ATE313335T1 - Wasserlösliche und stabilisierte, selbstorganisierende polyelektrolyte - Google Patents
Wasserlösliche und stabilisierte, selbstorganisierende polyelektrolyteInfo
- Publication number
- ATE313335T1 ATE313335T1 AT02740164T AT02740164T ATE313335T1 AT E313335 T1 ATE313335 T1 AT E313335T1 AT 02740164 T AT02740164 T AT 02740164T AT 02740164 T AT02740164 T AT 02740164T AT E313335 T1 ATE313335 T1 AT E313335T1
- Authority
- AT
- Austria
- Prior art keywords
- polyelectrolytes
- soluble
- self
- water
- stabilized
- Prior art date
Links
- 229920000867 polyelectrolyte Polymers 0.000 title abstract 4
- 230000002209 hydrophobic effect Effects 0.000 abstract 2
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000693 micelle Substances 0.000 abstract 1
- 239000000178 monomer Substances 0.000 abstract 1
- 238000001338 self-assembly Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
- C08L71/02—Polyalkylene oxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
- C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/008—Supramolecular polymers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
- C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Medicinal Preparation (AREA)
- Graft Or Block Polymers (AREA)
- Polyurethanes Or Polyureas (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Detergent Compositions (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/877,999 US6939564B2 (en) | 2001-06-08 | 2001-06-08 | Water-soluble stabilized self-assembled polyelectrolytes |
PCT/CA2002/000855 WO2002100439A1 (en) | 2001-06-08 | 2002-06-07 | Water-soluble stabilized self-assembled polyelectrolytes |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE313335T1 true ATE313335T1 (de) | 2006-01-15 |
Family
ID=25371168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02740164T ATE313335T1 (de) | 2001-06-08 | 2002-06-07 | Wasserlösliche und stabilisierte, selbstorganisierende polyelektrolyte |
Country Status (13)
Country | Link |
---|---|
US (3) | US6939564B2 (de) |
EP (1) | EP1465665B1 (de) |
JP (1) | JP4302509B2 (de) |
AT (1) | ATE313335T1 (de) |
AU (1) | AU2002315598B2 (de) |
BR (1) | BR0210284A (de) |
CA (1) | CA2452806C (de) |
DE (1) | DE60208237T2 (de) |
DK (1) | DK1465665T3 (de) |
ES (1) | ES2257556T3 (de) |
MX (1) | MXPA03011296A (de) |
PT (1) | PT1465665E (de) |
WO (1) | WO2002100439A1 (de) |
Families Citing this family (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003523544A (ja) * | 2000-02-17 | 2003-08-05 | レックスマーク・インターナショナル・インコーポレーテツド | 導電性駆動ハブを備えたトナーカートリッジ |
US6780428B2 (en) * | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
US7094810B2 (en) * | 2001-06-08 | 2006-08-22 | Labopharm, Inc. | pH-sensitive block copolymers for pharmaceutical compositions |
US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
US8048408B2 (en) | 2002-01-16 | 2011-11-01 | Biocompatibles Uk Limited | Polymer conjugates |
US8105652B2 (en) * | 2002-10-24 | 2012-01-31 | Massachusetts Institute Of Technology | Methods of making decomposable thin films of polyelectrolytes and uses thereof |
GB0301014D0 (en) | 2003-01-16 | 2003-02-19 | Biocompatibles Ltd | Conjugation reactions |
