DK1383526T3 - Immuniseringsterapi til behandling af aterosklerose - Google Patents

Immuniseringsterapi til behandling af aterosklerose

Info

Publication number
DK1383526T3
DK1383526T3 DK02714667T DK02714667T DK1383526T3 DK 1383526 T3 DK1383526 T3 DK 1383526T3 DK 02714667 T DK02714667 T DK 02714667T DK 02714667 T DK02714667 T DK 02714667T DK 1383526 T3 DK1383526 T3 DK 1383526T3
Authority
DK
Denmark
Prior art keywords
treatment
atherosclerosis
immunization therapy
cardiovascular diseases
peptides
Prior art date
Application number
DK02714667T
Other languages
Danish (da)
English (en)
Inventor
Prediman K Shah
Jan Nilsson
Original Assignee
Forskarpatent I Syd Ab
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0101232A external-priority patent/SE0101232D0/xx
Application filed by Forskarpatent I Syd Ab, Cedars Sinai Medical Center filed Critical Forskarpatent I Syd Ab
Application granted granted Critical
Publication of DK1383526T3 publication Critical patent/DK1383526T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
DK02714667T 2001-04-05 2002-04-05 Immuniseringsterapi til behandling af aterosklerose DK1383526T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0101232A SE0101232D0 (sv) 2001-04-05 2001-04-05 Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein
SE0103754A SE0103754L (sv) 2001-04-05 2001-11-09 Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
PCT/SE2002/000679 WO2002080954A1 (fr) 2001-04-05 2002-04-05 Therapie d'immunisation a base de peptides destinee au traitement d'atherosclerose et developpement d'un dosage a base de peptides permettant de determiner des reponses immunitaires contre la lipoproteine faible densite oxydee

Publications (1)

Publication Number Publication Date
DK1383526T3 true DK1383526T3 (da) 2009-03-30

Family

ID=26655437

Family Applications (3)

Application Number Title Priority Date Filing Date
DK08151489.5T DK2006301T3 (da) 2001-04-05 2002-04-05 Peptid-baseret immuniseringsterapi til behandling af atherosklerose
DK02714667T DK1383526T3 (da) 2001-04-05 2002-04-05 Immuniseringsterapi til behandling af aterosklerose
DK10181267.5T DK2295464T3 (en) 2001-04-05 2002-04-05 Peptide-based immunization therapy for the treatment of atherosclerosis targeting ApoB100

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK08151489.5T DK2006301T3 (da) 2001-04-05 2002-04-05 Peptid-baseret immuniseringsterapi til behandling af atherosklerose

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10181267.5T DK2295464T3 (en) 2001-04-05 2002-04-05 Peptide-based immunization therapy for the treatment of atherosclerosis targeting ApoB100

Country Status (18)

