DK1465665T3 - Vandoplöselige stabiliserede selvsamlende polyelektrolytter - Google Patents

Vandoplöselige stabiliserede selvsamlende polyelektrolytter

Info

Publication number
DK1465665T3
DK1465665T3 DK02740164T DK02740164T DK1465665T3 DK 1465665 T3 DK1465665 T3 DK 1465665T3 DK 02740164 T DK02740164 T DK 02740164T DK 02740164 T DK02740164 T DK 02740164T DK 1465665 T3 DK1465665 T3 DK 1465665T3
Authority
DK
Denmark
Prior art keywords
polyelectrolytes
water
assembling
soluble
hydrophobic
Prior art date
Application number
DK02740164T
Other languages
English (en)
Inventor
Maxime Ranger
Jean-Cristophe Leroux
Original Assignee
Labopharm Inc
Labopharm Barbados Ltd
Labopharm Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Inc, Labopharm Barbados Ltd, Labopharm Europe Ltd filed Critical Labopharm Inc
Application granted granted Critical
Publication of DK1465665T3 publication Critical patent/DK1465665T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/008—Supramolecular polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Graft Or Block Polymers (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Detergent Compositions (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
DK02740164T 2001-06-08 2002-06-07 Vandoplöselige stabiliserede selvsamlende polyelektrolytter DK1465665T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/877,999 US6939564B2 (en) 2001-06-08 2001-06-08 Water-soluble stabilized self-assembled polyelectrolytes

Publications (1)

Publication Number Publication Date
DK1465665T3 true DK1465665T3 (da) 2006-05-08

Family

ID=25371168

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02740164T DK1465665T3 (da) 2001-06-08 2002-06-07 Vandoplöselige stabiliserede selvsamlende polyelektrolytter

Country Status (13)