US7217776B1 (en) * | 2003-02-14 | 2007-05-15 | Iowa State University Research Foundation | pH-sensitive methacrylic copolymer gels and the production thereof |
US7807722B2 (en) * | 2003-11-26 | 2010-10-05 | Advanced Cardiovascular Systems, Inc. | Biobeneficial coating compositions and methods of making and using thereof |
US20070293539A1 (en) * | 2004-03-18 | 2007-12-20 | Lansbury Peter T | Methods for the treatment of synucleinopathies |
US20060106060A1 (en) * | 2004-03-18 | 2006-05-18 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies (Lansbury) |
EP1744751A4 (de) * | 2004-03-18 | 2010-03-10 | Brigham & Womens Hospital | Verfahren zur behandlung von synucleinopathien |
US20050288298A1 (en) * | 2004-03-18 | 2005-12-29 | The Brigham And Women's Hospital, Inc. | Methods for the treatment of synucleinopathies |
US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
US7727554B2 (en) | 2004-12-21 | 2010-06-01 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Sustained-release nanoparticle compositions and methods for using the same |
TW200624464A (en) * | 2004-12-31 | 2006-07-16 | Ind Tech Res Inst | Amphiphilic block copolymer and pharmaceutical formulation comprising the same |
US7534756B2 (en) * | 2005-02-25 | 2009-05-19 | Solutions Biomed, Llc | Devices, systems, and methods for dispensing disinfectant solutions comprising a peroxygen and transition metal |
US7504369B2 (en) * | 2005-02-25 | 2009-03-17 | Solutions Biomed, Llc | Methods and compositions for decontaminating surfaces exposed to chemical and/or biological warfare compounds |
KR101323982B1 (ko) | 2005-02-25 | 2013-10-30 | 솔루션스 바이오메드, 엘엘씨 | 수용성 소독제 및 멸균제 |
US7511007B2 (en) * | 2005-02-25 | 2009-03-31 | Solutions Biomed, Llc | Aqueous sanitizers, disinfectants, and/or sterilants with low peroxygen content |
US7507701B2 (en) * | 2005-02-25 | 2009-03-24 | Solutions Biomed, Llc | Aqueous disinfectants and sterilants including transition metals |
US7462590B2 (en) | 2005-02-25 | 2008-12-09 | Solutions Biomed, Llc | Aqueous disinfectants and sterilants comprising a peroxide/peracid/transition metal mixture |
US7473675B2 (en) * | 2005-02-25 | 2009-01-06 | Solutions Biomed, Llc | Disinfectant systems and methods comprising a peracid, alcohol, and transition metal |
US7553805B2 (en) * | 2005-02-25 | 2009-06-30 | Solutions Biomed, Llc | Methods and compositions for treating viral, fungal, and bacterial infections |
KR100626767B1 (ko) * | 2005-07-07 | 2006-09-25 | 한국과학기술연구원 | 사슬 말단 기능성화된 폴리에틸렌옥사이드 및 이를 사용한나노 크기 전이금속 및 금속염의 제조 방법 |
KR101306150B1 (ko) * | 2005-10-24 | 2013-09-10 | 삼성전자주식회사 | 탑 코팅 막용 고분자, 탑 코팅 용액 조성물 및 이를 이용한 이머젼 리소그라피 공정 |
EP2230264B1 (de) | 2006-06-29 | 2019-10-09 | Life Technologies AS | Teilchen enthaltend multiblockcopolymere |
BRPI0716890A2 (pt) * | 2006-09-22 | 2013-10-22 | Labopharm Inc | Composição, e, método de produção de uma composição, de administração de um agente farmaceuticamente ativo insolúvel em água a um mamífero, e de tratamento de câncer em um mamífero |
US20080081075A1 (en) * | 2006-10-02 | 2008-04-03 | National Tsing Hua University | Multifunctional mixed micelle of graft and block copolymers and preparation thereof |