Country Link
EP (42) EP2289925A1 (fr)
JP (6) JP2004529143A (fr)
CN (4) CN1505525B (fr)
AT (2) ATE510851T1 (fr)
AU (1) AU2002246484B8 (fr)
BR (1) BR0208685A (fr)
CA (3) CA2606839C (fr)
CY (1) CY1108817T1 (fr)
DE (1) DE60230029D1 (fr)
DK (3) DK2006301T3 (fr)
EE (2) EE200700052A (fr)
ES (2) ES2546293T3 (fr)
IL (4) IL158285A0 (fr)
PL (4) PL217858B1 (fr)
PT (1) PT1383526E (fr)
RU (1) RU2296582C2 (fr)
SE (1) SE0103754L (fr)
WO (1) WO2002080954A1 (fr)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
JP2005504085A (ja) 2001-09-28 2005-02-10 エスペリオン セラピューティクス，インコーポレイテッド 薬剤の局所投与による再狭窄の予防および治療
CA2500895A1 (fr) * 2002-10-04 2004-04-15 Forskarpatent I Syd Ab Therapie d'immunisation passive a base peptidique pour le traitement de l'atherosclerose
SE0302312D0 (sv) 2002-10-04 2003-08-27 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302422D0 (sv) * 2003-09-11 2003-09-11 Forskarpatent I Syd Ab Peptide-based immunization therapy for treatment of atherosclerosis
SE0400683D0 (sv) * 2004-03-19 2004-03-19 Forskarpatent I Syd Ab Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis
EP1732383A4 (fr) 2004-04-06 2007-05-02 Cedars Sinai Medical Center Prevention et traitement des maladies vasculaires avec des vecteurs de virus associes aux adenovirus de recombinaison codant l'apolipoproteine a-i et l'apolipoproteine a-i milano
PL1735349T3 (pl) 2004-04-15 2011-03-31 Athera Biotechnologies Ab Sposób oceny ryzyka niedokrwiennego schorzenia układu sercowo-naczyniowego za pomocą koniugatów fosforylocholiny
EP1676602A1 (fr) * 2005-01-04 2006-07-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Administration continue d'épitopes derivés de protéinse présentes dans la plaque atèrosclérotique pour le traitement de l'athérosclérose
GB0517878D0 (en) 2005-09-02 2005-10-12 Bioinvent Int Ab Immunotherapeutic treatment
JP2010515023A (ja) * 2006-12-22 2010-05-06 アボット・ラボラトリーズ 心血管系自己免疫疾患パネルおよびその使用方法
WO2008104194A1 (fr) * 2007-02-28 2008-09-04 Bioinvent International Ab Lipoprotéines de basse densité oxyde et leurs anticorps pour le traitement de plaques d'athérosclérose
AU2008225766B2 (en) 2007-03-15 2012-06-07 Novartis Ag Organic compounds and their uses
EP2538221A3 (fr) * 2007-11-05 2013-04-24 Nordic Bioscience A/S Marqueurs biochimiques pour évaluation de risque CVD
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
WO2010018870A1 (fr) * 2008-08-15 2010-02-18 藤倉化成株式会社 Marqueur polypeptidique pour le diagnostic de l'artériosclérose, procédé de détection de l'artériosclérose à l'aide du marqueur ou similaire, et trousse de diagnostic de l'artériosclérose
CA2780753A1 (fr) * 2009-11-14 2011-05-19 Kuang-Yuh Chyu Procedes et systemes d'immunomodulation pour le traitement et/ou la prevention de l'atherosclerose
US8506964B2 (en) * 2010-02-05 2013-08-13 Cardiovax, Llc Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis
WO2012024309A2 (fr) 2010-08-18 2012-02-23 Cedars-Sinai Medical Center Inhibition de l'athérosclérose par le biais de la modulation du phénotype des monocytes-macrophages en utilisant le transfert du gène apo a-i milano
US20130302362A1 (en) 2010-11-12 2013-11-14 Cedars-Sinai Medical Center Immunomodulatory Compositions, Methods and Systems Comprising Immunogenic Fragments of ApoB-100
CN103501806A (zh) * 2010-11-12 2014-01-08 赛达斯西奈医疗中心 用于治疗和/或预防动脉瘤的免疫调节方法和系统
CA2817543A1 (fr) * 2010-11-12 2012-06-07 Cedars-Sinai Medical Center Procedes et systemes immunomodulateurs pour le traitement et/ou la prevention de l'hypertension
PL2742068T3 (pl) 2011-08-09 2020-01-31 Athera Biotechnologies Ab Nowe przeciwciała przeciwko fosforylcholinie
US9796786B2 (en) 2011-08-09 2017-10-24 Athera Biotechnologies Ab Antibodies binding to phosphorylcholine (PC) and/or PC conjugates
RU2495048C1 (ru) * 2012-04-18 2013-10-10 Андрей Валентинович Исаев Пептид, обладающий антиатеросклеротическим действием и композиция для профилактики и лечения атеросклероза сосудов
JP6499967B2 (ja) * 2012-11-06 2019-04-10 レ オピト ユニベルシテル ドゥ ジュネーブＬｅｓ Ｈｏｐｉｔａｕｘ Ｕｎｉｖｅｒｓｉｔａｉｒｅｓ Ｄｅ Ｇｅｎｅｖｅ 模倣ペプチド
CN103520713B (zh) * 2013-10-16 2015-10-28 西北农林科技大学 一种ApoB100酵母重组疫苗及其制备方法和应用
CN103860470A (zh) * 2014-03-05 2014-06-18 贵州中泰生物科技有限公司 一种口服高密度脂蛋白脂质体的制备方法
CN105315364B (zh) * 2014-06-17 2018-09-18 广州文瑞生物科技有限公司 胶原蛋白vi疫苗预防动脉粥样硬化
US11130798B2 (en) 2015-05-19 2021-09-28 La Jolla Institute For Allergy And Immunology Human APOB100 epitopes, methods and uses for modulating inflammatory responses, and treating adverse cardiovascular events, disease and atherosclerosis
US10858422B2 (en) 2016-05-31 2020-12-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
CN108478817B (zh) * 2018-03-16 2020-10-27 北京大学 一种动脉粥样硬化检测试剂及其制备方法
WO2019232081A1 (fr) 2018-05-29 2019-12-05 Abcentra, Llc Compositions et procédés pour le traitement de la polyarthrite rhumatoïde et de l'athérosclérose accélérée

