ITTO950554A0 - Diamidi aromatiche acide ad attivita' antigastrinica, procedimento perla loro preparazione e loro uso farmaceutico - Google Patents

Diamidi aromatiche acide ad attivita' antigastrinica, procedimento perla loro preparazione e loro uso farmaceutico

Info

Publication number
ITTO950554A0
ITTO950554A0 ITTO950554A ITTO950554A ITTO950554A0 IT TO950554 A0 ITTO950554 A0 IT TO950554A0 IT TO950554 A ITTO950554 A IT TO950554A IT TO950554 A ITTO950554 A IT TO950554A IT TO950554 A0 ITTO950554 A0 IT TO950554A0
Authority
IT
Italy
Prior art keywords
antigastrinic
activity
procedure
preparation
pharmaceutical use
Prior art date
Application number
ITTO950554A
Other languages
English (en)
Inventor
Francesco Makovec
Walter Peris
Lucio Rovati
Luigi Rovati
Original Assignee
Rotta Research Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rotta Research Lab filed Critical Rotta Research Lab
Publication of ITTO950554A0 publication Critical patent/ITTO950554A0/it
Priority to IT95TO000554A priority Critical patent/IT1276462B1/it
Priority to JP50479697A priority patent/JP4021481B2/ja
Priority to CA002224369A priority patent/CA2224369C/en
Priority to PCT/EP1996/002829 priority patent/WO1997002248A1/en
Priority to US08/981,804 priority patent/US5922875A/en
Priority to DK96923967T priority patent/DK0839137T3/da
Priority to AU64182/96A priority patent/AU702749B2/en
Priority to AT96923967T priority patent/ATE204257T1/de
Priority to DE69614553T priority patent/DE69614553T2/de
Priority to ES96923967T priority patent/ES2162086T3/es
Priority to EP96923967A priority patent/EP0839137B1/en
Priority to PT96923967T priority patent/PT839137E/pt
Publication of ITTO950554A1 publication Critical patent/ITTO950554A1/it
Application granted granted Critical
Publication of IT1276462B1 publication Critical patent/IT1276462B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)
IT95TO000554A 1995-07-03 1995-07-03 Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico IT1276462B1 (it)

Priority Applications (12)

Application Number Priority Date Filing Date Title
IT95TO000554A IT1276462B1 (it) 1995-07-03 1995-07-03 Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico
AU64182/96A AU702749B2 (en) 1995-07-03 1996-06-28 Aromatic acid diamides with antigastrin activity, a method for their preparation and their pharmaceutical use
DE69614553T DE69614553T2 (de) 1995-07-03 1996-06-28 Aromatische carbonsaürediamide mit antigastrin wirkung, ihre herstellung und pharmazeutische verwendung
PCT/EP1996/002829 WO1997002248A1 (en) 1995-07-03 1996-06-28 Aromatic acid diamides with antigastrin activity, a method for their preparation and their pharmaceutical use
US08/981,804 US5922875A (en) 1995-07-03 1996-06-28 Aromatic acid diamides with antigastrin activity, a method for their preparation and their pharmaceutical use
DK96923967T DK0839137T3 (da) 1995-07-03 1996-06-28 Aromatiske carboxylsyrediamider med antigastrinvirkning, fremgangsmåde til deres fremstilling samt deres anvendelse som lægemidler
JP50479697A JP4021481B2 (ja) 1995-07-03 1996-06-28 抗ガストリン活性を持つ芳香族酸ジアミド類、その製造法および医薬用途
AT96923967T ATE204257T1 (de) 1995-07-03 1996-06-28 Aromatische carbonsaürediamide mit antigastrin wirkung, ihre herstellung und pharmazeutische verwendung
CA002224369A CA2224369C (en) 1995-07-03 1996-06-28 Aromatic acid diamides with antigastrin activity, a method for their preparation and their pharmaceutical use
ES96923967T ES2162086T3 (es) 1995-07-03 1996-06-28 Diamidas acidas aromaticas con actividad antigastrina, un metodo para su preparacion y su uso farmaceutico.
EP96923967A EP0839137B1 (en) 1995-07-03 1996-06-28 Aromatic acid diamides with antigastrin activity, a method for their preparation and their pharmaceutical use
PT96923967T PT839137E (pt) 1995-07-03 1996-06-28 Diamidas acidas aromaticas com accao antigastrina um metodo para a sua preparacao e para o seu uso farmaceutico