JP5340956B2 (ja) * | 2006-12-20 | 2013-11-13 | アーケマ・インコーポレイテッド | ポリマーの封入および/または結合 |
WO2008157372A2 (en) | 2007-06-14 | 2008-12-24 | Massachusetts Institute Of Technology | Self assembled films for protein and drug delivery applications |
US8464910B2 (en) * | 2008-03-14 | 2013-06-18 | Solutions Biomed, Llc | Multi-chamber container system for storing and mixing fluids |
AU2009246321A1 (en) * | 2008-05-13 | 2009-11-19 | Phaserx, Inc. | Polymeric carrier |
WO2009140427A2 (en) | 2008-05-13 | 2009-11-19 | University Of Washington | Diblock copolymers and polynucleotide complexes thereof for delivery into cells |
WO2009140423A2 (en) * | 2008-05-13 | 2009-11-19 | University Of Washington | Targeted polymer bioconjugates |
WO2009140432A2 (en) * | 2008-05-13 | 2009-11-19 | University Of Washington | Micelles for intracellular delivery of therapeutic agents |
CN102066444A (zh) * | 2008-05-13 | 2011-05-18 | 华盛顿大学 | 胶束装配体 |
CA2724004C (en) * | 2008-05-16 | 2016-08-23 | The University Of Sydney | Administrable compositions comprising particulate material dispersed throughout a liquid carrier |
CA2635187A1 (en) | 2008-06-05 | 2009-12-05 | The Royal Institution For The Advancement Of Learning/Mcgill University | Oligonucleotide duplexes and uses thereof |
US9198875B2 (en) * | 2008-08-17 | 2015-12-01 | Massachusetts Institute Of Technology | Controlled delivery of bioactive agents from decomposable films |
CA2734917A1 (en) * | 2008-08-22 | 2010-02-25 | University Of Washington | Heterogeneous polymeric micelles for intracellular delivery |
KR20110095292A (ko) | 2008-11-06 | 2011-08-24 | 유니버시티 오브 워싱톤 | 다중블록 공중합체 |
CA2742955A1 (en) | 2008-11-06 | 2010-05-14 | University Of Washington | Bispecific intracellular delivery vehicles |
WO2010056871A2 (en) * | 2008-11-12 | 2010-05-20 | Solutions Biomed, Llc | Two-part disinfectant system and related methods |
US20100120913A1 (en) * | 2008-11-12 | 2010-05-13 | Larson Brian G | Resin catalyzed and stabilized peracid compositions and associated methods |
WO2010056881A1 (en) * | 2008-11-12 | 2010-05-20 | Solutions Biomed, Llc | Multi-chamber container system for storing and mixing liquids |
JP2012511053A (ja) | 2008-12-08 | 2012-05-17 | ユニヴァーシティ オブ ワシントン | オメガ機能性化ポリマー、ジャンクション機能性化ブロック共重合体、およびラジカル連鎖延長重合 |
CN101701068B (zh) * | 2009-10-30 | 2011-09-21 | 北京化工大学 | 一种pH响应性的Y型药物输送材料及其制备方法 |
WO2011062965A2 (en) | 2009-11-18 | 2011-05-26 | University Of Washington Through Its Center For Commercialization | Targeting monomers and polymers having targeting blocks |
US9474269B2 (en) | 2010-03-29 | 2016-10-25 | The Clorox Company | Aqueous compositions comprising associative polyelectrolyte complexes (PEC) |
US20110236582A1 (en) | 2010-03-29 | 2011-09-29 | Scheuing David R | Polyelectrolyte Complexes |
US9309435B2 (en) | 2010-03-29 | 2016-04-12 | The Clorox Company | Precursor polyelectrolyte complexes compositions comprising oxidants |
EP2425817A1 (de) | 2010-08-09 | 2012-03-07 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Polymerisierbare Mizellen zur Diagnose |
