DK13788A - Fremgangsmaade til fremstilling af et polypeptid - Google Patents

Fremgangsmaade til fremstilling af et polypeptid

Info

Publication number
DK13788A
DK13788A DK013788A DK13788A DK13788A DK 13788 A DK13788 A DK 13788A DK 013788 A DK013788 A DK 013788A DK 13788 A DK13788 A DK 13788A DK 13788 A DK13788 A DK 13788A
Authority
DK
Denmark
Prior art keywords
pct
polypeptide
secretion sequence
terminal secretion
preparing
Prior art date
Application number
DK013788A
Other languages
English (en)
Other versions
DK13788D0 (da
Inventor
Ian Barry Holland
Nigel Mackman
Jean-Marc Nicaud
Original Assignee
Ian Barry Holland
Nigel Mackman
Nicaud Jean Marc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ian Barry Holland, Nigel Mackman, Nicaud Jean Marc filed Critical Ian Barry Holland
Publication of DK13788D0 publication Critical patent/DK13788D0/da
Publication of DK13788A publication Critical patent/DK13788A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6478—Aspartic endopeptidases (3.4.23)
    • C12N9/6481—Pepsins (3.4.23.1; 3.4.23.2; 3.4.23.3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK013788A 1986-05-15 1988-01-13 Fremgangsmaade til fremstilling af et polypeptid DK13788A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868611832A GB8611832D0 (en) 1986-05-15 1986-05-15 Polypeptide
PCT/GB1987/000331 WO1987006953A1 (en) 1986-05-15 1987-05-14 Process for the production of a polypeptide

Publications (2)

Publication Number Publication Date
DK13788D0 DK13788D0 (da) 1988-01-13
DK13788A true DK13788A (da) 1988-03-15

Family

ID=10597902

Family Applications (1)

Application Number Title Priority Date Filing Date
DK013788A DK13788A (da) 1986-05-15 1988-01-13 Fremgangsmaade til fremstilling af et polypeptid

Country Status (9)

Country Link
US (1) US5143830A (da)
EP (1) EP0267224B1 (da)
JP (1) JPS63503274A (da)
AT (1) ATE80660T1 (da)
AU (1) AU600949B2 (da)
DE (1) DE3781765T2 (da)
DK (1) DK13788A (da)
GB (2) GB8611832D0 (da)
WO (1) WO1987006953A1 (da)

