CY1106597T1 - Μεθοδος συνθεσης της ιβαβραδινης και των αλατων προσθηκης αυτης με φαρμακευτικως αποδεκτο οξυ - Google Patents

Μεθοδος συνθεσης της ιβαβραδινης και των αλατων προσθηκης αυτης με φαρμακευτικως αποδεκτο οξυ

Info

Publication number
CY1106597T1
CY1106597T1 CY20071100664T CY071100664T CY1106597T1 CY 1106597 T1 CY1106597 T1 CY 1106597T1 CY 20071100664 T CY20071100664 T CY 20071100664T CY 071100664 T CY071100664 T CY 071100664T CY 1106597 T1 CY1106597 T1 CY 1106597T1
Authority
CY
Cyprus
Prior art keywords
ivabradine
synthesis
pharmaceutically acceptable
acceptable acid
addition salts
Prior art date
Application number
CY20071100664T
Other languages
English (en)
Inventor
Jean-Michel Lerestif
Jean-Pierre Lecouve
Jean-Claude Souvie
Daniel Brigot
Stephane Horvath
Marie-Noelle Auguste
Gerard Damien
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34941959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1106597(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of CY1106597T1 publication Critical patent/CY1106597T1/el

Links

Classifications

    • E—FIXED CONSTRUCTIONS
    • E01—CONSTRUCTION OF ROADS, RAILWAYS, OR BRIDGES
    • E01C—CONSTRUCTION OF, OR SURFACES FOR, ROADS, SPORTS GROUNDS, OR THE LIKE; MACHINES OR AUXILIARY TOOLS FOR CONSTRUCTION OR REPAIR
    • E01C11/00—Details of pavings
    • E01C11/16—Reinforcements
    • E01C11/165—Reinforcements particularly for bituminous or rubber- or plastic-bound pavings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Architecture (AREA)
  • Civil Engineering (AREA)
  • Structural Engineering (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Μέθοδος σύνθεσης της ιβαβραδίνης του τύπου (I): των αλάτων αυτής από την προσθήκη με φαρμακευτικώς αποδεκτό οξύ και των ένυδρων αλάτων της. Κρυσταλλική μορφή α της υδροχλωρικής ιβαβραδίνης. Φάρμακα.
CY20071100664T 2004-04-13 2007-05-16 Μεθοδος συνθεσης της ιβαβραδινης και των αλατων προσθηκης αυτης με φαρμακευτικως αποδεκτο οξυ CY1106597T1 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0403830A FR2868777B1 (fr) 2004-04-13 2004-04-13 Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (1)

Publication Number Publication Date
CY1106597T1 true CY1106597T1 (el) 2012-01-25

Family

ID=34941959

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100664T CY1106597T1 (el) 2004-04-13 2007-05-16 Μεθοδος συνθεσης της ιβαβραδινης και των αλατων προσθηκης αυτης με φαρμακευτικως αποδεκτο οξυ

Country Status (43)

Country Link
US (2) US7176197B2 (el)
EP (1) EP1589005B1 (el)
JP (2) JP4515934B2 (el)
KR (1) KR100677019B1 (el)
CN (1) CN1305856C (el)
AP (1) AP1821A (el)
AR (1) AR047745A1 (el)
AT (1) ATE358123T1 (el)
AU (1) AU2005200861B2 (el)
BR (1) BRPI0500585B8 (el)
CA (1) CA2496723C (el)
CO (1) CO5670092A1 (el)
CR (2) CR7691A (el)
CU (1) CU23465B7 (el)
CY (1) CY1106597T1 (el)
DE (1) DE602005000765T2 (el)
DK (1) DK1589005T3 (el)
EA (1) EA007745B1 (el)
EC (1) ECSP055610A (el)
ES (1) ES2285651T3 (el)
FR (1) FR2868777B1 (el)
GE (1) GEP20074138B (el)
HK (1) HK1080362B (el)
HR (1) HRP20070246T5 (el)
IL (1) IL167013A (el)
MA (1) MA27600A1 (el)
ME (1) ME01396B (el)
MX (1) MXPA05003694A (el)
MY (1) MY141194A (el)
NI (1) NI200500031A (el)
NO (1) NO329807B1 (el)
NZ (1) NZ538326A (el)
OA (1) OA12913A (el)
PL (1) PL1589005T3 (el)
PT (1) PT1589005E (el)
RS (1) RS50511B (el)
SA (1) SA05260016B1 (el)
SG (1) SG116575A1 (el)
SI (1) SI1589005T1 (el)
UA (1) UA80834C2 (el)
UY (1) UY28759A1 (el)
WO (1) WO2005110993A1 (el)
ZA (1) ZA200501466B (el)

Families Citing this family (64)