EP3170846A1 (de) | 2010-09-22 | 2017-05-24 | The Board of Regents of The University of Texas System | Neuartiges blockcopolymer und mizellenzusammensetzungen und verfahren zur verwendung davon |
CN102070756B (zh) * | 2010-12-10 | 2012-03-28 | 北京化工大学 | 一种糖响应型药物输送材料及其制备方法 |
US10278927B2 (en) | 2012-04-23 | 2019-05-07 | Massachusetts Institute Of Technology | Stable layer-by-layer coated particles |
WO2014134029A1 (en) | 2013-02-26 | 2014-09-04 | Massachusetts Institute Of Technology | Nucleic acid particles, methods and use thereof |
US9463244B2 (en) | 2013-03-15 | 2016-10-11 | Massachusetts Institute Of Technology | Compositions and methods for nucleic acid delivery |
CA2919828C (en) | 2013-07-30 | 2022-07-19 | Phaserx, Inc. | Block copolymers and their conjugates or complexes with oligonucleotides |
US9084735B2 (en) | 2013-08-01 | 2015-07-21 | International Business Machines Corporation | Self-assembling bis-urea compounds for drug delivery |
NL2013317B1 (en) | 2014-08-11 | 2016-09-21 | Univ Utrecht Holding Bv | Amphiphilic block copolymers for delivery of active agents. |
US8975220B1 (en) | 2014-08-11 | 2015-03-10 | The Clorox Company | Hypohalite compositions comprising a cationic polymer |
FR3030530B1 (fr) * | 2014-12-23 | 2017-01-27 | Arkema France | Copolymere dibloc hydrosoluble |
FR3030529B1 (fr) | 2014-12-23 | 2017-01-27 | Arkema France | Copolymere a blocs hydrosoluble et son utilisation comme materiau support pour impression 3d |
CA2974503A1 (en) | 2015-01-21 | 2016-07-28 | Phaserx, Inc. | Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells |
US10792477B2 (en) | 2016-02-08 | 2020-10-06 | Orbusneich Medical Pte. Ltd. | Drug eluting balloon |
JP7173958B2 (ja) * | 2016-08-12 | 2022-11-16 | パーデュー・リサーチ・ファウンデーション | ポリマー肺サーファクタント |
KR102071912B1 (ko) * | 2016-10-31 | 2020-01-31 | 주식회사 엘지화학 | 고분자 전해질 및 이를 포함하는 전기변색소자 |
WO2018126084A1 (en) | 2016-12-30 | 2018-07-05 | Phaserx, Inc. | Branched peg molecules and related compositions and methods |
US11419947B2 (en) | 2017-10-30 | 2022-08-23 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
CN107857846B (zh) * | 2017-11-23 | 2019-10-11 | 常州大学 | 一种聚乙二醇接枝聚甲基丙烯酸丁酯两亲性接枝共聚物的制备方法 |
WO2021002984A1 (en) | 2019-05-30 | 2021-01-07 | Massachusetts Institute Of Technology | Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids |
US11786464B2 (en) | 2020-04-24 | 2023-10-17 | The Board Of Regents Of The University Of Texas System | PH responsive block copolymer compositions and micelles that inhibit MCT 1 and related proteins |
CN114163591B (zh) * | 2021-11-29 | 2023-08-01 | 南方医科大学 | 一种嵌段共聚物、嵌段共聚物载药胶束及其制备方法和应用 |
Family Cites Families (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4016332A (en) | 1972-05-01 | 1977-04-05 | Ppg Industries, Inc. | Mercaptan blocked thermosetting copolymers |
US3933940A (en) | 1973-02-08 | 1976-01-20 | Ppg Industries, Inc. | Mercaptan blocked thermosetting copolymers |
GB1411843A (en) | 1973-02-28 | 1975-10-29 | Univ Strathclyde | Method of modifying the properties of a polymer |
GB1575343A (en) | 1977-05-10 | 1980-09-17 | Ici Ltd | Method for preparing liposome compositions containing biologically active compounds |
