DK1522539T3 - Krystallinsk komposition indeholdende excitalopram - Google Patents
Krystallinsk komposition indeholdende excitalopramInfo
- Publication number
- DK1522539T3 DK1522539T3 DK04029282T DK04029282T DK1522539T3 DK 1522539 T3 DK1522539 T3 DK 1522539T3 DK 04029282 T DK04029282 T DK 04029282T DK 04029282 T DK04029282 T DK 04029282T DK 1522539 T3 DK1522539 T3 DK 1522539T3
- Authority
- DK
- Denmark
- Prior art keywords
- excitalopram
- composition containing
- crystalline composition
- crystalline
- containing excitalopram
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101164 | 2001-07-31 | ||
| PCT/DK2002/000513 WO2003011278A1 (en) | 2001-07-31 | 2002-07-25 | Crystalline composition containing escitalopram |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1522539T3 true DK1522539T3 (da) | 2007-05-07 |
Family
ID=8160647
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04029282T DK1522539T3 (da) | 2001-07-31 | 2002-07-25 | Krystallinsk komposition indeholdende excitalopram |
| DK02750846T DK1414435T3 (da) | 2001-07-31 | 2002-07-25 | Krystallinsk komposition indeholdende escitalopram |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02750846T DK1414435T3 (da) | 2001-07-31 | 2002-07-25 | Krystallinsk komposition indeholdende escitalopram |
Country Status (40)
| Country | Link |
|---|---|
| US (3) | US6916941B2 (pt) |
| EP (2) | EP1414435B1 (pt) |
| JP (4) | JP2005525993A (pt) |
| KR (1) | KR20040028947A (pt) |
| CN (2) | CN1311819C (pt) |
| AR (1) | AR034898A1 (pt) |
| AT (2) | ATE286730T1 (pt) |
| AU (1) | AU2002355624B2 (pt) |
| BG (1) | BG108571A (pt) |
| BR (1) | BR0206164A (pt) |
| CA (1) | CA2451915C (pt) |
| CO (1) | CO5560540A2 (pt) |
| CY (1) | CY1106413T1 (pt) |
| DE (2) | DE60202615T2 (pt) |
| DK (2) | DK1522539T3 (pt) |
| EA (1) | EA006213B1 (pt) |
| EG (1) | EG24206A (pt) |
| ES (2) | ES2233842T3 (pt) |
| HK (1) | HK1070000A1 (pt) |
| HR (2) | HRP20031073A2 (pt) |
| HU (1) | HUP0401946A2 (pt) |
| IL (2) | IL159326A0 (pt) |
| IS (1) | IS7077A (pt) |
| MA (1) | MA27349A1 (pt) |
| ME (1) | MEP2108A (pt) |
| MX (1) | MXPA04000849A (pt) |
| MY (1) | MY126238A (pt) |
| NO (1) | NO328346B1 (pt) |
| NZ (1) | NZ530157A (pt) |
| PE (1) | PE20030304A1 (pt) |
| PL (1) | PL366995A1 (pt) |
| PT (2) | PT1522539E (pt) |
| RS (1) | RS8304A (pt) |
| SI (1) | SI1414435T1 (pt) |
| TN (1) | TNSN04021A1 (pt) |
| TR (1) | TR200400189T2 (pt) |
| UA (1) | UA79930C2 (pt) |
| UY (1) | UY27404A1 (pt) |
| WO (1) | WO2003011278A1 (pt) |
| ZA (1) | ZA200309684B (pt) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2291129C (en) | 1999-04-14 | 2002-10-22 | H. Lundbeck A/S | Method for the preparation of citalopram |
| US20030232881A1 (en) * | 2000-10-27 | 2003-12-18 | H. Lundbeck A/S | Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them |
| US20030109577A1 (en) * | 2000-10-27 | 2003-06-12 | Ken Liljegren | Pharmaceutical composition containing citalopram |
| ES2233842T3 (es) * | 2001-07-31 | 2005-06-16 | H. Lundbeck A/S | Composicion cristalina que contiene escitalopram. |
| PE20040991A1 (es) | 2002-08-12 | 2004-12-27 | Lundbeck & Co As H | Separacion de intermediarios para la preparacion de escitalopram |
| AU2003223105A1 (en) * | 2003-03-24 | 2004-10-18 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| US20040265375A1 (en) * | 2003-04-16 | 2004-12-30 | Platteeuw Johannes J. | Orally disintegrating tablets |
| TWI339651B (en) * | 2004-02-12 | 2011-04-01 | Lundbeck & Co As H | Method for the separation of intermediates which may be used for the preparation of escitalopram |
