DK158348C - Terapeutisk virksomme n-substituerede 4-oxypiperidinderivater samt farmaceutisk praeparat med indhold heraf - Google Patents

Terapeutisk virksomme n-substituerede 4-oxypiperidinderivater samt farmaceutisk praeparat med indhold heraf

Info

Publication number
DK158348C
DK158348C DK378784A DK378784A DK158348C DK 158348 C DK158348 C DK 158348C DK 378784 A DK378784 A DK 378784A DK 378784 A DK378784 A DK 378784A DK 158348 C DK158348 C DK 158348C
Authority
DK
Denmark
Prior art keywords
group
atom
alkyl group
lower alkyl
substituted
Prior art date
Application number
DK378784A
Other languages
Danish (da)
English (en)
Other versions
DK378784A (da
DK378784D0 (da
DK158348B (da
Inventor
Jose Manuel Prieto Soto
Armando Vega Noverola
Jacinto Moragues Mauri
Robert Geoffrey Willi Spickett
Original Assignee
Fordonal Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10546879&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK158348(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Fordonal Sa filed Critical Fordonal Sa
Publication of DK378784D0 publication Critical patent/DK378784D0/da
Publication of DK378784A publication Critical patent/DK378784A/da
Publication of DK158348B publication Critical patent/DK158348B/da
Application granted granted Critical
Publication of DK158348C publication Critical patent/DK158348C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK378784A 1983-08-05 1984-08-03 Terapeutisk virksomme n-substituerede 4-oxypiperidinderivater samt farmaceutisk praeparat med indhold heraf DK158348C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8321157 1983-08-05
GB838321157A GB8321157D0 (en) 1983-08-05 1983-08-05 Piperidine derivatives

Publications (4)

Publication Number Publication Date
DK378784D0 DK378784D0 (da) 1984-08-03
DK378784A DK378784A (da) 1985-02-06
DK158348B DK158348B (da) 1990-05-07
DK158348C true DK158348C (da) 1990-10-08

Family

ID=10546879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK378784A DK158348C (da) 1983-08-05 1984-08-03 Terapeutisk virksomme n-substituerede 4-oxypiperidinderivater samt farmaceutisk praeparat med indhold heraf

Country Status (22)

Country Link
US (1) US4550116A (es)
EP (1) EP0134124B1 (es)
JP (1) JPS6094962A (es)
KR (1) KR910009937B1 (es)
AT (1) ATE30418T1 (es)
AU (1) AU565293B2 (es)
CA (1) CA1264324A (es)
DE (2) DE19875026I2 (es)
DK (1) DK158348C (es)
EG (1) EG16936A (es)
ES (5) ES8507128A1 (es)
FI (1) FI81567C (es)
GB (1) GB8321157D0 (es)
GR (1) GR80031B (es)
HU (1) HU196370B (es)
IL (1) IL72465A (es)
MX (2) MX156547A (es)
MY (1) MY101017A (es)
NZ (1) NZ209023A (es)
PH (1) PH19880A (es)
PT (1) PT79028B (es)
ZA (1) ZA845968B (es)