Families Citing this family (140)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
US5037743A (en) * 1988-08-05 1991-08-06 Zymogenetics, Inc. BAR1 secretion signal
US6210948B1 (en) 1992-06-09 2001-04-03 The University Of British Columbia Expression and secretion of heterologous polypeptides from caulobacter
US5914254A (en) * 1993-08-02 1999-06-22 Celtrix Pharmaceuticals, Inc. Expression of fusion polypeptides transported out of the cytoplasm without leader sequences
US5563046A (en) * 1993-08-02 1996-10-08 Celtrix Pharmaceuticals, Inc. Fusion polypeptides and proteins
US6214794B1 (en) 1994-12-02 2001-04-10 The Johns Hopkins University School Of Medicine Method of using hedgehog polypeptides to regulate neuronal cell growth
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US6911528B1 (en) * 1994-12-02 2005-06-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US6057091A (en) * 1994-12-02 2000-05-02 The Johns Hopkins University School Of Medicine Method of identifying compounds affecting hedgehog cholesterol transfer
JPH1075774A (ja) * 1996-05-31 1998-03-24 Akzo Nobel Nv パスツレラ科の弱毒化ｒｔｘ産生細菌
CA2269083C (en) 1996-10-16 2009-06-09 Zymogenetics, Inc. Novel fgf homologs
US6036953A (en) * 1996-11-29 2000-03-14 The General Hospital Corporation Heterologous antigens in live cell V. cholerae strains
WO1998042840A1 (en) 1997-03-24 1998-10-01 Zymogenetics, Inc. Motilin homologs
JP4047545B2 (ja) 1998-06-10 2008-02-13 ノボザイムス アクティーゼルスカブ 新規マンナナーゼ
EA201001190A1 (ru) 1998-09-23 2011-04-29 Займодженетикс, Инк. Выделенное антитело, специфически связанное с полипептидом, состоящее из последовательности аминокислотных остатков
WO2000034474A2 (en) 1998-12-07 2000-06-15 Zymogenetics, Inc. Growth factor homolog zvegf3
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
PT1642972E (pt) 1999-01-07 2010-04-07 Zymogenetics Inc Utilizações terapêuticas de receptores solúveis br43x2
CA2261186A1 (en) 1999-02-19 2000-08-19 University Of British Columbia Expression and secretion of heterologous polypeptides from freshwater caulobacter
UA84387C2 (ru) 1999-03-09 2008-10-27 Займодженетикс, Инк. Человеческий цитокин как лиганд зальфа рецептора и его применение
US6664386B1 (en) 1999-04-08 2003-12-16 The Research Foundation Of State University Of New York System for efficient secretion of recombinant proteins
EP2241623A3 (en) 1999-07-07 2010-12-01 ZymoGenetics, Inc. Monoclonal antibody against a human cytokine receptor
WO2001044289A2 (en) 1999-12-17 2001-06-21 University Of Guelph Office Of The Vice President Of Research Modified leukotoxin gene and protein
WO2001046422A1 (en) 1999-12-23 2001-06-28 Zymogenetics, Inc. Novel cytokine zcyto18
DK1749888T3 (da) 2000-04-05 2010-05-10 Zymogenetics Inc Opløselige Zalph11a-cytokinreceptorer
EP1325115B1 (en) 2000-06-26 2016-07-27 ZymoGenetics, Inc. Cytokine receptor zcytor17
US7795002B2 (en) * 2000-06-28 2010-09-14 Glycofi, Inc. Production of galactosylated glycoproteins in lower eukaryotes
US7863020B2 (en) 2000-06-28 2011-01-04 Glycofi, Inc. Production of sialylated N-glycans in lower eukaryotes
CN100448993C (zh) 2000-06-30 2009-01-07 津莫吉尼蒂克斯公司 干扰素样蛋白质Zcyto21
EP1736545A3 (en) 2000-08-08 2007-03-28 ZymoGenetics, Inc. Soluble zcytor 11 cytokine receptors
KR100447530B1 (ko) * 2001-08-14 2004-09-08 한국과학기술원 ＯｍｐＦ를 이용하여 목적 단백질을 대장균 세포외로분비생산하는 방법
EP2302063B1 (en) 2001-10-15 2016-05-04 EnGeneIC Molecular Delivery Pty Ltd. Intact minicells as vectors for DNA transfer and gene therapy in vitro and in vivo
EP2130919A1 (en) 2001-11-05 2009-12-09 ZymoGenetics, Inc. IL-21 antagonists
WO2003054155A2 (en) * 2001-12-19 2003-07-03 Bristol-Myers Squibb Company Pichia pastoris formate dehydrogenase and uses therefor
ES2546797T3 (es) 2002-01-18 2015-09-28 Zymogenetics, Inc. Multímeros Zcytor17 receptores de citocinas
RU2360923C2 (ru) 2002-01-18 2009-07-10 Займоджинетикс, Инк. Новый лиганд рецептора цитокина zcytor17
JP4409962B2 (ja) 2002-04-19 2010-02-03 ザイモジェネティクス，インコーポレイティド サイトカイン受容体