| BRPI0508266A (pt) * | 2004-03-05 | 2007-07-31 | Lundbeck & Co As H | partìculas cristalinas de oxalato de escitalopram, forma de dosagem única sólida, e, métodos para a fabricação de partìculas cristalinas de oxalato de escitalopram e para reduzir a quantidade de hidroxila que contém impurezas no citalopram, escitalopram ou uma mistura não racêmica de r- e s-citalopram |
| US20050196453A1 (en) | 2004-03-05 | 2005-09-08 | H. Lundbeck A/S | Crystalline composition containing escitalopram |
| EP1901714A2 (en) * | 2005-05-20 | 2008-03-26 | Aurobindo Pharma Limited | Pharmaceutical dosage forms comprising escitalopram in form of granules |
| US7834201B2 (en) | 2005-06-22 | 2010-11-16 | H. Lundbeck A/S | Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base |
| TWI358407B (en) * | 2005-06-22 | 2012-02-21 | Lundbeck & Co As H | Crystalline base of escitalopram and orodispersibl |
| KR20070067173A (ko) * | 2005-08-29 | 2007-06-27 | 테바 파마슈티컬 인더스트리즈 리미티드 | 이정점 입도 분포를 갖는 고체 미립자 타달라필 |
| CA2625835A1 (en) | 2005-10-14 | 2007-05-10 | Forest Laboratories, Inc. | Methods of treating central nervous system disorders with a low dose combination of escitalopram and bupropion |
| US20070134322A1 (en) * | 2005-12-14 | 2007-06-14 | Forest Laboratories, Inc. | Modified and pulsatile release pharmaceutical formulations of escitalopram |
| GB0601286D0 (en) | 2006-01-23 | 2006-03-01 | Sandoz Ag | Asymmetric synthesis |
| WO2008059514A2 (en) * | 2006-07-31 | 2008-05-22 | Cadila Healthcare Limited | Process for preparing escitalopram |
| WO2008046617A1 (en) * | 2006-10-20 | 2008-04-24 | Ratiopharm Gmbh | Escitalopram and solid pharmaceutical composition comprising the same |
| US20090048336A1 (en) * | 2007-08-17 | 2009-02-19 | Naveen Kumar Kolla | Escitalopram oxalate powders |
| EP2291177A2 (en) * | 2008-05-05 | 2011-03-09 | Farmaprojects, S.A. | Stable pharmaceutical compositions and their processes for preparation suitable for industrial scale |
| EP2116231A1 (en) | 2008-05-07 | 2009-11-11 | Hexal Ag | Granulate comprising escitalopram oxalate |
| GR20080100696A (el) | 2008-10-23 | 2010-05-13 | Genepharm �.�. | Φαρμακοτεχνικη μορφη με βελτιωμενη γευση του φαρμακευτικα αποδεκτου αλατος εσιταλοπραμης |
| ITMI20120106A1 (it) * | 2012-01-30 | 2013-07-31 | Carthesia S A S | Pastiglie liofilizzate di escitalopram ossalato per somministrazione sublinguale |
| ITMI20120448A1 (it) * | 2012-01-30 | 2013-07-31 | Carthesia Sas | Composizione liofilizzata di escitalopram ossalato per somministrazione sublinguale |
| CN106397248A (zh) * | 2015-08-03 | 2017-02-15 | 深圳信立泰药业股份有限公司 | 一种lcz696结晶粉末及其制备方法 |
| JP2018016569A (ja) * | 2016-07-26 | 2018-02-01 | 株式会社トクヤマ | （１ｓ）−１−［３−（ジメチルアミノ）プロピル］−１−（４−フルオロフェニル）−１，３−ジヒドロイソベンゾフラン−５−カルボニトリル蓚酸塩の製造方法 |
| WO2018190294A1 (ja) * | 2017-04-10 | 2018-10-18 | 東和薬品株式会社 | エスシタロプラム医薬組成物 |
| CN107441052A (zh) * | 2017-06-21 | 2017-12-08 | 山东京卫制药有限公司 | 一种含有草酸艾司西酞普兰的片剂及其制备方法 |
| KR102089737B1 (ko) | 2017-11-01 | 2020-03-16 | 한국화학연구원 | 에씨탈로프람을 함유한 미립구형 서방출 주사제 및 그의 제조방법 |
| JP7453859B2 (ja) | 2020-06-22 | 2024-03-21 | 東和薬品株式会社 | エスシタロプラム錠剤 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1143703A (pt) | 1965-03-18 | |||
| GB1358915A (en) | 1971-09-13 | 1974-07-03 | Merck & Co Inc | Directly compressed tablet and composition therefor |
| GB1526331A (en) * | 1976-01-14 | 1978-09-27 | Kefalas As | Phthalanes |
| GB8419963D0 (en) | 1984-08-06 | 1984-09-12 | Lundbeck & Co As H | Intermediate compound and method |