DE3001013A1 (de) | 1980-01-12 | 1981-07-23 | Basf Ag, 6700 Ludwigshafen | Vinylpyrrolidonpolymerisate, ihre herstellung und ihre verwendung zur herstellung von blutersatzfluessigkeiten |
JPS5767860A (en) | 1980-10-15 | 1982-04-24 | Fuji Photo Film Co Ltd | Material for multilayer analysis |
ATE37983T1 (de) | 1982-04-22 | 1988-11-15 | Ici Plc | Mittel mit verzoegerter freigabe. |
US4565854A (en) | 1983-04-07 | 1986-01-21 | Kuraray Co., Ltd. | Polymer having thiol end group |
US4826689A (en) | 1984-05-21 | 1989-05-02 | University Of Rochester | Method for making uniformly sized particles from water-insoluble organic compounds |
GB8416234D0 (en) | 1984-06-26 | 1984-08-01 | Ici Plc | Biodegradable amphipathic copolymers |
US6312679B1 (en) | 1986-08-18 | 2001-11-06 | The Dow Chemical Company | Dense star polymer conjugates as dyes |
US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
JP2517760B2 (ja) | 1989-05-11 | 1996-07-24 | 新技術事業団 | 水溶性高分子化医薬製剤 |
US5041516A (en) | 1989-06-21 | 1991-08-20 | Cornell Research Foundation, Inc. | Dendritic molecules and method of production |
US5206410A (en) | 1989-08-31 | 1993-04-27 | University Of South Florida | Multifunctional synthons as used in the preparation of cascade polymers or unimolecular micelles |
US5154853A (en) | 1991-02-19 | 1992-10-13 | University Of South Florida | Unimolecular micelles and method of making the same |
FR2678168B1 (fr) | 1991-06-28 | 1993-09-03 | Rhone Poulenc Rorer Sa | Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge. |
KR940003548U (ko) * | 1992-08-14 | 1994-02-21 | 김형술 | 세탁물 건조기 |
US5840319A (en) | 1992-10-08 | 1998-11-24 | Alakhov; Valery Yu | Biological agent compositions |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
EP0639592A1 (de) | 1993-08-18 | 1995-02-22 | Nippon Shokubai Co., Ltd. | Wasserlösliche Pfropfcopolymerisate und Verfahren zur Herstellung davon |
ZA951877B (en) | 1994-03-07 | 1996-09-09 | Dow Chemical Co | Bioactive and/or targeted dendrimer conjugates |
US5786387A (en) | 1994-03-23 | 1998-07-28 | Meiji Seika Kabushiki Kaisha | Lipid double-chain derivative containing polyoxyethylene |
NL9401886A (nl) | 1994-05-27 | 1996-01-02 | Dsm Nv | Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof. |
US5863919A (en) | 1994-07-25 | 1999-01-26 | University Of South Florida | Lock and key micelles and monomer building blocks therefor |
US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
US5997861A (en) | 1994-10-31 | 1999-12-07 | Burstein Laboratories, Inc. | Antiviral supramolecules containing target-binding molecules and therapeutic molecules bound to spectrin |
US6221959B1 (en) * | 1994-11-18 | 2001-04-24 | Supratek Pharma, Inc. | Polynucleotide compositions |
US5656611A (en) | 1994-11-18 | 1997-08-12 | Supratek Pharma Inc. | Polynucleotide compositions |
WO1996021036A2 (en) | 1994-12-30 | 1996-07-11 | Chiron Viagene, Inc. | Nucleic acid condensing agents with reduced immunogenicity |
US5492996A (en) | 1995-02-21 | 1996-02-20 | The United States Of America As Represented By The Secretary Of The Air Force | Alcohol soluble benzazole polymers |
CN1085987C (zh) | 1995-04-19 | 2002-06-05 | 片冈一则 | 杂远螯嵌段共聚物及其制备方法 |
US5908777A (en) | 1995-06-23 | 1999-06-01 | University Of Pittsburgh | Lipidic vector for nucleic acid delivery |
US6143211A (en) | 1995-07-21 | 2000-11-07 | Brown University Foundation | Process for preparing microparticles through phase inversion phenomena |
JPH11510837A (ja) | 1995-07-28 | 1999-09-21 | フォーカル,インコーポレイテッド | 薬物送達のための制御された放出薬剤および組織処置薬剤としての使用のためのマルチブロック生分解性ヒドロゲル |
NZ313769A (en) | 1995-08-10 | 2000-02-28 | Kazunori Kataoka | block polymer having a functional group presented on each end |
US5770627A (en) | 1995-08-16 | 1998-06-23 | University Of Washington | Hydrophobically-modified bioadhesive polyelectrolytes and methods relating thereto |
WO1997010814A1 (en) | 1995-09-18 | 1997-03-27 | Vesifact Ag | Propofol nanodispersions |
KR0180334B1 (ko) | 1995-09-21 | 1999-03-20 | 김윤 | 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법 |
CN1069099C (zh) | 1995-09-29 | 2001-08-01 | 科学技术振兴事业团 | 阿霉素的二聚物和三聚物 |
US5702717A (en) | 1995-10-25 | 1997-12-30 | Macromed, Inc. | Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers |
DE69707853T2 (de) | 1996-03-15 | 2002-06-27 | President And Fellows Of Harvard College, Cambridge | Verfahren zum formen von gegenständen und zum mikrostrukturieren von oberflächen durch giessformen mit kapillarwirkung |
US5955509A (en) | 1996-05-01 | 1999-09-21 | Board Of Regents, The University Of Texas System | pH dependent polymer micelles |
EP0910351A1 (de) | 1996-06-27 | 1999-04-28 | G.D. Searle & Co. | Amphiphile copolymere umfassende teilchen mit einem quervernetzten hüll- und einem inneren kernbereich, verwendbar für pharmazeutische und andere anwendungen |
US6284267B1 (en) | 1996-08-14 | 2001-09-04 | Nutrimed Biotech | Amphiphilic materials and liposome formulations thereof |
US6060518A (en) | 1996-08-16 | 2000-05-09 | Supratek Pharma Inc. | Polymer compositions for chemotherapy and methods of treatment using the same |
TW520297B (en) | 1996-10-11 | 2003-02-11 | Sequus Pharm Inc | Fusogenic liposome composition and method |
GB9623051D0 (en) | 1996-11-06 | 1997-01-08 | Schacht Etienne H | Delivery of DNA to target cells in biological systems |
AU733692B2 (en) | 1997-02-28 | 2001-05-24 | Regents Of The University Of California, The | Inhibition of cell-cell binding by lipid assemblies |
EP0963758A3 (de) | 1998-05-07 | 2000-03-22 | Universiteit Gent | Synthetische polyamiosaure Komplexen zur Verabreichung von Nukleinsäuren zur Zielzellen |
US5939453A (en) | 1998-06-04 | 1999-08-17 | Advanced Polymer Systems, Inc. | PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers |
CN1313873A (zh) | 1998-07-13 | 2001-09-19 | 表达遗传学公司 | 作为可溶性,生物可降解基因送递载体的聚-l-赖氨酸的聚酯类似物 |
IN191203B (de) | 1999-02-17 | 2003-10-04 | Amarnath Prof Maitra | |
DE19919785A1 (de) * | 1999-04-30 | 2000-12-07 | Wella Ag | Haarbehandlungsmittel mit Polymeren aus ungesättigten Sacchariden, ungesättigten Saccharidsäuren oder deren Derivaten |
JP3523821B2 (ja) | 2000-02-09 | 2004-04-26 | ナノキャリア株式会社 | 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物 |
DE10008895A1 (de) | 2000-02-25 | 2001-08-30 | Beiersdorf Ag | Stabilisierung oxidations- und/oder UV-empfindlicher Wirkstoffe |
GB2359747B (en) | 2000-02-29 | 2002-04-24 | Maelor Pharmaceuticals Ltd | Anaesthetic formulations |
