DK2135861T3 - Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre - Google Patents

Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre

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Publication number
DK2135861T3
DK2135861T3 DK09290466.3T DK09290466T DK2135861T3 DK 2135861 T3 DK2135861 T3 DK 2135861T3 DK 09290466 T DK09290466 T DK 09290466T DK 2135861 T3 DK2135861 T3 DK 2135861T3
Authority
DK
Denmark
Prior art keywords
synthesis
ivabradine
benzazepin
dimethoxy
dihydro
Prior art date
Application number
DK09290466.3T
Other languages
English (en)
Other versions
DK2135861T4 (da
Inventor
Jean-Michel Lerestif
Jean-Pierre Lecouve
Daniel Brigot
Original Assignee
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
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Application filed by Servier Lab filed Critical Servier Lab
Application granted granted Critical
Publication of DK2135861T3 publication Critical patent/DK2135861T3/da
Publication of DK2135861T4 publication Critical patent/DK2135861T4/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
DK09290466.3T 2008-06-20 2009-06-19 Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre DK2135861T4 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0803452A FR2932800B1 (fr) 2008-06-20 2008-06-20 Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Publications (2)

Publication Number Publication Date
DK2135861T3 true DK2135861T3 (da) 2014-10-20
DK2135861T4 DK2135861T4 (da) 2021-03-22

Family

ID=40347797

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09290466.3T DK2135861T4 (da) 2008-06-20 2009-06-19 Fremgangsmåde til syntese af 7,8-dimethoxy-1,3-dihydro-2H-3-benzazepin-2-on og dets anvendelse ved syntese af ivabradin såvel som dets additionssalte med en farmaceutisk acceptabel syre

Country Status (36)

Country Link
US (1) US7928223B2 (da)
EP (1) EP2135861B2 (da)
JP (1) JP5216697B2 (da)
KR (1) KR101119296B1 (da)
CN (1) CN101607939B (da)
AR (1) AR072175A1 (da)
AU (1) AU2009202314B2 (da)
BR (1) BRPI0902105A2 (da)
CA (1) CA2668524C (da)
CL (1) CL2009001414A1 (da)
CY (1) CY1115623T1 (da)
DK (1) DK2135861T4 (da)
EA (1) EA017333B1 (da)
ES (1) ES2522625T5 (da)
FR (1) FR2932800B1 (da)
GE (1) GEP20125407B (da)
HK (1) HK1140188A1 (da)
HR (1) HRP20140928T4 (da)
JO (1) JO3806B1 (da)
MA (1) MA31071B1 (da)
ME (1) ME00814B (da)
MX (1) MX2009006288A (da)
MY (1) MY146245A (da)
NZ (1) NZ577540A (da)
PE (1) PE20100051A1 (da)
PL (1) PL2135861T5 (da)
PT (1) PT2135861E (da)
RS (1) RS53495B2 (da)
SA (1) SA109300396B1 (da)
SG (1) SG158026A1 (da)
SI (1) SI2135861T2 (da)
TW (1) TWI374134B (da)
UA (1) UA107779C2 (da)
UY (1) UY31883A (da)
WO (1) WO2009153461A2 (da)
ZA (1) ZA200904316B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5632279B2 (ja) * 2007-05-30 2014-11-26 アイエヌディー−スイフト ラボラトリーズ リミテッド 塩酸イバブラジンの調製方法及びポリモルフ
CN101774969B (zh) * 2009-01-13 2012-07-04 江苏恒瑞医药股份有限公司 硫酸伊伐布雷定及其i型结晶的制备方法
EP2902384B1 (en) 2010-02-12 2017-11-08 KRKA, D.D., Novo Mesto Form of ivabradine hydrochloride
FR2956401B1 (fr) 2010-02-17 2012-02-03 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
WO2011104723A2 (en) * 2010-02-23 2011-09-01 Ind-Swift Laboratories Limited Acid addition salts of ivabradine and preparation thereof
HUP1000245A2 (en) * 2010-05-07 2011-11-28 Richter Gedeon Nyrt Industrial process for the production ivabradin salts
FR2984320B1 (fr) * 2011-12-20 2013-11-29 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
FR3003859B1 (fr) * 2013-03-26 2015-03-13 Servier Lab "procede de synthese de derives de la 7,8-dimethoxy-1,3-dihydro-2h-3-benzazepin-2-one et application a la synthese de l'ivabradine"
HU230826B1 (hu) * 2014-11-19 2018-07-30 Richter Gedeon Nyrt. Eljárás benzazepin származékok előállítására
EP3101010A1 (en) 2015-06-03 2016-12-07 Urquima S.A. New method for the preparation of highly pure ivabradine base and salts thereof
CN108424389A (zh) * 2017-02-13 2018-08-21 浙江京新药业股份有限公司 一种伊伐布雷定杂质的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
ZA84758B (en) * 1983-02-04 1985-09-25 Lilly Co Eli Benzazepines
DE3343801A1 (de) * 1983-12-03 1985-06-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418271A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3418270A1 (de) * 1984-05-17 1985-11-21 Dr. Karl Thomae Gmbh, 7950 Biberach Neue aminotetralinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
EP0204349A3 (de) * 1985-06-01 1990-01-03 Dr. Karl Thomae GmbH Neue heteroaromatische Aminderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
FR2681862B1 (fr) * 1991-09-27 1993-11-12 Adir Cie Nouvelles (benzocycloalkyl)alkylamines, leur procede de preparation, et les compositions pharmaceutiques qui les contiennent.
UA77165C2 (en) * 2000-11-17 2006-11-15 Lilly Co Eli (n)-((s)-2-hydroxy-3-methyl-butyryl)-1-(l-alaninyl)-(s)-1-amino-3-methyl-4,5,6,7-tetrahydro-2h-3-benzazepin-2-one dihydrate, processes for manufacturing and pharmaceutical composition
JPWO2002074746A1 (ja) * 2001-03-16 2004-07-08 山之内製薬株式会社 ベンゾアゼピン誘導体
CN100441188C (zh) * 2003-10-23 2008-12-10 弗·哈夫曼-拉罗切有限公司 作为mao－b抑制剂的苯并氮杂衍生物
FR2868777B1 (fr) * 2004-04-13 2006-05-26 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
CA2615403C (en) * 2005-07-15 2015-06-16 Amr Technology, Inc. Aryl-and heteroaryl-substituted tetrahydrobenzazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Also Published As