AU2003243415A1 (en) 2002-06-07 2003-12-22 Zymogenetics, Inc. Use of il-21 in cancer and other therapeutic applications
DE602004029868D1 (de) * 2003-03-05 2010-12-16 Chemo Sero Therapeut Res Inst Verfahren zur herstellung eines heterologen proteins in e. coli
US20040241677A1 (en) * 2003-05-29 2004-12-02 Lin Jeffrey S Techniques for automated diagnosis of cell-borne anomalies with digital optical microscope
ES2296423B1 (es) * 2003-07-31 2009-03-16 Consejo Sup. Investig. Cientificas Construccion de adn para la produccion de proteinas de fusion dimericas y sus aplicaciones.
DK1668031T3 (da) 2003-08-07 2008-06-30 Zymogenetics Inc Homogene præparater af IL-29
JP2007501813A (ja) 2003-08-08 2007-02-01 ノボ　ノルディスク　アクティーゼルスカブ 新生血管形成と関連した症状を治療および診断するためのインターロイキン−２０
EP2263684A1 (en) 2003-10-10 2010-12-22 Novo Nordisk A/S IL-21 derivatives
ES2428358T3 (es) 2003-10-17 2013-11-07 Novo Nordisk A/S Terapia de combinación
CA2549840C (en) 2003-12-09 2012-03-20 Engeneic Molecular Delivery Pty Ltd. Targeted gene delivery to non-phagocytic mammalian cells via bacterially derived intact minicells
ATE517914T1 (de) 2004-03-08 2011-08-15 Zymogenetics Inc Dimere fusionsproteine und materialien und verfahren zu deren herstellung
US7351689B2 (en) 2004-07-29 2008-04-01 Zymogenetics, Inc. Use of IL-28 and IL-29 to treat cancer and autoimmune disorders
AU2005268917B2 (en) 2004-08-02 2010-05-20 Basf Plant Science Gmbh Method for isolation of transcription termination sequences
SI2386640T1 (sl) 2004-08-26 2015-06-30 Engeneic Molecular Delivery Pty Ltd Dostava funkcionalnih nukleinskih kislin celicam sesalcev preko bakterijsko izvirajočih, intaktnih minicelic
CA2596390A1 (en) 2005-02-08 2006-08-17 Zymogenetics, Inc. Anti-il-20, anti-il-22 and anti-il-22ra antibodies and binding partners and methods of using in inflammation
EP1891107B1 (en) 2005-05-12 2011-07-06 ZymoGenetics, Inc. Compositions and methods for modulating immune responses
US7393667B2 (en) * 2005-05-31 2008-07-01 Bristol-Myers Squibb Company Stereoselective reduction process for the preparation of pyrrolotriazine compounds
EA016083B1 (ru) * 2005-08-09 2012-02-28 Займоджинетикс, Инк. СПОСОБ ЛЕЧЕНИЯ НЕХОДЖКИНСКОЙ ЛИМФОМЫ С ПОМОЩЬЮ СЛИТОЙ МОЛЕКУЛЫ TACI-Ig
WO2007019573A2 (en) 2005-08-09 2007-02-15 Zymogenetics, Inc. Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
CN101489573B (zh) * 2006-05-15 2013-05-22 阿雷斯贸易股份有限公司 用TACI-Ig融合分子治疗自身免疫疾病的方法
US9878043B2 (en) 2006-06-23 2018-01-30 Engeneic Molecular Delivery Pty Ltd Targeted delivery of drugs, therapeutic nucleic acids and functional nucleic acids to mammalian cells via intact killed bacterial cells
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
CA2686803C (en) * 2007-05-31 2016-05-03 Ezio Ghigo Unacylated ghrelin as therapeutic agent in the treatment of metabolic disorders
US8318664B2 (en) 2007-05-31 2012-11-27 Alize Pharma Sas Unacylated ghrelin fragments as therapeutic agent in the treatment of obesity
CA2971794C (en) 2007-10-04 2020-03-24 Zymogenetics, Inc. B7 family member zb7h6 and related compositions and methods
WO2009065415A1 (en) 2007-11-21 2009-05-28 Roskilde Universitet Polypeptides comprising an ice-binding activity
WO2009080054A1 (en) * 2007-12-21 2009-07-02 Ifxa A/S Protease inhibitor
DK2245052T3 (da) * 2008-01-25 2017-09-11 Univ Aarhus Selektiv exosite-inhibering af papp-a-aktivitet mod igfbp-4
SI2274008T1 (sl) 2008-03-27 2014-08-29 Zymogenetics, Inc. Sestavki in metode za zaviranje PDGFRBETA in VEGF-A
CN102131517B (zh) 2008-06-27 2014-12-17 津莫吉尼蒂克斯公司 可溶性杂合Fc γ受体和相关的方法
EP2318515A4 (en) 2008-08-06 2012-11-14 Emergent Product Dev Uk Ltd DIFFICULT CLOSTRIDIUM VACCINES, AND METHODS OF USE
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US8241623B1 (en) 2009-02-09 2012-08-14 David Bermudes Protease sensitivity expression system
US8771669B1 (en) 2010-02-09 2014-07-08 David Gordon Bermudes Immunization and/or treatment of parasites and infectious agents by live bacteria
