ME01396B - Postupak za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina - Google Patents

Postupak za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina

Info

Publication number
ME01396B
ME01396B MEP-2007-219A MEP2007219A ME01396B ME 01396 B ME01396 B ME 01396B ME P2007219 A MEP2007219 A ME P2007219A ME 01396 B ME01396 B ME 01396B
Authority
ME
Montenegro
Prior art keywords
ivabradine
synthesis
pharmaceutically acceptable
acid addition
addition salts
Prior art date
Application number
MEP-2007-219A
Other languages
German (de)
English (en)
French (fr)
Inventor
Jean Claude Souvie
Stephane Horvath
Gerard Damien
Marie Noelle Auguste
Jean Michel Lerestif
Jean Pierre Lecouve
Daniel Brigot
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34941959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME01396(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab filed Critical Servier Lab
Publication of ME01396B publication Critical patent/ME01396B/me

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • E—FIXED CONSTRUCTIONS
    • E01—CONSTRUCTION OF ROADS, RAILWAYS, OR BRIDGES
    • E01C—CONSTRUCTION OF, OR SURFACES FOR, ROADS, SPORTS GROUNDS, OR THE LIKE; MACHINES OR AUXILIARY TOOLS FOR CONSTRUCTION OR REPAIR
    • E01C11/00—Details of pavings
    • E01C11/16—Reinforcements
    • E01C11/165—Reinforcements particularly for bituminous or rubber- or plastic-bound pavings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Architecture (AREA)
  • Civil Engineering (AREA)
  • Structural Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
MEP-2007-219A 2004-04-13 2005-02-21 Postupak za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina ME01396B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0403830A FR2868777B1 (fr) 2004-04-13 2004-04-13 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
EP05290381A EP1589005B1 (fr) 2004-04-13 2005-02-21 Procédé de synthèse de l'ivabradine et de ses sels d'addition à un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
ME01396B true ME01396B (me) 2010-03-02

Family

ID=34941959

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2007-219A ME01396B (me) 2004-04-13 2005-02-21 Postupak za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina

Country Status (43)

