xx)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2894826B1 (fr) * 2005-12-21 2010-10-22 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur calcique et les compositions pharmaceutiques qui la contiennent
ATE544754T1 (de) * 2006-11-30 2012-02-15 Cadila Healthcare Ltd Verfahren zur herstellung von ivabradinhydrochlorid
WO2008125006A1 (fr) * 2007-04-12 2008-10-23 Utopharm (Shanghai) Co., Ltd Procédés de préparation du chlorhydrate d'ivabradine et de sa forme cristalline stable
JP5632279B2 (ja) * 2007-05-30 2014-11-26 アイエヌディー−スイフト ラボラトリーズ リミテッド 塩酸イバブラジンの調製方法及びポリモルフ
SI22750A (sl) * 2008-04-07 2009-10-31 Krka D.D. Ivabradin hidrobromid
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2933975B1 (fr) 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
CN101723897B (zh) * 2008-10-31 2011-11-16 齐鲁制药有限公司 伊伐布雷定的合成方法
CN102264689B (zh) * 2008-12-22 2014-12-31 新梅斯托克尔卡公司 制备伊伐布雷定的方法
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
CN101768117B (zh) * 2008-12-29 2014-05-07 北京德众万全药物技术开发有限公司 一种盐酸伊伐布雷定晶型及其制备方法
CN101768116B (zh) * 2008-12-29 2014-06-18 北京德众万全药物技术开发有限公司 一种伊伐布雷定的制备方法
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2943667B1 (fr) * 2009-03-31 2011-05-06 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
ME00986B (me) * 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom
WO2010128525A2 (en) 2009-05-04 2010-11-11 Dinesh Shantilal Patel A formulation of ivabradine for treating the cardiovascular disease
HUE035588T2 (en) 2010-02-12 2018-05-28 Krka D D Novo Mesto Form of ivabradine hydrochloride
FR2956401B1 (fr) * 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2011104723A2 (en) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Acid addition salts of ivabradine and preparation thereof
HUP1000245A2 (en) 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
TWI499587B (zh) * 2010-06-03 2015-09-11 Jiangsu Hengrui Medicine Co 硫酸伊伐佈雷定及其ｉ型結晶的製備方法
EP2579860B1 (en) * 2010-06-14 2014-04-23 Ratiopharm GmbH Ivabradine-containing pharmaceutical composition with modified release
WO2012025940A1 (en) 2010-08-25 2012-03-01 Cadila Healthcare Limited Polymorphic form of ivabradine hydrochloride and process for preparation thereof
FR2971507B1 (fr) * 2011-02-14 2013-01-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN102304088B (zh) * 2011-07-07 2013-06-19 石药集团欧意药业有限公司 一种伊伐布雷定化合物、制备方法及其药物组合物
EP2726462B1 (en) 2011-08-02 2017-03-22 Sandoz AG Acetone solvate of ivabradine hydrochloride
WO2013064427A1 (en) 2011-11-04 2013-05-10 Synthon Bv A process for making crystalline delta-form of ivabradine hydrochloride
EP2589594A1 (en) * 2011-11-04 2013-05-08 Urquima S.A. Ivabradine hydrochloride Form IV
EP2780327A1 (en) * 2011-11-14 2014-09-24 Cadila Healthcare Limited Polymorphic forms of ivabradine hydrochloride
FR2984319B1 (fr) 2011-12-20 2013-12-27 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) * 2012-07-17 2014-10-31 Servier Lab Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
CN103012268B (zh) * 2013-01-05 2015-02-25 江苏宇田生物医药科技有限公司 一种伊伐布雷定制备方法
WO2014114341A1 (en) 2013-01-24 2014-07-31 Synthon Bv Process for making ivabradine
ITMI20130416A1 (it) * 2013-03-19 2014-09-20 Chemo Res S L Nuovo polimorfo del cloridrato di ivabradina e metodo per la sua preparazione
ITMI20130684A1 (it) * 2013-04-24 2014-10-25 Chemo Res S L Nuovo polimorfo del cloridrato di ivabradina e metodo per la sua preparazione
FI2781509T4 (fi) 2013-03-19 2023-09-07 Ivabradiinihydrokloridin uusi polymorfi ja sen valmistusmenetelmä
CZ305096B6 (cs) 2013-10-02 2015-04-29 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice
MX363389B (es) 2013-12-12 2019-03-20 Synthon Bv Composicion farmaceutica que comprende ivabradina amorfa.
