DE60208237D1 - Wasserlösliche und stabilisierte, selbstorganisierende polyelektrolyte - Google Patents

Wasserlösliche und stabilisierte, selbstorganisierende polyelektrolyte

Info

Publication number
DE60208237D1
DE60208237D1 DE60208237T DE60208237T DE60208237D1 DE 60208237 D1 DE60208237 D1 DE 60208237D1 DE 60208237 T DE60208237 T DE 60208237T DE 60208237 T DE60208237 T DE 60208237T DE 60208237 D1 DE60208237 D1 DE 60208237D1
Authority
DE
Germany
Prior art keywords
polyelectrolyte
soluble
self
water
organizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60208237T
Other languages
English (en)
Other versions
DE60208237T2 (de
Inventor
Maxime Ranger
Jean-Cristophe Leroux
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labopharm Barbados Ltd
Labopharm Inc
Paladin Labs Europe Ltd
Original Assignee
Labopharm Barbados Ltd
Labopharm Inc
Paladin Labs Europe Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labopharm Barbados Ltd, Labopharm Inc, Paladin Labs Europe Ltd filed Critical Labopharm Barbados Ltd
Publication of DE60208237D1 publication Critical patent/DE60208237D1/de
Application granted granted Critical
Publication of DE60208237T2 publication Critical patent/DE60208237T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F293/00—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule
    • C08F293/005—Macromolecular compounds obtained by polymerisation on to a macromolecule having groups capable of inducing the formation of new polymer chains bound exclusively at one or both ends of the starting macromolecule using free radical "living" or "controlled" polymerisation, e.g. using a complexing agent
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/008—Supramolecular polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L51/00—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
    • C08L51/003—Compositions of graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers grafted on to macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L53/00—Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Detergent Compositions (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Graft Or Block Polymers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
DE60208237T 2001-06-08 2002-06-07 Wasserlösliche und stabilisierte, selbstorganisierende polyelektrolyte Expired - Lifetime DE60208237T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US877999 2001-06-08
US09/877,999 US6939564B2 (en) 2001-06-08 2001-06-08 Water-soluble stabilized self-assembled polyelectrolytes
PCT/CA2002/000855 WO2002100439A1 (en) 2001-06-08 2002-06-07 Water-soluble stabilized self-assembled polyelectrolytes

Publications (2)

Publication Number Publication Date
DE60208237D1 true DE60208237D1 (de) 2006-01-26
DE60208237T2 DE60208237T2 (de) 2007-01-11

Family

ID=25371168

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60208237T Expired - Lifetime DE60208237T2 (de) 2001-06-08 2002-06-07 Wasserlösliche und stabilisierte, selbstorganisierende polyelektrolyte

Country Status (13)