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4970144A (en) 1984-12-31 1990-11-13 International Genetic Engineering Peptide fragments of human apolipoprotein, type-specific antibodies and methods of use
US5972890A (en) 1988-05-02 1999-10-26 New England Deaconess Hospital Corporation Synthetic peptides for arterial imaging
WO1993018067A1 (fr) * 1992-03-06 1993-09-16 Abbott Laboratories Dosage par immunocapture pour quantification directe de niveaux de cholesterol de lipoproteines specifiques
WO1994000592A1 (fr) * 1992-06-26 1994-01-06 Exocell, Inc. Anticorps monoclonaux agissant contre des lipoproteines glycatees de faible densite
CA2142007C (fr) * 1992-08-11 2007-10-30 Robert Glen Urban Peptides immunomodulateurs
KR0185334B1 (ko) 1995-11-02 1999-04-01 김은영 인간 혈장 아포지단백질 비-100에 결합하는 생쥐 항체를 암호하는 씨디엔에이
GB9609702D0 (en) * 1996-05-09 1996-07-10 Royal Free Hosp School Med Anticoagulant peptides
GB9620153D0 (en) * 1996-09-27 1996-11-13 Univ Strathclyde Non-naturally occurring lipoprotein particle
GB9705831D0 (en) * 1997-03-20 1997-05-07 Univ Leicester Oxidised ldl
US6635623B1 (en) * 1997-06-13 2003-10-21 Baylor College Of Medicine Lipoproteins as nucleic acid vectors
US6225070B1 (en) 1997-08-07 2001-05-01 The Regents Of The University Of California Antibodies to oxidation-specific epitopes on lipoprotein and methods for their use in detecting, monitoring and inhibiting the growth of atheroma
US6156315A (en) * 1997-10-10 2000-12-05 The Trustees Of Columbia University In The City Of New York Method for inhibiting the binding of low density lipoprotein to blood vessel matrix
US6309844B1 (en) * 1997-10-15 2001-10-30 Fujirebio Inc. Anti-apo-B-48 monoclonal antibody, hybridoma producing the same, and method for measuring apo-B-48 using the same
CA2323056A1 (fr) * 1998-03-10 1999-09-16 Regents Of The University Of California Procedes et outils utilises pour identifier des composes qui modulent l'atherosclerose par alteration de la liaison ldl-proteoglycane
WO2000002920A1 (fr) * 1998-07-13 2000-01-20 University Of Otago Inhibition de la formation de lipoproteines
IL126447A (en) * 1998-10-04 2004-09-27 Vascular Biogenics Ltd An immune preparation that confers tolerance in oral administration and its use in the prevention and / or treatment of atherosclerosis
MXPA02004244A (es) * 1999-10-26 2002-11-04 Univ California Reactivos y metodos para el diagnostico, la formacion de imagenes y el tratamiento del padecimiento de la ateroesclerosis..
AU3087801A (en) * 2000-02-04 2001-08-14 Molecular Dynamics Inc Human genome-derived single exon nucleic acid probes useful for analysis of geneexpression in human breast and hbl 100 cells
CN1418106A (zh) * 2000-03-03 2003-05-14 史密丝克莱恩比彻姆生物有限公司 疫苗
SE0000855D0 (sv) * 2000-03-15 2000-03-15 Karolinska Innovations Ab Antigenic composition useful as a vaccine against atherosclerosis
GB0017641D0 (en) * 2000-07-18 2000-09-06 Medigene Oy Peptides and their use
EP1186299A1 (fr) * 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht Diagnostic, prévention et/ou traitement d' athérosclérose, infections et perturbations du système immunitaire
EP1592445A4 (fr) * 2000-10-25 2007-01-10 Vincent Agnello Procede d'inhibition de l'infection au virus de l'hepatite c (vhc) et autres virus de la famille des i flaviridae /i , et a tout autre virus formant dans le sang un complexe avec une lipoproteine de basse densite ou tres basse densite, par empechement de l'entree virale dans une cellule
AU2002241603A1 (en) * 2000-11-10 2002-06-03 University Of Utah Research Foundation Carrier system for specific artery wall gene delivery
SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
RU2003136090A (ru) * 2001-05-15 2005-04-20 Джэпэн Иммьюнорисерч Лэборэтериз Ко., Лтд (Jp) Пептид, взаимодействующий с липопротеином высокой плотности
JP2005504025A (ja) * 2001-07-20 2005-02-10 アイトゲネシシェ テクニシェ ホッヒシュル チューリッヒ（エーテーハーツェット） スルフォネート化またはスルフェート化アミノ酸から誘導された生物学的薬剤の使用法と組成物