US8524220B1 (en) 2010-02-09 2013-09-03 David Gordon Bermudes Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
EP2580238A1 (en) 2010-06-09 2013-04-17 Zymogenetics, Inc. Dimeric vstm3 fusion proteins and related compositions and methods
US9428565B2 (en) 2011-01-31 2016-08-30 The General Hospital Corporation Treatment and bioluminescent visualization using multimodal TRAIL molecules
EP2583975A1 (en) * 2011-10-21 2013-04-24 Heinrich-Heine-Universität Düsseldorf Agents and methods for the expression and secretion of peptides and proteins
EP3597764A3 (en) 2012-02-01 2020-05-06 SGI-DNA, Inc. Material and methods for the synthesis of error-minimized nucleic acid molecules
WO2014018113A1 (en) 2012-07-24 2014-01-30 The General Hospital Corporation Oncolytic virus therapy for resistant tumors
EP2890720B1 (en) 2012-08-30 2019-07-17 The General Hospital Corporation Compositions and methods for treating cancer
EP2893004B1 (en) 2012-09-04 2018-10-24 Cellectis Multi-chain chimeric antigen receptor and uses thereof
US9593339B1 (en) 2013-02-14 2017-03-14 David Gordon Bermudes Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment
JP6465794B2 (ja) * 2013-04-25 2019-02-06 株式会社カネカ Ｆａｂ型抗体の分泌量を増大できるＦｄ鎖遺伝子又はＬ鎖遺伝子
MX2015015662A (es) 2013-05-13 2016-09-16 Cellectis Receptor quimérico de antígeno especifico para cd19 y sus usos.
WO2014202089A2 (en) 2013-06-18 2014-12-24 Roskilde Universitet Variants of anti-freeze polypeptides
WO2015089280A1 (en) 2013-12-11 2015-06-18 The General Hospital Corporation Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors
EP3808410A1 (en) 2013-12-20 2021-04-21 Cellectis Method of engineering multi-input signal sensitive t cell for immunotherapy
US9737592B1 (en) 2014-02-14 2017-08-22 David Gordon Bermudes Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment
ES2740903T3 (es) 2014-03-19 2020-02-07 Cellectis Receptores antigénicos quiméricos específicos de CD123 para inmunoterapia del cáncer
CA2947646A1 (en) 2014-05-02 2015-11-05 Cellectis Cs1 specific multi-chain chimeric antigen receptor
EA034081B1 (ru) 2014-07-29 2019-12-25 Селлектис Ror1-(ntrkr1)-специфические химерные антигенные рецепторы для иммунотерапии рака
JP2017522893A (ja) 2014-07-31 2017-08-17 セレクティスＣｅｌｌｅｃｔｉｓ Ｒｏｒ１特異的多重鎖キメラ抗原受容体
EP3699188A1 (en) 2014-09-04 2020-08-26 Cellectis 5t4 (tpbg) specific chimeric antigen receptors for cancer immunotherapy
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
MX2017009181A (es) 2015-01-26 2017-11-22 Cellectis Receptores de antigenos quimericos de cadena sencilla especificos de anti-cll1 para inmunoterapia de cancer.
US10294304B2 (en) 2015-04-13 2019-05-21 Pfizer Inc. Chimeric antigen receptors targeting B-cell maturation antigen
US20180112006A1 (en) 2015-04-17 2018-04-26 The General Hospital Corporation Agents, systems and methods for treating cancer
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US10752670B2 (en) 2015-05-20 2020-08-25 Cellectis Anti-GD3 specific chimeric antigen receptors for cancer immunotherapy
CA2997263C (en) 2015-09-08 2022-10-04 Theripion, Inc. Apoa-1 fusion polypeptides and related compositions and methods
NZ744821A (en) 2016-01-21 2023-06-30 Pfizer Chimeric antigen receptors targeting epidermal growth factor receptor variant iii
CN110022905B (zh) 2016-10-06 2024-02-06 安吉尼科分子传输公司 用于递送核酸佐剂的细菌小细胞和使用其的方法
WO2018073394A1 (en) 2016-10-19 2018-04-26 Cellectis Cell death inducing chimeric antigen receptors
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
WO2018136163A2 (en) 2016-12-09 2018-07-26 Theripion, Inc. Tandem apoa-1 fusion polypeptides
CN110869046A (zh) 2017-03-31 2020-03-06 塞勒克提斯公司 通用型抗cd22嵌合抗原受体工程化的免疫细胞
WO2018193394A1 (en) 2017-04-19 2018-10-25 Allogene Therapeutics, Inc. Improved t cell compositions and methods
PE20241587A1 (es) 2017-06-02 2024-08-01 Pfizer Inc Receptores de antigenos quimericos que se dirigen a flt3
AU2018292181A1 (en) 2017-06-30 2020-01-23 Cellectis Cellular immunotherapy for repetitive administration