Country Link
US (3) US6939564B2 (de)
EP (1) EP1465665B1 (de)
JP (1) JP4302509B2 (de)
AT (1) ATE313335T1 (de)
AU (1) AU2002315598B2 (de)
BR (1) BR0210284A (de)
CA (1) CA2452806C (de)
DE (1) DE60208237T2 (de)
DK (1) DK1465665T3 (de)
ES (1) ES2257556T3 (de)
MX (1) MXPA03011296A (de)
PT (1) PT1465665E (de)
WO (1) WO2002100439A1 (de)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523544A (ja) * 2000-02-17 2003-08-05 レックスマーク・インターナショナル・インコーポレーテツド 導電性駆動ハブを備えたトナーカートリッジ
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
US7094810B2 (en) * 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
DE60315949T2 (de) 2002-01-16 2008-06-12 Biocompatibles Uk Ltd., Farnham Polymerkonjugate
US8105652B2 (en) * 2002-10-24 2012-01-31 Massachusetts Institute Of Technology Methods of making decomposable thin films of polyelectrolytes and uses thereof
GB0301014D0 (en) 2003-01-16 2003-02-19 Biocompatibles Ltd Conjugation reactions
US7217776B1 (en) * 2003-02-14 2007-05-15 Iowa State University Research Foundation pH-sensitive methacrylic copolymer gels and the production thereof
US7807722B2 (en) * 2003-11-26 2010-10-05 Advanced Cardiovascular Systems, Inc. Biobeneficial coating compositions and methods of making and using thereof
US20070293539A1 (en) * 2004-03-18 2007-12-20 Lansbury Peter T Methods for the treatment of synucleinopathies
CA2559285A1 (en) * 2004-03-18 2005-09-29 Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
WO2005089504A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
WO2005089496A2 (en) * 2004-03-18 2005-09-29 The Brigham And Women's Hospital, Inc. Methods for the treatment of synucleinopathies
US20060198891A1 (en) 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents
US7727554B2 (en) * 2004-12-21 2010-06-01 Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center Sustained-release nanoparticle compositions and methods for using the same
TW200624464A (en) * 2004-12-31 2006-07-16 Ind Tech Res Inst Amphiphilic block copolymer and pharmaceutical formulation comprising the same
US7507701B2 (en) 2005-02-25 2009-03-24 Solutions Biomed, Llc Aqueous disinfectants and sterilants including transition metals
US7473675B2 (en) * 2005-02-25 2009-01-06 Solutions Biomed, Llc Disinfectant systems and methods comprising a peracid, alcohol, and transition metal
US7462590B2 (en) 2005-02-25 2008-12-09 Solutions Biomed, Llc Aqueous disinfectants and sterilants comprising a peroxide/peracid/transition metal mixture
WO2006093792A1 (en) * 2005-02-25 2006-09-08 Solutions Biomed, Llc Aqueous disinfectants and sterilants
US7511007B2 (en) * 2005-02-25 2009-03-31 Solutions Biomed, Llc Aqueous sanitizers, disinfectants, and/or sterilants with low peroxygen content
US7553805B2 (en) * 2005-02-25 2009-06-30 Solutions Biomed, Llc Methods and compositions for treating viral, fungal, and bacterial infections
US7534756B2 (en) * 2005-02-25 2009-05-19 Solutions Biomed, Llc Devices, systems, and methods for dispensing disinfectant solutions comprising a peroxygen and transition metal
