DK149615B - Fremgangsmaade til fremstilling af humaninsulin, hvori pheb1 eventuelt er fraspaltet, og som eventuelt baerer beskyttelsesgrupper - Google Patents

Fremgangsmaade til fremstilling af humaninsulin, hvori pheb1 eventuelt er fraspaltet, og som eventuelt baerer beskyttelsesgrupper Download PDF

Info

Publication number
DK149615B
DK149615B DK16682A DK16682A DK149615B DK 149615 B DK149615 B DK 149615B DK 16682 A DK16682 A DK 16682A DK 16682 A DK16682 A DK 16682A DK 149615 B DK149615 B DK 149615B
Authority
DK
Denmark
Prior art keywords
insulin
human insulin
optionally
trypsin
process according
Prior art date
Application number
DK16682A
Other languages
Danish (da)
English (en)
Other versions
DK16682A (da
Inventor
Rainer Obermeier
Juergen Ludwig
Gerhard Seipke
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK16682A publication Critical patent/DK16682A/da
Publication of DK149615B publication Critical patent/DK149615B/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK16682A 1981-01-17 1982-01-15 Fremgangsmaade til fremstilling af humaninsulin, hvori pheb1 eventuelt er fraspaltet, og som eventuelt baerer beskyttelsesgrupper DK149615B (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3101382 1981-01-17
DE19813101382 DE3101382A1 (de) 1981-01-17 1981-01-17 "verfahren zur herstellung von humanisulin oder dessen derivaten aus schweineinsulin oder dessen derivaten"

Publications (2)

Publication Number Publication Date
DK16682A DK16682A (da) 1982-07-18
DK149615B true DK149615B (da) 1986-08-11

Family

ID=6122819

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16682A DK149615B (da) 1981-01-17 1982-01-15 Fremgangsmaade til fremstilling af humaninsulin, hvori pheb1 eventuelt er fraspaltet, og som eventuelt baerer beskyttelsesgrupper

Country Status (14)

Country Link
US (1) US4601852A (xx)
EP (1) EP0056951B1 (xx)
JP (1) JPS57138396A (xx)
KR (1) KR880001107B1 (xx)
AT (1) ATE13893T1 (xx)
AU (1) AU559235B2 (xx)
CA (1) CA1190496A (xx)
DE (2) DE3101382A1 (xx)
DK (1) DK149615B (xx)
ES (1) ES8301206A1 (xx)
FI (1) FI79860C (xx)
GR (1) GR74758B (xx)
IL (1) IL64789A (xx)
ZA (1) ZA82261B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
WO1983002772A1 (en) * 1982-02-08 1983-08-18 Robin Ewart Offord An improved method for preparing human insulin from non-human insulin
DE3209184A1 (de) * 1982-03-13 1983-09-15 Hoechst Ag, 6230 Frankfurt Verfahren zur umwandlung von praeproinsulinanaloga zu insulinen
EP0367302A3 (en) * 1982-04-23 1991-06-19 Wako Pure Chemical Industries, Ltd. Process for semi-synthesis of human insulin, water-soluble cross-linked achromobacter protease i for use therein and a process for preparing the same
IT1189353B (it) * 1982-06-07 1988-02-04 Nordisk Insulinlab Procedimento per la preparazione di insulina umana e suoi esteri
DE3333640A1 (de) * 1983-09-17 1985-04-25 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von insulin-derivaten, deren b-kette c-terminal verlaengert ist, neue basisch modifizierte insulin-derivate diese enthaltende mittel und ihre verwendung
DE3334407A1 (de) * 1983-09-23 1985-04-04 Hoechst Ag, 6230 Frankfurt In position b 30 modifizierte insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
DE4028120C2 (de) * 1990-09-05 1996-09-19 Hoechst Ag Verfahren zur Reinigung von Insulin und/oder Insulinderivaten
US5106510A (en) * 1991-03-08 1992-04-21 Enviroguard, Inc. Combined filtration and fixation of heavy metals
DK0547544T3 (da) * 1991-12-18 1997-09-08 Hoechst Ag Fremgangsmåde til fremstilling af insulinholdige opløsninger.
DE4404168A1 (de) * 1994-02-10 1995-08-17 Hoechst Ag Hirudinderivate und Verfahren zu deren Herstellung
HUP0004169A3 (en) 1997-10-24 2001-06-28 Lilly Co Eli Insoluble insulin compositions and process for production thereof
CO4970787A1 (es) * 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
US6964561B2 (en) * 2002-04-23 2005-11-15 V System Composites, Inc. High-performance infusion system for VARTM fabrication
US20070108646A1 (en) * 2005-11-15 2007-05-17 Louderback Michael J Method of fabricating a composite structure with details