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95TO000554A IT1276462B1 (it) 1995-07-03 1995-07-03 Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico

Publications (3)

Publication Number Publication Date
ITTO950554A0 true ITTO950554A0 (it) 1995-07-03
ITTO950554A1 ITTO950554A1 (it) 1997-01-03
IT1276462B1 IT1276462B1 (it) 1997-10-31

Family

ID=11413693

Family Applications (1)

Application Number Title Priority Date Filing Date
IT95TO000554A IT1276462B1 (it) 1995-07-03 1995-07-03 Diamidi aromatiche acide ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico

Country Status (12)

Country Link
US (1) US5922875A (it)
EP (1) EP0839137B1 (it)
JP (1) JP4021481B2 (it)
AT (1) ATE204257T1 (it)
AU (1) AU702749B2 (it)
CA (1) CA2224369C (it)
DE (1) DE69614553T2 (it)
DK (1) DK0839137T3 (it)
ES (1) ES2162086T3 (it)
IT (1) IT1276462B1 (it)
PT (1) PT839137E (it)
WO (1) WO1997002248A1 (it)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1286141B1 (it) * 1996-07-02 1998-07-07 Rotta Research Lab Derivati diammidici dell'acido antranilico ad attivita' antigastrinica procedimento per la loro preparazione e loro uso farmaceutico.
DE19935219A1 (de) 1999-07-27 2001-02-01 Boehringer Ingelheim Pharma Carbonsäureamide, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Herstellung
HUE028983T2 (en) 2010-05-06 2017-01-30 Vertex Pharma Heterocyclic chromene-spirocyclic piperidine amides as ion channel modulators
EP3056495A1 (en) 2011-02-02 2016-08-17 Vertex Pharmaceuticals Inc. Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
US10385070B2 (en) 2011-02-18 2019-08-20 Vertex Pharmaceuticals Incorporated Chroman-spirocyclic piperidine amides as modulators of ion channels
WO2012125613A1 (en) 2011-03-14 2012-09-20 Vertex Pharmaceuticals Incorporated Morpholine-spirocyclic piperidine amides as modulators of ion channels
UA111854C2 (uk) * 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1241029B (it) * 1990-12-11 1993-12-27 Rotta Research Lab Derivati amidici biciclici e policiclici degli acidi glutammico, aspartico e 2-ammino adipico ad attivita' antigastrinica e procedimento per la loro preparazione
IT1263116B (it) * 1992-04-09 1996-07-30 Rotta Research Lab Derivati basici dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso farmaceutico
IT1264765B1 (it) * 1993-03-10 1996-10-04 Rotta Research Lab Derivati dell'acido glutammico ed acido aspartico, procedimento per la loro preparazione e loro uso come farmaci potenzianti la
IT1261255B (it) * 1993-09-09 1996-05-09 Rotta Research Lab Derivati acidi poliamidici ad attivita' antigastrinica, procedimento per la loro preparazione e loro uso farmaceutico.

Also Published As

Publication number Publication date
WO1997002248A1 (en) 1997-01-23
JP4021481B2 (ja) 2007-12-12
EP0839137A1 (en) 1998-05-06
ITTO950554A1 (it) 1997-01-03
PT839137E (pt) 2001-11-30
AU702749B2 (en) 1999-03-04
AU6418296A (en) 1997-02-05
ATE204257T1 (de) 2001-09-15
ES2162086T3 (es) 2001-12-16
EP0839137B1 (en) 2001-08-16
JPH11508892A (ja) 1999-08-03
IT1276462B1 (it) 1997-10-31
CA2224369A1 (en) 1997-01-23
DE69614553D1 (de) 2001-09-20
US5922875A (en) 1999-07-13
CA2224369C (en) 2008-11-25
DK0839137T3 (da) 2001-10-08
DE69614553T2 (de) 2002-04-18

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