US7504369B2 (en) * 2005-02-25 2009-03-17 Solutions Biomed, Llc Methods and compositions for decontaminating surfaces exposed to chemical and/or biological warfare compounds
KR100626767B1 (ko) * 2005-07-07 2006-09-25 한국과학기술연구원 사슬 말단 기능성화된 폴리에틸렌옥사이드 및 이를 사용한나노 크기 전이금속 및 금속염의 제조 방법
KR101306150B1 (ko) * 2005-10-24 2013-09-10 삼성전자주식회사 탑 코팅 막용 고분자, 탑 코팅 용액 조성물 및 이를 이용한 이머젼 리소그라피 공정
CN101511892B (zh) 2006-06-29 2012-02-29 英维特罗根戴内尔公司 含有多嵌段聚合物的颗粒
WO2008035229A2 (en) * 2006-09-22 2008-03-27 Labopharm, Inc. Compositions and methods for ph targeted drug delivery
US20080081075A1 (en) * 2006-10-02 2008-04-03 National Tsing Hua University Multifunctional mixed micelle of graft and block copolymers and preparation thereof
EP2097140B1 (de) * 2006-12-20 2012-09-26 Arkema Inc. Polymer-verkapselung und/oder bindung
US20080311177A1 (en) 2007-06-14 2008-12-18 Massachusetts Institute Of Technology Self Assembled Films for Protein and Drug Delivery Applications
WO2009114754A1 (en) * 2008-03-14 2009-09-17 Solutions Biomed, Llc Multi-chamber container system for storing and mixing fluids
EP2285853B1 (de) * 2008-05-13 2013-02-27 University of Washington Micellenanordnungen
CN102083878B (zh) 2008-05-13 2013-07-10 华盛顿大学 用于向细胞内递送的二嵌段共聚物和其多核苷酸复合物
WO2009140423A2 (en) * 2008-05-13 2009-11-19 University Of Washington Targeted polymer bioconjugates
MX2010012236A (es) * 2008-05-13 2011-06-20 Univ Washington Portador polimerico.
MX2010012237A (es) * 2008-05-13 2011-04-28 Univ Washington Micelas para el suministro intracelular de agentes terapeuticos.
CN102099010B (zh) * 2008-05-16 2016-09-14 悉尼大学 可给予的组合物
CA2635187A1 (en) 2008-06-05 2009-12-05 The Royal Institution For The Advancement Of Learning/Mcgill University Oligonucleotide duplexes and uses thereof
US9198875B2 (en) * 2008-08-17 2015-12-01 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
WO2010021770A1 (en) * 2008-08-22 2010-02-25 University Of Washington Heterogeneous polymeric micelles for intracellular delivery
EP2352522A4 (de) 2008-11-06 2014-03-05 Univ Washington Bispezifische hilfsstoffe für intrazelluläre freisetzung
CA2742880A1 (en) 2008-11-06 2010-05-14 University Of Washington Multiblock copolymers
US20100120913A1 (en) * 2008-11-12 2010-05-13 Larson Brian G Resin catalyzed and stabilized peracid compositions and associated methods
US8716339B2 (en) 2008-11-12 2014-05-06 Solutions Biomed, Llc Two-part disinfectant system and related methods
US8789716B2 (en) * 2008-11-12 2014-07-29 Solutions Biomed, Llc Multi-chamber container system for storing and mixing liquids
US9593169B2 (en) 2008-12-08 2017-03-14 University Of Washington Omega-functionalized polymers, junction-functionalized block copolymers, polymer bioconjugates, and radical chain extension polymerization
CN101701068B (zh) * 2009-10-30 2011-09-21 北京化工大学 一种pH响应性的Y型药物输送材料及其制备方法
WO2011062965A2 (en) 2009-11-18 2011-05-26 University Of Washington Through Its Center For Commercialization Targeting monomers and polymers having targeting blocks