Publication number Publication date
SI2135861T1 (sl) 2014-10-30
CN101607939B (zh) 2012-05-02
CL2009001414A1 (es) 2010-06-04
EA200900707A1 (ru) 2010-04-30
PT2135861E (pt) 2014-09-02
FR2932800A1 (fr) 2009-12-25
ES2522625T3 (es) 2014-11-17
HRP20140928T1 (en) 2014-11-21
MX2009006288A (es) 2010-02-17
CA2668524A1 (fr) 2009-12-20
BRPI0902105A2 (pt) 2010-04-13
SI2135861T2 (sl) 2021-04-30
HRP20140928T4 (hr) 2021-03-05
CY1115623T1 (el) 2017-01-04
RS53495B1 (en) 2015-02-27
FR2932800B1 (fr) 2015-02-20
EP2135861A1 (fr) 2009-12-23
WO2009153461A3 (fr) 2010-04-29
HK1140188A1 (en) 2010-10-08
US7928223B2 (en) 2011-04-19
AU2009202314A1 (en) 2010-01-14
EP2135861B2 (fr) 2020-12-16
GEP20125407B (en) 2012-02-27
AR072175A1 (es) 2010-08-11
AU2009202314B2 (en) 2013-01-24
PL2135861T5 (pl) 2022-07-18
PE20100051A1 (es) 2010-02-06
EP2135861B1 (fr) 2014-07-30
UY31883A (es) 2010-01-29
ES2522625T5 (es) 2021-07-29
RS53495B2 (sr) 2021-02-26
TWI374134B (en) 2012-10-11
DK2135861T4 (da) 2021-03-22
MY146245A (en) 2012-07-31
CN101607939A (zh) 2009-12-23
JP2010006807A (ja) 2010-01-14
ME00814B (me) 2012-03-20
CA2668524C (fr) 2012-09-11
JP5216697B2 (ja) 2013-06-19
NZ577540A (en) 2010-10-29
US20090318682A1 (en) 2009-12-24
EA017333B1 (ru) 2012-11-30
PL2135861T3 (pl) 2014-11-28
SA109300396B1 (ar) 2013-09-08
MA31071B1 (fr) 2010-01-04
KR20090132544A (ko) 2009-12-30
JO3806B1 (ar) 2021-01-31
TW201002671A (en) 2010-01-16
WO2009153461A2 (fr) 2009-12-23
SG158026A1 (en) 2010-01-29
KR101119296B1 (ko) 2012-03-15
UA107779C2 (en) 2015-02-25
ZA200904316B (en) 2010-05-26

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