Country Link
US (2) US7176197B2 (me)
EP (1) EP1589005B1 (me)
JP (2) JP4515934B2 (me)
KR (1) KR100677019B1 (me)
CN (1) CN1305856C (me)
AP (1) AP1821A (me)
AR (1) AR047745A1 (me)
AT (1) ATE358123T1 (me)
AU (1) AU2005200861B2 (me)
BR (1) BRPI0500585B8 (me)
CA (1) CA2496723C (me)
CO (1) CO5670092A1 (me)
CR (2) CR7691A (me)
CU (1) CU23465B7 (me)
CY (1) CY1106597T1 (me)
DE (1) DE602005000765T2 (me)
DK (1) DK1589005T3 (me)
EA (1) EA007745B1 (me)
EC (1) ECSP055610A (me)
ES (1) ES2285651T3 (me)
FR (1) FR2868777B1 (me)
GE (1) GEP20074138B (me)
HK (1) HK1080362B (me)
HR (1) HRP20070246T5 (me)
IL (1) IL167013A (me)
MA (1) MA27600A1 (me)
ME (1) ME01396B (me)
MX (1) MXPA05003694A (me)
MY (1) MY141194A (me)
NI (1) NI200500031A (me)
NO (1) NO329807B1 (me)
NZ (1) NZ538326A (me)
OA (1) OA12913A (me)
PL (1) PL1589005T3 (me)
PT (1) PT1589005E (me)
RS (1) RS50511B (me)
SA (1) SA05260016B1 (me)
SG (1) SG116575A1 (me)
SI (1) SI1589005T1 (me)
UA (1) UA80834C2 (me)
UY (1) UY28759A1 (me)
WO (1) WO2005110993A1 (me)
ZA (1) ZA200501466B (me)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2894826B1 (fr) * 2005-12-21 2010-10-22 Servier Lab Nouvelle association d'un inhibiteur du courant if sinusal et d'un inhibiteur calcique et les compositions pharmaceutiques qui la contiennent
EP2097383B1 (en) * 2006-11-30 2012-02-08 Cadila Healthcare Limited Process for preparation of ivabradine hydrochloride
WO2008125006A1 (fr) * 2007-04-12 2008-10-23 Utopharm (Shanghai) Co., Ltd Procédés de préparation du chlorhydrate d'ivabradine et de sa forme cristalline stable
PT2471780E (pt) 2007-05-30 2015-02-24 Ind Swift Lab Ltd Sais oxalato de ivabradina cristalinos e seus polimorfos
SI22750A (sl) * 2008-04-07 2009-10-31 Krka D.D. Ivabradin hidrobromid
FR2932800B1 (fr) 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2933975B1 (fr) 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) * 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
CN101723897B (zh) * 2008-10-31 2011-11-16 齐鲁制药有限公司 伊伐布雷定的合成方法
CN102264689B (zh) * 2008-12-22 2014-12-31 新梅斯托克尔卡公司 制备伊伐布雷定的方法
FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
CN101768117B (zh) * 2008-12-29 2014-05-07 北京德众万全药物技术开发有限公司 一种盐酸伊伐布雷定晶型及其制备方法
CN101768116B (zh) * 2008-12-29 2014-06-18 北京德众万全药物技术开发有限公司 一种伊伐布雷定的制备方法
FR2941695B1 (fr) * 2009-02-04 2011-02-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
ME00986B (me) 2009-03-31 2012-06-20 Servier Lab Novi postupak sinteze ivabradina i njegovih adicionih soli sa farmaceutski prihvatljivom kiselinom
FR2943667B1 (fr) * 2009-03-31 2011-05-06 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
WO2010128525A2 (en) 2009-05-04 2010-11-11 Dinesh Shantilal Patel A formulation of ivabradine for treating the cardiovascular disease
EP2534135A2 (en) 2010-02-12 2012-12-19 KRKA, D.D., Novo Mesto Novel forms of ivabradine hydrochloride
FR2956401B1 (fr) * 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2011104723A2 (en) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Acid addition salts of ivabradine and preparation thereof
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
TWI499587B (zh) * 2010-06-03 2015-09-11 Jiangsu Hengrui Medicine Co 硫酸伊伐佈雷定及其ｉ型結晶的製備方法
PT2579860E (pt) 2010-06-14 2014-05-30 Ratiopharm Gmbh Composição farmacêutica que contém ivabradina com libertação modificada
WO2012025940A1 (en) 2010-08-25 2012-03-01 Cadila Healthcare Limited Polymorphic form of ivabradine hydrochloride and process for preparation thereof