US9474269B2 (en) 2010-03-29 2016-10-25 The Clorox Company Aqueous compositions comprising associative polyelectrolyte complexes (PEC)
US9309435B2 (en) 2010-03-29 2016-04-12 The Clorox Company Precursor polyelectrolyte complexes compositions comprising oxidants
US20110236582A1 (en) 2010-03-29 2011-09-29 Scheuing David R Polyelectrolyte Complexes
EP2425817A1 (de) * 2010-08-09 2012-03-07 Commissariat à l'Énergie Atomique et aux Énergies Alternatives Polymerisierbare Mizellen zur Diagnose
EP3170846A1 (de) 2010-09-22 2017-05-24 The Board of Regents of The University of Texas System Neuartiges blockcopolymer und mizellenzusammensetzungen und verfahren zur verwendung davon
CN102070756B (zh) * 2010-12-10 2012-03-28 北京化工大学 一种糖响应型药物输送材料及其制备方法
EP2841056A4 (de) 2012-04-23 2015-09-16 Massachusetts Inst Technology Stabile schichtweise beschichtete teilchen
WO2014134029A1 (en) 2013-02-26 2014-09-04 Massachusetts Institute Of Technology Nucleic acid particles, methods and use thereof
US9463244B2 (en) 2013-03-15 2016-10-11 Massachusetts Institute Of Technology Compositions and methods for nucleic acid delivery
EP3027221A1 (de) 2013-07-30 2016-06-08 PhaseRx, Inc. Blockcopolymere und deren konjugate oder komplexe mit oligonukleotiden
US9084735B2 (en) 2013-08-01 2015-07-21 International Business Machines Corporation Self-assembling bis-urea compounds for drug delivery
US8975220B1 (en) 2014-08-11 2015-03-10 The Clorox Company Hypohalite compositions comprising a cationic polymer
NL2013317B1 (en) 2014-08-11 2016-09-21 Univ Utrecht Holding Bv Amphiphilic block copolymers for delivery of active agents.
FR3030529B1 (fr) * 2014-12-23 2017-01-27 Arkema France Copolymere a blocs hydrosoluble et son utilisation comme materiau support pour impression 3d
FR3030530B1 (fr) * 2014-12-23 2017-01-27 Arkema France Copolymere dibloc hydrosoluble
US11219634B2 (en) 2015-01-21 2022-01-11 Genevant Sciences Gmbh Methods, compositions, and systems for delivering therapeutic and diagnostic agents into cells
US10792477B2 (en) 2016-02-08 2020-10-06 Orbusneich Medical Pte. Ltd. Drug eluting balloon
CA3032457A1 (en) 2016-08-12 2018-02-15 Purdue Research Foundation Polymer lung surfactants
KR102071912B1 (ko) * 2016-10-31 2020-01-31 주식회사 엘지화학 고분자 전해질 및 이를 포함하는 전기변색소자
US11684584B2 (en) 2016-12-30 2023-06-27 Genevant Sciences Gmbh Branched peg molecules and related compositions and methods
US11419947B2 (en) 2017-10-30 2022-08-23 Massachusetts Institute Of Technology Layer-by-layer nanoparticles for cytokine therapy in cancer treatment
CN107857846B (zh) * 2017-11-23 2019-10-11 常州大学 一种聚乙二醇接枝聚甲基丙烯酸丁酯两亲性接枝共聚物的制备方法
WO2021002984A1 (en) 2019-05-30 2021-01-07 Massachusetts Institute Of Technology Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids
WO2021217111A1 (en) 2020-04-24 2021-10-28 The Board Of Regents Of The University Of Texas System Ph responsive block copolymer compositions and micelles that inhibit mct 1 and related proteins
CN114163591B (zh) * 2021-11-29 2023-08-01 南方医科大学 一种嵌段共聚物、嵌段共聚物载药胶束及其制备方法和应用