Country Link
US (3) US6939564B2 (da)
EP (1) EP1465665B1 (da)
JP (1) JP4302509B2 (da)
AT (1) ATE313335T1 (da)
AU (1) AU2002315598B2 (da)
BR (1) BR0210284A (da)
CA (1) CA2452806C (da)
DE (1) DE60208237T2 (da)
DK (1) DK1465665T3 (da)
ES (1) ES2257556T3 (da)
MX (1) MXPA03011296A (da)
PT (1) PT1465665E (da)
WO (1) WO2002100439A1 (da)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523544A (ja) * 2000-02-17 2003-08-05 レックスマーク・インターナショナル・インコーポレーテツド 導電性駆動ハブを備えたトナーカートリッジ
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US7094810B2 (en) * 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US8048408B2 (en) 2002-01-16 2011-11-01 Biocompatibles Uk Limited Polymer conjugates
US8105652B2 (en) * 2002-10-24 2012-01-31 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
GB0301014D0 (en) 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
US7217776B1 (en) * 2003-02-14 2007-05-15 Iowa State University Research Foundation pH-sensitive methacrylic copolymer gels and the production thereof
US7807722B2 (en) * 2003-11-26 2010-10-05 Advanced Cardiovascular Systems, Inc. Biobeneficial coating compositions and methods of making and using thereof
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
US20060106060A1 (en) * 2004-03-18 2006-05-18 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies (Lansbury)
EP1744751A4 (en) * 2004-03-18 2010-03-10 Brigham & Womens Hospital TREATMENT OF SYNUCLEINOPATHIES
US20050288298A1 (en) * 2004-03-18 2005-12-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
US7727554B2 (en) 2004-12-21 2010-06-01 Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center Sustained-release nanoparticle compositions and methods for using the same
TW200624464A (en) * 2004-12-31 2006-07-16 Ind Tech Res Inst Amphiphilic block copolymer and pharmaceutical formulation comprising the same
US7534756B2 (en) * 2005-02-25 2009-05-19 Solutions Biomed, Llc Devices, systems, and methods for dispensing disinfectant solutions comprising a peroxygen and transition metal
US7504369B2 (en) * 2005-02-25 2009-03-17 Solutions Biomed, Llc Methods and compositions for decontaminating surfaces exposed to chemical and/or biological warfare compounds
KR101323982B1 (ko) 2005-02-25 2013-10-30 솔루션스 바이오메드, 엘엘씨 수용성 소독제 및 멸균제
US7511007B2 (en) * 2005-02-25 2009-03-31 Solutions Biomed, Llc Aqueous sanitizers, disinfectants, and/or sterilants with low peroxygen content
US7507701B2 (en) * 2005-02-25 2009-03-24 Solutions Biomed, Llc Aqueous disinfectants and sterilants including transition metals
US7462590B2 (en) 2005-02-25 2008-12-09 Solutions Biomed, Llc Aqueous disinfectants and sterilants comprising a peroxide/peracid/transition metal mixture
US7473675B2 (en) * 2005-02-25 2009-01-06 Solutions Biomed, Llc Disinfectant systems and methods comprising a peracid, alcohol, and transition metal
US7553805B2 (en) * 2005-02-25 2009-06-30 Solutions Biomed, Llc Methods and compositions for treating viral, fungal, and bacterial infections
KR100626767B1 (ko) * 2005-07-07 2006-09-25 한국과학기술연구원 사슬 말단 기능성화된 폴리에틸렌옥사이드 및 이를 사용한나노 크기 전이금속 및 금속염의 제조 방법
KR101306150B1 (ko) * 2005-10-24 2013-09-10 삼성전자주식회사 탑 코팅 막용 고분자, 탑 코팅 용액 조성물 및 이를 이용한 이머젼 리소그라피 공정
EP2230264B1 (en) 2006-06-29 2019-10-09 Life Technologies AS Particles containing multi-block polymers
BRPI0716890A2 (pt) * 2006-09-22 2013-10-22 Labopharm Inc Composição, e, método de produção de uma composição, de administração de um agente farmaceuticamente ativo insolúvel em água a um mamífero, e de tratamento de câncer em um mamífero
US20080081075A1 (en) * 2006-10-02 2008-04-03 National Tsing Hua University Multifunctional mixed micelle of graft and block copolymers and preparation thereof
JP5340956B2 (ja) * 2006-12-20 2013-11-13 アーケマ・インコーポレイテッド ポリマーの封入および／または結合
WO2008157372A2 (en) 2007-06-14 2008-12-24 Massachusetts Institute Of Technology Self assembled films for protein and drug delivery applications
US8464910B2 (en) * 2008-03-14 2013-06-18 Solutions Biomed, Llc Multi-chamber container system for storing and mixing fluids
AU2009246321A1 (en) * 2008-05-13 2009-11-19 Phaserx, Inc. Polymeric carrier
WO2009140427A2 (en) 2008-05-13 2009-11-19 University Of Washington Diblock copolymers and polynucleotide complexes thereof for delivery into cells