Also Published As

Publication number Publication date
EP2147930A3 (fr) 2010-04-14
DK2295464T3 (en) 2015-08-17
SE0103754L (sv) 2002-10-06
CN101284874A (zh) 2008-10-15
EP2295458A1 (fr) 2011-03-16
AU2002246484B2 (en) 2007-04-19
EP2289927A1 (fr) 2011-03-02
EP2289931A1 (fr) 2011-03-02
CN101284874B (zh) 2012-10-03
SE0103754D0 (sv) 2001-11-09
EP2289924A1 (fr) 2011-03-02
EP2289934B1 (fr) 2013-11-13
CN101486766A (zh) 2009-07-22
CN103122031B (zh) 2015-07-22
JP2004529143A (ja) 2004-09-24
EP2147680A2 (fr) 2010-01-27
JP5300819B2 (ja) 2013-09-25
EP2295463A1 (fr) 2011-03-16
ATE510851T1 (de) 2011-06-15
EP2147928A3 (fr) 2010-04-14
EP2289925A1 (fr) 2011-03-02
JP2011068654A (ja) 2011-04-07
JP2008169215A (ja) 2008-07-24
IL158285A0 (en) 2004-05-12
EP2289929A1 (fr) 2011-03-02
EP2289922A1 (fr) 2011-03-02
JP2013144687A (ja) 2013-07-25
EP2147929A3 (fr) 2010-04-14
ES2317999T3 (es) 2009-05-01
CN1505525B (zh) 2012-11-07
EP2295461A1 (fr) 2011-03-16
CA2606839C (fr) 2015-06-09
CY1108817T1 (el) 2014-04-09
CA2443223A1 (fr) 2002-10-17
DE60230029D1 (de) 2009-01-08
EP2289913A1 (fr) 2011-03-02
PL217858B1 (pl) 2014-08-29
BR0208685A (pt) 2004-03-30
JP5300820B2 (ja) 2013-09-25
CN103122031A (zh) 2013-05-29
EP2289930A1 (fr) 2011-03-02
EP2289918A1 (fr) 2011-03-02
EP2295460B1 (fr) 2015-06-03
JP2011063598A (ja) 2011-03-31
EP2147928A2 (fr) 2010-01-27
IL158285A (en) 2009-12-24
EP2147680A3 (fr) 2010-04-14
EP2305706A1 (fr) 2011-04-06
EP2289926A1 (fr) 2011-03-02
EE200700052A (et) 2008-08-15
EP2006301A1 (fr) 2008-12-24
ATE415423T1 (de) 2008-12-15
EP2295464B1 (fr) 2015-06-03
DK2006301T3 (da) 2011-09-12
EP2289921A1 (fr) 2011-03-02
EP1918300A3 (fr) 2009-06-17
EP2295457A1 (fr) 2011-03-16
EP2305708A1 (fr) 2011-04-06
CN1505525A (zh) 2004-06-16
EP2289916A1 (fr) 2011-03-02
PT1383526E (pt) 2009-02-27
EP2289935A1 (fr) 2011-03-02
PL400308A1 (pl) 2012-12-17
ES2546293T3 (es) 2015-09-22
EP2147929A2 (fr) 2010-01-27
PL367301A1 (en) 2005-02-21
EP2289934A1 (fr) 2011-03-02
EP2147930A2 (fr) 2010-01-27
EP1383526B1 (fr) 2008-11-26
EE200300487A (et) 2004-02-16
RU2003132443A (ru) 2005-02-27
EP1918300A2 (fr) 2008-05-07
WO2002080954A1 (fr) 2002-10-17
CA2827167A1 (fr) 2002-10-17
AU2002246484A1 (en) 2002-10-21
EP2289933A1 (fr) 2011-03-02
CA2606839A1 (fr) 2002-10-17
IL188286A0 (en) 2008-03-20
EP1383526A1 (fr) 2004-01-28
EP2289932A1 (fr) 2011-03-02
EP2295459A1 (fr) 2011-03-16
EP2295464A1 (fr) 2011-03-16
EP2289928A1 (fr) 2011-03-02
EP2289919A1 (fr) 2011-03-02
EP2289912A1 (fr) 2011-03-02
EP2295460A1 (fr) 2011-03-16
EP2289923A1 (fr) 2011-03-02
EP2006301B1 (fr) 2011-05-25
EP2305707A1 (fr) 2011-04-06
AU2002246484B8 (en) 2007-06-14
RU2296582C2 (ru) 2007-04-10
EP2289914A1 (fr) 2011-03-02
EP2289920A1 (fr) 2011-03-02
PL215401B1 (pl) 2013-12-31
EP2289917A1 (fr) 2011-03-02
JP2009191078A (ja) 2009-08-27
JP5613890B2 (ja) 2014-10-29
IL195356A0 (en) 2009-08-03
CA2443223C (fr) 2013-11-26
EP2289915A1 (fr) 2011-03-02
EP2295462A1 (fr) 2011-03-16
JP5270456B2 (ja) 2013-08-21

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