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4016332A (en) * 1972-05-01 1977-04-05 Ppg Industries, Inc. Mercaptan blocked thermosetting copolymers
US3933940A (en) * 1973-02-08 1976-01-20 Ppg Industries, Inc. Mercaptan blocked thermosetting copolymers
GB1411843A (en) 1973-02-28 1975-10-29 Univ Strathclyde Method of modifying the properties of a polymer
GB1575343A (en) * 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
DE3001013A1 (de) * 1980-01-12 1981-07-23 Basf Ag, 6700 Ludwigshafen Vinylpyrrolidonpolymerisate, ihre herstellung und ihre verwendung zur herstellung von blutersatzfluessigkeiten
JPS5767860A (en) * 1980-10-15 1982-04-24 Fuji Photo Film Co Ltd Material for multilayer analysis
DE3378250D1 (en) * 1982-04-22 1988-11-24 Ici Plc Continuous release formulations
US4565854A (en) * 1983-04-07 1986-01-21 Kuraray Co., Ltd. Polymer having thiol end group
US4826689A (en) * 1984-05-21 1989-05-02 University Of Rochester Method for making uniformly sized particles from water-insoluble organic compounds
GB8416234D0 (en) * 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US6312679B1 (en) * 1986-08-18 2001-11-06 The Dow Chemical Company Dense star polymer conjugates as dyes
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
JP2517760B2 (ja) 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
US5041516A (en) * 1989-06-21 1991-08-20 Cornell Research Foundation, Inc. Dendritic molecules and method of production
US5206410A (en) * 1989-08-31 1993-04-27 University Of South Florida Multifunctional synthons as used in the preparation of cascade polymers or unimolecular micelles
US5154853A (en) * 1991-02-19 1992-10-13 University Of South Florida Unimolecular micelles and method of making the same
FR2678168B1 (fr) 1991-06-28 1993-09-03 Rhone Poulenc Rorer Sa Nanoparticules ayant un temps de capture par le dysteme reticulo endothelial allonge.
KR940003548U (ko) 1992-08-14 1994-02-21 김형술 세탁물 건조기
US5840319A (en) 1992-10-08 1998-11-24 Alakhov; Valery Yu Biological agent compositions
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
EP0639592A1 (de) 1993-08-18 1995-02-22 Nippon Shokubai Co., Ltd. Wasserlösliche Pfropfcopolymerisate und Verfahren zur Herstellung davon
MX9504664A (es) * 1994-03-07 1997-05-31 Dow Chemical Co Conjugados de dendrimeros bioactivos y/o dirigidos.
JP3631755B2 (ja) 1994-03-23 2005-03-23 明治製菓株式会社 ポリオキシエチレン含有脂質二本鎖誘導体
NL9401886A (nl) * 1994-05-27 1996-01-02 Dsm Nv Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof.
US5863919A (en) * 1994-07-25 1999-01-26 University Of South Florida Lock and key micelles and monomer building blocks therefor
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
US5997861A (en) 1994-10-31 1999-12-07 Burstein Laboratories, Inc. Antiviral supramolecules containing target-binding molecules and therapeutic molecules bound to spectrin
US5656611A (en) 1994-11-18 1997-08-12 Supratek Pharma Inc. Polynucleotide compositions
US6221959B1 (en) 1994-11-18 2001-04-24 Supratek Pharma, Inc. Polynucleotide compositions
AU4690596A (en) 1994-12-30 1996-07-24 Chiron Viagene, Inc. Nucleic acid condensing agents with reduced immunogenicity
US5492996A (en) * 1995-02-21 1996-02-20 The United States Of America As Represented By The Secretary Of The Air Force Alcohol soluble benzazole polymers
NZ305471A (en) 1995-04-19 2000-02-28 Kazunori Kataoka Use of heterotelechelic block copolymers as carriers for medicaments
US5908777A (en) 1995-06-23 1999-06-01 University Of Pittsburgh Lipidic vector for nucleic acid delivery
US6143211A (en) 1995-07-21 2000-11-07 Brown University Foundation Process for preparing microparticles through phase inversion phenomena
EP0842209B1 (de) * 1995-07-28 2006-10-11 Genzyme Corporation Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
NZ313769A (en) 1995-08-10 2000-02-28 Kazunori Kataoka block polymer having a functional group presented on each end
US5770627A (en) 1995-08-16 1998-06-23 University Of Washington Hydrophobically-modified bioadhesive polyelectrolytes and methods relating thereto
WO1997010814A1 (en) 1995-09-18 1997-03-27 Vesifact Ag Propofol nanodispersions
KR0180334B1 (ko) * 1995-09-21 1999-03-20 김윤 블럭 공중합체 미셀을 이용한 약물전달체 및 이에 약물을 봉입하는 방법
KR100413029B1 (ko) 1995-09-29 2004-04-30 가가쿠 기쥬츠 신코 지교단 신규안트라시클린화합물유도체및이를함유하는의약제제