| EP0223403B1 (en) | 1985-10-25 | 1993-08-04 | Beecham Group Plc | Piperidine derivative, its preparation, and its use as medicament |
| GB8814057D0 (en) * | 1988-06-14 | 1988-07-20 | Lundbeck & Co As H | New enantiomers & their isolation |
| US5296507A (en) | 1990-09-06 | 1994-03-22 | H.Lundbeck A/S | Treatment of cerbrovascular disorders |
| GB9325644D0 (en) | 1993-12-15 | 1994-02-16 | Smithkline Beecham Plc | Novel formulation |
| US5683720A (en) | 1994-10-28 | 1997-11-04 | Fuisz Technologies Ltd. | Liquiflash particles and method of making same |
| EP0714663A3 (en) | 1994-11-28 | 1997-01-15 | Lilly Co Eli | Potentiation of drug responses by serotonin 1A receptor antagonists |
| WO1996041633A1 (en) | 1995-06-08 | 1996-12-27 | Eli Lilly And Company | Methods of treating cold and allergic rhinitis |
| NZ501737A (en) | 1997-07-08 | 2001-10-26 | H | Method for the preparation of citalopram using Grignard reagent 4-halogen-fluorophenyl and 3-halogen-N,N-dimethyl-propylamine |
| GB9714841D0 (en) | 1997-07-14 | 1997-09-17 | Smithkline Beecham Plc | Treatment method |
| US5980941A (en) | 1997-08-20 | 1999-11-09 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
| US5869098A (en) | 1997-08-20 | 1999-02-09 | Fuisz Technologies Ltd. | Fast-dissolving comestible units formed under high-speed/high-pressure conditions |
| US5840334A (en) | 1997-08-20 | 1998-11-24 | Fuisz Technologies Ltd. | Self-binding shearform compositions |
| UA62985C2 (en) | 1997-11-10 | 2004-01-15 | Lunnbeck As H | A method for the preparation of citalopram |
| EA002770B1 (ru) | 1997-11-11 | 2002-08-29 | Х.Лундбекк А/С | Способ получения циталопрама |
| PL199423B1 (pl) | 1998-10-20 | 2008-09-30 | Lundbeck & Co As H | Sposób wytwarzania citalopramu |
| TWI230618B (en) * | 1998-12-15 | 2005-04-11 | Gilead Sciences Inc | Pharmaceutical compositions of 9-[2-[[bis[(pivaloyloxy)methyl]phosphono]methoxy]ethyl]adenine and tablets or capsules containing the same |
| CA2291129C (en) | 1999-04-14 | 2002-10-22 | H. Lundbeck A/S | Method for the preparation of citalopram |
| ITMI991579A1 (it) | 1999-06-25 | 2001-01-15 | Lundbeck & Co As H | Metodo per la preparazione di citalopram |
| AR021155A1 (es) | 1999-07-08 | 2002-06-12 | Lundbeck & Co As H | Tratamiento de desordenes neuroticos |
| CA2385749A1 (en) * | 1999-09-28 | 2001-04-05 | H. Lundbeck A/S | Melt granulated composition and modified release dosage form prepared from said composition |
| GB2357762B (en) | 2000-03-13 | 2002-01-30 | Lundbeck & Co As H | Crystalline base of citalopram |
| US6977306B2 (en) | 2000-05-02 | 2005-12-20 | Sumitomo Chemical Company, Limited | Citalopram hydrobromide crystal and method for crystallization thereof |
| US20030232881A1 (en) * | 2000-10-27 | 2003-12-18 | H. Lundbeck A/S | Crystals of pharmaceutically acceptable salts of citalopram, methods of crystallization, and pharmaceutical compositions comprising them |
| ES2233842T3 (es) * | 2001-07-31 | 2005-06-16 | H. Lundbeck A/S | Composicion cristalina que contiene escitalopram. |
-
2002
- 2002-07-25 ES ES02750846T patent/ES2233842T3/es not_active Expired - Lifetime
- 2002-07-25 PT PT04029282T patent/PT1522539E/pt unknown
- 2002-07-25 CN CNB028150317A patent/CN1311819C/zh not_active Expired - Lifetime
- 2002-07-25 ZA ZA200309684A patent/ZA200309684B/xx unknown
- 2002-07-25 CA CA2451915A patent/CA2451915C/en not_active Expired - Fee Related
- 2002-07-25 UA UA20031212659A patent/UA79930C2/uk unknown