CN103864690B (zh) * 2014-01-06 2016-09-14 北京莱瑞森医药科技有限公司 伊伐布雷定盐酸盐的s晶型、其制备方法和药物组合物
SI2774606T1 (sl) 2014-02-14 2019-05-31 Synthon B.V. Farmacevtski sestavek, ki obsega polimorf IV ivabradin hidroklorida
CN103880748B (zh) * 2014-04-03 2015-09-16 南京正大天晴制药有限公司 一种盐酸伊伐布雷定结构类似物及其制备方法和应用
CZ2014478A3 (cs) 2014-07-10 2015-09-16 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice
WO2016102423A1 (en) 2014-12-22 2016-06-30 Ratiopharm Gmbh Composition comprising ivabradine in a dissolved form
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN107056706B (zh) * 2015-12-21 2020-05-05 江苏恒瑞医药股份有限公司 一种用于制备盐酸伊伐布雷定α晶型的方法
TR201703066A2 (tr) 2017-02-28 2018-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari
EP3366282A1 (en) 2017-02-28 2018-08-29 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral pharmaceutical compositions of ivabradine
US20230140818A1 (en) 2017-04-27 2023-05-04 The University Of Hong Kong Use of hcn inhibitors for treatment of cancer
WO2020092288A1 (en) 2018-10-30 2020-05-07 Amgen Inc. Process of making ivabradine hydrochloride drug product
IT202000025312A1 (it) 2020-10-26 2022-04-26 Cambrex Profarmaco Milano S R L Processi per la preparazione di polimorfi di ivabradina hcl
CN115286577B (zh) * 2022-08-25 2023-10-20 江苏永安制药有限公司 一种盐酸伊伐布雷定及其中间体的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3519735A1 (de) * 1985-06-01 1986-12-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2834896B1 (fr) * 2002-01-23 2004-02-27 Servier Lab Composition pharmaceutique orodispersible d'ivabradine
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
BRPI0500585B1 (pt) 2020-11-03
ME01396B (me) 2010-03-02
WO2005110993A1 (fr) 2005-11-24
US20070135411A1 (en) 2007-06-14
JP2010047578A (ja) 2010-03-04
BRPI0500585B8 (pt) 2021-05-25
CN1683341A (zh) 2005-10-19
US20050228177A1 (en) 2005-10-13
CR11780A (es) 2010-12-09
BRPI0500585A (pt) 2005-11-16
AR047745A1 (es) 2006-02-15
DE602005000765T2 (de) 2008-01-10
NO20050884D0 (no) 2005-02-18
CA2496723C (fr) 2010-05-25
HK1080362A1 (en) 2006-04-28
CO5670092A1 (es) 2006-08-31
HRP20070246T3 (en) 2007-08-31
EP1589005A1 (fr) 2005-10-26
UA80834C2 (en) 2007-11-12
JP4515934B2 (ja) 2010-08-04
RS50511B (sr) 2010-03-02
NZ538326A (en) 2005-11-25
CN1305856C (zh) 2007-03-21
US7176197B2 (en) 2007-02-13
UY28759A1 (es) 2005-12-30
ECSP055610A (es) 2006-03-01
MA27600A1 (fr) 2005-11-01
HRP20070246T5 (en) 2008-10-31
AU2005200861B2 (en) 2010-07-15
NO329807B1 (no) 2010-12-20
SG116575A1 (en) 2005-11-28
NO20050884L (no) 2005-10-14
JP2005298480A (ja) 2005-10-27
AP1821A (en) 2008-01-21
NI200500031A (es) 2006-05-25
EA200500238A1 (ru) 2005-10-27
EP1589005B1 (fr) 2007-03-28
KR20060042116A (ko) 2006-05-12
FR2868777A1 (fr) 2005-10-14
EA007745B1 (ru) 2006-12-29
AU2005200861A1 (en) 2005-10-27
ZA200501466B (en) 2005-11-30
ATE358123T1 (de) 2007-04-15
CY1106597T1 (el) 2012-01-25
MY141194A (en) 2010-03-31
SA05260016B1 (ar) 2009-06-06
MXPA05003694A (es) 2006-01-24
HK1080362B (zh) 2007-07-20
JP4848449B2 (ja) 2011-12-28
CU23465B7 (es) 2009-12-17
GEP20074138B (en) 2007-06-25
PL1589005T3 (pl) 2007-07-31
CA2496723A1 (fr) 2005-10-13
CR7691A (es) 2008-09-23
KR100677019B1 (ko) 2007-02-01
PT1589005E (pt) 2007-06-18
SI1589005T1 (sl) 2007-08-31
DE602005000765D1 (de) 2007-05-10
FR2868777B1 (fr) 2006-05-26
US7867994B2 (en) 2011-01-11
AP2005003222A0 (en) 2005-03-31
IL167013A (en) 2011-08-31
OA12913A (en) 2006-10-13
ES2285651T3 (es) 2007-11-16

Similar Documents

Publication Publication Date Title
DK1589005T3 (da) Fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre
DK1598333T3 (da) Fremgangsmåde til fremstilling af (1S)-4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutan og syreadditionssalte heraf samt anvendelse til syntese af ivabradin og syreadditionssalte heraf med farmaceutisk acceptable syrer
DK2202225T3 (da) Ny fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre
DK3385267T3 (da) Syntese af boronestere og syreforbindelser
IL177511A (en) Process for the synthesis of a cxcr4 antagonist
NO20050888D0 (no) Ny fremgangsmate for syntesen av 1,3,4,5-tetrahydro-2H-3-benzazepin-2-onforbindelser, og anvendelse i syntesen av ivabradin og addisjonssalter derav med en farmasoytisk akseptabel syre
DK2135861T3 (da) Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre
DK1589014T3 (da) Fremgangsmåde til syntese af derivater af 1,3-dihydro-2H-3-benzazepin-2-on og anvendelse heraf ved syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre
PT1753720E (pt) Processo para a preparação de perindopril e sais do mesmo
ZA200902575B (en) Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
DK2241554T3 (da) Ny fremgangsmåde til syntese af ivabradin og additionssalte heraf med en farmaceutisk acceptabel syre
DK1420028T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1367061T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1371659T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1420029T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1380591T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutiske acceptable salte heraf
DK1786913T3 (da) Fremgangsmåde til fremstilling af diarylcycloalkylderivater
DK1497290T3 (da) Fremgangsmåde til fremstilling af syresalte af gemifloxacin
DK1948609T3 (da) Fremgangsmåde til fremstilling af pyridylcarboxylsyreamider og estere
DK1403275T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DK1735297T3 (da) Fremgangsmåde til fremstilling af benzoxathiepinderivater
DK1367063T3 (da) Fremgangsmåde til syntese af perindopril og farmaceutisk acceptable salte heraf
DE602004012275D1 (de) zu dessen Herstellung und Impstoffderivate davon
DK1893208T3 (da) Farmaceutisk sammensætning med en 1-(3-chlorophenyl)-3-alkylpiperazin til behandling af appetitforstyrrelser