US5702717A (en) 1995-10-25 1997-12-30 Macromed, Inc. Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers
ATE207798T1 (de) 1996-03-15 2001-11-15 Harvard College Verfahren zum formen von gegenständen und zum mikrostrukturieren von oberflächen durch giessformen mit kapillarwirkung
US5955509A (en) 1996-05-01 1999-09-21 Board Of Regents, The University Of Texas System pH dependent polymer micelles
JP2001508762A (ja) * 1996-06-27 2001-07-03 ジー．ディー．サール アンド カンパニー 架橋した外殻領域および内部芯領域を有する両親媒性コポリマーからなり、医薬およびその他の用途に有用な粒子
US6284267B1 (en) * 1996-08-14 2001-09-04 Nutrimed Biotech Amphiphilic materials and liposome formulations thereof
US6060518A (en) 1996-08-16 2000-05-09 Supratek Pharma Inc. Polymer compositions for chemotherapy and methods of treatment using the same
TW520297B (en) * 1996-10-11 2003-02-11 Sequus Pharm Inc Fusogenic liposome composition and method
GB9623051D0 (en) 1996-11-06 1997-01-08 Schacht Etienne H Delivery of DNA to target cells in biological systems
WO1998037902A1 (en) 1997-02-28 1998-09-03 The Regents Of The University Of California Inhibition of cell-cell binding by lipid assemblies
EP0963758A3 (de) 1998-05-07 2000-03-22 Universiteit Gent Synthetische polyamiosaure Komplexen zur Verabreichung von Nukleinsäuren zur Zielzellen
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
TR200100254T2 (tr) 1998-07-13 2001-06-21 Expression Genetics, Inc. Eriyebilir ve bakterilerle ayrışabilir bir gen iletim taşıyıcısı olarak poly-l-lysine benzeri bir poliyester.
IN191203B (de) * 1999-02-17 2003-10-04 Amarnath Prof Maitra
DE19919785A1 (de) * 1999-04-30 2000-12-07 Wella Ag Haarbehandlungsmittel mit Polymeren aus ungesättigten Sacchariden, ungesättigten Saccharidsäuren oder deren Derivaten
JP3523821B2 (ja) 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
DE10008895A1 (de) * 2000-02-25 2001-08-30 Beiersdorf Ag Stabilisierung oxidations- und/oder UV-empfindlicher Wirkstoffe
GB2359747B (en) * 2000-02-29 2002-04-24 Maelor Pharmaceuticals Ltd Anaesthetic formulations
AU2001276627A1 (en) 2000-05-17 2001-11-26 Labopharm Inc. Drug containing polymeric micelles
US6338859B1 (en) * 2000-06-29 2002-01-15 Labopharm Inc. Polymeric micelle compositions
IN188917B (de) 2000-12-07 2002-11-23 Bharat Surums & Vaccines Ltd
US6939564B2 (en) * 2001-06-08 2005-09-06 Labopharm, Inc. Water-soluble stabilized self-assembled polyelectrolytes
US7094810B2 (en) * 2001-06-08 2006-08-22 Labopharm, Inc. pH-sensitive block copolymers for pharmaceutical compositions
US6780428B2 (en) * 2001-06-08 2004-08-24 Labopharm, Inc. Unimolecular polymeric micelles with an ionizable inner core
AU2002302814A1 (en) * 2001-06-08 2002-12-23 Powderject Vaccines, Inc. Spray freeze-dried compositions
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
US6756449B2 (en) * 2002-02-27 2004-06-29 Medtronic, Inc. AnB block copolymers containing poly (vinyl pyrrolidone) units, medical devices, and methods
US6780324B2 (en) 2002-03-18 2004-08-24 Labopharm, Inc. Preparation of sterile stabilized nanodispersions
US7018655B2 (en) * 2002-03-18 2006-03-28 Labopharm, Inc. Amphiphilic diblock, triblock and star-block copolymers and their pharmaceutical compositions
WO2004035013A2 (en) 2002-10-21 2004-04-29 L'oreal Process for dissolving lipophilic compounds, and cosmetic composition
US7262253B2 (en) * 2003-12-02 2007-08-28 Labopharm, Inc. Process for the preparation of amphiphilic poly (N-vinyl-2-pyrrolidone) block copolymers
US20060198891A1 (en) * 2004-11-29 2006-09-07 Francois Ravenelle Solid formulations of liquid biologically active agents

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WO2002100439A1 (en) 2002-12-19
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JP2004534879A (ja) 2004-11-18
ES2257556T3 (es) 2006-08-01
MXPA03011296A (es) 2004-10-28
DK1465665T3 (da) 2006-05-08
US20070110709A1 (en) 2007-05-17
PT1465665E (pt) 2006-05-31
US20050244501A1 (en) 2005-11-03
US6939564B2 (en) 2005-09-06
ATE313335T1 (de) 2006-01-15
EP1465665A1 (de) 2004-10-13
CA2452806A1 (en) 2002-12-19
US7510731B2 (en) 2009-03-31
CA2452806C (en) 2011-12-13
BR0210284A (pt) 2004-07-20
JP4302509B2 (ja) 2009-07-29
US20030059398A1 (en) 2003-03-27

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