WO2009140423A2 (en) * 2008-05-13 2009-11-19 University Of Washington Targeted polymer bioconjugates
WO2009140432A2 (en) * 2008-05-13 2009-11-19 University Of Washington Micelles for intracellular delivery of therapeutic agents
CN102066444A (zh) * 2008-05-13 2011-05-18 华盛顿大学 胶束装配体
CA2724004C (en) * 2008-05-16 2016-08-23 The University Of Sydney Administrable compositions comprising particulate material dispersed throughout a liquid carrier
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
US9198875B2 (en) * 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
CA2734917A1 (en) * 2008-08-22 2010-02-25 University Of Washington Heterogeneous polymeric micelles for intracellular delivery
KR20110095292A (ko) 2008-11-06 2011-08-24 유니버시티 오브 워싱톤 다중블록 공중합체
CA2742955A1 (en) 2008-11-06 2010-05-14 University Of Washington Bispecific intracellular delivery vehicles
WO2010056871A2 (en) * 2008-11-12 2010-05-20 Solutions Biomed, Llc Two-part disinfectant system and related methods
US20100120913A1 (en) * 2008-11-12 2010-05-13 Larson Brian G Resin catalyzed and stabilized peracid compositions and associated methods
WO2010056881A1 (en) * 2008-11-12 2010-05-20 Solutions Biomed, Llc Multi-chamber container system for storing and mixing liquids
JP2012511053A (ja) 2008-12-08 2012-05-17 ユニヴァーシティ オブ ワシントン オメガ機能性化ポリマー、ジャンクション機能性化ブロック共重合体、およびラジカル連鎖延長重合
CN101701068B (zh) * 2009-10-30 2011-09-21 北京化工大学 一种pH响应性的Y型药物输送材料及其制备方法
WO2011062965A2 (en) 2009-11-18 2011-05-26 University Of Washington Through Its Center For Commercialization Targeting monomers and polymers having targeting blocks
US9474269B2 (en) 2010-03-29 2016-10-25 The Clorox Company Aqueous compositions comprising associative polyelectrolyte complexes (PEC)
US20110236582A1 (en) 2010-03-29 2011-09-29 Scheuing David R Polyelectrolyte Complexes
US9309435B2 (en) 2010-03-29 2016-04-12 The Clorox Company Precursor polyelectrolyte complexes compositions comprising oxidants
EP2425817A1 (en) 2010-08-09 2012-03-07 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Polymerized micelles for diagnosis
EP3170846A1 (en) 2010-09-22 2017-05-24 The Board of Regents of The University of Texas System Novel block copolymer and micelle compositions and methods of use thereof
CN102070756B (zh) * 2010-12-10 2012-03-28 北京化工大学 一种糖响应型药物输送材料及其制备方法
US10278927B2 (en) 2012-04-23 2019-05-07 Massachusetts Institute Of Technology Stable layer-by-layer coated particles
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
US9463244B2 (en) 2013-03-15 2016-10-11 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
CA2919828C (en) 2013-07-30 2022-07-19 Phaserx, Inc. Block copolymers and their conjugates or complexes with oligonucleotides
US9084735B2 (en) 2013-08-01 2015-07-21 International Business Machines Corporation Self-assembling bis-urea compounds for drug delivery
NL2013317B1 (en) 2014-08-11 2016-09-21 Univ Utrecht Holding Bv Amphiphilic block copolymers for delivery of active agents.
US8975220B1 (en) 2014-08-11 2015-03-10 The Clorox Company Hypohalite compositions comprising a cationic polymer
FR3030530B1 (fr) * 2014-12-23 2017-01-27 Arkema France Copolymere dibloc hydrosoluble
FR3030529B1 (fr) 2014-12-23 2017-01-27 Arkema France Copolymere a blocs hydrosoluble et son utilisation comme materiau support pour impression 3d
CA2974503A1 (en) 2015-01-21 2016-07-28 Phaserx, Inc. Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
JP7173958B2 (ja) * 2016-08-12 2022-11-16 パーデュー・リサーチ・ファウンデーション ポリマー肺サーファクタント
KR102071912B1 (ko) * 2016-10-31 2020-01-31 주식회사 엘지화학 고분자 전해질 및 이를 포함하는 전기변색소자
WO2018126084A1 (en) 2016-12-30 2018-07-05 Phaserx, Inc. Branched peg molecules and related compositions and methods
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
CN107857846B (zh) * 2017-11-23 2019-10-11 常州大学 一种聚乙二醇接枝聚甲基丙烯酸丁酯两亲性接枝共聚物的制备方法
WO2021002984A1 (en) 2019-05-30 2021-01-07 Massachusetts Institute Of Technology Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids
US11786464B2 (en) 2020-04-24 2023-10-17 The Board Of Regents Of The University Of Texas System PH responsive block copolymer compositions and micelles that inhibit MCT 1 and related proteins
CN114163591B (zh) * 2021-11-29 2023-08-01 南方医科大学 一种嵌段共聚物、嵌段共聚物载药胶束及其制备方法和应用