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FR2868775B1 (fr) * 2004-04-13 2008-04-11 Servier Lab Nouveau procede de synthese de derives de la 1,3,4,5- tetrahydro-2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2868776B1 (fr) * 2004-04-13 2008-04-18 Servier Lab Nouveau procede de synthese de derives de la 1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2882554B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme critalline beta d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882553B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline beta du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882555B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2882556B1 (fr) * 2005-02-28 2007-05-04 Servier Lab Forme cristalline gamma d du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891827B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline deltad du chlorhydrate de l'ivabradine, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2891826B1 (fr) * 2005-10-11 2007-12-28 Servier Lab Forme cristalline 6 du chlorhydrate de l'ivabradine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
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SI22750A (sl) * 2008-04-07 2009-10-31 Krka D.D. Ivabradin hidrobromid
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2933975B1 (fr) 2008-07-17 2011-02-18 Servier Lab Nouveau procede de preparation de benzocyclobutenes fonctionnalises,et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
FR2935381B1 (fr) 2008-08-29 2010-12-17 Servier Lab Nouveau procede de resolution des enantiomerees du (3,4-dimethoxy-bicyclo°4.2.0!octa-1,3,5-trien-7-yl)nitrile et application a la synthese de l'ivabradine
CN101723897B (zh) * 2008-10-31 2011-11-16 齐鲁制药有限公司 伊伐布雷定的合成方法
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FR2940287B1 (fr) * 2008-12-24 2010-12-24 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
CN101768116B (zh) * 2008-12-29 2014-06-18 北京德众万全药物技术开发有限公司 一种伊伐布雷定的制备方法
CN101768117B (zh) * 2008-12-29 2014-05-07 北京德众万全药物技术开发有限公司 一种盐酸伊伐布雷定晶型及其制备方法
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FR2943667B1 (fr) * 2009-03-31 2011-05-06 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable.
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CN102304088B (zh) * 2011-07-07 2013-06-19 石药集团欧意药业有限公司 一种伊伐布雷定化合物、制备方法及其药物组合物
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FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2984319B1 (fr) * 2011-12-20 2013-12-27 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2986804A1 (fr) * 2012-02-09 2013-08-16 Servier Lab Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR2993561B1 (fr) * 2012-07-17 2014-10-31 Servier Lab Procede de synthese enzymatique de la (7s)-1-(3,4-dimethoxy bicyclo[4.2.0]octa-1,3,5-triene 7-yl) n-methyl methanamine, et application a la synthese de l'ivabradine et de ses sels
CN103848789B (zh) * 2012-11-29 2016-05-18 江苏恒瑞医药股份有限公司 一种伊伐布雷定的制备方法
CN103012268B (zh) * 2013-01-05 2015-02-25 江苏宇田生物医药科技有限公司 一种伊伐布雷定制备方法
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CN103864690B (zh) * 2014-01-06 2016-09-14 北京莱瑞森医药科技有限公司 伊伐布雷定盐酸盐的s晶型、其制备方法和药物组合物
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CN103880748B (zh) * 2014-04-03 2015-09-16 南京正大天晴制药有限公司 一种盐酸伊伐布雷定结构类似物及其制备方法和应用
CZ305436B6 (cs) 2014-07-10 2015-09-16 Zentiva, K.S. Pevná forma Ivabradin hydrochloridu a (R)-mandlové kyseliny a její farmaceutická kompozice
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CN107056706B (zh) * 2015-12-21 2020-05-05 江苏恒瑞医药股份有限公司 一种用于制备盐酸伊伐布雷定α晶型的方法
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Also Published As

Publication number Publication date
SG116575A1 (en) 2005-11-28
GEP20074138B (en) 2007-06-25
CU23465B7 (es) 2009-12-17
PT1589005E (pt) 2007-06-18
DE602005000765D1 (de) 2007-05-10
JP4515934B2 (ja) 2010-08-04
AU2005200861B2 (en) 2010-07-15
PL1589005T3 (pl) 2007-07-31
FR2868777A1 (fr) 2005-10-14
HK1080362B (zh) 2007-07-20
ECSP055610A (es) 2006-03-01
JP2005298480A (ja) 2005-10-27
CA2496723C (fr) 2010-05-25
HK1080362A1 (en) 2006-04-28
US20070135411A1 (en) 2007-06-14
KR100677019B1 (ko) 2007-02-01
CN1305856C (zh) 2007-03-21
CO5670092A1 (es) 2006-08-31
SI1589005T1 (sl) 2007-08-31
MXPA05003694A (es) 2006-01-24
US7867994B2 (en) 2011-01-11
BRPI0500585A (pt) 2005-11-16
NO20050884D0 (no) 2005-02-18
EA007745B1 (ru) 2006-12-29
CA2496723A1 (fr) 2005-10-13
NO20050884L (no) 2005-10-14
ME01396B (me) 2010-03-02
BRPI0500585B1 (pt) 2020-11-03
JP4848449B2 (ja) 2011-12-28
NO329807B1 (no) 2010-12-20
EA200500238A1 (ru) 2005-10-27
RS50511B (sr) 2010-03-02
JP2010047578A (ja) 2010-03-04
FR2868777B1 (fr) 2006-05-26
BRPI0500585B8 (pt) 2021-05-25
SA05260016B1 (ar) 2009-06-06
EP1589005B1 (fr) 2007-03-28
CR11780A (es) 2010-12-09
AP1821A (en) 2008-01-21
ATE358123T1 (de) 2007-04-15
HRP20070246T5 (en) 2008-10-31
US7176197B2 (en) 2007-02-13
DK1589005T3 (da) 2007-07-30
MA27600A1 (fr) 2005-11-01
ZA200501466B (en) 2005-11-30
HRP20070246T3 (en) 2007-08-31
NZ538326A (en) 2005-11-25
ES2285651T3 (es) 2007-11-16
AU2005200861A1 (en) 2005-10-27
IL167013A (en) 2011-08-31
UA80834C2 (en) 2007-11-12
AP2005003222A0 (en) 2005-03-31
OA12913A (en) 2006-10-13
NI200500031A (es) 2006-05-25
AR047745A1 (es) 2006-02-15
CN1683341A (zh) 2005-10-19
UY28759A1 (es) 2005-12-30
DE602005000765T2 (de) 2008-01-10
WO2005110993A1 (fr) 2005-11-24
KR20060042116A (ko) 2006-05-12
US20050228177A1 (en) 2005-10-13
EP1589005A1 (fr) 2005-10-26
CR7691A (es) 2008-09-23
MY141194A (en) 2010-03-31

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