EP1286643A2 (de) | 2000-05-17 | 2003-03-05 | Labopharm Inc. | Arzneistoff enthaltende polymere mizellen |
US6338859B1 (en) | 2000-06-29 | 2002-01-15 | Labopharm Inc. | Polymeric micelle compositions |
IN188917B (de) | 2000-12-07 | 2002-11-23 | Bharat Surums & Vaccines Ltd | |
EP1399131A2 (de) | 2001-06-08 | 2004-03-24 | Powderject Vaccines, Inc. | Sprüh- gefriergetrockneten zubereitungen |
US6780428B2 (en) * | 2001-06-08 | 2004-08-24 | Labopharm, Inc. | Unimolecular polymeric micelles with an ionizable inner core |
US7094810B2 (en) * | 2001-06-08 | 2006-08-22 | Labopharm, Inc. | pH-sensitive block copolymers for pharmaceutical compositions |
US6939564B2 (en) * | 2001-06-08 | 2005-09-06 | Labopharm, Inc. | Water-soluble stabilized self-assembled polyelectrolytes |
US20060003012A9 (en) | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
US6756449B2 (en) | 2002-02-27 | 2004-06-29 | Medtronic, Inc. | AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods |
US6780324B2 (en) | 2002-03-18 | 2004-08-24 | Labopharm, Inc. | Preparation of sterile stabilized nanodispersions |
US7018655B2 (en) | 2002-03-18 | 2006-03-28 | Labopharm, Inc. | Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions |
WO2004035013A2 (en) | 2002-10-21 | 2004-04-29 | L'oreal | Process for dissolving lipophilic compounds, and cosmetic composition |
US7262253B2 (en) | 2003-12-02 | 2007-08-28 | Labopharm, Inc. | Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers |
US20060198891A1 (en) | 2004-11-29 | 2006-09-07 | Francois Ravenelle | Solid formulations of liquid biologically active agents |
-
2001
- 2001-06-08 US US09/877,999 patent/US6939564B2/en not_active Expired - Lifetime
-
2002
- 2002-06-07 BR BR0210284-6A patent/BR0210284A/pt not_active IP Right Cessation
- 2002-06-07 CA CA2452806A patent/CA2452806C/en not_active Expired - Lifetime
- 2002-06-07 MX MXPA03011296A patent/MXPA03011296A/es active IP Right Grant
- 2002-06-07 WO PCT/CA2002/000855 patent/WO2002100439A1/en active IP Right Grant
- 2002-06-07 AT AT02740164T patent/ATE313335T1/de not_active IP Right Cessation
- 2002-06-07 EP EP02740164A patent/EP1465665B1/de not_active Expired - Lifetime
- 2002-06-07 AU AU2002315598A patent/AU2002315598B2/en not_active Ceased
- 2002-06-07 ES ES02740164T patent/ES2257556T3/es not_active Expired - Lifetime
- 2002-06-07 JP JP2003503258A patent/JP4302509B2/ja not_active Expired - Fee Related
- 2002-06-07 DE DE60208237T patent/DE60208237T2/de not_active Expired - Lifetime
- 2002-06-07 DK DK02740164T patent/DK1465665T3/da active
- 2002-06-07 PT PT02740164T patent/PT1465665E/pt unknown
-
2005
- 2005-07-05 US US11/175,796 patent/US20050244501A1/en not_active Abandoned
-
2006
- 2006-11-10 US US11/558,543 patent/US7510731B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US20050244501A1 (en) | 2005-11-03 |
MXPA03011296A (es) | 2004-10-28 |
CA2452806A1 (en) | 2002-12-19 |
AU2002315598B2 (en) | 2006-08-24 |
WO2002100439A1 (en) | 2002-12-19 |
ES2257556T3 (es) | 2006-08-01 |
EP1465665B1 (de) | 2005-12-21 |
DK1465665T3 (da) | 2006-05-08 |
DE60208237T2 (de) | 2007-01-11 |
JP2004534879A (ja) | 2004-11-18 |