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016332A (en) 1972-05-01 1977-04-05 Ppg Industries, Inc. Mercaptan blocked thermosetting copolymers
US3933940A (en) 1973-02-08 1976-01-20 Ppg Industries, Inc. Mercaptan blocked thermosetting copolymers
GB1411843A (en) 1973-02-28 1975-10-29 Univ Strathclyde Method of modifying the properties of a polymer
GB1575343A (en) 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
DE3001013A1 (de) 1980-01-12 1981-07-23 Basf Ag, 6700 Ludwigshafen Vinylpyrrolidonpolymerisate, ihre herstellung und ihre verwendung zur herstellung von blutersatzfluessigkeiten
JPS5767860A (en) 1980-10-15 1982-04-24 Fuji Photo Film Co Ltd Material for multilayer analysis
ATE37983T1 (de) 1982-04-22 1988-11-15 Ici Plc Mittel mit verzoegerter freigabe.
US4565854A (en) 1983-04-07 1986-01-21 Kuraray Co., Ltd. Polymer having thiol end group
US4826689A (en) 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US6312679B1 (en) 1986-08-18 2001-11-06 The Dow Chemical Company Dense star polymer conjugates as dyes
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US5041516A (en) 1989-06-21 1991-08-20 Cornell Research Foundation, Inc. Dendritic molecules and method of production
US5206410A (en) 1989-08-31 1993-04-27 University Of South Florida Multifunctional synthons as used in the preparation of cascade polymers or unimolecular micelles
US5154853A (en) 1991-02-19 1992-10-13 University Of South Florida Unimolecular micelles and method of making the same
FR2678168B1 (fr) 1991-06-28 1993-09-03 Rhone Poulenc Rorer Sa Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge.
KR940003548U (ko) * 1992-08-14 1994-02-21 김형술 세탁물 건조기
US5840319A (en) 1992-10-08 1998-11-24 Alakhov; Valery Yu Biological agent compositions
US5543158A (en) 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
EP0639592A1 (en) 1993-08-18 1995-02-22 Nippon Shokubai Co., Ltd. Water-soluble graft polymers and production process thereof
ZA951877B (en) 1994-03-07 1996-09-09 Dow Chemical Co Bioactive and/or targeted dendrimer conjugates
US5786387A (en) 1994-03-23 1998-07-28 Meiji Seika Kabushiki Kaisha Lipid double-chain derivative containing polyoxyethylene
NL9401886A (nl) 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof.
US5863919A (en) 1994-07-25 1999-01-26 University Of South Florida Lock and key micelles and monomer building blocks therefor
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5997861A (en) 1994-10-31 1999-12-07 Burstein Laboratories, Inc. Antiviral supramolecules containing target-binding molecules and therapeutic molecules bound to spectrin
US6221959B1 (en) * 1994-11-18 2001-04-24 Supratek Pharma, Inc. Polynucleotide compositions
US5656611A (en) 1994-11-18 1997-08-12 Supratek Pharma Inc. Polynucleotide compositions
WO1996021036A2 (en) 1994-12-30 1996-07-11 Chiron Viagene, Inc. Nucleic acid condensing agents with reduced immunogenicity
US5492996A (en) 1995-02-21 1996-02-20 The United States Of America As Represented By The Secretary Of The Air Force Alcohol soluble benzazole polymers
CN1085987C (zh) 1995-04-19 2002-06-05 片冈一则 杂远螯嵌段共聚物及其制备方法
US5908777A (en) 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
JPH11510837A (ja) 1995-07-28 1999-09-21 フォーカル，インコーポレイテッド 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル
NZ313769A (en) 1995-08-10 2000-02-28 Kazunori Kataoka block polymer having a functional group presented on each end
US5770627A (en) 1995-08-16 1998-06-23 University Of Washington Hydrophobically-modified bioadhesive polyelectrolytes and methods relating thereto
WO1997010814A1 (en) 1995-09-18 1997-03-27 Vesifact Ag Propofol nanodispersions
KR0180334B1 (ko) 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
CN1069099C (zh) 1995-09-29 2001-08-01 科学技术振兴事业团 阿霉素的二聚物和三聚物
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
DE69707853T2 (de) 1996-03-15 2002-06-27 President And Fellows Of Harvard College, Cambridge Verfahren zum formen von gegenständen und zum mikrostrukturieren von oberflächen durch giessformen mit kapillarwirkung
US5955509A (en) 1996-05-01 1999-09-21 Board Of Regents, The University Of Texas System pH dependent polymer micelles
EP0910351A1 (en) 1996-06-27 1999-04-28 G.D. Searle & Co. Particles comprising amphiphilic copolymers, having a cross-linked shell domain and an interior core domain, useful for pharmaceutical and other applications
US6284267B1 (en) 1996-08-14 2001-09-04 Nutrimed Biotech Amphiphilic materials and liposome formulations thereof
US6060518A (en) 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
TW520297B (en) 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
GB9623051D0 (en) 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
AU733692B2 (en) 1997-02-28 2001-05-24 Regents Of The University Of California, The Inhibition of cell-cell binding by lipid assemblies
EP0963758A3 (en) 1998-05-07 2000-03-22 Universiteit Gent Synthetic polyaminoacid complexes for delivery of nucleic acids to target cells
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
CN1313873A (zh) 1998-07-13 2001-09-19 表达遗传学公司 作为可溶性,生物可降解基因送递载体的聚－l－赖氨酸的聚酯类似物
IN191203B (da) 1999-02-17 2003-10-04 Amarnath Prof Maitra
DE19919785A1 (de) * 1999-04-30 2000-12-07 Wella Ag Haarbehandlungsmittel mit Polymeren aus ungesättigten Sacchariden, ungesättigten Saccharidsäuren oder deren Derivaten
JP3523821B2 (ja) 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
DE10008895A1 (de) 2000-02-25 2001-08-30 Beiersdorf Ag Stabilisierung oxidations- und/oder UV-empfindlicher Wirkstoffe
GB2359747B (en) 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
EP1286643A2 (en) 2000-05-17 2003-03-05 Labopharm Inc. Drug containing polymeric micelles
US6338859B1 (en) 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
IN188917B (da) 2000-12-07 2002-11-23 Bharat Surums & Vaccines Ltd
EP1399131A2 (en) 2001-06-08 2004-03-24 Powderject Vaccines, Inc. Spray freeze-dried compositions
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US7094810B2 (en) * 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US6756449B2 (en) 2002-02-27 2004-06-29 Medtronic, Inc. AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods
US6780324B2 (en) 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US7018655B2 (en) 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
WO2004035013A2 (en) 2002-10-21 2004-04-29 L'oreal Process for dissolving lipophilic compounds, and cosmetic composition
US7262253B2 (en) 2003-12-02 2007-08-28 Labopharm, Inc. Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents