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3276961A (en) * 1963-04-08 1966-10-04 Squibb & Sons Inc Process for preparing human insulin
US3903068A (en) * 1972-12-26 1975-09-02 Us Health Education & Welfare Facile synthesis of human insulin by modification of porcine insulin
DE2460753A1 (de) * 1974-12-21 1976-06-24 Hoechst Ag Verfahren zur herstellung von humaninsulin
NO153061C (no) * 1979-04-13 1986-01-08 Shionogi & Co Fremgangsmaate for fremstilling av et b30-threonininsulin
DK147437A (en) * 1980-02-11 1900-01-01 Process for preparing human insulin or threonine B30 esters of human insulin, or a salt or complex thereof
DK319780A (da) * 1980-07-24 1982-01-25 Forenede Bryggerier As Fremgangsmaade til enzymatisk udskiftning af b-30 aminosyren i insuliner

Also Published As

Publication number Publication date
ES508657A0 (es) 1982-11-16
DE3101382A1 (de) 1982-09-02
GR74758B (xx) 1984-07-11
KR830008995A (ko) 1983-12-16
KR880001107B1 (ko) 1988-06-29
IL64789A (en) 1985-09-29
AU559235B2 (en) 1987-03-05
CA1190496A (en) 1985-07-16
AU7955482A (en) 1982-07-29
IL64789A0 (en) 1982-03-31
JPS57138396A (en) 1982-08-26
DE3264149D1 (en) 1985-07-25
DK16682A (da) 1982-07-18
FI79860B (fi) 1989-11-30
JPH0141317B2 (xx) 1989-09-05
ZA82261B (en) 1982-12-29
FI820117L (fi) 1982-07-18
ES8301206A1 (es) 1982-11-16
EP0056951A1 (de) 1982-08-04
ATE13893T1 (de) 1985-07-15
US4601852A (en) 1986-07-22
FI79860C (fi) 1990-03-12
EP0056951B1 (de) 1985-06-19

Similar Documents

Publication Publication Date Title
US4343898A (en) Process for preparing esters of human insulin
DK149615B (da) Fremgangsmaade til fremstilling af humaninsulin, hvori pheb1 eventuelt er fraspaltet, og som eventuelt baerer beskyttelsesgrupper
US5015728A (en) Process for the preparation of insulin derivatives, the B chain of which is lengthened c-terminally
FI77876C (fi) Foerfarande foer framstaellning av humaninsulin eller en treoninb30-ester av humaninsulin eller ett salt eller komplex daerav.
CZ259898A3 (cs) Způsob získávání prekurzoru insulínu nebo derivátů inzulínu
NO864555L (no) Fremgangsmaate ved fremstilling av insulinpreparat.
EP3398957A1 (en) Method for synthesizing etelcalcetide
US4489159A (en) Process for preparing esters of human insulin
US4029642A (en) Process for the manufacture of human insulin
HU228934B1 (hu) Eljárás inzulinvegyületek elõállítására
US3883500A (en) Process for the manufacture of insulin, analogs and derivatives thereof
US3883496A (en) Process for the manufacture of insulin, analogs and derivatives thereof
FI79853C (fi) Foerfarande foer framstaellning av insulinderivat.
CA1195273A (en) Process for converting preproinsulin analogs into insulin
FI78119B (fi) Foerfarande foer framstaellning av maenskligt insulin eller b-30-estrar daerav.
CN111057129A (zh) 一种用于合成含有两对二硫键的多肽的制备方法及其试剂盒，以及普利卡那肽的制备方法
US4013628A (en) Process for the preparation of insulin, analogs and derivatives thereof
CA1045626A (en) Process for the manufacture of peptides containing cystine
CA1327868C (en) Arginine derivative, process for the preparation thereof and its use in peptide synthesis
JPS62295A (ja) コレシストキニンパンクレオザイミンｃ端ペプチドおよびその類縁体の製造方法
DK149314B (da) Fremgangsmaade til fremstilling af humaninsulin eller threonin-b30-derivater af humaninsulin eller et salt eller kompleks deraf
WO1984003107A1 (en) A process for the preparation of human insulin

Legal Events

Date Code Title Description
PRF Application refused