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US4766215A (en) * 1987-02-27 1988-08-23 American Home Products Corporation Histamine H1 -receptor antagonists
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
US5231104A (en) * 1988-07-08 1993-07-27 Pfizer Inc. 1-arylethyl-3-substituted piperidines
CA2015949A1 (en) * 1989-05-22 1990-11-22 Yasuo Ito Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same
FR2655649B1 (fr) * 1989-12-12 1994-07-08 Adir Nouveaux derives de la piperidine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
DE4034218A1 (de) * 1990-10-27 1992-04-30 Merck Patent Gmbh Verfahren zur herstellung von carebastin
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FR2673842B1 (fr) * 1991-03-13 1993-12-24 Rhone Poulenc Rorer Sa Nouvelles compositions liquides a base de derives de la piperidine substitues en 1,4.
US5190959A (en) * 1991-08-08 1993-03-02 Kaken Pharmaceutical Co. Ltd. Piperidine compounds which have useful pharmaceutical activity
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DE69415319T2 (de) * 1993-06-24 1999-06-10 Albany Molecular Research, Inc., Albany, N.Y. Verfahren zur herstellung von piperidinderivaten
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
ATE230395T1 (de) 1993-06-25 2003-01-15 Merrell Pharma Inc Neue zwischenprodukte für die herstellung von antihistaminschen 4- diphenylmethyl/diphenylmethoxypiperidin-derivat n
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US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6153754A (en) 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5922737A (en) * 1996-02-21 1999-07-13 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-Benzimidazol-2-YL-amino) piperidin-1-YL)-2-(arlyl) butyl) benzamides useful for the treatment of allergic diseases
US5998439A (en) 1996-02-21 1999-12-07 Hoescht Marion Roussel, Inc. Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) * 1996-02-21 1999-08-03 Hoechst Marion Roussel, Inc. Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US6541479B1 (en) 1997-12-02 2003-04-01 Massachusetts College Of Pharmacy Calcium channel blockers
US6683094B2 (en) 1998-07-02 2004-01-27 Aventis Pharmaceuticals Inc. Antihistaminic piperidine derivatives and intermediates for the preparation thereof
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US20070059371A1 (en) * 2005-06-09 2007-03-15 Elan Pharma International, Limited Nanoparticulate ebastine formulations
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US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment
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WO2013062498A1 (en) * 2011-10-13 2013-05-02 Mahmut Bilgic Solid oral formulations comprising ebastine
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CN109593058B (zh) * 2019-01-23 2021-09-24 江苏联环药业股份有限公司 一种依巴斯汀的制备方法
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CN112574097B (zh) * 2020-12-21 2023-01-03 杭州仟源保灵药业有限公司 Ebastine及其富马酸盐的制备方法
CN114014796A (zh) * 2021-11-16 2022-02-08 江苏联环药业股份有限公司 一类依巴斯汀的盐及其制备方法和应用
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Also Published As

Publication number Publication date
JPH0432821B2 (es) 1992-06-01
ES8505979A1 (es) 1985-06-16
ES534436A0 (es) 1985-09-01
DK378784A (da) 1985-02-06
FI81567C (fi) 1990-11-12
GR80031B (en) 1984-12-11
ES534439A0 (es) 1985-09-01
GB8321157D0 (en) 1983-09-07
US4550116A (en) 1985-10-29
EG16936A (en) 1994-02-28
EP0134124A1 (en) 1985-03-13
IL72465A0 (en) 1984-11-30
HUT34446A (en) 1985-03-28
IL72465A (en) 1988-08-31
ES534438A0 (es) 1985-07-01
DE3466982D1 (en) 1987-12-03
ES534437A0 (es) 1985-07-16
ES534435A0 (es) 1985-06-16
MX9203149A (es) 1992-07-01
FI843053A0 (fi) 1984-08-02
ES8505980A1 (es) 1985-07-01
ES8507128A1 (es) 1985-09-01
DK378784D0 (da) 1984-08-03
AU3146584A (en) 1985-02-14
MX156547A (es) 1988-09-06
HU196370B (en) 1988-11-28
MY101017A (en) 1991-06-29
FI81567B (fi) 1990-07-31
NZ209023A (en) 1988-02-29
JPS6094962A (ja) 1985-05-28
PT79028B (en) 1986-08-22
KR910009937B1 (ko) 1991-12-06
FI843053A (fi) 1985-02-06
PH19880A (en) 1986-08-13
ATE30418T1 (de) 1987-11-15
PT79028A (en) 1984-09-01
ES8507127A1 (es) 1985-09-01
ES8506298A1 (es) 1985-07-16
ZA845968B (en) 1985-03-27
EP0134124B1 (en) 1987-10-28
CA1264324A (en) 1990-01-09
DK158348B (da) 1990-05-07
DE19875026I2 (de) 2002-01-31
AU565293B2 (en) 1987-09-10
KR850001902A (ko) 1985-04-10

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