Also Published As

Publication number Publication date
US20050244501A1 (en) 2005-11-03
MXPA03011296A (es) 2004-10-28
CA2452806A1 (en) 2002-12-19
AU2002315598B2 (en) 2006-08-24
WO2002100439A1 (en) 2002-12-19
ES2257556T3 (es) 2006-08-01
EP1465665B1 (en) 2005-12-21
DE60208237T2 (de) 2007-01-11
JP2004534879A (ja) 2004-11-18
ATE313335T1 (de) 2006-01-15
JP4302509B2 (ja) 2009-07-29
US7510731B2 (en) 2009-03-31
BR0210284A (pt) 2004-07-20
US20070110709A1 (en) 2007-05-17
US6939564B2 (en) 2005-09-06
US20030059398A1 (en) 2003-03-27
PT1465665E (pt) 2006-05-31
DE60208237D1 (de) 2006-01-26
CA2452806C (en) 2011-12-13
EP1465665A1 (en) 2004-10-13

Similar Documents

Publication Publication Date Title
DK1465665T3 (da) Vandoplöselige stabiliserede selvsamlende polyelektrolytter
RS50876B (sr) Upotreba flibanserina u lečenju seksualnih poremećaja
FI20011851A (fi) Fluoksetiinia tai sen happoadditiosuolaa sisältävä dispergoituva tabletti
ATE544447T1 (de) Arzneistoffcoating mit hohem wirkstoffanteil sowie methoden zu dessen herstellung
ATE211907T1 (de) Osmotisches arzneimittelfreisetzungssystem
WO2002072073A3 (en) Pharmaceutical formulation comprising atorvastatin calcium
TR200103575T2 (tr) Sülfonamid ve sülfamid ikameli/katkılı imidazokinolinler
ATE358669T1 (de) Pyrazolderivate zur behandlung von hiv
WO1997048391A3 (en) Methods and compositions comprising r-ibuprofen
MY130332A (en) Pharmaceutical formulation comprising iota-carrageenan and at least one neutral gelling polymer
HUP0302636A2 (hu) Hasított burkolt víruskészítmény
HUP0401811A2 (hu) Javított vízoldékonyságú gyógyszerkészítmény és eljárás az előállítására
TNSN03106A1 (fr) Procede pour la production d'une composition pharmaceutique a faible dose ayant une distribution et activite medicamenteuse uniforme
DK1957037T3 (da) Farmaceutisk præparat til nasal anvendelse af fentanyl
ATE296607T1 (de) Zubereitung zur entfernung von abnormen keratinmaterial
DE10197042T1 (de) Phosphat stabilisierende Zusammensetzungen
WO2000064423A3 (fr) Utilisation du saredutant et de ses sels pharmaceutiquement acceptables dans le traitement ou la prevention des troubles de l'humeur d'adaptation et de l'anxiete-depression
PL368737A1 (en) Use of irbesartan for the preparation of medicaments that are used to prevent or treat pulmonary hypertension
HUP0203324A3 (en) Novel fluoroalkylsubstituted cyclotrisiloxanes, their use for preparation of new polymers and novel block or random polymers
NO20032597D0 (no) Anvendelse av SARP-1 for behandlingen og/eller forebyggingen av skleroderma
WO2000061125A3 (fr) L'osanetant dans le traitement des troubles de l'humeur
ITTO950554A0 (it) Diamidi aromatiche acide ad attivita' antigastrinica, procedimento perla loro preparazione e loro uso farmaceutico
ATE262362T1 (de) Verwendung von cyamemazin zur behandlung von entwöhnungserscheinungen der benzodiazepinbehandlung
GEP20063857B (en) Intraorally disintegrating valdecoxib compositions prepared by spray drying process
GR1003969B (el) Σταθερα φαρμακευτικα διαλυματα νιμεσουλιδης.