- 2002-07-25 DE DE60202615T patent/DE60202615T2/de not_active Revoked
- 2002-07-25 AU AU2002355624A patent/AU2002355624B2/en not_active Ceased
- 2002-07-25 DK DK04029282T patent/DK1522539T3/da active
- 2002-07-25 DK DK02750846T patent/DK1414435T3/da active
- 2002-07-25 RS YU8304A patent/RS8304A/sr unknown
- 2002-07-25 SI SI200230091T patent/SI1414435T1/xx unknown
- 2002-07-25 ES ES04029282T patent/ES2280892T3/es not_active Expired - Lifetime
- 2002-07-25 DE DE60217932T patent/DE60217932T2/de not_active Revoked
- 2002-07-25 EA EA200400243A patent/EA006213B1/ru not_active IP Right Cessation
- 2002-07-25 IL IL15932602A patent/IL159326A0/xx unknown
- 2002-07-25 AT AT02750846T patent/ATE286730T1/de active
- 2002-07-25 KR KR10-2004-7001140A patent/KR20040028947A/ko not_active Application Discontinuation
- 2002-07-25 TR TR2004/00189T patent/TR200400189T2/xx unknown
- 2002-07-25 EP EP02750846A patent/EP1414435B1/en not_active Revoked
- 2002-07-25 ME MEP-21/08A patent/MEP2108A/xx unknown
- 2002-07-25 EP EP04029282A patent/EP1522539B1/en not_active Revoked
- 2002-07-25 HU HU0401946A patent/HUP0401946A2/hu unknown
- 2002-07-25 NZ NZ530157A patent/NZ530157A/en not_active IP Right Cessation
- 2002-07-25 WO PCT/DK2002/000513 patent/WO2003011278A1/en active Application Filing
- 2002-07-25 PL PL02366995A patent/PL366995A1/xx unknown
- 2002-07-25 MX MXPA04000849A patent/MXPA04000849A/es active IP Right Grant
- 2002-07-25 BR BR0206164-3A patent/BR0206164A/pt not_active Application Discontinuation
- 2002-07-25 AR ARP020102808A patent/AR034898A1/es unknown
- 2002-07-25 PT PT02750846T patent/PT1414435E/pt unknown
- 2002-07-25 AT AT04029282T patent/ATE352546T1/de not_active IP Right Cessation
- 2002-07-25 JP JP2003516508A patent/JP2005525993A/ja active Pending
- 2002-07-25 CN CN2004100941660A patent/CN1660074A/zh active Pending
- 2002-07-26 PE PE2002000675A patent/PE20030304A1/es not_active Application Discontinuation
- 2002-07-28 EG EG2002070849A patent/EG24206A/xx active
- 2002-07-30 UY UY27404A patent/UY27404A1/es not_active Application Discontinuation
- 2002-07-30 MY MYPI20022871A patent/MY126238A/en unknown
-
2003
- 2003-03-31 US US10/403,453 patent/US6916941B2/en not_active Expired - Lifetime
- 2003-12-11 IL IL159326A patent/IL159326A/en unknown
- 2003-12-15 IS IS7077A patent/IS7077A/is unknown
- 2003-12-23 HR HR20031073A patent/HRP20031073A2/xx not_active Application Discontinuation
-
2004
- 2004-01-27 TN TNP2004000021A patent/TNSN04021A1/en unknown
- 2004-01-28 NO NO20040380A patent/NO328346B1/no not_active IP Right Cessation
- 2004-02-04 MA MA27512A patent/MA27349A1/fr unknown
- 2004-02-09 BG BG108571A patent/BG108571A/xx unknown
- 2004-02-25 CO CO04016758A patent/CO5560540A2/es not_active Application Discontinuation
-
2005
- 2005-02-07 US US11/053,641 patent/US7420069B2/en not_active Expired - Lifetime
- 2005-04-04 HK HK05102804A patent/HK1070000A1/xx not_active IP Right Cessation
-
2007
- 2007-03-23 CY CY20071100411T patent/CY1106413T1/el unknown
-
2008
- 2008-08-22 HR HR20080410A patent/HRPK20080410B3/xx not_active IP Right Cessation
- 2008-08-22 US US12/196,812 patent/US20080305164A1/en not_active Abandoned
-
2010
- 2010-03-16 JP JP2010059368A patent/JP4971477B2/ja not_active Expired - Lifetime
-
2011
- 2011-05-30 JP JP2011120483A patent/JP5192568B2/ja not_active Expired - Lifetime
-
2012
- 2012-07-26 JP JP2012166170A patent/JP5719811B2/ja not_active Expired - Lifetime
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