US11725060B2 (en) 2017-07-20 2023-08-15 Aptevo Reserch and Development LLC Antigen binding proteins binding to 5T4 and 4-1BB and related compositions and methods
WO2019072824A1 (en) 2017-10-09 2019-04-18 Cellectis IMPROVED ANTI-CD123 CAR IN UNIVERSAL MODIFIED IMMUNE T LYMPHOCYTES
WO2019089844A1 (en) 2017-11-01 2019-05-09 Allogene Therapeutics, Inc. Modified caspase-9 polypeptides and methods of use thereof
CA3085861C (en) 2017-12-20 2023-09-26 Harbour Biomed (Shanghai) Co., Ltd Antibodies binding ctla-4 and uses thereof
CA3082769A1 (en) 2017-12-27 2019-07-04 Imunami Laboratories Pte. Ltd. Recombinant polypeptides and methods of use thereof
US10150801B1 (en) 2017-12-27 2018-12-11 Imunami Laboratories Pte. Ltd. Recombinant polypeptides and methods of use thereof
BR112020015641A2 (pt) 2018-02-01 2021-01-05 Pfizer Inc. Anticorpos específicos para cd70 e seus usos
WO2019152742A1 (en) 2018-02-01 2019-08-08 Pfizer Inc. Chimeric antigen receptors targeting cd70
CA3091681A1 (en) 2018-03-02 2019-09-06 Allogene Therapeutics, Inc. Inducible chimeric cytokine receptors
EP3817767A1 (en) 2018-07-02 2021-05-12 Cellectis Chimeric antigen receptors (car)-expressing cells and combination treatment for immunotherapy of patients with relapse refractory adverse genetic risk aml
EP3880307A1 (en) 2018-11-14 2021-09-22 Fundación Pública Andaluza Progreso Y Salud Polynucleotide for safer and more effective immunotherapies
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
EP4013506A1 (en) 2019-08-12 2022-06-22 Aptevo Research and Development LLC 4-1bb and ox40 binding proteins and related compositions and methods, antibodies against 4-1bb, antibodies against ox40
US10675332B1 (en) 2019-08-26 2020-06-09 Imunami Laboratories Pte. Ltd. Recombinant polypeptides and methods of use thereof
WO2021040610A1 (en) 2019-08-26 2021-03-04 Imunami Laboratories Pte. Ltd. Recombinant polypeptides and methods of use thereof
WO2021185968A1 (en) 2020-03-18 2021-09-23 Numaferm Gmbh Fragments of hlya and uses thereof
EP3882260A1 (en) * 2020-03-18 2021-09-22 NUMAFERM GmbH Fragments of hlya and uses thereof
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
CN116568317A (zh) 2020-06-22 2023-08-08 免疫实验室私人有限公司 用于癌症治疗的重组多肽和组合
WO2022020456A2 (en) 2020-07-21 2022-01-27 Allogene Therapeutics, Inc. Chimeric antigen receptors with enhanced signaling and activities and uses thereof
WO2022058640A1 (es) 2020-09-21 2022-03-24 Fundación Pública Andaluza Progreso Y Salud Polinucleótido para expresión fisiológica en células t
WO2022119976A1 (en) 2020-12-01 2022-06-09 Aptevo Research And Development Llc Heterodimeric psma and cd3-binding bispecific antibodies
JP2024500189A (ja) 2020-12-21 2024-01-04 アロジーン セラピューティクス，インコーポレイテッド プロテアーゼ活性化ｃｄ４５ゲートｃａｒ
JP2024505075A (ja) 2021-01-29 2024-02-02 アロジーン セラピューティクス，インコーポレイテッド 同種細胞産物のＴ細胞認識を軽減するための、ＴＡＰ２、ＮＬＲＣ５、β２ｍ、ＴＲＡＣ、ＲＦＸ５、ＲＦＸＡＰ及びＲＦＸＡＮＫのうち１つ以上のノックダウン又はノックアウト
WO2022178090A2 (en) 2021-02-19 2022-08-25 Theripion, Inc. Dnase fusion polypeptides and related compositions and methods
US20220281950A1 (en) 2021-03-04 2022-09-08 Allogene Therapeutics, Inc. Fasl expression and fasr gene knockout to protect therapeutic cells from allogeneic rejection and activation-induced cell death
US20240228553A1 (en) 2021-03-18 2024-07-11 Numaferm Gmbh Fusion proteins comprising gg repeat sequences
AU2022292640A1 (en) 2021-06-15 2023-11-30 Allogene Therapeutics, Inc. Selective targeting of host cd70+ alloreactive cells to prolong allogeneic car t cell persistence
AU2023244350A1 (en) 2022-03-29 2024-09-05 Allogene Therapeutics Inc. Chimeric switch receptors for the conversion of immunesuppressive signals to costimulatory signals
WO2024026445A1 (en) 2022-07-29 2024-02-01 Allogene Therapeutics Inc. Engineered cells with reduced gene expression to mitigate immune cell recognition
EP4339202A1 (en) 2022-09-16 2024-03-20 NUMAFERM GmbH Fusion proteins comprising gg repeat sequences ii
WO2024148328A2 (en) 2023-01-06 2024-07-11 Aptevo Research And Development Llc Bispecific pd-l1 and cd40 binding molecules and uses thereof