JP4302509B2 (ja) | 2009-07-29 |
US7510731B2 (en) | 2009-03-31 |
BR0210284A (pt) | 2004-07-20 |
US20070110709A1 (en) | 2007-05-17 |
US6939564B2 (en) | 2005-09-06 |
US20030059398A1 (en) | 2003-03-27 |
PT1465665E (pt) | 2006-05-31 |
DE60208237D1 (de) | 2006-01-26 |
CA2452806C (en) | 2011-12-13 |
EP1465665A1 (de) | 2004-10-13 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE313335T1 (de) | Wasserlösliche und stabilisierte, selbstorganisierende polyelektrolyte | |
RS50876B (sr) | Upotreba flibanserina u lečenju seksualnih poremećaja | |
BG109297A (en) | 2-oxo-1-pyrrolidine derivatives, a process for their preparation and their use | |
MY130332A (en) | Pharmaceutical formulation comprising iota-carrageenan and at least one neutral gelling polymer | |
ATE544447T1 (de) | Arzneistoffcoating mit hohem wirkstoffanteil sowie methoden zu dessen herstellung | |
TR200103575T2 (tr) | Sülfonamid ve sülfamid ikameli/katkılı imidazokinolinler | |
CY1107054T1 (el) | Ενωσεις διτοσυλικου αλατος κιναζολινης | |
FI20011851A (fi) | Fluoksetiinia tai sen happoadditiosuolaa sisältävä dispergoituva tabletti | |
HUP0302636A2 (hu) | Hasított burkolt víruskészítmény | |
DK1339406T3 (da) | Piperazinderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf til behandling af lidelser i centralnervesystemet | |
WO2002051385A8 (en) | Solid dispersions of nitrate active principles | |
HUP0401811A2 (hu) | Javított vízoldékonyságú gyógyszerkészítmény és eljárás az előállítására | |
DE69936285D1 (de) | INDOLOi2,1-BöQUINAZOLIN-6,12-DIONE ANTIMALARIA DERIVATE UND METHODEN ZUR BEHANDLUNG VON MALARIA | |
TNSN03106A1 (fr) | Procede pour la production d'une composition pharmaceutique a faible dose ayant une distribution et activite medicamenteuse uniforme | |
DE60042972D1 (de) | Trimetazidine enthaltendes Arzneimittel mit verzögerter Wirkstoffabgabe und Verfahren zur Herstellung | |
DE50203283D1 (de) | Zubereitung zur entfernung von abnormen keratinmaterial | |
WO2000064423A3 (fr) | Utilisation du saredutant et de ses sels pharmaceutiquement acceptables dans le traitement ou la prevention des troubles de l'humeur d'adaptation et de l'anxiete-depression | |
ATE286894T1 (de) | 2h-1-benzopyran-derivate, prozesse zu ihrer herstellung und pharmazeutische zusammensetzungen | |
PL368737A1 (en) | Use of irbesartan for the preparation of medicaments that are used to prevent or treat pulmonary hypertension | |
HUP0203324A3 (en) | Novel fluoroalkylsubstituted cyclotrisiloxanes, their use for preparation of new polymers and novel block or random polymers | |
WO2000061125A3 (fr) | L'osanetant dans le traitement des troubles de l'humeur | |
ATE286893T1 (de) | 2h-1-benzopyran-derivative, prozesse zu ihrer herstellung und pharmazeutische zusammensetzungen | |
HUP0101748A2 (hu) | Reboxetin alkalmazása idegrendszeri zavarok kezelésére szolgáló gyógyszerkészítmények előállítására | |
HUP0202791A2 (hu) | Pikkelysömör kezelésére alkalmas gyógyszerkészítmények | |
GR1003969B (el) | Σταθερα φαρμακευτικα διαλυματα νιμεσουλιδης. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1465665 Country of ref document: EP |
|
REN | Ceased due to non-payment of the annual fee |