FR2971507B1 (fr) * 2011-02-14 2013-01-18 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CN102304088B (zh) * 2011-07-07 2013-06-19 石药集团欧意药业有限公司 一种伊伐布雷定化合物、制备方法及其药物组合物
WO2013017582A1 (en) 2011-08-02 2013-02-07 Sandoz Ag Acetone solvate of ivabradine hydrochloride
EP2589594A1 (en) * 2011-11-04 2013-05-08 Urquima S.A. Ivabradine hydrochloride Form IV
EP2773621B1 (en) 2011-11-04 2015-12-30 Synthon BV A process for making crystalline delta-form of ivabradine hydrochloride
US9120755B2 (en) 2011-11-14 2015-09-01 Cadila Healthcare Limited Polymorphic forms of ivabradine hydrochloride
FR2984319B1 (fr) * 2011-12-20 2013-12-27 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) * 2012-07-17 2014-10-31 Servier Lab Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
CN103012268B (zh) * 2013-01-05 2015-02-25 江苏宇田生物医药科技有限公司 一种伊伐布雷定制备方法
WO2014114341A1 (en) 2013-01-24 2014-07-31 Synthon Bv Process for making ivabradine
SI2781509T2 (sl) 2013-03-19 2023-10-30 Chemo Research, S.L. Novi polimorf ivabradin hidroklorida in postopek za njegovo pripravo
ITMI20130684A1 (it) * 2013-04-24 2014-10-25 Chemo Res S L Nuovo polimorfo del cloridrato di ivabradina e metodo per la sua preparazione
ITMI20130416A1 (it) * 2013-03-19 2014-09-20 Chemo Res S L Nuovo polimorfo del cloridrato di ivabradina e metodo per la sua preparazione
CZ2013767A3 (cs) 2013-10-02 2015-04-29 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (S)-mandlové kyseliny a její farmaceutická kompozice
ES2672472T3 (es) 2013-12-12 2018-06-14 Synthon Bv Composición farmacéutica que comprende ivabradina amorfa
CN103864690B (zh) * 2014-01-06 2016-09-14 北京莱瑞森医药科技有限公司 伊伐布雷定盐酸盐的s晶型、其制备方法和药物组合物
EP2774606B1 (en) 2014-02-14 2019-01-30 Synthon B.V. Pharmaceutical composition comprising ivabradine hydrochloride polymorph IV
CN103880748B (zh) * 2014-04-03 2015-09-16 南京正大天晴制药有限公司 一种盐酸伊伐布雷定结构类似物及其制备方法和应用
CZ2014478A3 (cs) 2014-07-10 2015-09-16 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice
WO2016102423A1 (en) 2014-12-22 2016-06-30 Ratiopharm Gmbh Composition comprising ivabradine in a dissolved form
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN107056706B (zh) * 2015-12-21 2020-05-05 江苏恒瑞医药股份有限公司 一种用于制备盐酸伊伐布雷定α晶型的方法
EP3366282A1 (en) 2017-02-28 2018-08-29 Sanovel Ilac Sanayi ve Ticaret A.S. Solid oral pharmaceutical compositions of ivabradine
TR201703066A2 (tr) 2017-02-28 2018-09-21 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi İvabradi̇ni̇n kati oral farmasöti̇k kompozi̇syonlari
WO2018196782A1 (en) 2017-04-27 2018-11-01 The University Of Hong Kong Use of hcn inhibitors for treatment of cancer
WO2020092288A1 (en) 2018-10-30 2020-05-07 Amgen Inc. Process of making ivabradine hydrochloride drug product
IT202000025312A1 (it) 2020-10-26 2022-04-26 Cambrex Profarmaco Milano S R L Processi per la preparazione di polimorfi di ivabradina hcl
CN115286577B (zh) * 2022-08-25 2023-10-20 江苏永安制药有限公司 一种盐酸伊伐布雷定及其中间体的制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119874A1 (de) 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
DE3418270A1 (de) 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3519735A1 (de) * 1985-06-01 1986-12-04 Dr. Karl Thomae Gmbh, 7950 Biberach Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2681862B1 (fr) 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
FR2834896B1 (fr) * 2002-01-23 2004-02-27 Servier Lab Composition pharmaceutique orodispersible d'ivabradine
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent

Also Published As

Publication number Publication date
HRP20070246T3 (en) 2007-08-31
AU2005200861A1 (en) 2005-10-27
CR11780A (es) 2010-12-09
ATE358123T1 (de) 2007-04-15
EA007745B1 (ru) 2006-12-29
BRPI0500585A (pt) 2005-11-16
US7867994B2 (en) 2011-01-11
HK1080362A1 (en) 2006-04-28
SA05260016B1 (ar) 2009-06-06
PL1589005T3 (pl) 2007-07-31
JP4848449B2 (ja) 2011-12-28
CN1305856C (zh) 2007-03-21
UY28759A1 (es) 2005-12-30
MXPA05003694A (es) 2006-01-24
JP2005298480A (ja) 2005-10-27
OA12913A (en) 2006-10-13
DK1589005T3 (da) 2007-07-30
CY1106597T1 (el) 2012-01-25
WO2005110993A1 (fr) 2005-11-24
AU2005200861B2 (en) 2010-07-15
KR100677019B1 (ko) 2007-02-01
AR047745A1 (es) 2006-02-15
AP2005003222A0 (en) 2005-03-31
ZA200501466B (en) 2005-11-30
NO20050884D0 (no) 2005-02-18
CR7691A (es) 2008-09-23
SI1589005T1 (sl) 2007-08-31
CU23465B7 (es) 2009-12-17
MA27600A1 (fr) 2005-11-01
CN1683341A (zh) 2005-10-19
SG116575A1 (en) 2005-11-28
RS50511B (sr) 2010-03-02
CA2496723C (fr) 2010-05-25
NO20050884L (no) 2005-10-14
FR2868777B1 (fr) 2006-05-26
CO5670092A1 (es) 2006-08-31
GEP20074138B (en) 2007-06-25
CA2496723A1 (fr) 2005-10-13
EP1589005B1 (fr) 2007-03-28
EP1589005A1 (fr) 2005-10-26
UA80834C2 (en) 2007-11-12
PT1589005E (pt) 2007-06-18
NI200500031A (es) 2006-05-25
FR2868777A1 (fr) 2005-10-14
IL167013A (en) 2011-08-31
KR20060042116A (ko) 2006-05-12
ECSP055610A (es) 2006-03-01
US20050228177A1 (en) 2005-10-13
US20070135411A1 (en) 2007-06-14
BRPI0500585B8 (pt) 2021-05-25
HK1080362B (zh) 2007-07-20
EA200500238A1 (ru) 2005-10-27
NO329807B1 (no) 2010-12-20
HRP20070246T5 (en) 2008-10-31
BRPI0500585B1 (pt) 2020-11-03
NZ538326A (en) 2005-11-25
JP4515934B2 (ja) 2010-08-04
MY141194A (en) 2010-03-31
US7176197B2 (en) 2007-02-13
DE602005000765T2 (de) 2008-01-10
JP2010047578A (ja) 2010-03-04
DE602005000765D1 (de) 2007-05-10
ES2285651T3 (es) 2007-11-16
AP1821A (en) 2008-01-21

Similar Documents

Publication Publication Date Title
ME01396B (me) Postupak za sintezu ivabradina i njegovih farmaceutski prihvatljivih aditivnih soli kiselina
SI1598333T1 (sl) Postopek za pripravo (1s)-4,5-dimetoksi-1-(metilaminometil)-benzociklobutana in njegovih adicijskih soli, kot tudi uporaba za sintezo ivabradina in njegovih adicijskih soli s farmacevtsko sprejemljivo kislino
ZA200501468B (en) Process for the synthesis of 1,3,4,5-tetrahydro-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
SI2086945T1 (sl) Novi postopek za pripravo statinov in njihovih farmacevtsko sprejemljivih soli
HK1145833A1 (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
IL226404A0 (en) A process for the synthesis of mendipropamide and its history
ZA200904316B (en) Process for the synthesis of 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
ZA200902451B (en) Process for the synthesis of derivatives of 3-amino-tetrahydrofuran-3-carboxylic acid and use thereof as medicaments
EP1883619A4 (en) PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRAFLUOROBENZYLANILINE COMPOUND AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
ZA200501467B (en) Process for the synthesis of 1,3-dihydro-2h-3-benzazepin-2-one compounds, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
SI1753720T1 (sl) Postopek za pripravo perindoprila in njegovih soli
ZA200902575B (en) Process for the synthesis of clopidogrel and new forms of pharmaceutically acceptable salts thereof
GB2441840B (en) Process for the synthesis of arylfluorenes and analogues thereof
HK1078878A1 (en) Process for the preparation of delta(15-16)-17-ketsteroids and use thereof in the synthesis of pharmacologically active compounds (15-16)-17-
SI1403275T1 (sl) Nov postopek sinteze perindoprila in njegovih farmacevtsko sprejemljivih soli