Also Published As

Publication number Publication date
JPS63503274A (ja) 1988-12-02
DE3781765D1 (de) 1992-10-22
AU7392387A (en) 1987-12-01
GB8800141D0 (en) 1988-03-02
DK13788D0 (da) 1988-01-13
EP0267224B1 (en) 1992-09-16
WO1987006953A1 (en) 1987-11-19
GB8611832D0 (en) 1986-06-25
GB2197324A (da) 1988-05-18
GB2197324B (en) 1990-04-11
EP0267224A1 (en) 1988-05-18
US5143830A (en) 1992-09-01
AU600949B2 (en) 1990-08-30
ATE80660T1 (de) 1992-10-15
DE3781765T2 (de) 1993-04-22

Similar Documents

Publication Publication Date Title
DK13788D0 (da) Fremgangsmaade til fremstilling af et polypeptid
DK0423302T3 (da) Anvendelse af hidtil ukendte DNA-fragmenter som kodende sekvens for et signalpeptid til sekretion af modne proteiner i rekombinant gær, ekspressionskassetter, transformeret gær og tilsvarende fremgangsmåde til fremstilling af proteiner
ATE46536T1 (de) Verfahren zur herstellung von reifen proteinen in wirtzellen von wirbeltieren.
DE69128285D1 (de) Expression rekombinanter polypeptide mit verbesserter möglichkeit zur reinigung
DK219087D0 (da) Vektorsystem til brug ved transformation af trichoderma, transformerede trichodermastammer og fremgangsmaade til fremstilling af proteiner heri
DK161152C (da) Polypeptid med egenskaber som human beta-nervevaekstfaktor og fremgangsmaade til fremstilling deraf, dna-isolat omfattende en sekvens som koder for polypeptidet, replicerbar udtrykkelsesvektor for dna-sekvensen, rekombinant vaertscelle transformeret med vektoren, farmaceutisk praeparat indeholdende polypeptidet og fremg. der omfatter anvendelsen af polypeptidet til fremst. af et farmaceutisk praeparat
HU9203449D0 (en) Varied cd44 surfacial proteins, dna sequences coding them, antibodies acting against these proteins as well as application of all these things in diagnostics and therapy
DK645887A (da) Gamma-hesteinterferon, fremgangsmaade til fremstilling af, samt anvendelse af en saadan forbindelse
DE69233463D1 (de) Expression und reinigung von kloniertem humanen alpha-fetoprotein
DE3881023D1 (de) Proteine, expressionsvektoren, die fuer solche proteine kodierende dna enthalten und zellen, die solche expressionsvektoren enthalten.
NO930428L (no) Proteinstrukturen til plantetoksingelonin
DE3877035D1 (de) Gentechnologisches verfahren zur herstellung von polypeptiden.
DK35888D0 (da) Fremgangsmaade til fremstilling af rekombinant polypeptider
FI861559A (fi) Menetelmä hepatitis B-viruksen pinta-antigeenin PreS1-PreS2-S-proteiinin koodaavan alueen koodaamia proteiineja käsittävän proteiinin valmistamiseksi sekä menetelmässä käytettävät yhdistelmä-DNA-vektorit ja -kontameerit sekä nisäkässolut

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment